Amino acid dipepetide frequency for Paracoccus chinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.785AlaAla: 20.785 ± 0.241
1.085AlaCys: 1.085 ± 0.031
7.169AlaAsp: 7.169 ± 0.084
9.759AlaGlu: 9.759 ± 0.122
3.925AlaPhe: 3.925 ± 0.066
12.136AlaGly: 12.136 ± 0.115
2.356AlaHis: 2.356 ± 0.053
5.75AlaIle: 5.75 ± 0.091
2.748AlaLys: 2.748 ± 0.067
15.42AlaLeu: 15.42 ± 0.158
3.934AlaMet: 3.934 ± 0.064
2.337AlaAsn: 2.337 ± 0.049
7.165AlaPro: 7.165 ± 0.12
4.988AlaGln: 4.988 ± 0.069
11.087AlaArg: 11.087 ± 0.13
5.692AlaSer: 5.692 ± 0.081
6.361AlaThr: 6.361 ± 0.091
9.201AlaVal: 9.201 ± 0.101
1.752AlaTrp: 1.752 ± 0.046
2.242AlaTyr: 2.242 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.026CysAla: 1.026 ± 0.033
0.102CysCys: 0.102 ± 0.011
0.516CysAsp: 0.516 ± 0.02
0.397CysGlu: 0.397 ± 0.021
0.27CysPhe: 0.27 ± 0.014
0.911CysGly: 0.911 ± 0.033
0.257CysHis: 0.257 ± 0.017
0.351CysIle: 0.351 ± 0.018
0.137CysLys: 0.137 ± 0.012
0.783CysLeu: 0.783 ± 0.028
0.171CysMet: 0.171 ± 0.015
0.188CysAsn: 0.188 ± 0.014
0.517CysPro: 0.517 ± 0.027
0.209CysGln: 0.209 ± 0.013
0.601CysArg: 0.601 ± 0.026
0.399CysSer: 0.399 ± 0.021
0.394CysThr: 0.394 ± 0.022
0.529CysVal: 0.529 ± 0.024
0.103CysTrp: 0.103 ± 0.008
0.148CysTyr: 0.148 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.192AspAla: 7.192 ± 0.103
0.53AspCys: 0.53 ± 0.022
3.227AspAsp: 3.227 ± 0.06
3.563AspGlu: 3.563 ± 0.069
2.108AspPhe: 2.108 ± 0.037
5.11AspGly: 5.11 ± 0.072
1.426AspHis: 1.426 ± 0.035
2.502AspIle: 2.502 ± 0.048
1.28AspLys: 1.28 ± 0.038
6.423AspLeu: 6.423 ± 0.076
1.398AspMet: 1.398 ± 0.038
1.091AspAsn: 1.091 ± 0.037
4.143AspPro: 4.143 ± 0.062
1.713AspGln: 1.713 ± 0.043
5.22AspArg: 5.22 ± 0.07
2.155AspSer: 2.155 ± 0.051
2.577AspThr: 2.577 ± 0.058
3.586AspVal: 3.586 ± 0.059
1.183AspTrp: 1.183 ± 0.034
1.426AspTyr: 1.426 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
8.832GluAla: 8.832 ± 0.112
0.299GluCys: 0.299 ± 0.017
3.111GluAsp: 3.111 ± 0.07
3.106GluGlu: 3.106 ± 0.07
1.595GluPhe: 1.595 ± 0.041
5.505GluGly: 5.505 ± 0.091
1.001GluHis: 1.001 ± 0.035
3.191GluIle: 3.191 ± 0.057
1.519GluLys: 1.519 ± 0.042
5.334GluLeu: 5.334 ± 0.074
1.626GluMet: 1.626 ± 0.033
1.428GluAsn: 1.428 ± 0.032
3.001GluPro: 3.001 ± 0.061
1.955GluGln: 1.955 ± 0.043
4.916GluArg: 4.916 ± 0.069
2.158GluSer: 2.158 ± 0.048
3.295GluThr: 3.295 ± 0.052
4.315GluVal: 4.315 ± 0.075
0.757GluTrp: 0.757 ± 0.024
0.87GluTyr: 0.87 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.209PheAla: 4.209 ± 0.065
0.383PheCys: 0.383 ± 0.019
2.442PheAsp: 2.442 ± 0.044
1.749PheGlu: 1.749 ± 0.041
1.171PhePhe: 1.171 ± 0.04
3.378PheGly: 3.378 ± 0.066
0.733PheHis: 0.733 ± 0.029
1.34PheIle: 1.34 ± 0.041
0.636PheLys: 0.636 ± 0.025
3.211PheLeu: 3.211 ± 0.061
0.713PheMet: 0.713 ± 0.028
0.821PheAsn: 0.821 ± 0.029
1.52PhePro: 1.52 ± 0.04
0.913PheGln: 0.913 ± 0.032
2.361PheArg: 2.361 ± 0.05
1.739PheSer: 1.739 ± 0.041
1.851PheThr: 1.851 ± 0.044
2.457PheVal: 2.457 ± 0.051
0.553PheTrp: 0.553 ± 0.027
0.749PheTyr: 0.749 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.882GlyAla: 10.882 ± 0.115
0.803GlyCys: 0.803 ± 0.031
4.703GlyAsp: 4.703 ± 0.071
4.968GlyGlu: 4.968 ± 0.077
3.545GlyPhe: 3.545 ± 0.056
7.908GlyGly: 7.908 ± 0.123
1.968GlyHis: 1.968 ± 0.048
4.534GlyIle: 4.534 ± 0.066
2.593GlyLys: 2.593 ± 0.056
9.712GlyLeu: 9.712 ± 0.116
2.754GlyMet: 2.754 ± 0.049
2.124GlyAsn: 2.124 ± 0.057
4.228GlyPro: 4.228 ± 0.07
3.313GlyGln: 3.313 ± 0.052
7.375GlyArg: 7.375 ± 0.097
4.257GlySer: 4.257 ± 0.08
4.981GlyThr: 4.981 ± 0.082
6.276GlyVal: 6.276 ± 0.077
1.657GlyTrp: 1.657 ± 0.04
2.063GlyTyr: 2.063 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.437HisAla: 2.437 ± 0.051
0.21HisCys: 0.21 ± 0.015
1.281HisAsp: 1.281 ± 0.037
1.113HisGlu: 1.113 ± 0.034
0.692HisPhe: 0.692 ± 0.027
2.077HisGly: 2.077 ± 0.048
0.591HisHis: 0.591 ± 0.027
0.743HisIle: 0.743 ± 0.031
0.379HisLys: 0.379 ± 0.018
2.187HisLeu: 2.187 ± 0.052
0.517HisMet: 0.517 ± 0.022
0.368HisAsn: 0.368 ± 0.017
1.57HisPro: 1.57 ± 0.039
0.54HisGln: 0.54 ± 0.024
1.591HisArg: 1.591 ± 0.043
0.812HisSer: 0.812 ± 0.03
0.693HisThr: 0.693 ± 0.027
1.623HisVal: 1.623 ± 0.035
0.332HisTrp: 0.332 ± 0.019
0.507HisTyr: 0.507 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.744IleAla: 6.744 ± 0.085
0.487IleCys: 0.487 ± 0.022
3.138IleAsp: 3.138 ± 0.058
3.239IleGlu: 3.239 ± 0.055
1.517IlePhe: 1.517 ± 0.035
4.4IleGly: 4.4 ± 0.065
0.925IleHis: 0.925 ± 0.031
1.741IleIle: 1.741 ± 0.045
0.964IleLys: 0.964 ± 0.033
4.455IleLeu: 4.455 ± 0.072
1.001IleMet: 1.001 ± 0.032
1.08IleAsn: 1.08 ± 0.031
2.327IlePro: 2.327 ± 0.041
1.02IleGln: 1.02 ± 0.029
3.575IleArg: 3.575 ± 0.059
2.327IleSer: 2.327 ± 0.054
2.472IleThr: 2.472 ± 0.052
3.593IleVal: 3.593 ± 0.067
0.63IleTrp: 0.63 ± 0.025
0.94IleTyr: 0.94 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.163LysAla: 3.163 ± 0.068
0.13LysCys: 0.13 ± 0.011
1.293LysAsp: 1.293 ± 0.038
1.054LysGlu: 1.054 ± 0.04
0.607LysPhe: 0.607 ± 0.024
2.297LysGly: 2.297 ± 0.056
0.427LysHis: 0.427 ± 0.017
1.113LysIle: 1.113 ± 0.036
0.749LysLys: 0.749 ± 0.032
2.29LysLeu: 2.29 ± 0.058
0.604LysMet: 0.604 ± 0.024
0.549LysAsn: 0.549 ± 0.023
1.486LysPro: 1.486 ± 0.042
0.709LysGln: 0.709 ± 0.026
1.727LysArg: 1.727 ± 0.046
1.209LysSer: 1.209 ± 0.031
1.359LysThr: 1.359 ± 0.039
1.75LysVal: 1.75 ± 0.043
0.294LysTrp: 0.294 ± 0.017
0.438LysTyr: 0.438 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
15.149LeuAla: 15.149 ± 0.146
0.852LeuCys: 0.852 ± 0.03
6.416LeuAsp: 6.416 ± 0.085
4.792LeuGlu: 4.792 ± 0.077
3.113LeuPhe: 3.113 ± 0.055
9.071LeuGly: 9.071 ± 0.101
1.857LeuHis: 1.857 ± 0.038
4.894LeuIle: 4.894 ± 0.076
2.625LeuLys: 2.625 ± 0.053
9.108LeuLeu: 9.108 ± 0.125
2.659LeuMet: 2.659 ± 0.059
2.341LeuAsn: 2.341 ± 0.044
6.37LeuPro: 6.37 ± 0.086
2.623LeuGln: 2.623 ± 0.044
8.24LeuArg: 8.24 ± 0.103
6.522LeuSer: 6.522 ± 0.085
6.048LeuThr: 6.048 ± 0.082
7.404LeuVal: 7.404 ± 0.091
1.353LeuTrp: 1.353 ± 0.036
1.849LeuTyr: 1.849 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.636MetAla: 3.636 ± 0.062
0.139MetCys: 0.139 ± 0.012
1.385MetAsp: 1.385 ± 0.038
1.203MetGlu: 1.203 ± 0.036
0.706MetPhe: 0.706 ± 0.027
2.346MetGly: 2.346 ± 0.046
0.431MetHis: 0.431 ± 0.022
1.441MetIle: 1.441 ± 0.037
0.786MetLys: 0.786 ± 0.025
2.662MetLeu: 2.662 ± 0.061
0.74MetMet: 0.74 ± 0.027
0.785MetAsn: 0.785 ± 0.021
1.545MetPro: 1.545 ± 0.033
0.915MetGln: 0.915 ± 0.029
2.05MetArg: 2.05 ± 0.043
1.503MetSer: 1.503 ± 0.035
2.074MetThr: 2.074 ± 0.044
1.765MetVal: 1.765 ± 0.041
0.235MetTrp: 0.235 ± 0.015
0.281MetTyr: 0.281 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.847AsnAla: 2.847 ± 0.057
0.231AsnCys: 0.231 ± 0.015
1.27AsnAsp: 1.27 ± 0.048
0.996AsnGlu: 0.996 ± 0.035
0.722AsnPhe: 0.722 ± 0.027
2.079AsnGly: 2.079 ± 0.045
0.462AsnHis: 0.462 ± 0.019
1.102AsnIle: 1.102 ± 0.032
0.469AsnLys: 0.469 ± 0.022
2.386AsnLeu: 2.386 ± 0.042
0.552AsnMet: 0.552 ± 0.022
0.502AsnAsn: 0.502 ± 0.022
1.786AsnPro: 1.786 ± 0.04
0.57AsnGln: 0.57 ± 0.026
1.767AsnArg: 1.767 ± 0.042
0.944AsnSer: 0.944 ± 0.031
1.031AsnThr: 1.031 ± 0.031
1.529AsnVal: 1.529 ± 0.037
0.402AsnTrp: 0.402 ± 0.02
0.517AsnTyr: 0.517 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.998ProAla: 7.998 ± 0.133
0.377ProCys: 0.377 ± 0.02
4.072ProAsp: 4.072 ± 0.071
4.586ProGlu: 4.586 ± 0.076
1.907ProPhe: 1.907 ± 0.043
5.559ProGly: 5.559 ± 0.071
1.157ProHis: 1.157 ± 0.037
2.05ProIle: 2.05 ± 0.052
1.193ProLys: 1.193 ± 0.037
5.119ProLeu: 5.119 ± 0.068
1.359ProMet: 1.359 ± 0.035
1.146ProAsn: 1.146 ± 0.034
3.188ProPro: 3.188 ± 0.073
2.031ProGln: 2.031 ± 0.046
3.876ProArg: 3.876 ± 0.069
2.64ProSer: 2.64 ± 0.053
2.465ProThr: 2.465 ± 0.05
4.982ProVal: 4.982 ± 0.076
0.778ProTrp: 0.778 ± 0.03
1.031ProTyr: 1.031 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.796GlnAla: 4.796 ± 0.078
0.15GlnCys: 0.15 ± 0.013
1.609GlnAsp: 1.609 ± 0.041
1.366GlnGlu: 1.366 ± 0.032
0.937GlnPhe: 0.937 ± 0.028
3.221GlnGly: 3.221 ± 0.051
0.543GlnHis: 0.543 ± 0.023
1.709GlnIle: 1.709 ± 0.044
0.834GlnLys: 0.834 ± 0.033
2.705GlnLeu: 2.705 ± 0.054
0.975GlnMet: 0.975 ± 0.032
0.775GlnAsn: 0.775 ± 0.027
2.011GlnPro: 2.011 ± 0.048
1.128GlnGln: 1.128 ± 0.039
2.396GlnArg: 2.396 ± 0.045
1.537GlnSer: 1.537 ± 0.033
1.655GlnThr: 1.655 ± 0.04
2.602GlnVal: 2.602 ± 0.052
0.381GlnTrp: 0.381 ± 0.017
0.48GlnTyr: 0.48 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
10.129ArgAla: 10.129 ± 0.106
0.525ArgCys: 0.525 ± 0.023
4.712ArgAsp: 4.712 ± 0.074
4.439ArgGlu: 4.439 ± 0.063
2.771ArgPhe: 2.771 ± 0.052
5.567ArgGly: 5.567 ± 0.074
1.901ArgHis: 1.901 ± 0.048
4.323ArgIle: 4.323 ± 0.071
1.955ArgLys: 1.955 ± 0.049
9.149ArgLeu: 9.149 ± 0.117
2.367ArgMet: 2.367 ± 0.05
1.799ArgAsn: 1.799 ± 0.038
4.494ArgPro: 4.494 ± 0.087
2.822ArgGln: 2.822 ± 0.059
6.82ArgArg: 6.82 ± 0.091
3.585ArgSer: 3.585 ± 0.068
3.434ArgThr: 3.434 ± 0.056
5.465ArgVal: 5.465 ± 0.075
1.213ArgTrp: 1.213 ± 0.033
1.55ArgTyr: 1.55 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.084SerAla: 6.084 ± 0.083
0.409SerCys: 0.409 ± 0.022
2.749SerAsp: 2.749 ± 0.048
2.383SerGlu: 2.383 ± 0.047
1.98SerPhe: 1.98 ± 0.045
5.194SerGly: 5.194 ± 0.084
1.009SerHis: 1.009 ± 0.035
2.073SerIle: 2.073 ± 0.042
1.003SerLys: 1.003 ± 0.034
4.785SerLeu: 4.785 ± 0.072
1.187SerMet: 1.187 ± 0.03
1.07SerAsn: 1.07 ± 0.037
2.83SerPro: 2.83 ± 0.053
1.376SerGln: 1.376 ± 0.038
3.596SerArg: 3.596 ± 0.059
2.283SerSer: 2.283 ± 0.061
2.257SerThr: 2.257 ± 0.046
3.5SerVal: 3.5 ± 0.056
0.68SerTrp: 0.68 ± 0.028
1.047SerTyr: 1.047 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.413ThrAla: 6.413 ± 0.091
0.426ThrCys: 0.426 ± 0.02
2.987ThrAsp: 2.987 ± 0.054
2.886ThrGlu: 2.886 ± 0.054
1.567ThrPhe: 1.567 ± 0.038
5.467ThrGly: 5.467 ± 0.074
1.08ThrHis: 1.08 ± 0.029
2.43ThrIle: 2.43 ± 0.047
0.966ThrLys: 0.966 ± 0.035
5.793ThrLeu: 5.793 ± 0.075
1.211ThrMet: 1.211 ± 0.032
1.126ThrAsn: 1.126 ± 0.034
3.556ThrPro: 3.556 ± 0.064
1.458ThrGln: 1.458 ± 0.038
3.906ThrArg: 3.906 ± 0.066
2.389ThrSer: 2.389 ± 0.046
2.744ThrThr: 2.744 ± 0.064
4.266ThrVal: 4.266 ± 0.068
0.657ThrTrp: 0.657 ± 0.025
1.005ThrTyr: 1.005 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.743ValAla: 9.743 ± 0.113
0.559ValCys: 0.559 ± 0.024
3.636ValAsp: 3.636 ± 0.059
4.524ValGlu: 4.524 ± 0.069
2.539ValPhe: 2.539 ± 0.048
5.438ValGly: 5.438 ± 0.089
1.342ValHis: 1.342 ± 0.036
3.954ValIle: 3.954 ± 0.072
1.561ValLys: 1.561 ± 0.045
7.917ValLeu: 7.917 ± 0.095
2.095ValMet: 2.095 ± 0.052
1.732ValAsn: 1.732 ± 0.039
4.019ValPro: 4.019 ± 0.061
2.292ValGln: 2.292 ± 0.045
4.977ValArg: 4.977 ± 0.08
3.697ValSer: 3.697 ± 0.07
4.895ValThr: 4.895 ± 0.071
5.779ValVal: 5.779 ± 0.085
0.974ValTrp: 0.974 ± 0.035
1.25ValTyr: 1.25 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.492TrpAla: 1.492 ± 0.045
0.115TrpCys: 0.115 ± 0.01
0.756TrpAsp: 0.756 ± 0.03
0.601TrpGlu: 0.601 ± 0.026
0.573TrpPhe: 0.573 ± 0.023
1.054TrpGly: 1.054 ± 0.037
0.338TrpHis: 0.338 ± 0.018
0.698TrpIle: 0.698 ± 0.026
0.407TrpLys: 0.407 ± 0.02
1.879TrpLeu: 1.879 ± 0.046
0.397TrpMet: 0.397 ± 0.02
0.42TrpAsn: 0.42 ± 0.021
0.751TrpPro: 0.751 ± 0.028
0.634TrpGln: 0.634 ± 0.026
1.338TrpArg: 1.338 ± 0.038
0.757TrpSer: 0.757 ± 0.024
0.872TrpThr: 0.872 ± 0.03
0.922TrpVal: 0.922 ± 0.031
0.252TrpTrp: 0.252 ± 0.018
0.229TrpTyr: 0.229 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.335TyrAla: 2.335 ± 0.043
0.196TyrCys: 0.196 ± 0.013
1.382TyrAsp: 1.382 ± 0.031
1.09TyrGlu: 1.09 ± 0.029
0.685TyrPhe: 0.685 ± 0.023
1.922TyrGly: 1.922 ± 0.049
0.458TyrHis: 0.458 ± 0.02
0.638TyrIle: 0.638 ± 0.027
0.446TyrLys: 0.446 ± 0.021
1.968TyrLeu: 1.968 ± 0.046
0.367TyrMet: 0.367 ± 0.02
0.483TyrAsn: 0.483 ± 0.02
1.008TyrPro: 1.008 ± 0.033
0.599TyrGln: 0.599 ± 0.023
1.599TyrArg: 1.599 ± 0.038
0.893TyrSer: 0.893 ± 0.03
0.877TyrThr: 0.877 ± 0.03
1.381TyrVal: 1.381 ± 0.037
0.296TyrTrp: 0.296 ± 0.018
0.492TyrTyr: 0.492 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3544 proteins (1077329 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski