Amino acid dipepetide frequency for Halomonas olivaria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.67AlaAla: 11.67 ± 0.106	1.298AlaCys: 1.298 ± 0.036	5.345AlaAsp: 5.345 ± 0.059	6.738AlaGlu: 6.738 ± 0.087	4.017AlaPhe: 4.017 ± 0.054	8.104AlaGly: 8.104 ± 0.09	2.262AlaHis: 2.262 ± 0.038	5.694AlaIle: 5.694 ± 0.07	3.352AlaLys: 3.352 ± 0.06	13.538AlaLeu: 13.538 ± 0.129	3.538AlaMet: 3.538 ± 0.051	3.178AlaAsn: 3.178 ± 0.049	4.617AlaPro: 4.617 ± 0.059	4.378AlaGln: 4.378 ± 0.068	6.375AlaArg: 6.375 ± 0.075	6.546AlaSer: 6.546 ± 0.076	5.624AlaThr: 5.624 ± 0.073	7.174AlaVal: 7.174 ± 0.084	1.753AlaTrp: 1.753 ± 0.043	2.49AlaTyr: 2.49 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.033CysAla: 1.033 ± 0.026	0.265CysCys: 0.265 ± 0.014	0.588CysAsp: 0.588 ± 0.022	0.526CysGlu: 0.526 ± 0.021	0.422CysPhe: 0.422 ± 0.02	0.95CysGly: 0.95 ± 0.025	0.339CysHis: 0.339 ± 0.015	0.453CysIle: 0.453 ± 0.018	0.254CysLys: 0.254 ± 0.013	1.186CysLeu: 1.186 ± 0.031	0.361CysMet: 0.361 ± 0.015	0.234CysAsn: 0.234 ± 0.013	0.602CysPro: 0.602 ± 0.022	0.445CysGln: 0.445 ± 0.018	0.854CysArg: 0.854 ± 0.024	0.695CysSer: 0.695 ± 0.021	0.481CysThr: 0.481 ± 0.018	0.722CysVal: 0.722 ± 0.023	0.265CysTrp: 0.265 ± 0.013	0.311CysTyr: 0.311 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.747AspAla: 5.747 ± 0.07	0.428AspCys: 0.428 ± 0.018	3.252AspAsp: 3.252 ± 0.056	3.728AspGlu: 3.728 ± 0.059	1.94AspPhe: 1.94 ± 0.039	3.935AspGly: 3.935 ± 0.058	1.31AspHis: 1.31 ± 0.031	3.086AspIle: 3.086 ± 0.048	1.609AspLys: 1.609 ± 0.038	4.777AspLeu: 4.777 ± 0.06	1.35AspMet: 1.35 ± 0.034	1.746AspAsn: 1.746 ± 0.04	2.593AspPro: 2.593 ± 0.044	2.095AspGln: 2.095 ± 0.038	2.815AspArg: 2.815 ± 0.047	2.859AspSer: 2.859 ± 0.049	2.8AspThr: 2.8 ± 0.043	3.813AspVal: 3.813 ± 0.056	0.836AspTrp: 0.836 ± 0.024	1.605AspTyr: 1.605 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.137GluAla: 7.137 ± 0.088	0.469GluCys: 0.469 ± 0.017	2.622GluAsp: 2.622 ± 0.045	4.02GluGlu: 4.02 ± 0.076	1.672GluPhe: 1.672 ± 0.033	4.434GluGly: 4.434 ± 0.058	1.704GluHis: 1.704 ± 0.032	3.026GluIle: 3.026 ± 0.056	1.982GluLys: 1.982 ± 0.044	6.461GluLeu: 6.461 ± 0.082	1.543GluMet: 1.543 ± 0.026	1.815GluAsn: 1.815 ± 0.038	2.403GluPro: 2.403 ± 0.044	3.657GluGln: 3.657 ± 0.051	5.121GluArg: 5.121 ± 0.072	3.277GluSer: 3.277 ± 0.05	3.076GluThr: 3.076 ± 0.043	4.194GluVal: 4.194 ± 0.054	0.95GluTrp: 0.95 ± 0.026	1.292GluTyr: 1.292 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.608PheAla: 3.608 ± 0.056	0.455PheCys: 0.455 ± 0.016	2.309PheAsp: 2.309 ± 0.042	2.113PheGlu: 2.113 ± 0.039	1.259PhePhe: 1.259 ± 0.03	3.107PheGly: 3.107 ± 0.047	0.828PheHis: 0.828 ± 0.024	2.035PheIle: 2.035 ± 0.04	1.11PheLys: 1.11 ± 0.033	2.943PheLeu: 2.943 ± 0.055	1.102PheMet: 1.102 ± 0.03	1.267PheAsn: 1.267 ± 0.029	1.505PhePro: 1.505 ± 0.033	1.227PheGln: 1.227 ± 0.032	1.781PheArg: 1.781 ± 0.04	2.616PheSer: 2.616 ± 0.045	2.083PheThr: 2.083 ± 0.044	2.379PheVal: 2.379 ± 0.045	0.557PheTrp: 0.557 ± 0.021	1.021PheTyr: 1.021 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.009GlyAla: 7.009 ± 0.081	1.004GlyCys: 1.004 ± 0.031	3.984GlyAsp: 3.984 ± 0.06	5.018GlyGlu: 5.018 ± 0.069	3.186GlyPhe: 3.186 ± 0.053	5.865GlyGly: 5.865 ± 0.079	1.955GlyHis: 1.955 ± 0.042	4.554GlyIle: 4.554 ± 0.061	2.836GlyLys: 2.836 ± 0.049	8.463GlyLeu: 8.463 ± 0.086	2.549GlyMet: 2.549 ± 0.045	2.283GlyAsn: 2.283 ± 0.044	2.384GlyPro: 2.384 ± 0.037	3.09GlyGln: 3.09 ± 0.049	4.73GlyArg: 4.73 ± 0.068	4.614GlySer: 4.614 ± 0.062	3.624GlyThr: 3.624 ± 0.061	5.942GlyVal: 5.942 ± 0.072	1.343GlyTrp: 1.343 ± 0.033	2.468GlyTyr: 2.468 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.397HisAla: 2.397 ± 0.041	0.349HisCys: 0.349 ± 0.015	1.319HisAsp: 1.319 ± 0.033	1.203HisGlu: 1.203 ± 0.03	1.053HisPhe: 1.053 ± 0.028	1.972HisGly: 1.972 ± 0.04	0.821HisHis: 0.821 ± 0.027	1.071HisIle: 1.071 ± 0.028	0.61HisLys: 0.61 ± 0.021	2.585HisLeu: 2.585 ± 0.045	0.574HisMet: 0.574 ± 0.02	0.646HisAsn: 0.646 ± 0.025	1.507HisPro: 1.507 ± 0.038	1.165HisGln: 1.165 ± 0.026	1.562HisArg: 1.562 ± 0.031	1.376HisSer: 1.376 ± 0.037	1.147HisThr: 1.147 ± 0.028	1.362HisVal: 1.362 ± 0.035	0.431HisTrp: 0.431 ± 0.017	0.862HisTyr: 0.862 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.245IleAla: 6.245 ± 0.071	0.543IleCys: 0.543 ± 0.022	3.408IleAsp: 3.408 ± 0.055	3.691IleGlu: 3.691 ± 0.062	1.61IlePhe: 1.61 ± 0.035	4.457IleGly: 4.457 ± 0.07	1.053IleHis: 1.053 ± 0.03	2.499IleIle: 2.499 ± 0.049	1.556IleLys: 1.556 ± 0.036	4.101IleLeu: 4.101 ± 0.057	1.203IleMet: 1.203 ± 0.032	2.025IleAsn: 2.025 ± 0.042	2.412IlePro: 2.412 ± 0.042	1.646IleGln: 1.646 ± 0.035	2.83IleArg: 2.83 ± 0.044	3.413IleSer: 3.413 ± 0.045	3.097IleThr: 3.097 ± 0.046	3.515IleVal: 3.515 ± 0.058	0.594IleTrp: 0.594 ± 0.019	1.244IleTyr: 1.244 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.49LysAla: 3.49 ± 0.059	0.265LysCys: 0.265 ± 0.014	1.249LysAsp: 1.249 ± 0.037	1.721LysGlu: 1.721 ± 0.041	0.638LysPhe: 0.638 ± 0.023	2.291LysGly: 2.291 ± 0.04	0.766LysHis: 0.766 ± 0.023	1.315LysIle: 1.315 ± 0.029	0.955LysLys: 0.955 ± 0.028	3.155LysLeu: 3.155 ± 0.051	0.785LysMet: 0.785 ± 0.025	0.774LysAsn: 0.774 ± 0.024	1.836LysPro: 1.836 ± 0.039	1.469LysGln: 1.469 ± 0.038	2.81LysArg: 2.81 ± 0.045	1.773LysSer: 1.773 ± 0.038	1.667LysThr: 1.667 ± 0.032	2.209LysVal: 2.209 ± 0.043	0.392LysTrp: 0.392 ± 0.016	0.56LysTyr: 0.56 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.139LeuAla: 13.139 ± 0.131	1.194LeuCys: 1.194 ± 0.031	5.996LeuAsp: 5.996 ± 0.075	6.711LeuGlu: 6.711 ± 0.091	3.941LeuPhe: 3.941 ± 0.059	8.353LeuGly: 8.353 ± 0.084	2.22LeuHis: 2.22 ± 0.041	5.771LeuIle: 5.771 ± 0.074	3.839LeuLys: 3.839 ± 0.06	11.958LeuLeu: 11.958 ± 0.139	3.081LeuMet: 3.081 ± 0.048	3.679LeuAsn: 3.679 ± 0.053	6.444LeuPro: 6.444 ± 0.078	3.427LeuGln: 3.427 ± 0.053	6.391LeuArg: 6.391 ± 0.073	7.438LeuSer: 7.438 ± 0.083	6.405LeuThr: 6.405 ± 0.068	7.504LeuVal: 7.504 ± 0.077	1.377LeuTrp: 1.377 ± 0.036	2.423LeuTyr: 2.423 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.595MetAla: 3.595 ± 0.057	0.223MetCys: 0.223 ± 0.011	1.204MetAsp: 1.204 ± 0.032	1.393MetGlu: 1.393 ± 0.03	0.797MetPhe: 0.797 ± 0.027	2.217MetGly: 2.217 ± 0.039	0.583MetHis: 0.583 ± 0.02	1.485MetIle: 1.485 ± 0.033	0.925MetLys: 0.925 ± 0.025	3.218MetLeu: 3.218 ± 0.054	0.815MetMet: 0.815 ± 0.022	0.866MetAsn: 0.866 ± 0.029	1.634MetPro: 1.634 ± 0.039	1.225MetGln: 1.225 ± 0.034	1.795MetArg: 1.795 ± 0.038	1.956MetSer: 1.956 ± 0.036	1.769MetThr: 1.769 ± 0.034	2.17MetVal: 2.17 ± 0.047	0.279MetTrp: 0.279 ± 0.014	0.405MetTyr: 0.405 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.518AsnAla: 3.518 ± 0.049	0.285AsnCys: 0.285 ± 0.014	1.766AsnAsp: 1.766 ± 0.037	1.707AsnGlu: 1.707 ± 0.037	0.977AsnPhe: 0.977 ± 0.029	2.442AsnGly: 2.442 ± 0.048	0.69AsnHis: 0.69 ± 0.023	1.575AsnIle: 1.575 ± 0.037	0.77AsnLys: 0.77 ± 0.022	2.844AsnLeu: 2.844 ± 0.047	0.717AsnMet: 0.717 ± 0.023	1.004AsnAsn: 1.004 ± 0.03	1.815AsnPro: 1.815 ± 0.035	1.35AsnGln: 1.35 ± 0.031	1.977AsnArg: 1.977 ± 0.039	1.687AsnSer: 1.687 ± 0.036	1.593AsnThr: 1.593 ± 0.031	2.164AsnVal: 2.164 ± 0.042	0.45AsnTrp: 0.45 ± 0.02	0.818AsnTyr: 0.818 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.825ProAla: 4.825 ± 0.063	0.498ProCys: 0.498 ± 0.017	2.773ProAsp: 2.773 ± 0.046	3.576ProGlu: 3.576 ± 0.057	1.755ProPhe: 1.755 ± 0.039	3.944ProGly: 3.944 ± 0.058	1.077ProHis: 1.077 ± 0.028	2.383ProIle: 2.383 ± 0.042	1.523ProLys: 1.523 ± 0.036	5.774ProLeu: 5.774 ± 0.076	1.457ProMet: 1.457 ± 0.032	1.502ProAsn: 1.502 ± 0.038	2.311ProPro: 2.311 ± 0.044	1.826ProGln: 1.826 ± 0.038	2.684ProArg: 2.684 ± 0.048	3.179ProSer: 3.179 ± 0.046	2.675ProThr: 2.675 ± 0.044	3.513ProVal: 3.513 ± 0.052	0.91ProTrp: 0.91 ± 0.028	1.101ProTyr: 1.101 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	5.435GlnAla: 5.435 ± 0.074	0.382GlnCys: 0.382 ± 0.017	1.705GlnAsp: 1.705 ± 0.036	2.283GlnGlu: 2.283 ± 0.041	1.157GlnPhe: 1.157 ± 0.03	3.208GlnGly: 3.208 ± 0.047	1.212GlnHis: 1.212 ± 0.03	1.763GlnIle: 1.763 ± 0.037	1.016GlnLys: 1.016 ± 0.03	5.06GlnLeu: 5.06 ± 0.071	1.039GlnMet: 1.039 ± 0.027	0.973GlnAsn: 0.973 ± 0.031	2.096GlnPro: 2.096 ± 0.031	2.796GlnGln: 2.796 ± 0.052	3.797GlnArg: 3.797 ± 0.057	2.173GlnSer: 2.173 ± 0.044	1.94GlnThr: 1.94 ± 0.04	2.985GlnVal: 2.985 ± 0.047	0.764GlnTrp: 0.764 ± 0.022	0.795GlnTyr: 0.795 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.509ArgAla: 5.509 ± 0.065	0.886ArgCys: 0.886 ± 0.027	3.439ArgAsp: 3.439 ± 0.047	4.274ArgGlu: 4.274 ± 0.057	2.767ArgPhe: 2.767 ± 0.045	3.929ArgGly: 3.929 ± 0.052	2.074ArgHis: 2.074 ± 0.045	3.218ArgIle: 3.218 ± 0.05	1.805ArgLys: 1.805 ± 0.046	8.19ArgLeu: 8.19 ± 0.095	2.035ArgMet: 2.035 ± 0.036	1.732ArgAsn: 1.732 ± 0.039	2.766ArgPro: 2.766 ± 0.052	3.329ArgGln: 3.329 ± 0.058	4.753ArgArg: 4.753 ± 0.075	3.497ArgSer: 3.497 ± 0.053	2.709ArgThr: 2.709 ± 0.045	4.167ArgVal: 4.167 ± 0.056	1.328ArgTrp: 1.328 ± 0.036	2.222ArgTyr: 2.222 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.313SerAla: 6.313 ± 0.07	0.604SerCys: 0.604 ± 0.022	3.191SerAsp: 3.191 ± 0.057	3.426SerGlu: 3.426 ± 0.06	2.173SerPhe: 2.173 ± 0.038	5.316SerGly: 5.316 ± 0.062	1.448SerHis: 1.448 ± 0.03	2.936SerIle: 2.936 ± 0.046	1.57SerLys: 1.57 ± 0.036	7.047SerLeu: 7.047 ± 0.078	1.732SerMet: 1.732 ± 0.037	1.664SerAsn: 1.664 ± 0.038	3.228SerPro: 3.228 ± 0.05	2.636SerGln: 2.636 ± 0.048	3.994SerArg: 3.994 ± 0.047	3.821SerSer: 3.821 ± 0.067	3.222SerThr: 3.222 ± 0.05	4.242SerVal: 4.242 ± 0.055	0.894SerTrp: 0.894 ± 0.023	1.45SerTyr: 1.45 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.496ThrAla: 5.496 ± 0.069	0.523ThrCys: 0.523 ± 0.018	2.494ThrAsp: 2.494 ± 0.039	2.392ThrGlu: 2.392 ± 0.043	1.893ThrPhe: 1.893 ± 0.045	4.138ThrGly: 4.138 ± 0.06	1.276ThrHis: 1.276 ± 0.03	2.466ThrIle: 2.466 ± 0.042	1.18ThrLys: 1.18 ± 0.035	7.505ThrLeu: 7.505 ± 0.079	1.299ThrMet: 1.299 ± 0.031	1.426ThrAsn: 1.426 ± 0.029	3.676ThrPro: 3.676 ± 0.052	2.306ThrGln: 2.306 ± 0.044	3.156ThrArg: 3.156 ± 0.045	3.125ThrSer: 3.125 ± 0.048	3.043ThrThr: 3.043 ± 0.05	3.496ThrVal: 3.496 ± 0.059	0.816ThrTrp: 0.816 ± 0.026	1.194ThrTyr: 1.194 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.701ValAla: 7.701 ± 0.08	0.714ValCys: 0.714 ± 0.022	3.82ValAsp: 3.82 ± 0.059	4.41ValGlu: 4.41 ± 0.055	2.512ValPhe: 2.512 ± 0.046	5.281ValGly: 5.281 ± 0.072	1.333ValHis: 1.333 ± 0.035	4.073ValIle: 4.073 ± 0.055	2.168ValLys: 2.168 ± 0.047	7.299ValLeu: 7.299 ± 0.088	2.236ValMet: 2.236 ± 0.044	2.28ValAsn: 2.28 ± 0.046	3.261ValPro: 3.261 ± 0.045	2.108ValGln: 2.108 ± 0.04	3.822ValArg: 3.822 ± 0.052	4.504ValSer: 4.504 ± 0.055	4.13ValThr: 4.13 ± 0.059	5.655ValVal: 5.655 ± 0.075	0.933ValTrp: 0.933 ± 0.027	1.571ValTyr: 1.571 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.303TrpAla: 1.303 ± 0.035	0.264TrpCys: 0.264 ± 0.014	0.543TrpAsp: 0.543 ± 0.021	0.726TrpGlu: 0.726 ± 0.026	0.561TrpPhe: 0.561 ± 0.02	0.931TrpGly: 0.931 ± 0.027	0.42TrpHis: 0.42 ± 0.019	0.716TrpIle: 0.716 ± 0.023	0.518TrpLys: 0.518 ± 0.019	2.284TrpLeu: 2.284 ± 0.048	0.544TrpMet: 0.544 ± 0.02	0.41TrpAsn: 0.41 ± 0.017	0.867TrpPro: 0.867 ± 0.028	1.079TrpGln: 1.079 ± 0.026	1.338TrpArg: 1.338 ± 0.033	0.877TrpSer: 0.877 ± 0.026	0.556TrpThr: 0.556 ± 0.017	1.05TrpVal: 1.05 ± 0.026	0.303TrpTrp: 0.303 ± 0.014	0.345TrpTyr: 0.345 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.523TyrAla: 2.523 ± 0.037	0.335TyrCys: 0.335 ± 0.014	1.317TyrAsp: 1.317 ± 0.033	1.199TyrGlu: 1.199 ± 0.033	0.975TyrPhe: 0.975 ± 0.028	2.029TyrGly: 2.029 ± 0.037	0.645TyrHis: 0.645 ± 0.023	1.023TyrIle: 1.023 ± 0.03	0.541TyrLys: 0.541 ± 0.02	2.902TyrLeu: 2.902 ± 0.041	0.592TyrMet: 0.592 ± 0.018	0.645TyrAsn: 0.645 ± 0.02	1.327TyrPro: 1.327 ± 0.034	1.323TyrGln: 1.323 ± 0.03	2.042TyrArg: 2.042 ± 0.047	1.485TyrSer: 1.485 ± 0.036	1.259TyrThr: 1.259 ± 0.029	1.554TyrVal: 1.554 ± 0.037	0.458TyrTrp: 0.458 ± 0.019	0.745TyrTyr: 0.745 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7365 proteins (1383111 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---