Amino acid dipepetide frequency for Myotis davidii (David s myotis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.681AlaAla: 6.681 ± 0.05	1.485AlaCys: 1.485 ± 0.021	2.948AlaAsp: 2.948 ± 0.026	4.683AlaGlu: 4.683 ± 0.042	2.643AlaPhe: 2.643 ± 0.024	4.828AlaGly: 4.828 ± 0.035	1.726AlaHis: 1.726 ± 0.035	2.82AlaIle: 2.82 ± 0.02	3.417AlaLys: 3.417 ± 0.034	7.436AlaLeu: 7.436 ± 0.046	1.564AlaMet: 1.564 ± 0.016	2.01AlaAsn: 2.01 ± 0.016	4.397AlaPro: 4.397 ± 0.038	3.392AlaGln: 3.392 ± 0.032	3.736AlaArg: 3.736 ± 0.029	5.847AlaSer: 5.847 ± 0.034	3.567AlaThr: 3.567 ± 0.029	4.82AlaVal: 4.82 ± 0.032	0.855AlaTrp: 0.855 ± 0.014	1.532AlaTyr: 1.532 ± 0.014	0.013AlaXaa: 0.013 ± 0.001
Cys	1.341CysAla: 1.341 ± 0.016	0.612CysCys: 0.612 ± 0.013	0.995CysAsp: 0.995 ± 0.016	1.256CysGlu: 1.256 ± 0.017	0.835CysPhe: 0.835 ± 0.01	1.773CysGly: 1.773 ± 0.027	0.681CysHis: 0.681 ± 0.012	0.915CysIle: 0.915 ± 0.013	1.116CysLys: 1.116 ± 0.018	2.206CysLeu: 2.206 ± 0.022	0.423CysMet: 0.423 ± 0.007	0.765CysAsn: 0.765 ± 0.012	1.466CysPro: 1.466 ± 0.022	1.067CysGln: 1.067 ± 0.014	1.333CysArg: 1.333 ± 0.017	2.057CysSer: 2.057 ± 0.023	1.141CysThr: 1.141 ± 0.016	1.303CysVal: 1.303 ± 0.017	0.307CysTrp: 0.307 ± 0.006	0.574CysTyr: 0.574 ± 0.009	0.002CysXaa: 0.002 ± 0.0
Asp	2.85AspAla: 2.85 ± 0.022	1.052AspCys: 1.052 ± 0.016	2.521AspAsp: 2.521 ± 0.025	3.333AspGlu: 3.333 ± 0.031	2.074AspPhe: 2.074 ± 0.02	3.235AspGly: 3.235 ± 0.03	1.164AspHis: 1.164 ± 0.012	2.567AspIle: 2.567 ± 0.025	2.436AspLys: 2.436 ± 0.025	5.005AspLeu: 5.005 ± 0.034	1.144AspMet: 1.144 ± 0.014	1.6AspAsn: 1.6 ± 0.019	2.963AspPro: 2.963 ± 0.022	1.863AspGln: 1.863 ± 0.018	2.513AspArg: 2.513 ± 0.026	4.102AspSer: 4.102 ± 0.04	2.469AspThr: 2.469 ± 0.032	3.083AspVal: 3.083 ± 0.039	0.654AspTrp: 0.654 ± 0.011	1.412AspTyr: 1.412 ± 0.017	0.004AspXaa: 0.004 ± 0.001
Glu	5.348GluAla: 5.348 ± 0.044	1.386GluCys: 1.386 ± 0.032	4.352GluAsp: 4.352 ± 0.03	7.858GluGlu: 7.858 ± 0.079	1.993GluPhe: 1.993 ± 0.019	4.325GluGly: 4.325 ± 0.036	1.508GluHis: 1.508 ± 0.019	2.967GluIle: 2.967 ± 0.027	5.173GluLys: 5.173 ± 0.056	6.294GluLeu: 6.294 ± 0.042	1.634GluMet: 1.634 ± 0.016	2.964GluAsn: 2.964 ± 0.03	3.263GluPro: 3.263 ± 0.03	3.167GluGln: 3.167 ± 0.034	3.951GluArg: 3.951 ± 0.032	4.251GluSer: 4.251 ± 0.03	3.26GluThr: 3.26 ± 0.024	4.191GluVal: 4.191 ± 0.028	0.72GluTrp: 0.72 ± 0.011	1.49GluTyr: 1.49 ± 0.021	0.007GluXaa: 0.007 ± 0.001
Phe	1.967PheAla: 1.967 ± 0.019	0.949PheCys: 0.949 ± 0.014	1.631PheAsp: 1.631 ± 0.018	1.928PheGlu: 1.928 ± 0.019	1.582PhePhe: 1.582 ± 0.018	2.184PheGly: 2.184 ± 0.022	1.044PheHis: 1.044 ± 0.019	1.773PheIle: 1.773 ± 0.02	1.738PheLys: 1.738 ± 0.02	4.111PheLeu: 4.111 ± 0.035	0.765PheMet: 0.765 ± 0.011	1.298PheAsn: 1.298 ± 0.014	2.019PhePro: 2.019 ± 0.02	1.765PheGln: 1.765 ± 0.018	1.995PheArg: 1.995 ± 0.02	3.365PheSer: 3.365 ± 0.029	2.017PheThr: 2.017 ± 0.016	2.152PheVal: 2.152 ± 0.022	0.49PheTrp: 0.49 ± 0.01	1.168PheTyr: 1.168 ± 0.016	0.002PheXaa: 0.002 ± 0.001
Gly	4.635GlyAla: 4.635 ± 0.036	1.345GlyCys: 1.345 ± 0.017	3.147GlyAsp: 3.147 ± 0.021	4.131GlyGlu: 4.131 ± 0.036	2.41GlyPhe: 2.41 ± 0.023	4.959GlyGly: 4.959 ± 0.051	1.747GlyHis: 1.747 ± 0.02	2.672GlyIle: 2.672 ± 0.024	3.757GlyLys: 3.757 ± 0.034	6.079GlyLeu: 6.079 ± 0.035	1.312GlyMet: 1.312 ± 0.017	2.322GlyAsn: 2.322 ± 0.026	4.308GlyPro: 4.308 ± 0.052	2.85GlyGln: 2.85 ± 0.035	3.855GlyArg: 3.855 ± 0.028	5.814GlySer: 5.814 ± 0.041	3.657GlyThr: 3.657 ± 0.029	3.686GlyVal: 3.686 ± 0.032	0.829GlyTrp: 0.829 ± 0.013	1.653GlyTyr: 1.653 ± 0.016	0.01GlyXaa: 0.01 ± 0.001
His	1.387HisAla: 1.387 ± 0.015	0.756HisCys: 0.756 ± 0.011	0.873HisAsp: 0.873 ± 0.01	1.302HisGlu: 1.302 ± 0.015	1.093HisPhe: 1.093 ± 0.013	1.635HisGly: 1.635 ± 0.031	0.921HisHis: 0.921 ± 0.019	1.238HisIle: 1.238 ± 0.014	1.219HisLys: 1.219 ± 0.015	3.04HisLeu: 3.04 ± 0.027	0.609HisMet: 0.609 ± 0.01	0.846HisAsn: 0.846 ± 0.014	1.744HisPro: 1.744 ± 0.02	1.395HisGln: 1.395 ± 0.021	1.723HisArg: 1.723 ± 0.019	2.323HisSer: 2.323 ± 0.026	1.597HisThr: 1.597 ± 0.035	1.573HisVal: 1.573 ± 0.018	0.373HisTrp: 0.373 ± 0.009	0.817HisTyr: 0.817 ± 0.017	0.003HisXaa: 0.003 ± 0.001
Ile	2.597IleAla: 2.597 ± 0.023	1.055IleCys: 1.055 ± 0.014	1.947IleAsp: 1.947 ± 0.019	2.433IleGlu: 2.433 ± 0.027	1.829IlePhe: 1.829 ± 0.022	2.148IleGly: 2.148 ± 0.022	1.316IleHis: 1.316 ± 0.018	2.265IleIle: 2.265 ± 0.026	2.465IleLys: 2.465 ± 0.028	4.457IleLeu: 4.457 ± 0.032	0.98IleMet: 0.98 ± 0.014	1.741IleAsn: 1.741 ± 0.021	2.525IlePro: 2.525 ± 0.024	2.169IleGln: 2.169 ± 0.021	2.371IleArg: 2.371 ± 0.021	3.556IleSer: 3.556 ± 0.026	2.448IleThr: 2.448 ± 0.027	2.45IleVal: 2.45 ± 0.023	0.514IleTrp: 0.514 ± 0.009	1.34IleTyr: 1.34 ± 0.016	0.002IleXaa: 0.002 ± 0.001
Lys	4.043LysAla: 4.043 ± 0.034	1.094LysCys: 1.094 ± 0.018	3.025LysAsp: 3.025 ± 0.03	4.908LysGlu: 4.908 ± 0.051	1.677LysPhe: 1.677 ± 0.019	3.181LysGly: 3.181 ± 0.035	1.385LysHis: 1.385 ± 0.019	2.561LysIle: 2.561 ± 0.026	4.508LysLys: 4.508 ± 0.049	5.045LysLeu: 5.045 ± 0.034	1.428LysMet: 1.428 ± 0.021	2.241LysAsn: 2.241 ± 0.026	3.049LysPro: 3.049 ± 0.029	2.512LysGln: 2.512 ± 0.023	3.217LysArg: 3.217 ± 0.028	3.707LysSer: 3.707 ± 0.031	2.963LysThr: 2.963 ± 0.028	3.435LysVal: 3.435 ± 0.036	0.597LysTrp: 0.597 ± 0.011	1.504LysTyr: 1.504 ± 0.022	0.004LysXaa: 0.004 ± 0.001
Leu	7.043LeuAla: 7.043 ± 0.044	2.239LeuCys: 2.239 ± 0.022	4.727LeuAsp: 4.727 ± 0.028	7.033LeuGlu: 7.033 ± 0.049	3.347LeuPhe: 3.347 ± 0.029	6.135LeuGly: 6.135 ± 0.04	2.819LeuHis: 2.819 ± 0.026	3.785LeuIle: 3.785 ± 0.03	5.588LeuLys: 5.588 ± 0.04	10.914LeuLeu: 10.914 ± 0.075	2.064LeuMet: 2.064 ± 0.02	3.368LeuAsn: 3.368 ± 0.026	6.179LeuPro: 6.179 ± 0.041	5.776LeuGln: 5.776 ± 0.042	6.078LeuArg: 6.078 ± 0.048	8.069LeuSer: 8.069 ± 0.047	5.204LeuThr: 5.204 ± 0.033	5.706LeuVal: 5.706 ± 0.034	1.193LeuTrp: 1.193 ± 0.014	2.529LeuTyr: 2.529 ± 0.024	0.016LeuXaa: 0.016 ± 0.001
Met	1.959MetAla: 1.959 ± 0.016	0.421MetCys: 0.421 ± 0.009	1.266MetAsp: 1.266 ± 0.014	1.837MetGlu: 1.837 ± 0.018	0.722MetPhe: 0.722 ± 0.012	1.35MetGly: 1.35 ± 0.016	0.469MetHis: 0.469 ± 0.008	0.816MetIle: 0.816 ± 0.012	1.41MetLys: 1.41 ± 0.016	2.023MetLeu: 2.023 ± 0.02	0.554MetMet: 0.554 ± 0.01	0.882MetAsn: 0.882 ± 0.012	1.124MetPro: 1.124 ± 0.02	0.914MetGln: 0.914 ± 0.012	1.052MetArg: 1.052 ± 0.011	1.562MetSer: 1.562 ± 0.016	1.132MetThr: 1.132 ± 0.013	1.44MetVal: 1.44 ± 0.021	0.248MetTrp: 0.248 ± 0.006	0.594MetTyr: 0.594 ± 0.01	0.001MetXaa: 0.001 ± 0.0
Asn	2.022AsnAla: 2.022 ± 0.02	0.809AsnCys: 0.809 ± 0.014	1.441AsnAsp: 1.441 ± 0.021	2.086AsnGlu: 2.086 ± 0.02	1.418AsnPhe: 1.418 ± 0.017	2.309AsnGly: 2.309 ± 0.031	0.943AsnHis: 0.943 ± 0.014	1.999AsnIle: 1.999 ± 0.022	2.098AsnLys: 2.098 ± 0.022	3.588AsnLeu: 3.588 ± 0.025	0.887AsnMet: 0.887 ± 0.018	1.409AsnAsn: 1.409 ± 0.018	2.136AsnPro: 2.136 ± 0.019	1.579AsnGln: 1.579 ± 0.014	1.796AsnArg: 1.796 ± 0.014	2.914AsnSer: 2.914 ± 0.028	1.888AsnThr: 1.888 ± 0.022	2.144AsnVal: 2.144 ± 0.022	0.435AsnTrp: 0.435 ± 0.008	1.058AsnTyr: 1.058 ± 0.015	0.002AsnXaa: 0.002 ± 0.0
Pro	4.991ProAla: 4.991 ± 0.043	1.193ProCys: 1.193 ± 0.017	2.81ProAsp: 2.81 ± 0.026	4.475ProGlu: 4.475 ± 0.032	1.926ProPhe: 1.926 ± 0.02	5.287ProGly: 5.287 ± 0.062	1.521ProHis: 1.521 ± 0.018	1.85ProIle: 1.85 ± 0.022	2.737ProLys: 2.737 ± 0.037	5.453ProLeu: 5.453 ± 0.039	1.135ProMet: 1.135 ± 0.016	1.761ProAsn: 1.761 ± 0.018	5.962ProPro: 5.962 ± 0.068	2.875ProGln: 2.875 ± 0.032	3.521ProArg: 3.521 ± 0.031	5.653ProSer: 5.653 ± 0.04	3.126ProThr: 3.126 ± 0.029	3.89ProVal: 3.89 ± 0.029	0.757ProTrp: 0.757 ± 0.011	1.461ProTyr: 1.461 ± 0.023	0.01ProXaa: 0.01 ± 0.001
Gln	3.668GlnAla: 3.668 ± 0.03	0.962GlnCys: 0.962 ± 0.015	2.385GlnAsp: 2.385 ± 0.027	3.962GlnGlu: 3.962 ± 0.04	1.314GlnPhe: 1.314 ± 0.014	2.957GlnGly: 2.957 ± 0.024	1.357GlnHis: 1.357 ± 0.028	1.902GlnIle: 1.902 ± 0.018	2.833GlnLys: 2.833 ± 0.028	4.806GlnLeu: 4.806 ± 0.038	1.113GlnMet: 1.113 ± 0.014	1.735GlnAsn: 1.735 ± 0.017	2.765GlnPro: 2.765 ± 0.029	2.854GlnGln: 2.854 ± 0.035	3.027GlnArg: 3.027 ± 0.029	3.032GlnSer: 3.032 ± 0.023	2.231GlnThr: 2.231 ± 0.02	2.938GlnVal: 2.938 ± 0.028	0.566GlnTrp: 0.566 ± 0.01	1.093GlnTyr: 1.093 ± 0.013	0.004GlnXaa: 0.004 ± 0.001
Arg	4.023ArgAla: 4.023 ± 0.031	1.236ArgCys: 1.236 ± 0.017	2.83ArgAsp: 2.83 ± 0.028	4.107ArgGlu: 4.107 ± 0.037	1.858ArgPhe: 1.858 ± 0.017	3.725ArgGly: 3.725 ± 0.034	1.629ArgHis: 1.629 ± 0.016	2.347ArgIle: 2.347 ± 0.021	3.634ArgLys: 3.634 ± 0.026	5.479ArgLeu: 5.479 ± 0.033	1.178ArgMet: 1.178 ± 0.013	2.066ArgAsn: 2.066 ± 0.017	3.326ArgPro: 3.326 ± 0.029	2.679ArgGln: 2.679 ± 0.028	4.26ArgArg: 4.26 ± 0.04	4.279ArgSer: 4.279 ± 0.04	2.837ArgThr: 2.837 ± 0.032	3.294ArgVal: 3.294 ± 0.027	0.721ArgTrp: 0.721 ± 0.012	1.438ArgTyr: 1.438 ± 0.016	0.01ArgXaa: 0.01 ± 0.001
Ser	5.32SerAla: 5.32 ± 0.035	1.841SerCys: 1.841 ± 0.021	3.787SerAsp: 3.787 ± 0.033	5.042SerGlu: 5.042 ± 0.033	3.018SerPhe: 3.018 ± 0.025	5.615SerGly: 5.615 ± 0.037	2.197SerHis: 2.197 ± 0.025	3.099SerIle: 3.099 ± 0.024	3.86SerLys: 3.86 ± 0.031	8.263SerLeu: 8.263 ± 0.045	1.585SerMet: 1.585 ± 0.017	2.547SerAsn: 2.547 ± 0.025	5.986SerPro: 5.986 ± 0.056	3.844SerGln: 3.844 ± 0.026	4.545SerArg: 4.545 ± 0.038	8.891SerSer: 8.891 ± 0.095	4.279SerThr: 4.279 ± 0.04	4.908SerVal: 4.908 ± 0.033	1.103SerTrp: 1.103 ± 0.014	2.032SerTyr: 2.032 ± 0.021	0.01SerXaa: 0.01 ± 0.001
Thr	3.842ThrAla: 3.842 ± 0.038	1.334ThrCys: 1.334 ± 0.02	2.462ThrAsp: 2.462 ± 0.038	3.433ThrGlu: 3.433 ± 0.028	2.103ThrPhe: 2.103 ± 0.017	3.62ThrGly: 3.62 ± 0.039	1.31ThrHis: 1.31 ± 0.016	2.32ThrIle: 2.32 ± 0.024	2.563ThrLys: 2.563 ± 0.026	5.282ThrLeu: 5.282 ± 0.037	1.112ThrMet: 1.112 ± 0.013	1.657ThrAsn: 1.657 ± 0.019	3.556ThrPro: 3.556 ± 0.038	2.247ThrGln: 2.247 ± 0.02	2.524ThrArg: 2.524 ± 0.032	4.438ThrSer: 4.438 ± 0.033	2.837ThrThr: 2.837 ± 0.029	3.864ThrVal: 3.864 ± 0.034	0.712ThrTrp: 0.712 ± 0.013	1.382ThrTyr: 1.382 ± 0.013	0.006ThrXaa: 0.006 ± 0.001
Val	4.415ValAla: 4.415 ± 0.029	1.464ValCys: 1.464 ± 0.017	2.961ValAsp: 2.961 ± 0.03	3.813ValGlu: 3.813 ± 0.03	2.423ValPhe: 2.423 ± 0.025	3.516ValGly: 3.516 ± 0.025	1.658ValHis: 1.658 ± 0.022	2.866ValIle: 2.866 ± 0.026	3.319ValLys: 3.319 ± 0.031	6.441ValLeu: 6.441 ± 0.035	1.379ValMet: 1.379 ± 0.016	2.193ValAsn: 2.193 ± 0.025	3.779ValPro: 3.779 ± 0.029	2.777ValGln: 2.777 ± 0.022	3.144ValArg: 3.144 ± 0.023	4.929ValSer: 4.929 ± 0.034	3.829ValThr: 3.829 ± 0.038	4.057ValVal: 4.057 ± 0.032	0.719ValTrp: 0.719 ± 0.011	1.596ValTyr: 1.596 ± 0.018	0.006ValXaa: 0.006 ± 0.001
Trp	0.873TrpAla: 0.873 ± 0.013	0.25TrpCys: 0.25 ± 0.006	0.684TrpAsp: 0.684 ± 0.011	0.838TrpGlu: 0.838 ± 0.01	0.445TrpPhe: 0.445 ± 0.008	0.789TrpGly: 0.789 ± 0.013	0.319TrpHis: 0.319 ± 0.008	0.542TrpIle: 0.542 ± 0.009	0.793TrpLys: 0.793 ± 0.011	1.235TrpLeu: 1.235 ± 0.016	0.314TrpMet: 0.314 ± 0.007	0.514TrpAsn: 0.514 ± 0.01	0.577TrpPro: 0.577 ± 0.009	0.559TrpGln: 0.559 ± 0.009	0.749TrpArg: 0.749 ± 0.011	0.899TrpSer: 0.899 ± 0.013	0.674TrpThr: 0.674 ± 0.013	0.769TrpVal: 0.769 ± 0.009	0.2TrpTrp: 0.2 ± 0.005	0.33TrpTyr: 0.33 ± 0.009	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.386TyrAla: 1.386 ± 0.016	0.679TyrCys: 0.679 ± 0.01	1.252TyrAsp: 1.252 ± 0.015	1.639TyrGlu: 1.639 ± 0.019	1.228TyrPhe: 1.228 ± 0.014	1.594TyrGly: 1.594 ± 0.017	0.748TyrHis: 0.748 ± 0.011	1.301TyrIle: 1.301 ± 0.016	1.417TyrLys: 1.417 ± 0.027	2.643TyrLeu: 2.643 ± 0.022	0.596TyrMet: 0.596 ± 0.01	1.039TyrAsn: 1.039 ± 0.014	1.254TyrPro: 1.254 ± 0.014	1.214TyrGln: 1.214 ± 0.014	1.559TyrArg: 1.559 ± 0.018	2.074TyrSer: 2.074 ± 0.021	1.443TyrThr: 1.443 ± 0.02	1.577TyrVal: 1.577 ± 0.015	0.36TyrTrp: 0.36 ± 0.009	0.902TyrTyr: 0.902 ± 0.013	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.012XaaAla: 0.012 ± 0.001	0.004XaaCys: 0.004 ± 0.001	0.003XaaAsp: 0.003 ± 0.001	0.005XaaGlu: 0.005 ± 0.001	0.003XaaPhe: 0.003 ± 0.001	0.012XaaGly: 0.012 ± 0.001	0.004XaaHis: 0.004 ± 0.001	0.003XaaIle: 0.003 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.011XaaLeu: 0.011 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.003XaaAsn: 0.003 ± 0.001	0.015XaaPro: 0.015 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.01XaaArg: 0.01 ± 0.001	0.009XaaSer: 0.009 ± 0.001	0.005XaaThr: 0.005 ± 0.001	0.006XaaVal: 0.006 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	5.559XaaXaa: 5.559 ± 0.393

Statistics based on 15446 proteins (7428624 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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