Amino acid dipepetide frequency for Granulicatella balaenopterae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.564AlaAla: 4.564 ± 0.124
0.605AlaCys: 0.605 ± 0.032
3.432AlaAsp: 3.432 ± 0.084
4.554AlaGlu: 4.554 ± 0.108
2.771AlaPhe: 2.771 ± 0.064
4.457AlaGly: 4.457 ± 0.114
1.293AlaHis: 1.293 ± 0.051
6.129AlaIle: 6.129 ± 0.123
5.523AlaLys: 5.523 ± 0.102
6.609AlaLeu: 6.609 ± 0.127
2.132AlaMet: 2.132 ± 0.059
3.327AlaAsn: 3.327 ± 0.083
1.95AlaPro: 1.95 ± 0.059
2.451AlaGln: 2.451 ± 0.089
2.32AlaArg: 2.32 ± 0.064
3.899AlaSer: 3.899 ± 0.084
4.459AlaThr: 4.459 ± 0.087
4.614AlaVal: 4.614 ± 0.098
0.574AlaTrp: 0.574 ± 0.032
2.448AlaTyr: 2.448 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.485CysAla: 0.485 ± 0.029
0.146CysCys: 0.146 ± 0.017
0.516CysAsp: 0.516 ± 0.033
0.558CysGlu: 0.558 ± 0.032
0.354CysPhe: 0.354 ± 0.026
0.684CysGly: 0.684 ± 0.04
0.255CysHis: 0.255 ± 0.023
0.629CysIle: 0.629 ± 0.035
0.404CysLys: 0.404 ± 0.026
0.842CysLeu: 0.842 ± 0.034
0.244CysMet: 0.244 ± 0.02
0.343CysAsn: 0.343 ± 0.027
0.323CysPro: 0.323 ± 0.024
0.398CysGln: 0.398 ± 0.027
0.288CysArg: 0.288 ± 0.022
0.53CysSer: 0.53 ± 0.032
0.344CysThr: 0.344 ± 0.024
0.534CysVal: 0.534 ± 0.031
0.068CysTrp: 0.068 ± 0.011
0.385CysTyr: 0.385 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.448AspAla: 3.448 ± 0.084
0.537AspCys: 0.537 ± 0.031
2.731AspAsp: 2.731 ± 0.083
4.574AspGlu: 4.574 ± 0.094
2.69AspPhe: 2.69 ± 0.066
3.945AspGly: 3.945 ± 0.125
0.925AspHis: 0.925 ± 0.042
4.751AspIle: 4.751 ± 0.096
4.047AspLys: 4.047 ± 0.112
5.136AspLeu: 5.136 ± 0.099
1.515AspMet: 1.515 ± 0.049
2.611AspAsn: 2.611 ± 0.074
1.651AspPro: 1.651 ± 0.06
1.856AspGln: 1.856 ± 0.064
1.735AspArg: 1.735 ± 0.051
3.043AspSer: 3.043 ± 0.066
3.014AspThr: 3.014 ± 0.09
3.802AspVal: 3.802 ± 0.087
0.655AspTrp: 0.655 ± 0.034
2.777AspTyr: 2.777 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
5.233GluAla: 5.233 ± 0.131
0.462GluCys: 0.462 ± 0.031
4.237GluAsp: 4.237 ± 0.096
7.115GluGlu: 7.115 ± 0.16
2.889GluPhe: 2.889 ± 0.074
3.95GluGly: 3.95 ± 0.103
1.284GluHis: 1.284 ± 0.059
5.633GluIle: 5.633 ± 0.107
6.113GluLys: 6.113 ± 0.114
7.621GluLeu: 7.621 ± 0.128
2.184GluMet: 2.184 ± 0.056
3.739GluAsn: 3.739 ± 0.088
1.911GluPro: 1.911 ± 0.06
3.458GluGln: 3.458 ± 0.087
2.96GluArg: 2.96 ± 0.087
3.492GluSer: 3.492 ± 0.092
3.718GluThr: 3.718 ± 0.094
5.615GluVal: 5.615 ± 0.119
0.865GluTrp: 0.865 ± 0.056
2.792GluTyr: 2.792 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
2.703PheAla: 2.703 ± 0.077
0.406PheCys: 0.406 ± 0.022
2.525PheAsp: 2.525 ± 0.067
2.986PheGlu: 2.986 ± 0.079
1.908PhePhe: 1.908 ± 0.066
2.934PheGly: 2.934 ± 0.078
0.715PheHis: 0.715 ± 0.034
3.545PheIle: 3.545 ± 0.081
2.684PheLys: 2.684 ± 0.077
3.857PheLeu: 3.857 ± 0.099
1.109PheMet: 1.109 ± 0.045
2.116PheAsn: 2.116 ± 0.059
1.347PhePro: 1.347 ± 0.045
1.35PheGln: 1.35 ± 0.051
1.332PheArg: 1.332 ± 0.053
2.917PheSer: 2.917 ± 0.088
2.627PheThr: 2.627 ± 0.068
3.023PheVal: 3.023 ± 0.079
0.414PheTrp: 0.414 ± 0.03
1.898PheTyr: 1.898 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.069GlyAla: 4.069 ± 0.099
0.576GlyCys: 0.576 ± 0.03
3.282GlyAsp: 3.282 ± 0.082
4.503GlyGlu: 4.503 ± 0.108
3.091GlyPhe: 3.091 ± 0.075
4.089GlyGly: 4.089 ± 0.122
1.253GlyHis: 1.253 ± 0.054
5.351GlyIle: 5.351 ± 0.112
4.622GlyLys: 4.622 ± 0.091
5.734GlyLeu: 5.734 ± 0.107
1.911GlyMet: 1.911 ± 0.057
2.69GlyAsn: 2.69 ± 0.064
1.213GlyPro: 1.213 ± 0.055
2.238GlyGln: 2.238 ± 0.076
2.254GlyArg: 2.254 ± 0.067
3.465GlySer: 3.465 ± 0.081
3.942GlyThr: 3.942 ± 0.103
4.819GlyVal: 4.819 ± 0.109
0.698GlyTrp: 0.698 ± 0.048
2.879GlyTyr: 2.879 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.061HisAla: 1.061 ± 0.038
0.233HisCys: 0.233 ± 0.022
1.072HisAsp: 1.072 ± 0.05
1.287HisGlu: 1.287 ± 0.049
0.947HisPhe: 0.947 ± 0.042
1.133HisGly: 1.133 ± 0.055
0.632HisHis: 0.632 ± 0.041
1.432HisIle: 1.432 ± 0.049
1.259HisLys: 1.259 ± 0.049
1.846HisLeu: 1.846 ± 0.056
0.522HisMet: 0.522 ± 0.028
0.917HisAsn: 0.917 ± 0.042
0.863HisPro: 0.863 ± 0.036
1.023HisGln: 1.023 ± 0.045
0.671HisArg: 0.671 ± 0.034
1.004HisSer: 1.004 ± 0.046
1.051HisThr: 1.051 ± 0.042
1.103HisVal: 1.103 ± 0.046
0.196HisTrp: 0.196 ± 0.017
1.091HisTyr: 1.091 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
6.034IleAla: 6.034 ± 0.119
0.865IleCys: 0.865 ± 0.036
5.026IleAsp: 5.026 ± 0.105
5.77IleGlu: 5.77 ± 0.108
3.4IlePhe: 3.4 ± 0.095
5.178IleGly: 5.178 ± 0.1
1.525IleHis: 1.525 ± 0.051
6.472IleIle: 6.472 ± 0.143
5.456IleLys: 5.456 ± 0.105
6.876IleLeu: 6.876 ± 0.133
1.916IleMet: 1.916 ± 0.062
3.993IleAsn: 3.993 ± 0.102
3.178IlePro: 3.178 ± 0.063
2.711IleGln: 2.711 ± 0.069
2.676IleArg: 2.676 ± 0.081
4.942IleSer: 4.942 ± 0.093
4.978IleThr: 4.978 ± 0.096
5.629IleVal: 5.629 ± 0.102
0.611IleTrp: 0.611 ± 0.035
3.022IleTyr: 3.022 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
5.028LysAla: 5.028 ± 0.1
0.362LysCys: 0.362 ± 0.027
4.583LysAsp: 4.583 ± 0.088
7.041LysGlu: 7.041 ± 0.122
2.086LysPhe: 2.086 ± 0.053
4.04LysGly: 4.04 ± 0.083
1.303LysHis: 1.303 ± 0.041
5.366LysIle: 5.366 ± 0.111
6.195LysLys: 6.195 ± 0.135
5.321LysLeu: 5.321 ± 0.102
2.229LysMet: 2.229 ± 0.054
4.081LysAsn: 4.081 ± 0.098
2.229LysPro: 2.229 ± 0.079
3.36LysGln: 3.36 ± 0.083
3.067LysArg: 3.067 ± 0.088
3.353LysSer: 3.353 ± 0.082
4.013LysThr: 4.013 ± 0.091
4.976LysVal: 4.976 ± 0.117
0.682LysTrp: 0.682 ± 0.03
2.689LysTyr: 2.689 ± 0.086
0.0LysXaa: 0.0 ± 0.0
Leu
7.715LeuAla: 7.715 ± 0.153
0.7LeuCys: 0.7 ± 0.036
4.991LeuAsp: 4.991 ± 0.101
6.806LeuGlu: 6.806 ± 0.145
3.92LeuPhe: 3.92 ± 0.1
5.646LeuGly: 5.646 ± 0.114
1.557LeuHis: 1.557 ± 0.052
6.231LeuIle: 6.231 ± 0.132
6.244LeuLys: 6.244 ± 0.106
9.066LeuLeu: 9.066 ± 0.2
2.773LeuMet: 2.773 ± 0.078
4.136LeuAsn: 4.136 ± 0.084
3.615LeuPro: 3.615 ± 0.077
3.6LeuGln: 3.6 ± 0.092
2.913LeuArg: 2.913 ± 0.086
6.108LeuSer: 6.108 ± 0.12
5.959LeuThr: 5.959 ± 0.122
7.081LeuVal: 7.081 ± 0.123
0.648LeuTrp: 0.648 ± 0.036
3.115LeuTyr: 3.115 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.136MetAla: 2.136 ± 0.072
0.186MetCys: 0.186 ± 0.016
1.546MetAsp: 1.546 ± 0.048
1.756MetGlu: 1.756 ± 0.066
1.028MetPhe: 1.028 ± 0.049
1.685MetGly: 1.685 ± 0.064
0.427MetHis: 0.427 ± 0.026
2.417MetIle: 2.417 ± 0.065
2.344MetLys: 2.344 ± 0.062
2.322MetLeu: 2.322 ± 0.064
1.062MetMet: 1.062 ± 0.051
1.707MetAsn: 1.707 ± 0.051
0.97MetPro: 0.97 ± 0.038
1.002MetGln: 1.002 ± 0.038
0.994MetArg: 0.994 ± 0.043
1.644MetSer: 1.644 ± 0.054
1.84MetThr: 1.84 ± 0.049
1.985MetVal: 1.985 ± 0.058
0.171MetTrp: 0.171 ± 0.016
0.854MetTyr: 0.854 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.91AsnAla: 2.91 ± 0.082
0.425AsnCys: 0.425 ± 0.028
2.467AsnAsp: 2.467 ± 0.073
3.566AsnGlu: 3.566 ± 0.088
1.934AsnPhe: 1.934 ± 0.06
3.542AsnGly: 3.542 ± 0.102
1.238AsnHis: 1.238 ± 0.055
3.739AsnIle: 3.739 ± 0.091
3.547AsnLys: 3.547 ± 0.084
4.163AsnLeu: 4.163 ± 0.088
1.227AsnMet: 1.227 ± 0.048
2.624AsnAsn: 2.624 ± 0.086
2.26AsnPro: 2.26 ± 0.066
2.719AsnGln: 2.719 ± 0.079
2.003AsnArg: 2.003 ± 0.055
2.459AsnSer: 2.459 ± 0.072
2.632AsnThr: 2.632 ± 0.082
2.95AsnVal: 2.95 ± 0.083
0.598AsnTrp: 0.598 ± 0.039
2.129AsnTyr: 2.129 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
2.071ProAla: 2.071 ± 0.072
0.236ProCys: 0.236 ± 0.019
1.819ProAsp: 1.819 ± 0.056
2.984ProGlu: 2.984 ± 0.098
1.502ProPhe: 1.502 ± 0.053
1.956ProGly: 1.956 ± 0.068
0.652ProHis: 0.652 ± 0.029
2.87ProIle: 2.87 ± 0.063
2.289ProLys: 2.289 ± 0.065
2.897ProLeu: 2.897 ± 0.074
0.784ProMet: 0.784 ± 0.035
1.699ProAsn: 1.699 ± 0.062
0.608ProPro: 0.608 ± 0.034
1.213ProGln: 1.213 ± 0.038
0.837ProArg: 0.837 ± 0.038
2.031ProSer: 2.031 ± 0.059
2.284ProThr: 2.284 ± 0.072
2.635ProVal: 2.635 ± 0.078
0.259ProTrp: 0.259 ± 0.024
1.368ProTyr: 1.368 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
2.993GlnAla: 2.993 ± 0.089
0.207GlnCys: 0.207 ± 0.018
1.942GlnAsp: 1.942 ± 0.061
3.457GlnGlu: 3.457 ± 0.089
1.622GlnPhe: 1.622 ± 0.06
1.982GlnGly: 1.982 ± 0.062
0.737GlnHis: 0.737 ± 0.04
2.87GlnIle: 2.87 ± 0.08
3.208GlnLys: 3.208 ± 0.072
4.454GlnLeu: 4.454 ± 0.101
1.248GlnMet: 1.248 ± 0.054
1.807GlnAsn: 1.807 ± 0.058
1.143GlnPro: 1.143 ± 0.05
2.212GlnGln: 2.212 ± 0.077
1.397GlnArg: 1.397 ± 0.053
2.097GlnSer: 2.097 ± 0.059
2.336GlnThr: 2.336 ± 0.059
2.828GlnVal: 2.828 ± 0.062
0.488GlnTrp: 0.488 ± 0.037
1.757GlnTyr: 1.757 ± 0.066
0.0GlnXaa: 0.0 ± 0.0
Arg
1.945ArgAla: 1.945 ± 0.058
0.291ArgCys: 0.291 ± 0.022
1.854ArgAsp: 1.854 ± 0.064
2.695ArgGlu: 2.695 ± 0.081
1.529ArgPhe: 1.529 ± 0.06
1.984ArgGly: 1.984 ± 0.061
0.723ArgHis: 0.723 ± 0.033
2.92ArgIle: 2.92 ± 0.075
2.779ArgLys: 2.779 ± 0.078
3.544ArgLeu: 3.544 ± 0.089
1.116ArgMet: 1.116 ± 0.045
1.656ArgAsn: 1.656 ± 0.061
1.015ArgPro: 1.015 ± 0.04
1.656ArgGln: 1.656 ± 0.063
1.518ArgArg: 1.518 ± 0.057
1.722ArgSer: 1.722 ± 0.049
1.862ArgThr: 1.862 ± 0.055
2.292ArgVal: 2.292 ± 0.074
0.278ArgTrp: 0.278 ± 0.022
1.575ArgTyr: 1.575 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.372SerAla: 3.372 ± 0.078
0.464SerCys: 0.464 ± 0.033
3.077SerAsp: 3.077 ± 0.075
3.967SerGlu: 3.967 ± 0.103
2.829SerPhe: 2.829 ± 0.079
3.777SerGly: 3.777 ± 0.086
1.177SerHis: 1.177 ± 0.05
4.622SerIle: 4.622 ± 0.098
3.575SerLys: 3.575 ± 0.085
5.568SerLeu: 5.568 ± 0.108
1.515SerMet: 1.515 ± 0.055
2.934SerAsn: 2.934 ± 0.072
1.814SerPro: 1.814 ± 0.062
2.359SerGln: 2.359 ± 0.064
1.934SerArg: 1.934 ± 0.057
3.503SerSer: 3.503 ± 0.11
3.043SerThr: 3.043 ± 0.071
3.969SerVal: 3.969 ± 0.079
0.577SerTrp: 0.577 ± 0.037
2.587SerTyr: 2.587 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
4.0ThrAla: 4.0 ± 0.084
0.407ThrCys: 0.407 ± 0.026
3.342ThrAsp: 3.342 ± 0.086
3.701ThrGlu: 3.701 ± 0.087
2.399ThrPhe: 2.399 ± 0.08
4.064ThrGly: 4.064 ± 0.1
1.145ThrHis: 1.145 ± 0.041
5.644ThrIle: 5.644 ± 0.107
4.312ThrLys: 4.312 ± 0.095
5.523ThrLeu: 5.523 ± 0.095
1.361ThrMet: 1.361 ± 0.048
3.267ThrAsn: 3.267 ± 0.092
2.663ThrPro: 2.663 ± 0.101
1.803ThrGln: 1.803 ± 0.059
1.751ThrArg: 1.751 ± 0.055
3.308ThrSer: 3.308 ± 0.078
4.034ThrThr: 4.034 ± 0.111
4.278ThrVal: 4.278 ± 0.09
0.527ThrTrp: 0.527 ± 0.032
2.313ThrTyr: 2.313 ± 0.084
0.0ThrXaa: 0.0 ± 0.0
Val
5.38ValAla: 5.38 ± 0.114
0.687ValCys: 0.687 ± 0.034
4.115ValAsp: 4.115 ± 0.074
5.188ValGlu: 5.188 ± 0.125
2.976ValPhe: 2.976 ± 0.074
4.57ValGly: 4.57 ± 0.101
1.107ValHis: 1.107 ± 0.042
5.836ValIle: 5.836 ± 0.091
4.498ValLys: 4.498 ± 0.098
6.2ValLeu: 6.2 ± 0.114
2.013ValMet: 2.013 ± 0.062
3.13ValAsn: 3.13 ± 0.079
2.527ValPro: 2.527 ± 0.066
2.191ValGln: 2.191 ± 0.059
2.331ValArg: 2.331 ± 0.062
4.338ValSer: 4.338 ± 0.082
5.025ValThr: 5.025 ± 0.144
5.489ValVal: 5.489 ± 0.099
0.553ValTrp: 0.553 ± 0.032
2.496ValTyr: 2.496 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.485TrpAla: 0.485 ± 0.027
0.1TrpCys: 0.1 ± 0.011
0.524TrpAsp: 0.524 ± 0.036
0.525TrpGlu: 0.525 ± 0.028
0.488TrpPhe: 0.488 ± 0.034
0.614TrpGly: 0.614 ± 0.037
0.22TrpHis: 0.22 ± 0.021
0.854TrpIle: 0.854 ± 0.048
0.574TrpLys: 0.574 ± 0.033
0.947TrpLeu: 0.947 ± 0.042
0.275TrpMet: 0.275 ± 0.02
0.49TrpAsn: 0.49 ± 0.03
0.22TrpPro: 0.22 ± 0.021
0.59TrpGln: 0.59 ± 0.042
0.336TrpArg: 0.336 ± 0.025
0.466TrpSer: 0.466 ± 0.028
0.462TrpThr: 0.462 ± 0.036
0.613TrpVal: 0.613 ± 0.041
0.074TrpTrp: 0.074 ± 0.009
0.501TrpTyr: 0.501 ± 0.048
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.48TyrAla: 2.48 ± 0.067
0.435TyrCys: 0.435 ± 0.027
2.362TyrAsp: 2.362 ± 0.07
2.239TyrGlu: 2.239 ± 0.06
2.032TyrPhe: 2.032 ± 0.062
2.448TyrGly: 2.448 ± 0.068
1.177TyrHis: 1.177 ± 0.044
2.947TyrIle: 2.947 ± 0.08
2.331TyrLys: 2.331 ± 0.08
4.297TyrLeu: 4.297 ± 0.108
0.938TyrMet: 0.938 ± 0.043
1.867TyrAsn: 1.867 ± 0.059
1.494TyrPro: 1.494 ± 0.052
2.595TyrGln: 2.595 ± 0.082
1.636TyrArg: 1.636 ± 0.055
2.344TyrSer: 2.344 ± 0.072
2.218TyrThr: 2.218 ± 0.072
2.414TyrVal: 2.414 ± 0.067
0.422TyrTrp: 0.422 ± 0.026
2.215TyrTyr: 2.215 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1916 proteins (618545 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski