Amino acid dipepetide frequency for Ectothiorhodospira mobilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.17AlaAla: 14.17 ± 0.201	1.214AlaCys: 1.214 ± 0.038	6.012AlaAsp: 6.012 ± 0.087	6.97AlaGlu: 6.97 ± 0.109	3.719AlaPhe: 3.719 ± 0.07	10.387AlaGly: 10.387 ± 0.136	2.835AlaHis: 2.835 ± 0.074	4.075AlaIle: 4.075 ± 0.088	1.897AlaLys: 1.897 ± 0.057	14.746AlaLeu: 14.746 ± 0.177	3.024AlaMet: 3.024 ± 0.057	1.82AlaAsn: 1.82 ± 0.047	5.597AlaPro: 5.597 ± 0.103	4.268AlaGln: 4.268 ± 0.071	11.055AlaArg: 11.055 ± 0.138	4.384AlaSer: 4.384 ± 0.08	4.466AlaThr: 4.466 ± 0.073	8.552AlaVal: 8.552 ± 0.121	1.676AlaTrp: 1.676 ± 0.052	2.28AlaTyr: 2.28 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.94CysAla: 0.94 ± 0.037	0.113CysCys: 0.113 ± 0.012	0.508CysAsp: 0.508 ± 0.025	0.494CysGlu: 0.494 ± 0.029	0.238CysPhe: 0.238 ± 0.018	1.0CysGly: 1.0 ± 0.04	0.31CysHis: 0.31 ± 0.022	0.406CysIle: 0.406 ± 0.02	0.158CysLys: 0.158 ± 0.013	1.079CysLeu: 1.079 ± 0.035	0.179CysMet: 0.179 ± 0.016	0.22CysAsn: 0.22 ± 0.017	0.679CysPro: 0.679 ± 0.035	0.319CysGln: 0.319 ± 0.021	0.893CysArg: 0.893 ± 0.037	0.414CysSer: 0.414 ± 0.026	0.484CysThr: 0.484 ± 0.026	0.605CysVal: 0.605 ± 0.034	0.12CysTrp: 0.12 ± 0.012	0.204CysTyr: 0.204 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.458AspAla: 6.458 ± 0.086	0.514AspCys: 0.514 ± 0.028	2.813AspAsp: 2.813 ± 0.061	3.558AspGlu: 3.558 ± 0.07	1.974AspPhe: 1.974 ± 0.056	4.796AspGly: 4.796 ± 0.088	1.576AspHis: 1.576 ± 0.05	2.213AspIle: 2.213 ± 0.057	1.127AspLys: 1.127 ± 0.045	7.274AspLeu: 7.274 ± 0.105	1.403AspMet: 1.403 ± 0.047	1.081AspAsn: 1.081 ± 0.043	4.56AspPro: 4.56 ± 0.086	1.852AspGln: 1.852 ± 0.049	5.034AspArg: 5.034 ± 0.088	2.017AspSer: 2.017 ± 0.058	3.153AspThr: 3.153 ± 0.063	3.563AspVal: 3.563 ± 0.075	1.027AspTrp: 1.027 ± 0.04	1.631AspTyr: 1.631 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	9.529GluAla: 9.529 ± 0.136	0.439GluCys: 0.439 ± 0.027	4.054GluAsp: 4.054 ± 0.074	4.544GluGlu: 4.544 ± 0.104	1.519GluPhe: 1.519 ± 0.046	5.95GluGly: 5.95 ± 0.089	1.666GluHis: 1.666 ± 0.046	2.992GluIle: 2.992 ± 0.069	1.742GluLys: 1.742 ± 0.06	6.132GluLeu: 6.132 ± 0.106	1.678GluMet: 1.678 ± 0.045	1.355GluAsn: 1.355 ± 0.045	3.2GluPro: 3.2 ± 0.074	3.063GluGln: 3.063 ± 0.074	6.696GluArg: 6.696 ± 0.112	2.643GluSer: 2.643 ± 0.063	3.671GluThr: 3.671 ± 0.078	4.82GluVal: 4.82 ± 0.079	0.745GluTrp: 0.745 ± 0.031	1.247GluTyr: 1.247 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.052PheAla: 3.052 ± 0.06	0.376PheCys: 0.376 ± 0.022	2.117PheAsp: 2.117 ± 0.053	1.989PheGlu: 1.989 ± 0.052	1.21PhePhe: 1.21 ± 0.048	2.719PheGly: 2.719 ± 0.063	0.88PheHis: 0.88 ± 0.035	1.403PheIle: 1.403 ± 0.045	0.724PheLys: 0.724 ± 0.033	3.371PheLeu: 3.371 ± 0.083	0.724PheMet: 0.724 ± 0.032	0.912PheAsn: 0.912 ± 0.037	1.475PhePro: 1.475 ± 0.044	1.157PheGln: 1.157 ± 0.044	2.391PheArg: 2.391 ± 0.051	1.79PheSer: 1.79 ± 0.049	1.884PheThr: 1.884 ± 0.042	2.239PheVal: 2.239 ± 0.059	0.468PheTrp: 0.468 ± 0.03	0.85PheTyr: 0.85 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	8.344GlyAla: 8.344 ± 0.117	1.013GlyCys: 1.013 ± 0.04	5.179GlyAsp: 5.179 ± 0.075	6.24GlyGlu: 6.24 ± 0.087	3.097GlyPhe: 3.097 ± 0.063	7.64GlyGly: 7.64 ± 0.126	2.369GlyHis: 2.369 ± 0.051	4.28GlyIle: 4.28 ± 0.087	2.154GlyLys: 2.154 ± 0.064	9.957GlyLeu: 9.957 ± 0.143	2.659GlyMet: 2.659 ± 0.066	1.855GlyAsn: 1.855 ± 0.049	3.835GlyPro: 3.835 ± 0.082	3.228GlyGln: 3.228 ± 0.062	7.92GlyArg: 7.92 ± 0.105	3.787GlySer: 3.787 ± 0.078	4.086GlyThr: 4.086 ± 0.076	6.631GlyVal: 6.631 ± 0.107	1.29GlyTrp: 1.29 ± 0.044	2.317GlyTyr: 2.317 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.73HisAla: 2.73 ± 0.052	0.315HisCys: 0.315 ± 0.02	1.295HisAsp: 1.295 ± 0.042	1.336HisGlu: 1.336 ± 0.042	0.964HisPhe: 0.964 ± 0.034	2.403HisGly: 2.403 ± 0.056	0.891HisHis: 0.891 ± 0.037	0.99HisIle: 0.99 ± 0.042	0.536HisLys: 0.536 ± 0.024	3.314HisLeu: 3.314 ± 0.073	0.589HisMet: 0.589 ± 0.028	0.524HisAsn: 0.524 ± 0.024	2.123HisPro: 2.123 ± 0.06	0.905HisGln: 0.905 ± 0.034	2.392HisArg: 2.392 ± 0.058	0.926HisSer: 0.926 ± 0.034	1.224HisThr: 1.224 ± 0.041	1.642HisVal: 1.642 ± 0.045	0.519HisTrp: 0.519 ± 0.026	0.747HisTyr: 0.747 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.343IleAla: 4.343 ± 0.094	0.372IleCys: 0.372 ± 0.022	2.306IleAsp: 2.306 ± 0.061	2.401IleGlu: 2.401 ± 0.071	1.159IlePhe: 1.159 ± 0.045	3.303IleGly: 3.303 ± 0.072	1.307IleHis: 1.307 ± 0.043	1.642IleIle: 1.642 ± 0.056	0.959IleLys: 0.959 ± 0.041	4.834IleLeu: 4.834 ± 0.077	0.728IleMet: 0.728 ± 0.032	1.08IleAsn: 1.08 ± 0.039	2.698IlePro: 2.698 ± 0.054	1.788IleGln: 1.788 ± 0.052	3.856IleArg: 3.856 ± 0.07	1.921IleSer: 1.921 ± 0.046	2.404IleThr: 2.404 ± 0.052	2.445IleVal: 2.445 ± 0.066	0.367IleTrp: 0.367 ± 0.023	0.959IleTyr: 0.959 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.805LysAla: 2.805 ± 0.074	0.133LysCys: 0.133 ± 0.014	1.366LysAsp: 1.366 ± 0.048	1.389LysGlu: 1.389 ± 0.048	0.453LysPhe: 0.453 ± 0.028	2.115LysGly: 2.115 ± 0.06	0.5LysHis: 0.5 ± 0.028	0.91LysIle: 0.91 ± 0.042	0.817LysLys: 0.817 ± 0.043	1.902LysLeu: 1.902 ± 0.054	0.475LysMet: 0.475 ± 0.024	0.576LysAsn: 0.576 ± 0.029	1.243LysPro: 1.243 ± 0.043	0.737LysGln: 0.737 ± 0.035	1.783LysArg: 1.783 ± 0.046	1.0LysSer: 1.0 ± 0.039	1.269LysThr: 1.269 ± 0.044	1.602LysVal: 1.602 ± 0.051	0.209LysTrp: 0.209 ± 0.016	0.427LysTyr: 0.427 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.557LeuAla: 13.557 ± 0.183	1.042LeuCys: 1.042 ± 0.039	6.946LeuAsp: 6.946 ± 0.098	9.438LeuGlu: 9.438 ± 0.137	3.578LeuPhe: 3.578 ± 0.079	9.599LeuGly: 9.599 ± 0.148	2.783LeuHis: 2.783 ± 0.058	4.311LeuIle: 4.311 ± 0.083	2.755LeuLys: 2.755 ± 0.064	12.353LeuLeu: 12.353 ± 0.185	2.741LeuMet: 2.741 ± 0.054	2.34LeuAsn: 2.34 ± 0.052	6.544LeuPro: 6.544 ± 0.095	4.761LeuGln: 4.761 ± 0.096	9.243LeuArg: 9.243 ± 0.134	5.588LeuSer: 5.588 ± 0.091	5.223LeuThr: 5.223 ± 0.088	8.115LeuVal: 8.115 ± 0.129	1.403LeuTrp: 1.403 ± 0.042	2.277LeuTyr: 2.277 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.096MetAla: 3.096 ± 0.067	0.137MetCys: 0.137 ± 0.012	1.726MetAsp: 1.726 ± 0.052	1.788MetGlu: 1.788 ± 0.045	0.466MetPhe: 0.466 ± 0.024	2.103MetGly: 2.103 ± 0.05	0.594MetHis: 0.594 ± 0.025	0.964MetIle: 0.964 ± 0.036	0.803MetLys: 0.803 ± 0.033	2.136MetLeu: 2.136 ± 0.056	0.547MetMet: 0.547 ± 0.026	0.771MetAsn: 0.771 ± 0.03	1.392MetPro: 1.392 ± 0.045	1.004MetGln: 1.004 ± 0.035	1.797MetArg: 1.797 ± 0.045	1.322MetSer: 1.322 ± 0.042	1.469MetThr: 1.469 ± 0.046	1.657MetVal: 1.657 ± 0.042	0.137MetTrp: 0.137 ± 0.015	0.355MetTyr: 0.355 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.344AsnAla: 2.344 ± 0.059	0.199AsnCys: 0.199 ± 0.015	1.107AsnAsp: 1.107 ± 0.038	1.14AsnGlu: 1.14 ± 0.041	0.619AsnPhe: 0.619 ± 0.029	1.649AsnGly: 1.649 ± 0.049	0.531AsnHis: 0.531 ± 0.022	0.999AsnIle: 0.999 ± 0.039	0.46AsnLys: 0.46 ± 0.026	2.456AsnLeu: 2.456 ± 0.05	0.455AsnMet: 0.455 ± 0.023	0.468AsnAsn: 0.468 ± 0.028	1.638AsnPro: 1.638 ± 0.046	0.738AsnGln: 0.738 ± 0.032	1.966AsnArg: 1.966 ± 0.05	0.753AsnSer: 0.753 ± 0.047	1.126AsnThr: 1.126 ± 0.047	1.423AsnVal: 1.423 ± 0.047	0.248AsnTrp: 0.248 ± 0.018	0.494AsnTyr: 0.494 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.311ProAla: 6.311 ± 0.111	0.485ProCys: 0.485 ± 0.028	3.628ProAsp: 3.628 ± 0.065	5.183ProGlu: 5.183 ± 0.103	1.801ProPhe: 1.801 ± 0.053	6.017ProGly: 6.017 ± 0.099	1.327ProHis: 1.327 ± 0.042	1.651ProIle: 1.651 ± 0.055	1.021ProLys: 1.021 ± 0.038	5.854ProLeu: 5.854 ± 0.093	1.414ProMet: 1.414 ± 0.04	0.856ProAsn: 0.856 ± 0.036	3.531ProPro: 3.531 ± 0.086	2.266ProGln: 2.266 ± 0.056	4.265ProArg: 4.265 ± 0.086	2.261ProSer: 2.261 ± 0.062	1.978ProThr: 1.978 ± 0.053	4.782ProVal: 4.782 ± 0.079	0.889ProTrp: 0.889 ± 0.04	1.165ProTyr: 1.165 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.429GlnAla: 5.429 ± 0.103	0.268GlnCys: 0.268 ± 0.02	2.118GlnAsp: 2.118 ± 0.049	2.678GlnGlu: 2.678 ± 0.064	0.875GlnPhe: 0.875 ± 0.038	3.983GlnGly: 3.983 ± 0.078	0.8GlnHis: 0.8 ± 0.03	1.408GlnIle: 1.408 ± 0.048	0.808GlnLys: 0.808 ± 0.035	3.421GlnLeu: 3.421 ± 0.075	0.836GlnMet: 0.836 ± 0.033	0.631GlnAsn: 0.631 ± 0.028	1.831GlnPro: 1.831 ± 0.056	1.646GlnGln: 1.646 ± 0.042	3.807GlnArg: 3.807 ± 0.088	1.585GlnSer: 1.585 ± 0.047	1.728GlnThr: 1.728 ± 0.042	3.553GlnVal: 3.553 ± 0.069	0.593GlnTrp: 0.593 ± 0.031	0.686GlnTyr: 0.686 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.075ArgAla: 9.075 ± 0.133	0.765ArgCys: 0.765 ± 0.033	5.032ArgAsp: 5.032 ± 0.089	6.422ArgGlu: 6.422 ± 0.11	3.421ArgPhe: 3.421 ± 0.067	6.428ArgGly: 6.428 ± 0.1	2.711ArgHis: 2.711 ± 0.071	4.57ArgIle: 4.57 ± 0.079	1.749ArgLys: 1.749 ± 0.049	10.956ArgLeu: 10.956 ± 0.145	2.255ArgMet: 2.255 ± 0.051	1.782ArgAsn: 1.782 ± 0.051	4.632ArgPro: 4.632 ± 0.084	3.681ArgGln: 3.681 ± 0.077	8.666ArgArg: 8.666 ± 0.13	3.419ArgSer: 3.419 ± 0.07	3.336ArgThr: 3.336 ± 0.06	6.835ArgVal: 6.835 ± 0.103	1.25ArgTrp: 1.25 ± 0.045	2.268ArgTyr: 2.268 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	4.461SerAla: 4.461 ± 0.075	0.361SerCys: 0.361 ± 0.023	2.265SerAsp: 2.265 ± 0.056	2.52SerGlu: 2.52 ± 0.065	1.335SerPhe: 1.335 ± 0.041	4.793SerGly: 4.793 ± 0.08	1.099SerHis: 1.099 ± 0.036	1.768SerIle: 1.768 ± 0.05	0.903SerLys: 0.903 ± 0.038	4.917SerLeu: 4.917 ± 0.097	1.109SerMet: 1.109 ± 0.036	0.959SerAsn: 0.959 ± 0.036	2.639SerPro: 2.639 ± 0.059	1.457SerGln: 1.457 ± 0.042	3.923SerArg: 3.923 ± 0.071	1.956SerSer: 1.956 ± 0.06	2.044SerThr: 2.044 ± 0.058	2.995SerVal: 2.995 ± 0.072	0.517SerTrp: 0.517 ± 0.025	0.861SerTyr: 0.861 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.291ThrAla: 5.291 ± 0.076	0.468ThrCys: 0.468 ± 0.025	2.41ThrAsp: 2.41 ± 0.063	2.449ThrGlu: 2.449 ± 0.055	1.494ThrPhe: 1.494 ± 0.044	4.895ThrGly: 4.895 ± 0.074	1.193ThrHis: 1.193 ± 0.038	1.49ThrIle: 1.49 ± 0.042	0.695ThrLys: 0.695 ± 0.032	6.71ThrLeu: 6.71 ± 0.096	0.785ThrMet: 0.785 ± 0.033	0.803ThrAsn: 0.803 ± 0.038	3.544ThrPro: 3.544 ± 0.064	1.678ThrGln: 1.678 ± 0.046	4.159ThrArg: 4.159 ± 0.08	1.825ThrSer: 1.825 ± 0.056	2.232ThrThr: 2.232 ± 0.058	3.63ThrVal: 3.63 ± 0.068	0.623ThrTrp: 0.623 ± 0.027	0.986ThrTyr: 0.986 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.897ValAla: 7.897 ± 0.122	0.77ValCys: 0.77 ± 0.034	4.794ValAsp: 4.794 ± 0.092	5.183ValGlu: 5.183 ± 0.091	2.496ValPhe: 2.496 ± 0.064	5.193ValGly: 5.193 ± 0.092	1.96ValHis: 1.96 ± 0.047	3.344ValIle: 3.344 ± 0.077	1.635ValLys: 1.635 ± 0.042	8.548ValLeu: 8.548 ± 0.123	1.846ValMet: 1.846 ± 0.05	1.942ValAsn: 1.942 ± 0.051	3.729ValPro: 3.729 ± 0.073	2.703ValGln: 2.703 ± 0.062	5.818ValArg: 5.818 ± 0.1	3.65ValSer: 3.65 ± 0.073	3.816ValThr: 3.816 ± 0.072	5.911ValVal: 5.911 ± 0.114	0.728ValTrp: 0.728 ± 0.032	1.527ValTyr: 1.527 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.138TrpAla: 1.138 ± 0.037	0.125TrpCys: 0.125 ± 0.013	0.689TrpAsp: 0.689 ± 0.032	0.75TrpGlu: 0.75 ± 0.03	0.503TrpPhe: 0.503 ± 0.027	1.01TrpGly: 1.01 ± 0.042	0.323TrpHis: 0.323 ± 0.023	0.655TrpIle: 0.655 ± 0.031	0.284TrpLys: 0.284 ± 0.019	1.857TrpLeu: 1.857 ± 0.057	0.391TrpMet: 0.391 ± 0.023	0.324TrpAsn: 0.324 ± 0.02	0.666TrpPro: 0.666 ± 0.027	0.615TrpGln: 0.615 ± 0.032	1.248TrpArg: 1.248 ± 0.047	0.646TrpSer: 0.646 ± 0.03	0.582TrpThr: 0.582 ± 0.032	1.067TrpVal: 1.067 ± 0.038	0.21TrpTrp: 0.21 ± 0.018	0.314TrpTyr: 0.314 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.177TyrAla: 2.177 ± 0.053	0.252TyrCys: 0.252 ± 0.02	1.261TyrAsp: 1.261 ± 0.038	1.216TyrGlu: 1.216 ± 0.039	0.81TyrPhe: 0.81 ± 0.031	1.898TyrGly: 1.898 ± 0.057	0.71TyrHis: 0.71 ± 0.029	0.8TyrIle: 0.8 ± 0.034	0.486TyrLys: 0.486 ± 0.028	2.781TyrLeu: 2.781 ± 0.064	0.423TyrMet: 0.423 ± 0.023	0.514TyrAsn: 0.514 ± 0.03	1.128TyrPro: 1.128 ± 0.04	0.818TyrGln: 0.818 ± 0.031	2.34TyrArg: 2.34 ± 0.059	0.991TyrSer: 0.991 ± 0.038	1.185TyrThr: 1.185 ± 0.045	1.423TyrVal: 1.423 ± 0.035	0.38TyrTrp: 0.38 ± 0.022	0.612TyrTyr: 0.612 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2413 proteins (789774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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