Amino acid dipepetide frequency for Dragonfly-associated circular virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.176AlaAla: 2.176 ± 1.683
2.176AlaCys: 2.176 ± 1.085
4.353AlaAsp: 4.353 ± 2.171
10.881AlaGlu: 10.881 ± 5.427
2.176AlaPhe: 2.176 ± 2.089
9.793AlaGly: 9.793 ± 2.368
0.0AlaHis: 0.0 ± 0.0
6.529AlaIle: 6.529 ± 4.039
3.264AlaLys: 3.264 ± 2.525
0.0AlaLeu: 0.0 ± 0.0
0.0AlaMet: 0.0 ± 0.0
6.529AlaAsn: 6.529 ± 3.608
3.264AlaPro: 3.264 ± 1.804
1.088AlaGln: 1.088 ± 0.842
7.617AlaArg: 7.617 ± 1.864
4.353AlaSer: 4.353 ± 3.367
4.353AlaThr: 4.353 ± 1.218
2.176AlaVal: 2.176 ± 2.089
2.176AlaTrp: 2.176 ± 2.089
3.264AlaTyr: 3.264 ± 2.525
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
3.264CysPhe: 3.264 ± 0.789
4.353CysGly: 4.353 ± 2.171
4.353CysHis: 4.353 ± 2.171
3.264CysIle: 3.264 ± 0.789
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
1.088CysMet: 1.088 ± 0.841
2.176CysAsn: 2.176 ± 1.085
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
2.176CysSer: 2.176 ± 1.085
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.088CysTyr: 1.088 ± 0.842
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
0.0AspCys: 0.0 ± 0.0
8.705AspAsp: 8.705 ± 3.057
1.088AspGlu: 1.088 ± 0.842
3.264AspPhe: 3.264 ± 0.789
9.793AspGly: 9.793 ± 3.809
0.0AspHis: 0.0 ± 0.0
4.353AspIle: 4.353 ± 2.093
2.176AspLys: 2.176 ± 1.085
3.264AspLeu: 3.264 ± 2.525
0.0AspMet: 0.0 ± 0.0
0.0AspAsn: 0.0 ± 0.0
8.705AspPro: 8.705 ± 6.08
2.176AspGln: 2.176 ± 1.683
3.264AspArg: 3.264 ± 0.789
1.088AspSer: 1.088 ± 0.842
4.353AspThr: 4.353 ± 1.218
9.793AspVal: 9.793 ± 2.566
5.441AspTrp: 5.441 ± 1.701
3.264AspTyr: 3.264 ± 0.789
0.0AspXaa: 0.0 ± 0.0
Glu
4.353GluAla: 4.353 ± 1.887
3.264GluCys: 3.264 ± 1.647
4.353GluAsp: 4.353 ± 2.171
1.088GluGlu: 1.088 ± 0.841
2.176GluPhe: 2.176 ± 1.085
0.0GluGly: 0.0 ± 0.0
3.264GluHis: 3.264 ± 0.789
4.353GluIle: 4.353 ± 2.093
3.264GluLys: 3.264 ± 0.789
2.176GluLeu: 2.176 ± 1.085
1.088GluMet: 1.088 ± 1.588
0.0GluAsn: 0.0 ± 0.0
0.0GluPro: 0.0 ± 0.0
0.0GluGln: 0.0 ± 0.0
4.353GluArg: 4.353 ± 2.171
6.529GluSer: 6.529 ± 1.798
0.0GluThr: 0.0 ± 0.0
2.176GluVal: 2.176 ± 1.085
2.176GluTrp: 2.176 ± 2.089
4.353GluTyr: 4.353 ± 2.093
0.0GluXaa: 0.0 ± 0.0
Phe
4.353PheAla: 4.353 ± 2.171
0.0PheCys: 0.0 ± 0.0
6.529PheAsp: 6.529 ± 2.599
0.0PheGlu: 0.0 ± 0.0
3.264PhePhe: 3.264 ± 1.804
4.353PheGly: 4.353 ± 2.171
0.0PheHis: 0.0 ± 0.0
5.441PheIle: 5.441 ± 1.417
3.264PheLys: 3.264 ± 1.804
3.264PheLeu: 3.264 ± 0.789
0.0PheMet: 0.0 ± 0.0
1.088PheAsn: 1.088 ± 0.842
3.264PhePro: 3.264 ± 1.804
1.088PheGln: 1.088 ± 0.842
5.441PheArg: 5.441 ± 1.417
4.353PheSer: 4.353 ± 2.171
1.088PheThr: 1.088 ± 0.842
3.264PheVal: 3.264 ± 1.942
3.264PheTrp: 3.264 ± 0.789
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
9.793GlyAla: 9.793 ± 2.368
2.176GlyCys: 2.176 ± 1.085
6.529GlyAsp: 6.529 ± 1.579
2.176GlyGlu: 2.176 ± 1.683
3.264GlyPhe: 3.264 ± 0.789
15.234GlyGly: 15.234 ± 4.811
0.0GlyHis: 0.0 ± 0.0
4.353GlyIle: 4.353 ± 1.578
5.441GlyLys: 5.441 ± 2.45
10.881GlyLeu: 10.881 ± 3.402
3.264GlyMet: 3.264 ± 1.586
4.353GlyAsn: 4.353 ± 1.218
1.088GlyPro: 1.088 ± 0.842
5.441GlyGln: 5.441 ± 2.393
7.617GlyArg: 7.617 ± 3.713
5.441GlySer: 5.441 ± 3.048
6.529GlyThr: 6.529 ± 2.731
2.176GlyVal: 2.176 ± 1.683
0.0GlyTrp: 0.0 ± 0.0
3.264GlyTyr: 3.264 ± 0.789
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
2.176HisCys: 2.176 ± 1.085
0.0HisAsp: 0.0 ± 0.0
5.441HisGlu: 5.441 ± 1.701
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
2.176HisHis: 2.176 ± 1.085
2.176HisIle: 2.176 ± 0.854
0.0HisLys: 0.0 ± 0.0
2.176HisLeu: 2.176 ± 1.085
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
3.264HisPro: 3.264 ± 0.789
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
2.176HisThr: 2.176 ± 2.089
2.176HisVal: 2.176 ± 2.089
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.088IleAla: 1.088 ± 0.842
1.088IleCys: 1.088 ± 0.842
0.0IleAsp: 0.0 ± 0.0
2.176IleGlu: 2.176 ± 2.089
7.617IlePhe: 7.617 ± 3.481
5.441IleGly: 5.441 ± 2.973
0.0IleHis: 0.0 ± 0.0
0.0IleIle: 0.0 ± 0.0
4.353IleLys: 4.353 ± 2.093
1.088IleLeu: 1.088 ± 0.842
0.0IleMet: 0.0 ± 0.0
2.176IleAsn: 2.176 ± 2.089
0.0IlePro: 0.0 ± 0.0
3.264IleGln: 3.264 ± 0.789
4.353IleArg: 4.353 ± 1.887
2.176IleSer: 2.176 ± 2.089
2.176IleThr: 2.176 ± 1.085
4.353IleVal: 4.353 ± 1.218
2.176IleTrp: 2.176 ± 2.089
1.088IleTyr: 1.088 ± 0.841
0.0IleXaa: 0.0 ± 0.0
Lys
5.441LysAla: 5.441 ± 1.417
0.0LysCys: 0.0 ± 0.0
2.176LysAsp: 2.176 ± 1.085
3.264LysGlu: 3.264 ± 1.804
4.353LysPhe: 4.353 ± 2.093
4.353LysGly: 4.353 ± 1.218
0.0LysHis: 0.0 ± 0.0
0.0LysIle: 0.0 ± 0.0
1.088LysLys: 1.088 ± 0.842
3.264LysLeu: 3.264 ± 1.804
1.088LysMet: 1.088 ± 0.72
0.0LysAsn: 0.0 ± 0.0
2.176LysPro: 2.176 ± 2.089
0.0LysGln: 0.0 ± 0.0
6.529LysArg: 6.529 ± 2.903
2.176LysSer: 2.176 ± 1.085
4.353LysThr: 4.353 ± 1.212
0.0LysVal: 0.0 ± 0.0
2.176LysTrp: 2.176 ± 1.085
3.264LysTyr: 3.264 ± 0.789
0.0LysXaa: 0.0 ± 0.0
Leu
0.0LeuAla: 0.0 ± 0.0
4.353LeuCys: 4.353 ± 2.171
3.264LeuAsp: 3.264 ± 0.789
6.529LeuGlu: 6.529 ± 2.599
0.0LeuPhe: 0.0 ± 0.0
6.529LeuGly: 6.529 ± 2.599
4.353LeuHis: 4.353 ± 2.171
0.0LeuIle: 0.0 ± 0.0
1.088LeuLys: 1.088 ± 0.842
2.176LeuLeu: 2.176 ± 1.683
0.0LeuMet: 0.0 ± 0.0
2.176LeuAsn: 2.176 ± 1.683
1.088LeuPro: 1.088 ± 0.842
2.176LeuGln: 2.176 ± 1.683
1.088LeuArg: 1.088 ± 0.842
7.617LeuSer: 7.617 ± 1.229
0.0LeuThr: 0.0 ± 0.0
7.617LeuVal: 7.617 ± 2.301
4.353LeuTrp: 4.353 ± 2.241
4.353LeuTyr: 4.353 ± 1.834
0.0LeuXaa: 0.0 ± 0.0
Met
1.088MetAla: 1.088 ± 0.842
1.088MetCys: 1.088 ± 0.842
2.176MetAsp: 2.176 ± 2.089
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
1.088MetGly: 1.088 ± 0.842
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
2.176MetLys: 2.176 ± 2.089
2.176MetLeu: 2.176 ± 1.683
0.0MetMet: 0.0 ± 0.0
1.088MetAsn: 1.088 ± 0.842
2.176MetPro: 2.176 ± 1.085
0.0MetGln: 0.0 ± 0.0
1.088MetArg: 1.088 ± 0.842
1.088MetSer: 1.088 ± 0.842
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
6.529AsnAla: 6.529 ± 1.025
0.0AsnCys: 0.0 ± 0.0
4.353AsnAsp: 4.353 ± 1.887
0.0AsnGlu: 0.0 ± 0.0
1.088AsnPhe: 1.088 ± 0.842
4.353AsnGly: 4.353 ± 3.367
0.0AsnHis: 0.0 ± 0.0
2.176AsnIle: 2.176 ± 1.085
0.0AsnLys: 0.0 ± 0.0
4.353AsnLeu: 4.353 ± 1.218
0.0AsnMet: 0.0 ± 0.0
1.088AsnAsn: 1.088 ± 0.842
0.0AsnPro: 0.0 ± 0.0
1.088AsnGln: 1.088 ± 0.842
1.088AsnArg: 1.088 ± 0.842
5.441AsnSer: 5.441 ± 2.299
6.529AsnThr: 6.529 ± 2.903
2.176AsnVal: 2.176 ± 0.854
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
6.529ProAla: 6.529 ± 1.025
0.0ProCys: 0.0 ± 0.0
0.0ProAsp: 0.0 ± 0.0
2.176ProGlu: 2.176 ± 1.085
0.0ProPhe: 0.0 ± 0.0
2.176ProGly: 2.176 ± 1.085
2.176ProHis: 2.176 ± 2.089
2.176ProIle: 2.176 ± 1.085
4.353ProLys: 4.353 ± 2.093
0.0ProLeu: 0.0 ± 0.0
2.176ProMet: 2.176 ± 1.683
3.264ProAsn: 3.264 ± 0.789
0.0ProPro: 0.0 ± 0.0
2.176ProGln: 2.176 ± 1.085
3.264ProArg: 3.264 ± 1.804
8.705ProSer: 8.705 ± 4.186
1.088ProThr: 1.088 ± 0.842
2.176ProVal: 2.176 ± 0.854
1.088ProTrp: 1.088 ± 0.842
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.176GlnAla: 2.176 ± 1.683
2.176GlnCys: 2.176 ± 1.085
1.088GlnAsp: 1.088 ± 0.842
2.176GlnGlu: 2.176 ± 1.683
0.0GlnPhe: 0.0 ± 0.0
0.0GlnGly: 0.0 ± 0.0
2.176GlnHis: 2.176 ± 2.089
1.088GlnIle: 1.088 ± 0.842
0.0GlnLys: 0.0 ± 0.0
4.353GlnLeu: 4.353 ± 2.171
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
2.176GlnPro: 2.176 ± 1.085
0.0GlnGln: 0.0 ± 0.0
1.088GlnArg: 1.088 ± 0.842
3.264GlnSer: 3.264 ± 1.942
4.353GlnThr: 4.353 ± 3.367
1.088GlnVal: 1.088 ± 0.842
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.441ArgAla: 5.441 ± 1.417
0.0ArgCys: 0.0 ± 0.0
6.529ArgAsp: 6.529 ± 2.599
2.176ArgGlu: 2.176 ± 1.085
4.353ArgPhe: 4.353 ± 2.171
5.441ArgGly: 5.441 ± 2.299
0.0ArgHis: 0.0 ± 0.0
2.176ArgIle: 2.176 ± 1.683
5.441ArgLys: 5.441 ± 1.701
5.441ArgLeu: 5.441 ± 3.812
1.088ArgMet: 1.088 ± 0.842
4.353ArgAsn: 4.353 ± 3.367
4.353ArgPro: 4.353 ± 1.212
1.088ArgGln: 1.088 ± 0.842
10.881ArgArg: 10.881 ± 8.416
6.529ArgSer: 6.529 ± 1.798
7.617ArgThr: 7.617 ± 2.498
1.088ArgVal: 1.088 ± 0.842
0.0ArgTrp: 0.0 ± 0.0
3.264ArgTyr: 3.264 ± 0.789
0.0ArgXaa: 0.0 ± 0.0
Ser
5.441SerAla: 5.441 ± 1.417
0.0SerCys: 0.0 ± 0.0
4.353SerAsp: 4.353 ± 1.887
1.088SerGlu: 1.088 ± 0.842
6.529SerPhe: 6.529 ± 2.538
8.705SerGly: 8.705 ± 5.532
1.088SerHis: 1.088 ± 0.841
2.176SerIle: 2.176 ± 2.089
4.353SerLys: 4.353 ± 1.218
4.353SerLeu: 4.353 ± 2.379
2.176SerMet: 2.176 ± 2.089
5.441SerAsn: 5.441 ± 2.299
3.264SerPro: 3.264 ± 0.789
2.176SerGln: 2.176 ± 1.683
7.617SerArg: 7.617 ± 1.864
5.441SerSer: 5.441 ± 1.94
5.441SerThr: 5.441 ± 1.94
5.441SerVal: 5.441 ± 1.417
3.264SerTrp: 3.264 ± 1.804
2.176SerTyr: 2.176 ± 1.683
0.0SerXaa: 0.0 ± 0.0
Thr
4.353ThrAla: 4.353 ± 1.218
1.088ThrCys: 1.088 ± 0.842
3.264ThrAsp: 3.264 ± 0.789
2.176ThrGlu: 2.176 ± 2.089
5.441ThrPhe: 5.441 ± 1.701
9.793ThrGly: 9.793 ± 2.355
0.0ThrHis: 0.0 ± 0.0
1.088ThrIle: 1.088 ± 0.842
2.176ThrLys: 2.176 ± 1.683
2.176ThrLeu: 2.176 ± 0.854
1.088ThrMet: 1.088 ± 0.842
0.0ThrAsn: 0.0 ± 0.0
4.353ThrPro: 4.353 ± 1.218
1.088ThrGln: 1.088 ± 0.842
2.176ThrArg: 2.176 ± 1.683
5.441ThrSer: 5.441 ± 4.208
3.264ThrThr: 3.264 ± 0.789
4.353ThrVal: 4.353 ± 1.887
0.0ThrTrp: 0.0 ± 0.0
2.176ThrTyr: 2.176 ± 1.085
0.0ThrXaa: 0.0 ± 0.0
Val
6.529ValAla: 6.529 ± 1.025
2.176ValCys: 2.176 ± 1.085
8.705ValAsp: 8.705 ± 2.437
5.441ValGlu: 5.441 ± 1.417
2.176ValPhe: 2.176 ± 2.089
4.353ValGly: 4.353 ± 2.171
0.0ValHis: 0.0 ± 0.0
1.088ValIle: 1.088 ± 0.842
3.264ValLys: 3.264 ± 1.804
2.176ValLeu: 2.176 ± 0.854
0.0ValMet: 0.0 ± 0.0
2.176ValAsn: 2.176 ± 1.683
2.176ValPro: 2.176 ± 1.085
2.176ValGln: 2.176 ± 1.085
1.088ValArg: 1.088 ± 0.842
7.617ValSer: 7.617 ± 4.042
2.176ValThr: 2.176 ± 1.085
4.353ValVal: 4.353 ± 2.171
0.0ValTrp: 0.0 ± 0.0
1.088ValTyr: 1.088 ± 0.842
0.0ValXaa: 0.0 ± 0.0
Trp
3.264TrpAla: 3.264 ± 1.647
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
2.176TrpPhe: 2.176 ± 1.683
2.176TrpGly: 2.176 ± 2.089
2.176TrpHis: 2.176 ± 1.683
2.176TrpIle: 2.176 ± 2.089
0.0TrpLys: 0.0 ± 0.0
4.353TrpLeu: 4.353 ± 4.178
0.0TrpMet: 0.0 ± 0.0
2.176TrpAsn: 2.176 ± 1.683
0.0TrpPro: 0.0 ± 0.0
2.176TrpGln: 2.176 ± 1.085
3.264TrpArg: 3.264 ± 0.789
1.088TrpSer: 1.088 ± 0.842
0.0TrpThr: 0.0 ± 0.0
2.176TrpVal: 2.176 ± 1.085
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
7.617TyrAla: 7.617 ± 1.766
0.0TyrCys: 0.0 ± 0.0
4.353TyrAsp: 4.353 ± 1.218
2.176TyrGlu: 2.176 ± 1.085
2.176TyrPhe: 2.176 ± 1.085
1.088TyrGly: 1.088 ± 0.841
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
0.0TyrLys: 0.0 ± 0.0
1.088TyrLeu: 1.088 ± 0.842
1.088TyrMet: 1.088 ± 0.842
2.176TyrAsn: 2.176 ± 0.854
2.176TyrPro: 2.176 ± 1.085
0.0TyrGln: 0.0 ± 0.0
5.441TyrArg: 5.441 ± 2.299
0.0TyrSer: 0.0 ± 0.0
0.0TyrThr: 0.0 ± 0.0
2.176TyrVal: 2.176 ± 1.683
1.088TyrTrp: 1.088 ± 0.842
1.088TyrTyr: 1.088 ± 0.842
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (920 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski