Amino acid dipepetide frequency for Aeromonas phage 59.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.36AlaAla: 12.36 ± 1.446
0.719AlaCys: 0.719 ± 0.238
5.318AlaAsp: 5.318 ± 0.644
6.97AlaGlu: 6.97 ± 0.784
2.515AlaPhe: 2.515 ± 0.292
8.479AlaGly: 8.479 ± 0.903
1.437AlaHis: 1.437 ± 0.259
5.821AlaIle: 5.821 ± 0.638
6.467AlaLys: 6.467 ± 0.692
9.845AlaLeu: 9.845 ± 1.125
3.449AlaMet: 3.449 ± 0.647
3.162AlaAsn: 3.162 ± 0.435
4.024AlaPro: 4.024 ± 0.445
3.162AlaGln: 3.162 ± 0.616
4.599AlaArg: 4.599 ± 0.595
6.108AlaSer: 6.108 ± 0.75
5.461AlaThr: 5.461 ± 0.783
7.976AlaVal: 7.976 ± 0.863
1.078AlaTrp: 1.078 ± 0.277
2.659AlaTyr: 2.659 ± 0.468
0.0AlaXaa: 0.0 ± 0.0
Cys
0.862CysAla: 0.862 ± 0.248
0.287CysCys: 0.287 ± 0.132
0.503CysAsp: 0.503 ± 0.175
0.431CysGlu: 0.431 ± 0.226
0.359CysPhe: 0.359 ± 0.175
1.581CysGly: 1.581 ± 0.339
0.359CysHis: 0.359 ± 0.159
0.862CysIle: 0.862 ± 0.278
0.647CysLys: 0.647 ± 0.205
1.15CysLeu: 1.15 ± 0.32
0.287CysMet: 0.287 ± 0.15
0.287CysAsn: 0.287 ± 0.128
1.006CysPro: 1.006 ± 0.338
0.287CysGln: 0.287 ± 0.145
1.365CysArg: 1.365 ± 0.338
0.575CysSer: 0.575 ± 0.208
0.647CysThr: 0.647 ± 0.2
0.503CysVal: 0.503 ± 0.214
0.216CysTrp: 0.216 ± 0.116
0.503CysTyr: 0.503 ± 0.188
0.0CysXaa: 0.0 ± 0.0
Asp
4.886AspAla: 4.886 ± 0.695
0.862AspCys: 0.862 ± 0.292
2.587AspAsp: 2.587 ± 0.469
3.737AspGlu: 3.737 ± 0.595
1.725AspPhe: 1.725 ± 0.288
4.743AspGly: 4.743 ± 0.582
0.934AspHis: 0.934 ± 0.228
3.234AspIle: 3.234 ± 0.463
3.162AspLys: 3.162 ± 0.493
4.527AspLeu: 4.527 ± 0.439
1.293AspMet: 1.293 ± 0.319
2.443AspAsn: 2.443 ± 0.433
2.874AspPro: 2.874 ± 0.423
1.725AspGln: 1.725 ± 0.35
3.377AspArg: 3.377 ± 0.508
2.443AspSer: 2.443 ± 0.337
3.306AspThr: 3.306 ± 0.482
4.168AspVal: 4.168 ± 0.472
1.15AspTrp: 1.15 ± 0.368
1.437AspTyr: 1.437 ± 0.248
0.0AspXaa: 0.0 ± 0.0
Glu
6.252GluAla: 6.252 ± 0.731
0.503GluCys: 0.503 ± 0.173
3.018GluAsp: 3.018 ± 0.499
3.09GluGlu: 3.09 ± 0.499
3.018GluPhe: 3.018 ± 0.492
3.665GluGly: 3.665 ± 0.514
1.15GluHis: 1.15 ± 0.259
4.24GluIle: 4.24 ± 0.654
2.731GluLys: 2.731 ± 0.435
6.036GluLeu: 6.036 ± 0.664
2.515GluMet: 2.515 ± 0.659
1.653GluAsn: 1.653 ± 0.32
2.012GluPro: 2.012 ± 0.525
3.162GluGln: 3.162 ± 0.462
4.383GluArg: 4.383 ± 0.572
3.521GluSer: 3.521 ± 0.459
2.946GluThr: 2.946 ± 0.355
4.886GluVal: 4.886 ± 0.567
1.293GluTrp: 1.293 ± 0.391
1.581GluTyr: 1.581 ± 0.371
0.0GluXaa: 0.0 ± 0.0
Phe
2.874PheAla: 2.874 ± 0.391
0.647PheCys: 0.647 ± 0.193
2.012PheAsp: 2.012 ± 0.407
2.228PheGlu: 2.228 ± 0.399
0.719PhePhe: 0.719 ± 0.209
3.377PheGly: 3.377 ± 0.498
0.647PheHis: 0.647 ± 0.196
1.725PheIle: 1.725 ± 0.312
2.228PheLys: 2.228 ± 0.408
2.515PheLeu: 2.515 ± 0.465
1.222PheMet: 1.222 ± 0.258
1.509PheAsn: 1.509 ± 0.306
1.437PhePro: 1.437 ± 0.331
1.437PheGln: 1.437 ± 0.304
1.868PheArg: 1.868 ± 0.338
1.437PheSer: 1.437 ± 0.281
1.868PheThr: 1.868 ± 0.392
2.515PheVal: 2.515 ± 0.388
0.862PheTrp: 0.862 ± 0.239
0.503PheTyr: 0.503 ± 0.186
0.0PheXaa: 0.0 ± 0.0
Gly
7.042GlyAla: 7.042 ± 0.943
0.79GlyCys: 0.79 ± 0.239
5.389GlyAsp: 5.389 ± 0.933
5.964GlyGlu: 5.964 ± 0.574
3.952GlyPhe: 3.952 ± 0.516
6.611GlyGly: 6.611 ± 0.625
1.293GlyHis: 1.293 ± 0.285
4.527GlyIle: 4.527 ± 0.933
3.809GlyLys: 3.809 ± 0.589
6.97GlyLeu: 6.97 ± 0.68
3.162GlyMet: 3.162 ± 0.541
2.443GlyAsn: 2.443 ± 0.509
2.443GlyPro: 2.443 ± 0.496
2.084GlyGln: 2.084 ± 0.412
4.024GlyArg: 4.024 ± 0.637
5.318GlySer: 5.318 ± 0.603
4.24GlyThr: 4.24 ± 0.648
5.677GlyVal: 5.677 ± 0.618
1.581GlyTrp: 1.581 ± 0.312
2.587GlyTyr: 2.587 ± 0.517
0.0GlyXaa: 0.0 ± 0.0
His
1.293HisAla: 1.293 ± 0.356
0.719HisCys: 0.719 ± 0.245
0.719HisAsp: 0.719 ± 0.213
1.365HisGlu: 1.365 ± 0.335
1.006HisPhe: 1.006 ± 0.259
1.509HisGly: 1.509 ± 0.301
0.647HisHis: 0.647 ± 0.208
0.719HisIle: 0.719 ± 0.185
1.365HisLys: 1.365 ± 0.313
1.365HisLeu: 1.365 ± 0.278
1.006HisMet: 1.006 ± 0.306
0.719HisAsn: 0.719 ± 0.233
0.934HisPro: 0.934 ± 0.274
1.15HisGln: 1.15 ± 0.291
1.078HisArg: 1.078 ± 0.26
1.293HisSer: 1.293 ± 0.323
0.647HisThr: 0.647 ± 0.243
1.222HisVal: 1.222 ± 0.335
0.359HisTrp: 0.359 ± 0.136
0.503HisTyr: 0.503 ± 0.165
0.0HisXaa: 0.0 ± 0.0
Ile
6.036IleAla: 6.036 ± 0.645
0.647IleCys: 0.647 ± 0.193
3.162IleAsp: 3.162 ± 0.553
3.449IleGlu: 3.449 ± 0.531
1.222IlePhe: 1.222 ± 0.266
4.168IleGly: 4.168 ± 0.507
0.934IleHis: 0.934 ± 0.251
2.084IleIle: 2.084 ± 0.465
3.88IleLys: 3.88 ± 0.519
2.731IleLeu: 2.731 ± 0.423
1.078IleMet: 1.078 ± 0.244
2.371IleAsn: 2.371 ± 0.336
2.587IlePro: 2.587 ± 0.448
1.653IleGln: 1.653 ± 0.321
3.234IleArg: 3.234 ± 0.587
4.024IleSer: 4.024 ± 0.482
4.671IleThr: 4.671 ± 0.583
3.018IleVal: 3.018 ± 0.389
0.647IleTrp: 0.647 ± 0.167
1.078IleTyr: 1.078 ± 0.33
0.072IleXaa: 0.072 ± 0.061
Lys
8.048LysAla: 8.048 ± 0.694
0.647LysCys: 0.647 ± 0.189
2.731LysAsp: 2.731 ± 0.362
2.659LysGlu: 2.659 ± 0.493
1.293LysPhe: 1.293 ± 0.256
5.102LysGly: 5.102 ± 0.68
1.293LysHis: 1.293 ± 0.354
2.587LysIle: 2.587 ± 0.408
2.371LysLys: 2.371 ± 0.337
4.815LysLeu: 4.815 ± 0.607
2.731LysMet: 2.731 ± 0.439
1.293LysAsn: 1.293 ± 0.27
2.731LysPro: 2.731 ± 0.387
2.515LysGln: 2.515 ± 0.441
4.599LysArg: 4.599 ± 0.593
2.659LysSer: 2.659 ± 0.384
3.377LysThr: 3.377 ± 0.4
4.671LysVal: 4.671 ± 0.587
0.503LysTrp: 0.503 ± 0.188
1.078LysTyr: 1.078 ± 0.251
0.0LysXaa: 0.0 ± 0.0
Leu
7.258LeuAla: 7.258 ± 0.916
1.293LeuCys: 1.293 ± 0.372
5.246LeuAsp: 5.246 ± 0.586
6.467LeuGlu: 6.467 ± 0.694
2.012LeuPhe: 2.012 ± 0.352
5.605LeuGly: 5.605 ± 0.731
1.868LeuHis: 1.868 ± 0.33
4.096LeuIle: 4.096 ± 0.505
4.671LeuLys: 4.671 ± 0.627
6.252LeuLeu: 6.252 ± 0.61
3.234LeuMet: 3.234 ± 0.507
2.946LeuAsn: 2.946 ± 0.446
4.096LeuPro: 4.096 ± 0.632
2.587LeuGln: 2.587 ± 0.359
4.958LeuArg: 4.958 ± 0.555
6.036LeuSer: 6.036 ± 0.635
5.533LeuThr: 5.533 ± 0.646
5.749LeuVal: 5.749 ± 0.749
1.653LeuTrp: 1.653 ± 0.334
2.156LeuTyr: 2.156 ± 0.418
0.0LeuXaa: 0.0 ± 0.0
Met
4.312MetAla: 4.312 ± 0.715
0.287MetCys: 0.287 ± 0.158
2.012MetAsp: 2.012 ± 0.466
1.581MetGlu: 1.581 ± 0.387
1.006MetPhe: 1.006 ± 0.297
2.659MetGly: 2.659 ± 0.456
0.216MetHis: 0.216 ± 0.114
2.084MetIle: 2.084 ± 0.407
2.803MetLys: 2.803 ± 0.441
3.09MetLeu: 3.09 ± 0.521
0.934MetMet: 0.934 ± 0.249
1.222MetAsn: 1.222 ± 0.317
1.365MetPro: 1.365 ± 0.323
0.719MetGln: 0.719 ± 0.234
1.509MetArg: 1.509 ± 0.378
3.306MetSer: 3.306 ± 0.512
2.659MetThr: 2.659 ± 0.493
2.946MetVal: 2.946 ± 0.391
0.216MetTrp: 0.216 ± 0.125
0.647MetTyr: 0.647 ± 0.224
0.0MetXaa: 0.0 ± 0.0
Asn
3.377AsnAla: 3.377 ± 0.612
0.503AsnCys: 0.503 ± 0.186
1.725AsnAsp: 1.725 ± 0.309
1.796AsnGlu: 1.796 ± 0.351
1.006AsnPhe: 1.006 ± 0.28
3.521AsnGly: 3.521 ± 0.664
0.862AsnHis: 0.862 ± 0.274
1.796AsnIle: 1.796 ± 0.408
2.012AsnLys: 2.012 ± 0.385
3.306AsnLeu: 3.306 ± 0.491
1.437AsnMet: 1.437 ± 0.289
1.365AsnAsn: 1.365 ± 0.292
1.94AsnPro: 1.94 ± 0.373
1.365AsnGln: 1.365 ± 0.285
2.515AsnArg: 2.515 ± 0.417
1.796AsnSer: 1.796 ± 0.379
1.653AsnThr: 1.653 ± 0.4
1.868AsnVal: 1.868 ± 0.4
0.719AsnTrp: 0.719 ± 0.25
0.647AsnTyr: 0.647 ± 0.227
0.0AsnXaa: 0.0 ± 0.0
Pro
4.383ProAla: 4.383 ± 0.6
0.503ProCys: 0.503 ± 0.209
2.515ProAsp: 2.515 ± 0.362
3.09ProGlu: 3.09 ± 0.585
1.725ProPhe: 1.725 ± 0.381
3.234ProGly: 3.234 ± 0.558
0.647ProHis: 0.647 ± 0.235
2.587ProIle: 2.587 ± 0.466
2.874ProLys: 2.874 ± 0.487
4.024ProLeu: 4.024 ± 0.571
0.79ProMet: 0.79 ± 0.224
1.078ProAsn: 1.078 ± 0.257
1.796ProPro: 1.796 ± 0.387
0.862ProGln: 0.862 ± 0.232
1.868ProArg: 1.868 ± 0.561
2.946ProSer: 2.946 ± 0.551
2.587ProThr: 2.587 ± 0.393
3.88ProVal: 3.88 ± 0.547
0.359ProTrp: 0.359 ± 0.202
1.078ProTyr: 1.078 ± 0.279
0.0ProXaa: 0.0 ± 0.0
Gln
4.024GlnAla: 4.024 ± 0.519
0.719GlnCys: 0.719 ± 0.237
1.006GlnAsp: 1.006 ± 0.304
2.371GlnGlu: 2.371 ± 0.405
0.647GlnPhe: 0.647 ± 0.198
2.3GlnGly: 2.3 ± 0.367
0.719GlnHis: 0.719 ± 0.234
1.796GlnIle: 1.796 ± 0.341
1.94GlnLys: 1.94 ± 0.486
3.306GlnLeu: 3.306 ± 0.648
1.796GlnMet: 1.796 ± 0.344
0.647GlnAsn: 0.647 ± 0.186
0.575GlnPro: 0.575 ± 0.209
1.006GlnGln: 1.006 ± 0.278
2.515GlnArg: 2.515 ± 0.485
2.659GlnSer: 2.659 ± 0.504
1.868GlnThr: 1.868 ± 0.364
2.731GlnVal: 2.731 ± 0.419
0.862GlnTrp: 0.862 ± 0.208
0.862GlnTyr: 0.862 ± 0.244
0.0GlnXaa: 0.0 ± 0.0
Arg
5.318ArgAla: 5.318 ± 0.703
0.862ArgCys: 0.862 ± 0.265
3.449ArgAsp: 3.449 ± 0.422
3.449ArgGlu: 3.449 ± 0.514
2.515ArgPhe: 2.515 ± 0.441
4.24ArgGly: 4.24 ± 0.545
1.725ArgHis: 1.725 ± 0.359
3.09ArgIle: 3.09 ± 0.479
3.809ArgLys: 3.809 ± 0.508
5.461ArgLeu: 5.461 ± 0.655
1.653ArgMet: 1.653 ± 0.302
2.874ArgAsn: 2.874 ± 0.489
2.3ArgPro: 2.3 ± 0.424
1.94ArgGln: 1.94 ± 0.341
3.665ArgArg: 3.665 ± 0.902
4.455ArgSer: 4.455 ± 0.647
2.659ArgThr: 2.659 ± 0.465
4.024ArgVal: 4.024 ± 0.561
1.222ArgTrp: 1.222 ± 0.287
1.653ArgTyr: 1.653 ± 0.301
0.0ArgXaa: 0.0 ± 0.0
Ser
5.964SerAla: 5.964 ± 0.669
0.503SerCys: 0.503 ± 0.183
4.383SerAsp: 4.383 ± 0.633
3.449SerGlu: 3.449 ± 0.611
2.515SerPhe: 2.515 ± 0.404
5.533SerGly: 5.533 ± 0.639
1.437SerHis: 1.437 ± 0.283
2.731SerIle: 2.731 ± 0.494
3.809SerLys: 3.809 ± 0.505
5.246SerLeu: 5.246 ± 0.729
2.443SerMet: 2.443 ± 0.445
2.874SerAsn: 2.874 ± 0.554
3.665SerPro: 3.665 ± 0.646
1.868SerGln: 1.868 ± 0.382
2.515SerArg: 2.515 ± 0.478
3.234SerSer: 3.234 ± 0.491
3.88SerThr: 3.88 ± 0.491
3.377SerVal: 3.377 ± 0.486
0.862SerTrp: 0.862 ± 0.246
1.293SerTyr: 1.293 ± 0.285
0.0SerXaa: 0.0 ± 0.0
Thr
5.964ThrAla: 5.964 ± 0.844
0.575ThrCys: 0.575 ± 0.213
2.371ThrAsp: 2.371 ± 0.448
2.874ThrGlu: 2.874 ± 0.399
2.659ThrPhe: 2.659 ± 0.463
5.821ThrGly: 5.821 ± 0.754
0.79ThrHis: 0.79 ± 0.237
3.88ThrIle: 3.88 ± 0.553
3.521ThrLys: 3.521 ± 0.725
5.389ThrLeu: 5.389 ± 0.706
2.012ThrMet: 2.012 ± 0.347
1.653ThrAsn: 1.653 ± 0.401
3.521ThrPro: 3.521 ± 0.548
1.796ThrGln: 1.796 ± 0.331
3.952ThrArg: 3.952 ± 0.497
2.3ThrSer: 2.3 ± 0.312
3.737ThrThr: 3.737 ± 0.557
3.88ThrVal: 3.88 ± 0.446
0.647ThrTrp: 0.647 ± 0.158
1.365ThrTyr: 1.365 ± 0.29
0.0ThrXaa: 0.0 ± 0.0
Val
7.761ValAla: 7.761 ± 1.052
0.862ValCys: 0.862 ± 0.229
3.952ValAsp: 3.952 ± 0.568
4.599ValGlu: 4.599 ± 0.554
2.371ValPhe: 2.371 ± 0.372
4.383ValGly: 4.383 ± 0.648
1.437ValHis: 1.437 ± 0.346
3.593ValIle: 3.593 ± 0.59
4.096ValLys: 4.096 ± 0.516
4.312ValLeu: 4.312 ± 0.581
3.306ValMet: 3.306 ± 0.491
2.731ValAsn: 2.731 ± 0.545
2.515ValPro: 2.515 ± 0.502
2.587ValGln: 2.587 ± 0.398
4.599ValArg: 4.599 ± 0.563
5.03ValSer: 5.03 ± 0.607
5.605ValThr: 5.605 ± 0.655
6.539ValVal: 6.539 ± 0.843
1.222ValTrp: 1.222 ± 0.273
1.365ValTyr: 1.365 ± 0.262
0.072ValXaa: 0.072 ± 0.067
Trp
1.437TrpAla: 1.437 ± 0.307
0.431TrpCys: 0.431 ± 0.176
1.437TrpAsp: 1.437 ± 0.344
0.79TrpGlu: 0.79 ± 0.263
0.719TrpPhe: 0.719 ± 0.204
1.509TrpGly: 1.509 ± 0.314
0.359TrpHis: 0.359 ± 0.163
0.503TrpIle: 0.503 ± 0.169
0.575TrpLys: 0.575 ± 0.187
1.293TrpLeu: 1.293 ± 0.34
0.575TrpMet: 0.575 ± 0.199
0.79TrpAsn: 0.79 ± 0.273
0.359TrpPro: 0.359 ± 0.161
0.79TrpGln: 0.79 ± 0.255
1.437TrpArg: 1.437 ± 0.338
0.79TrpSer: 0.79 ± 0.268
0.503TrpThr: 0.503 ± 0.207
1.293TrpVal: 1.293 ± 0.287
0.0TrpTrp: 0.0 ± 0.0
0.431TrpTyr: 0.431 ± 0.177
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.156TyrAla: 2.156 ± 0.372
0.359TyrCys: 0.359 ± 0.174
1.078TyrAsp: 1.078 ± 0.257
1.293TyrGlu: 1.293 ± 0.279
0.647TyrPhe: 0.647 ± 0.178
1.796TyrGly: 1.796 ± 0.332
0.862TyrHis: 0.862 ± 0.27
0.79TyrIle: 0.79 ± 0.262
0.934TyrLys: 0.934 ± 0.254
2.084TyrLeu: 2.084 ± 0.385
0.503TyrMet: 0.503 ± 0.195
1.15TyrAsn: 1.15 ± 0.294
0.647TyrPro: 0.647 ± 0.172
1.653TyrGln: 1.653 ± 0.314
2.3TyrArg: 2.3 ± 0.449
1.653TyrSer: 1.653 ± 0.394
0.934TyrThr: 0.934 ± 0.206
2.012TyrVal: 2.012 ± 0.365
0.575TyrTrp: 0.575 ± 0.199
0.934TyrTyr: 0.934 ± 0.253
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.072XaaGly: 0.072 ± 0.067
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.072XaaMet: 0.072 ± 0.06
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 87 proteins (13917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski