Amino acid dipepetide frequency for Hubei astro-like virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.397AlaAla: 8.397 ± 1.72
1.599AlaCys: 1.599 ± 0.488
2.799AlaAsp: 2.799 ± 1.026
2.799AlaGlu: 2.799 ± 0.94
2.799AlaPhe: 2.799 ± 0.409
4.798AlaGly: 4.798 ± 1.289
0.4AlaHis: 0.4 ± 0.316
6.397AlaIle: 6.397 ± 0.628
3.599AlaLys: 3.599 ± 1.35
7.197AlaLeu: 7.197 ± 1.513
2.399AlaMet: 2.399 ± 0.853
3.199AlaAsn: 3.199 ± 0.631
4.798AlaPro: 4.798 ± 1.579
2.799AlaGln: 2.799 ± 0.708
5.198AlaArg: 5.198 ± 1.037
5.198AlaSer: 5.198 ± 0.964
4.798AlaThr: 4.798 ± 1.666
7.597AlaVal: 7.597 ± 1.701
1.999AlaTrp: 1.999 ± 0.276
2.399AlaTyr: 2.399 ± 1.272
0.0AlaXaa: 0.0 ± 0.0
Cys
1.999CysAla: 1.999 ± 1.263
0.0CysCys: 0.0 ± 0.0
0.4CysAsp: 0.4 ± 0.329
0.8CysGlu: 0.8 ± 0.669
0.8CysPhe: 0.8 ± 0.669
0.8CysGly: 0.8 ± 0.659
0.8CysHis: 0.8 ± 0.381
0.4CysIle: 0.4 ± 0.334
0.4CysLys: 0.4 ± 0.334
1.999CysLeu: 1.999 ± 0.651
0.0CysMet: 0.0 ± 0.0
1.599CysAsn: 1.599 ± 0.943
0.8CysPro: 0.8 ± 0.275
0.8CysGln: 0.8 ± 0.452
0.4CysArg: 0.4 ± 0.329
1.999CysSer: 1.999 ± 0.721
2.399CysThr: 2.399 ± 0.987
1.599CysVal: 1.599 ± 0.846
0.4CysTrp: 0.4 ± 0.334
0.8CysTyr: 0.8 ± 0.423
0.0CysXaa: 0.0 ± 0.0
Asp
4.798AspAla: 4.798 ± 1.612
1.999AspCys: 1.999 ± 1.672
4.398AspAsp: 4.398 ± 1.028
3.599AspGlu: 3.599 ± 1.388
1.599AspPhe: 1.599 ± 0.928
1.599AspGly: 1.599 ± 0.549
1.599AspHis: 1.599 ± 0.434
1.999AspIle: 1.999 ± 0.565
1.999AspLys: 1.999 ± 0.767
3.199AspLeu: 3.199 ± 1.256
0.8AspMet: 0.8 ± 0.275
2.399AspAsn: 2.399 ± 0.596
3.199AspPro: 3.199 ± 0.79
3.599AspGln: 3.599 ± 0.574
2.399AspArg: 2.399 ± 1.218
2.799AspSer: 2.799 ± 1.049
1.999AspThr: 1.999 ± 1.238
0.4AspVal: 0.4 ± 0.316
1.2AspTrp: 1.2 ± 0.636
1.999AspTyr: 1.999 ± 1.289
0.0AspXaa: 0.0 ± 0.0
Glu
3.599GluAla: 3.599 ± 1.326
0.0GluCys: 0.0 ± 0.0
1.999GluAsp: 1.999 ± 1.289
1.599GluGlu: 1.599 ± 0.761
0.4GluPhe: 0.4 ± 0.329
3.599GluGly: 3.599 ± 0.629
0.0GluHis: 0.0 ± 0.0
1.999GluIle: 1.999 ± 0.565
1.2GluLys: 1.2 ± 0.668
2.399GluLeu: 2.399 ± 0.596
0.8GluMet: 0.8 ± 0.452
0.8GluAsn: 0.8 ± 0.381
3.199GluPro: 3.199 ± 0.981
1.999GluGln: 1.999 ± 0.994
1.999GluArg: 1.999 ± 0.565
1.999GluSer: 1.999 ± 0.727
2.399GluThr: 2.399 ± 0.596
1.999GluVal: 1.999 ± 0.761
0.8GluTrp: 0.8 ± 0.423
3.199GluTyr: 3.199 ± 1.041
0.0GluXaa: 0.0 ± 0.0
Phe
1.599PheAla: 1.599 ± 0.488
1.2PheCys: 1.2 ± 0.44
2.799PheAsp: 2.799 ± 0.904
1.999PheGlu: 1.999 ± 1.035
1.999PhePhe: 1.999 ± 1.672
2.399PheGly: 2.399 ± 0.164
0.8PheHis: 0.8 ± 0.381
0.4PheIle: 0.4 ± 0.371
1.599PheLys: 1.599 ± 0.549
3.599PheLeu: 3.599 ± 0.574
0.8PheMet: 0.8 ± 0.423
1.2PheAsn: 1.2 ± 0.988
2.399PhePro: 2.399 ± 0.67
0.8PheGln: 0.8 ± 0.669
3.199PheArg: 3.199 ± 1.422
3.199PheSer: 3.199 ± 0.727
3.599PheThr: 3.599 ± 1.486
3.199PheVal: 3.199 ± 1.246
0.4PheTrp: 0.4 ± 0.334
1.999PheTyr: 1.999 ± 0.565
0.0PheXaa: 0.0 ± 0.0
Gly
4.798GlyAla: 4.798 ± 1.622
1.599GlyCys: 1.599 ± 0.761
1.999GlyAsp: 1.999 ± 1.056
1.2GlyGlu: 1.2 ± 0.255
5.198GlyPhe: 5.198 ± 1.846
5.998GlyGly: 5.998 ± 0.85
0.4GlyHis: 0.4 ± 0.316
2.799GlyIle: 2.799 ± 0.86
4.398GlyLys: 4.398 ± 1.05
7.997GlyLeu: 7.997 ± 1.658
1.999GlyMet: 1.999 ± 0.331
1.599GlyAsn: 1.599 ± 0.549
3.199GlyPro: 3.199 ± 0.749
2.399GlyGln: 2.399 ± 1.529
2.399GlyArg: 2.399 ± 0.708
7.197GlySer: 7.197 ± 1.477
6.397GlyThr: 6.397 ± 1.8
2.399GlyVal: 2.399 ± 0.67
1.599GlyTrp: 1.599 ± 0.943
3.199GlyTyr: 3.199 ± 0.59
0.0GlyXaa: 0.0 ± 0.0
His
1.2HisAla: 1.2 ± 0.255
0.8HisCys: 0.8 ± 0.669
0.4HisAsp: 0.4 ± 0.329
0.4HisGlu: 0.4 ± 0.329
0.8HisPhe: 0.8 ± 0.669
2.399HisGly: 2.399 ± 0.444
0.8HisHis: 0.8 ± 0.406
0.8HisIle: 0.8 ± 0.406
0.0HisLys: 0.0 ± 0.0
2.799HisLeu: 2.799 ± 0.763
0.0HisMet: 0.0 ± 0.0
1.599HisAsn: 1.599 ± 0.434
1.999HisPro: 1.999 ± 1.289
1.2HisGln: 1.2 ± 0.368
1.599HisArg: 1.599 ± 0.57
2.399HisSer: 2.399 ± 1.488
1.2HisThr: 1.2 ± 0.368
1.599HisVal: 1.599 ± 0.43
0.4HisTrp: 0.4 ± 0.316
0.4HisTyr: 0.4 ± 0.329
0.0HisXaa: 0.0 ± 0.0
Ile
4.398IleAla: 4.398 ± 1.581
0.8IleCys: 0.8 ± 0.381
1.999IleAsp: 1.999 ± 0.415
1.599IleGlu: 1.599 ± 0.521
2.399IlePhe: 2.399 ± 1.052
5.598IleGly: 5.598 ± 0.777
1.2IleHis: 1.2 ± 0.255
1.599IleIle: 1.599 ± 0.812
2.399IleLys: 2.399 ± 1.296
3.599IleLeu: 3.599 ± 2.889
1.599IleMet: 1.599 ± 0.825
1.2IleAsn: 1.2 ± 0.649
2.399IlePro: 2.399 ± 0.63
1.2IleGln: 1.2 ± 0.687
1.599IleArg: 1.599 ± 0.646
3.199IleSer: 3.199 ± 0.381
3.998IleThr: 3.998 ± 1.432
4.398IleVal: 4.398 ± 0.944
1.2IleTrp: 1.2 ± 0.666
1.999IleTyr: 1.999 ± 0.565
0.0IleXaa: 0.0 ± 0.0
Lys
2.799LysAla: 2.799 ± 0.628
0.4LysCys: 0.4 ± 0.329
2.399LysAsp: 2.399 ± 0.509
3.599LysGlu: 3.599 ± 1.78
1.999LysPhe: 1.999 ± 0.506
2.799LysGly: 2.799 ± 0.466
1.999LysHis: 1.999 ± 0.833
0.8LysIle: 0.8 ± 0.659
2.799LysLys: 2.799 ± 0.628
3.599LysLeu: 3.599 ± 1.589
1.2LysMet: 1.2 ± 0.668
1.599LysAsn: 1.599 ± 0.151
1.2LysPro: 1.2 ± 0.368
1.2LysGln: 1.2 ± 0.649
3.998LysArg: 3.998 ± 1.057
3.998LysSer: 3.998 ± 0.791
2.399LysThr: 2.399 ± 0.662
1.2LysVal: 1.2 ± 0.44
0.4LysTrp: 0.4 ± 0.316
0.8LysTyr: 0.8 ± 0.659
0.0LysXaa: 0.0 ± 0.0
Leu
7.997LeuAla: 7.997 ± 1.953
1.999LeuCys: 1.999 ± 0.721
3.199LeuAsp: 3.199 ± 1.163
1.599LeuGlu: 1.599 ± 0.969
1.999LeuPhe: 1.999 ± 1.037
5.598LeuGly: 5.598 ± 1.518
4.798LeuHis: 4.798 ± 0.51
5.198LeuIle: 5.198 ± 2.412
3.199LeuLys: 3.199 ± 1.163
11.196LeuLeu: 11.196 ± 4.125
3.199LeuMet: 3.199 ± 0.476
3.599LeuAsn: 3.599 ± 0.952
3.599LeuPro: 3.599 ± 1.114
1.999LeuGln: 1.999 ± 0.971
4.398LeuArg: 4.398 ± 0.863
8.796LeuSer: 8.796 ± 2.745
8.796LeuThr: 8.796 ± 1.962
9.996LeuVal: 9.996 ± 2.726
3.599LeuTrp: 3.599 ± 2.071
1.2LeuTyr: 1.2 ± 0.712
0.0LeuXaa: 0.0 ± 0.0
Met
1.2MetAla: 1.2 ± 0.368
0.0MetCys: 0.0 ± 0.0
1.2MetAsp: 1.2 ± 0.668
0.8MetGlu: 0.8 ± 0.406
1.2MetPhe: 1.2 ± 1.003
1.2MetGly: 1.2 ± 0.649
0.0MetHis: 0.0 ± 0.0
0.8MetIle: 0.8 ± 0.659
0.0MetLys: 0.0 ± 0.0
3.998MetLeu: 3.998 ± 1.542
0.8MetMet: 0.8 ± 0.748
0.8MetAsn: 0.8 ± 0.742
2.399MetPro: 2.399 ± 0.903
1.2MetGln: 1.2 ± 0.948
1.999MetArg: 1.999 ± 0.721
2.399MetSer: 2.399 ± 0.619
1.2MetThr: 1.2 ± 0.648
1.599MetVal: 1.599 ± 0.965
0.8MetTrp: 0.8 ± 0.659
0.8MetTyr: 0.8 ± 0.275
0.0MetXaa: 0.0 ± 0.0
Asn
1.2AsnAla: 1.2 ± 0.636
0.4AsnCys: 0.4 ± 0.329
2.799AsnAsp: 2.799 ± 0.656
0.4AsnGlu: 0.4 ± 0.329
1.2AsnPhe: 1.2 ± 1.003
2.399AsnGly: 2.399 ± 0.362
1.999AsnHis: 1.999 ± 0.415
2.799AsnIle: 2.799 ± 0.409
1.2AsnLys: 1.2 ± 0.44
3.599AsnLeu: 3.599 ± 1.156
2.799AsnMet: 2.799 ± 0.62
0.4AsnAsn: 0.4 ± 0.334
1.2AsnPro: 1.2 ± 0.255
1.999AsnGln: 1.999 ± 1.282
2.399AsnArg: 2.399 ± 0.979
2.399AsnSer: 2.399 ± 1.389
1.999AsnThr: 1.999 ± 0.994
2.799AsnVal: 2.799 ± 0.86
0.8AsnTrp: 0.8 ± 0.632
1.2AsnTyr: 1.2 ± 0.255
0.0AsnXaa: 0.0 ± 0.0
Pro
2.799ProAla: 2.799 ± 0.409
1.2ProCys: 1.2 ± 0.648
3.199ProAsp: 3.199 ± 0.874
2.399ProGlu: 2.399 ± 0.444
1.999ProPhe: 1.999 ± 0.506
6.797ProGly: 6.797 ± 1.456
0.8ProHis: 0.8 ± 0.381
3.998ProIle: 3.998 ± 1.608
1.2ProLys: 1.2 ± 0.636
5.198ProLeu: 5.198 ± 1.726
0.4ProMet: 0.4 ± 0.329
1.599ProAsn: 1.599 ± 0.43
3.199ProPro: 3.199 ± 2.168
0.8ProGln: 0.8 ± 0.632
3.998ProArg: 3.998 ± 0.604
3.599ProSer: 3.599 ± 0.913
3.599ProThr: 3.599 ± 0.271
5.998ProVal: 5.998 ± 1.065
0.8ProTrp: 0.8 ± 0.452
1.599ProTyr: 1.599 ± 0.434
0.0ProXaa: 0.0 ± 0.0
Gln
3.199GlnAla: 3.199 ± 1.163
0.4GlnCys: 0.4 ± 0.329
0.4GlnAsp: 0.4 ± 0.334
1.2GlnGlu: 1.2 ± 0.764
1.2GlnPhe: 1.2 ± 0.255
2.399GlnGly: 2.399 ± 0.594
0.4GlnHis: 0.4 ± 0.334
1.999GlnIle: 1.999 ± 0.332
1.599GlnLys: 1.599 ± 0.151
1.999GlnLeu: 1.999 ± 0.719
0.8GlnMet: 0.8 ± 0.452
0.8GlnAsn: 0.8 ± 0.632
1.999GlnPro: 1.999 ± 0.506
1.999GlnGln: 1.999 ± 0.71
2.399GlnArg: 2.399 ± 0.557
5.598GlnSer: 5.598 ± 1.332
1.999GlnThr: 1.999 ± 1.119
3.599GlnVal: 3.599 ± 0.997
1.2GlnTrp: 1.2 ± 0.331
1.2GlnTyr: 1.2 ± 0.44
0.0GlnXaa: 0.0 ± 0.0
Arg
4.798ArgAla: 4.798 ± 0.798
1.2ArgCys: 1.2 ± 1.003
1.2ArgAsp: 1.2 ± 0.668
1.599ArgGlu: 1.599 ± 0.835
1.599ArgPhe: 1.599 ± 0.521
3.599ArgGly: 3.599 ± 1.156
1.599ArgHis: 1.599 ± 0.941
3.599ArgIle: 3.599 ± 1.066
5.598ArgLys: 5.598 ± 1.953
5.598ArgLeu: 5.598 ± 1.997
1.999ArgMet: 1.999 ± 0.506
1.2ArgAsn: 1.2 ± 1.003
2.799ArgPro: 2.799 ± 1.124
2.799ArgGln: 2.799 ± 1.049
4.798ArgArg: 4.798 ± 1.42
1.999ArgSer: 1.999 ± 0.917
2.399ArgThr: 2.399 ± 0.995
6.397ArgVal: 6.397 ± 1.25
1.999ArgTrp: 1.999 ± 0.837
2.399ArgTyr: 2.399 ± 0.619
0.0ArgXaa: 0.0 ± 0.0
Ser
6.797SerAla: 6.797 ± 2.163
1.2SerCys: 1.2 ± 0.636
6.397SerAsp: 6.397 ± 1.57
1.2SerGlu: 1.2 ± 0.649
5.198SerPhe: 5.198 ± 0.964
3.998SerGly: 3.998 ± 1.119
1.599SerHis: 1.599 ± 0.634
3.599SerIle: 3.599 ± 1.137
2.799SerLys: 2.799 ± 1.151
5.998SerLeu: 5.998 ± 1.958
1.599SerMet: 1.599 ± 0.647
4.398SerAsn: 4.398 ± 0.999
4.398SerPro: 4.398 ± 1.239
2.399SerGln: 2.399 ± 0.557
1.999SerArg: 1.999 ± 0.721
7.997SerSer: 7.997 ± 1.496
5.998SerThr: 5.998 ± 2.134
7.197SerVal: 7.197 ± 0.723
2.399SerTrp: 2.399 ± 0.737
1.599SerTyr: 1.599 ± 0.647
0.0SerXaa: 0.0 ± 0.0
Thr
7.197ThrAla: 7.197 ± 0.819
1.999ThrCys: 1.999 ± 1.064
3.998ThrAsp: 3.998 ± 0.475
2.799ThrGlu: 2.799 ± 1.11
1.999ThrPhe: 1.999 ± 0.727
3.599ThrGly: 3.599 ± 1.039
0.8ThrHis: 0.8 ± 0.381
3.998ThrIle: 3.998 ± 0.155
3.199ThrLys: 3.199 ± 1.686
5.998ThrLeu: 5.998 ± 1.541
0.8ThrMet: 0.8 ± 0.426
2.399ThrAsn: 2.399 ± 0.871
4.798ThrPro: 4.798 ± 1.089
1.999ThrGln: 1.999 ± 0.792
6.397ThrArg: 6.397 ± 0.739
5.198ThrSer: 5.198 ± 2.406
7.597ThrThr: 7.597 ± 3.28
5.598ThrVal: 5.598 ± 1.765
1.999ThrTrp: 1.999 ± 0.69
1.599ThrTyr: 1.599 ± 0.646
0.0ThrXaa: 0.0 ± 0.0
Val
7.597ValAla: 7.597 ± 1.286
0.4ValCys: 0.4 ± 0.371
3.199ValAsp: 3.199 ± 1.885
3.998ValGlu: 3.998 ± 0.965
1.599ValPhe: 1.599 ± 0.943
7.997ValGly: 7.997 ± 0.722
1.999ValHis: 1.999 ± 0.565
2.399ValIle: 2.399 ± 0.88
1.999ValLys: 1.999 ± 0.907
9.596ValLeu: 9.596 ± 2.451
0.4ValMet: 0.4 ± 0.316
3.199ValAsn: 3.199 ± 0.854
3.599ValPro: 3.599 ± 0.721
3.599ValGln: 3.599 ± 0.971
3.599ValArg: 3.599 ± 0.799
5.998ValSer: 5.998 ± 1.821
5.998ValThr: 5.998 ± 1.22
5.198ValVal: 5.198 ± 2.389
1.599ValTrp: 1.599 ± 0.521
2.399ValTyr: 2.399 ± 0.164
0.0ValXaa: 0.0 ± 0.0
Trp
1.999TrpAla: 1.999 ± 0.565
1.2TrpCys: 1.2 ± 0.368
1.2TrpAsp: 1.2 ± 0.666
1.599TrpGlu: 1.599 ± 0.521
1.599TrpPhe: 1.599 ± 0.151
0.8TrpGly: 0.8 ± 0.742
0.4TrpHis: 0.4 ± 0.329
1.599TrpIle: 1.599 ± 0.634
0.8TrpLys: 0.8 ± 0.412
3.998TrpLeu: 3.998 ± 2.371
0.4TrpMet: 0.4 ± 0.329
1.2TrpAsn: 1.2 ± 0.649
0.4TrpPro: 0.4 ± 0.316
0.4TrpGln: 0.4 ± 0.334
1.599TrpArg: 1.599 ± 0.434
1.2TrpSer: 1.2 ± 0.331
1.999TrpThr: 1.999 ± 0.276
1.599TrpVal: 1.599 ± 0.943
0.8TrpTrp: 0.8 ± 0.742
1.2TrpTyr: 1.2 ± 0.255
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.799TyrAla: 2.799 ± 1.636
0.8TyrCys: 0.8 ± 0.406
1.599TyrAsp: 1.599 ± 0.761
0.8TyrGlu: 0.8 ± 0.381
1.599TyrPhe: 1.599 ± 0.43
0.4TyrGly: 0.4 ± 0.316
0.4TyrHis: 0.4 ± 0.334
1.2TyrIle: 1.2 ± 0.331
1.2TyrLys: 1.2 ± 1.003
2.399TyrLeu: 2.399 ± 0.444
1.599TyrMet: 1.599 ± 0.521
1.2TyrAsn: 1.2 ± 0.255
3.599TyrPro: 3.599 ± 1.246
1.2TyrGln: 1.2 ± 0.331
2.799TyrArg: 2.799 ± 0.98
1.599TyrSer: 1.599 ± 0.434
3.199TyrThr: 3.199 ± 0.901
1.999TyrVal: 1.999 ± 0.833
1.599TyrTrp: 1.599 ± 0.557
1.599TyrTyr: 1.599 ± 0.972
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski