Amino acid dipepetide frequency for Silicibacter phage DSS3-P1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.957AlaAla: 17.957 ± 2.126
0.686AlaCys: 0.686 ± 0.215
6.462AlaAsp: 6.462 ± 0.696
8.635AlaGlu: 8.635 ± 0.962
3.088AlaPhe: 3.088 ± 0.612
8.521AlaGly: 8.521 ± 1.039
2.173AlaHis: 2.173 ± 0.386
4.804AlaIle: 4.804 ± 0.559
5.433AlaLys: 5.433 ± 0.981
9.15AlaLeu: 9.15 ± 0.865
2.631AlaMet: 2.631 ± 0.38
3.66AlaAsn: 3.66 ± 0.497
4.804AlaPro: 4.804 ± 0.589
3.774AlaGln: 3.774 ± 0.879
9.036AlaArg: 9.036 ± 1.04
5.433AlaSer: 5.433 ± 0.651
6.291AlaThr: 6.291 ± 0.605
8.292AlaVal: 8.292 ± 0.606
1.773AlaTrp: 1.773 ± 0.358
3.603AlaTyr: 3.603 ± 0.483
0.0AlaXaa: 0.0 ± 0.0
Cys
1.029CysAla: 1.029 ± 0.244
0.057CysCys: 0.057 ± 0.048
0.343CysAsp: 0.343 ± 0.146
0.4CysGlu: 0.4 ± 0.156
0.229CysPhe: 0.229 ± 0.103
0.858CysGly: 0.858 ± 0.265
0.572CysHis: 0.572 ± 0.255
0.229CysIle: 0.229 ± 0.111
0.229CysLys: 0.229 ± 0.118
0.915CysLeu: 0.915 ± 0.29
0.114CysMet: 0.114 ± 0.077
0.114CysAsn: 0.114 ± 0.071
0.858CysPro: 0.858 ± 0.22
0.229CysGln: 0.229 ± 0.108
0.686CysArg: 0.686 ± 0.218
0.458CysSer: 0.458 ± 0.145
0.515CysThr: 0.515 ± 0.145
0.458CysVal: 0.458 ± 0.111
0.057CysTrp: 0.057 ± 0.064
0.229CysTyr: 0.229 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
7.492AspAla: 7.492 ± 0.862
0.572AspCys: 0.572 ± 0.181
4.804AspAsp: 4.804 ± 1.214
6.062AspGlu: 6.062 ± 0.967
2.002AspPhe: 2.002 ± 0.31
5.147AspGly: 5.147 ± 0.544
1.258AspHis: 1.258 ± 0.304
3.145AspIle: 3.145 ± 0.57
1.658AspLys: 1.658 ± 0.269
6.805AspLeu: 6.805 ± 0.581
1.658AspMet: 1.658 ± 0.377
1.315AspAsn: 1.315 ± 0.256
4.461AspPro: 4.461 ± 0.637
1.544AspGln: 1.544 ± 0.303
4.175AspArg: 4.175 ± 0.539
3.088AspSer: 3.088 ± 0.486
3.374AspThr: 3.374 ± 0.481
3.031AspVal: 3.031 ± 0.372
1.315AspTrp: 1.315 ± 0.326
2.059AspTyr: 2.059 ± 0.415
0.0AspXaa: 0.0 ± 0.0
Glu
8.35GluAla: 8.35 ± 1.034
0.458GluCys: 0.458 ± 0.168
3.889GluAsp: 3.889 ± 0.704
4.232GluGlu: 4.232 ± 0.516
2.802GluPhe: 2.802 ± 0.415
4.404GluGly: 4.404 ± 0.571
0.972GluHis: 0.972 ± 0.254
4.632GluIle: 4.632 ± 0.607
2.631GluLys: 2.631 ± 0.48
5.033GluLeu: 5.033 ± 0.675
2.002GluMet: 2.002 ± 0.346
3.031GluAsn: 3.031 ± 0.444
2.631GluPro: 2.631 ± 0.378
2.516GluGln: 2.516 ± 0.416
5.147GluArg: 5.147 ± 0.605
4.003GluSer: 4.003 ± 0.492
5.662GluThr: 5.662 ± 0.813
5.033GluVal: 5.033 ± 0.477
1.201GluTrp: 1.201 ± 0.204
1.43GluTyr: 1.43 ± 0.287
0.0GluXaa: 0.0 ± 0.0
Phe
2.974PheAla: 2.974 ± 0.347
0.515PheCys: 0.515 ± 0.184
2.974PheAsp: 2.974 ± 0.422
2.116PheGlu: 2.116 ± 0.502
0.972PhePhe: 0.972 ± 0.253
2.573PheGly: 2.573 ± 0.361
0.915PheHis: 0.915 ± 0.214
1.601PheIle: 1.601 ± 0.25
1.315PheLys: 1.315 ± 0.239
2.402PheLeu: 2.402 ± 0.305
0.858PheMet: 0.858 ± 0.246
1.144PheAsn: 1.144 ± 0.253
1.773PhePro: 1.773 ± 0.344
1.201PheGln: 1.201 ± 0.34
2.745PheArg: 2.745 ± 0.35
1.944PheSer: 1.944 ± 0.347
2.002PheThr: 2.002 ± 0.373
1.658PheVal: 1.658 ± 0.306
0.972PheTrp: 0.972 ± 0.228
0.972PheTyr: 0.972 ± 0.293
0.0PheXaa: 0.0 ± 0.0
Gly
7.778GlyAla: 7.778 ± 0.724
1.087GlyCys: 1.087 ± 0.239
4.632GlyAsp: 4.632 ± 0.509
5.662GlyGlu: 5.662 ± 0.542
3.26GlyPhe: 3.26 ± 0.493
8.407GlyGly: 8.407 ± 1.035
2.402GlyHis: 2.402 ± 0.408
3.489GlyIle: 3.489 ± 0.669
3.832GlyLys: 3.832 ± 0.475
7.149GlyLeu: 7.149 ± 0.674
2.002GlyMet: 2.002 ± 0.471
2.116GlyAsn: 2.116 ± 0.344
2.802GlyPro: 2.802 ± 0.401
2.802GlyGln: 2.802 ± 0.525
5.719GlyArg: 5.719 ± 0.655
5.09GlySer: 5.09 ± 0.594
4.575GlyThr: 4.575 ± 0.569
4.918GlyVal: 4.918 ± 0.543
1.258GlyTrp: 1.258 ± 0.273
2.23GlyTyr: 2.23 ± 0.376
0.0GlyXaa: 0.0 ± 0.0
His
1.201HisAla: 1.201 ± 0.269
0.4HisCys: 0.4 ± 0.13
1.658HisAsp: 1.658 ± 0.42
1.315HisGlu: 1.315 ± 0.318
0.4HisPhe: 0.4 ± 0.123
1.83HisGly: 1.83 ± 0.385
0.915HisHis: 0.915 ± 0.221
1.144HisIle: 1.144 ± 0.224
0.801HisLys: 0.801 ± 0.22
1.887HisLeu: 1.887 ± 0.336
0.515HisMet: 0.515 ± 0.187
1.029HisAsn: 1.029 ± 0.227
1.258HisPro: 1.258 ± 0.303
0.801HisGln: 0.801 ± 0.239
1.716HisArg: 1.716 ± 0.277
0.572HisSer: 0.572 ± 0.171
0.801HisThr: 0.801 ± 0.198
1.029HisVal: 1.029 ± 0.275
0.572HisTrp: 0.572 ± 0.233
0.629HisTyr: 0.629 ± 0.204
0.0HisXaa: 0.0 ± 0.0
Ile
5.261IleAla: 5.261 ± 0.608
0.4IleCys: 0.4 ± 0.168
3.66IleAsp: 3.66 ± 0.457
4.689IleGlu: 4.689 ± 0.462
1.258IlePhe: 1.258 ± 0.219
3.66IleGly: 3.66 ± 0.499
0.801IleHis: 0.801 ± 0.253
1.201IleIle: 1.201 ± 0.294
1.544IleLys: 1.544 ± 0.308
2.802IleLeu: 2.802 ± 0.377
0.858IleMet: 0.858 ± 0.25
1.601IleAsn: 1.601 ± 0.279
2.688IlePro: 2.688 ± 0.321
1.83IleGln: 1.83 ± 0.32
2.802IleArg: 2.802 ± 0.376
1.83IleSer: 1.83 ± 0.373
2.745IleThr: 2.745 ± 0.399
2.288IleVal: 2.288 ± 0.306
0.572IleTrp: 0.572 ± 0.237
0.915IleTyr: 0.915 ± 0.223
0.0IleXaa: 0.0 ± 0.0
Lys
5.319LysAla: 5.319 ± 0.651
0.172LysCys: 0.172 ± 0.102
2.402LysAsp: 2.402 ± 0.416
2.23LysGlu: 2.23 ± 0.489
1.029LysPhe: 1.029 ± 0.298
2.802LysGly: 2.802 ± 0.415
0.686LysHis: 0.686 ± 0.173
1.83LysIle: 1.83 ± 0.289
2.116LysLys: 2.116 ± 0.584
3.717LysLeu: 3.717 ± 0.507
1.315LysMet: 1.315 ± 0.26
1.315LysAsn: 1.315 ± 0.285
3.088LysPro: 3.088 ± 0.501
1.544LysGln: 1.544 ± 0.303
2.402LysArg: 2.402 ± 0.459
2.23LysSer: 2.23 ± 0.279
1.944LysThr: 1.944 ± 0.361
2.002LysVal: 2.002 ± 0.378
0.515LysTrp: 0.515 ± 0.153
0.572LysTyr: 0.572 ± 0.171
0.0LysXaa: 0.0 ± 0.0
Leu
11.895LeuAla: 11.895 ± 0.804
0.915LeuCys: 0.915 ± 0.273
6.005LeuAsp: 6.005 ± 0.49
5.49LeuGlu: 5.49 ± 0.6
2.002LeuPhe: 2.002 ± 0.505
7.206LeuGly: 7.206 ± 0.631
1.43LeuHis: 1.43 ± 0.298
3.203LeuIle: 3.203 ± 0.505
3.489LeuLys: 3.489 ± 0.523
7.091LeuLeu: 7.091 ± 0.891
1.144LeuMet: 1.144 ± 0.287
3.26LeuAsn: 3.26 ± 0.373
5.147LeuPro: 5.147 ± 0.579
2.631LeuGln: 2.631 ± 0.429
5.89LeuArg: 5.89 ± 0.658
5.033LeuSer: 5.033 ± 0.546
6.234LeuThr: 6.234 ± 0.677
4.689LeuVal: 4.689 ± 0.477
1.201LeuTrp: 1.201 ± 0.315
2.002LeuTyr: 2.002 ± 0.408
0.0LeuXaa: 0.0 ± 0.0
Met
2.116MetAla: 2.116 ± 0.388
0.286MetCys: 0.286 ± 0.122
0.915MetAsp: 0.915 ± 0.215
0.858MetGlu: 0.858 ± 0.213
0.915MetPhe: 0.915 ± 0.241
1.658MetGly: 1.658 ± 0.293
0.458MetHis: 0.458 ± 0.133
1.144MetIle: 1.144 ± 0.286
1.144MetLys: 1.144 ± 0.327
2.059MetLeu: 2.059 ± 0.332
0.572MetMet: 0.572 ± 0.221
1.087MetAsn: 1.087 ± 0.245
2.002MetPro: 2.002 ± 0.364
0.858MetGln: 0.858 ± 0.212
1.544MetArg: 1.544 ± 0.298
1.944MetSer: 1.944 ± 0.361
1.83MetThr: 1.83 ± 0.273
1.487MetVal: 1.487 ± 0.402
0.229MetTrp: 0.229 ± 0.112
0.172MetTyr: 0.172 ± 0.094
0.0MetXaa: 0.0 ± 0.0
Asn
3.889AsnAla: 3.889 ± 0.564
0.229AsnCys: 0.229 ± 0.111
1.716AsnAsp: 1.716 ± 0.245
1.773AsnGlu: 1.773 ± 0.308
0.629AsnPhe: 0.629 ± 0.171
3.489AsnGly: 3.489 ± 0.454
0.629AsnHis: 0.629 ± 0.209
0.858AsnIle: 0.858 ± 0.206
1.144AsnLys: 1.144 ± 0.29
3.203AsnLeu: 3.203 ± 0.494
0.915AsnMet: 0.915 ± 0.27
0.915AsnAsn: 0.915 ± 0.212
2.23AsnPro: 2.23 ± 0.413
1.201AsnGln: 1.201 ± 0.262
2.802AsnArg: 2.802 ± 0.428
1.201AsnSer: 1.201 ± 0.262
1.373AsnThr: 1.373 ± 0.263
1.601AsnVal: 1.601 ± 0.346
0.915AsnTrp: 0.915 ± 0.26
0.915AsnTyr: 0.915 ± 0.218
0.0AsnXaa: 0.0 ± 0.0
Pro
5.662ProAla: 5.662 ± 0.861
0.572ProCys: 0.572 ± 0.202
3.946ProAsp: 3.946 ± 0.47
4.003ProGlu: 4.003 ± 0.54
2.23ProPhe: 2.23 ± 0.377
5.319ProGly: 5.319 ± 0.605
1.201ProHis: 1.201 ± 0.375
1.658ProIle: 1.658 ± 0.307
1.83ProLys: 1.83 ± 0.32
3.889ProLeu: 3.889 ± 0.525
0.801ProMet: 0.801 ± 0.23
1.83ProAsn: 1.83 ± 0.412
3.031ProPro: 3.031 ± 0.531
0.972ProGln: 0.972 ± 0.189
3.832ProArg: 3.832 ± 0.547
2.688ProSer: 2.688 ± 0.435
3.088ProThr: 3.088 ± 0.467
4.003ProVal: 4.003 ± 0.522
0.572ProTrp: 0.572 ± 0.198
1.087ProTyr: 1.087 ± 0.287
0.0ProXaa: 0.0 ± 0.0
Gln
4.747GlnAla: 4.747 ± 0.772
0.172GlnCys: 0.172 ± 0.083
1.544GlnAsp: 1.544 ± 0.264
2.402GlnGlu: 2.402 ± 0.404
1.373GlnPhe: 1.373 ± 0.239
2.059GlnGly: 2.059 ± 0.374
0.458GlnHis: 0.458 ± 0.174
1.716GlnIle: 1.716 ± 0.344
1.373GlnLys: 1.373 ± 0.311
1.944GlnLeu: 1.944 ± 0.499
1.315GlnMet: 1.315 ± 0.254
1.029GlnAsn: 1.029 ± 0.197
1.544GlnPro: 1.544 ± 0.389
1.087GlnGln: 1.087 ± 0.298
2.859GlnArg: 2.859 ± 0.38
1.544GlnSer: 1.544 ± 0.238
2.459GlnThr: 2.459 ± 0.389
2.745GlnVal: 2.745 ± 0.42
0.343GlnTrp: 0.343 ± 0.135
1.087GlnTyr: 1.087 ± 0.269
0.0GlnXaa: 0.0 ± 0.0
Arg
7.492ArgAla: 7.492 ± 1.026
0.629ArgCys: 0.629 ± 0.179
4.461ArgAsp: 4.461 ± 0.491
5.261ArgGlu: 5.261 ± 0.65
3.603ArgPhe: 3.603 ± 0.531
5.49ArgGly: 5.49 ± 0.545
1.43ArgHis: 1.43 ± 0.368
3.031ArgIle: 3.031 ± 0.325
3.088ArgLys: 3.088 ± 0.498
7.835ArgLeu: 7.835 ± 0.675
1.887ArgMet: 1.887 ± 0.389
1.544ArgAsn: 1.544 ± 0.26
3.66ArgPro: 3.66 ± 0.58
3.26ArgGln: 3.26 ± 0.51
5.89ArgArg: 5.89 ± 0.58
3.774ArgSer: 3.774 ± 0.549
4.06ArgThr: 4.06 ± 0.605
6.119ArgVal: 6.119 ± 0.688
1.487ArgTrp: 1.487 ± 0.313
1.658ArgTyr: 1.658 ± 0.268
0.0ArgXaa: 0.0 ± 0.0
Ser
5.319SerAla: 5.319 ± 0.751
0.458SerCys: 0.458 ± 0.184
3.66SerAsp: 3.66 ± 0.531
3.774SerGlu: 3.774 ± 0.353
2.459SerPhe: 2.459 ± 0.424
5.204SerGly: 5.204 ± 0.569
0.743SerHis: 0.743 ± 0.219
2.688SerIle: 2.688 ± 0.345
1.83SerLys: 1.83 ± 0.288
4.689SerLeu: 4.689 ± 0.468
0.858SerMet: 0.858 ± 0.194
1.716SerAsn: 1.716 ± 0.281
2.002SerPro: 2.002 ± 0.393
1.087SerGln: 1.087 ± 0.264
5.033SerArg: 5.033 ± 0.644
2.802SerSer: 2.802 ± 0.418
3.145SerThr: 3.145 ± 0.468
3.374SerVal: 3.374 ± 0.408
0.972SerTrp: 0.972 ± 0.258
0.858SerTyr: 0.858 ± 0.18
0.0SerXaa: 0.0 ± 0.0
Thr
5.49ThrAla: 5.49 ± 0.527
0.229ThrCys: 0.229 ± 0.114
4.232ThrAsp: 4.232 ± 0.392
3.717ThrGlu: 3.717 ± 0.504
2.116ThrPhe: 2.116 ± 0.299
5.319ThrGly: 5.319 ± 0.741
1.144ThrHis: 1.144 ± 0.253
3.66ThrIle: 3.66 ± 0.437
2.002ThrLys: 2.002 ± 0.427
5.662ThrLeu: 5.662 ± 0.649
1.258ThrMet: 1.258 ± 0.294
1.315ThrAsn: 1.315 ± 0.233
3.546ThrPro: 3.546 ± 0.573
2.573ThrGln: 2.573 ± 0.377
4.118ThrArg: 4.118 ± 0.528
2.516ThrSer: 2.516 ± 0.514
3.088ThrThr: 3.088 ± 0.426
5.261ThrVal: 5.261 ± 0.721
0.972ThrTrp: 0.972 ± 0.204
1.773ThrTyr: 1.773 ± 0.314
0.0ThrXaa: 0.0 ± 0.0
Val
7.949ValAla: 7.949 ± 0.699
0.572ValCys: 0.572 ± 0.215
3.946ValAsp: 3.946 ± 0.449
5.319ValGlu: 5.319 ± 0.683
2.059ValPhe: 2.059 ± 0.368
4.06ValGly: 4.06 ± 0.448
0.972ValHis: 0.972 ± 0.247
1.658ValIle: 1.658 ± 0.29
2.631ValLys: 2.631 ± 0.426
5.547ValLeu: 5.547 ± 0.594
1.373ValMet: 1.373 ± 0.277
2.173ValAsn: 2.173 ± 0.393
2.859ValPro: 2.859 ± 0.407
2.516ValGln: 2.516 ± 0.337
5.376ValArg: 5.376 ± 0.555
3.889ValSer: 3.889 ± 0.445
4.06ValThr: 4.06 ± 0.497
4.575ValVal: 4.575 ± 0.532
1.201ValTrp: 1.201 ± 0.282
2.002ValTyr: 2.002 ± 0.35
0.0ValXaa: 0.0 ± 0.0
Trp
1.201TrpAla: 1.201 ± 0.355
0.057TrpCys: 0.057 ± 0.06
1.43TrpAsp: 1.43 ± 0.276
0.515TrpGlu: 0.515 ± 0.224
0.801TrpPhe: 0.801 ± 0.241
1.315TrpGly: 1.315 ± 0.306
0.458TrpHis: 0.458 ± 0.185
0.515TrpIle: 0.515 ± 0.17
0.458TrpLys: 0.458 ± 0.198
1.887TrpLeu: 1.887 ± 0.42
0.629TrpMet: 0.629 ± 0.162
0.572TrpAsn: 0.572 ± 0.239
0.915TrpPro: 0.915 ± 0.262
0.515TrpGln: 0.515 ± 0.205
1.544TrpArg: 1.544 ± 0.406
1.029TrpSer: 1.029 ± 0.243
1.258TrpThr: 1.258 ± 0.274
0.915TrpVal: 0.915 ± 0.259
0.458TrpTrp: 0.458 ± 0.182
0.515TrpTyr: 0.515 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.088TyrAla: 3.088 ± 0.507
0.114TyrCys: 0.114 ± 0.078
2.288TyrAsp: 2.288 ± 0.392
1.601TyrGlu: 1.601 ± 0.318
0.4TyrPhe: 0.4 ± 0.151
1.887TyrGly: 1.887 ± 0.45
0.858TyrHis: 0.858 ± 0.199
1.201TyrIle: 1.201 ± 0.251
0.686TyrLys: 0.686 ± 0.191
2.288TyrLeu: 2.288 ± 0.419
0.515TyrMet: 0.515 ± 0.188
0.858TyrAsn: 0.858 ± 0.208
0.972TyrPro: 0.972 ± 0.301
0.858TyrGln: 0.858 ± 0.195
2.345TyrArg: 2.345 ± 0.464
1.601TyrSer: 1.601 ± 0.305
1.487TyrThr: 1.487 ± 0.334
1.258TyrVal: 1.258 ± 0.247
0.4TyrTrp: 0.4 ± 0.15
0.629TyrTyr: 0.629 ± 0.19
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (17487 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski