Amino acid dipepetide frequency for Gracilimonas mengyeensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.518AlaAla: 5.518 ± 0.085
0.481AlaCys: 0.481 ± 0.019
4.217AlaAsp: 4.217 ± 0.063
5.526AlaGlu: 5.526 ± 0.082
3.38AlaPhe: 3.38 ± 0.058
5.78AlaGly: 5.78 ± 0.077
1.296AlaHis: 1.296 ± 0.037
4.676AlaIle: 4.676 ± 0.06
3.723AlaLys: 3.723 ± 0.066
6.649AlaLeu: 6.649 ± 0.086
1.801AlaMet: 1.801 ± 0.039
3.133AlaAsn: 3.133 ± 0.056
2.344AlaPro: 2.344 ± 0.042
2.819AlaGln: 2.819 ± 0.053
2.985AlaArg: 2.985 ± 0.051
4.646AlaSer: 4.646 ± 0.075
3.684AlaThr: 3.684 ± 0.074
4.582AlaVal: 4.582 ± 0.065
0.862AlaTrp: 0.862 ± 0.028
2.504AlaTyr: 2.504 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.391CysAla: 0.391 ± 0.019
0.072CysCys: 0.072 ± 0.007
0.317CysAsp: 0.317 ± 0.016
0.343CysGlu: 0.343 ± 0.018
0.287CysPhe: 0.287 ± 0.015
0.49CysGly: 0.49 ± 0.021
0.146CysHis: 0.146 ± 0.011
0.352CysIle: 0.352 ± 0.016
0.276CysLys: 0.276 ± 0.015
0.467CysLeu: 0.467 ± 0.019
0.135CysMet: 0.135 ± 0.01
0.232CysAsn: 0.232 ± 0.013
0.246CysPro: 0.246 ± 0.016
0.155CysGln: 0.155 ± 0.012
0.238CysArg: 0.238 ± 0.012
0.428CysSer: 0.428 ± 0.019
0.349CysThr: 0.349 ± 0.017
0.345CysVal: 0.345 ± 0.017
0.06CysTrp: 0.06 ± 0.006
0.2CysTyr: 0.2 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.099AspAla: 4.099 ± 0.065
0.237AspCys: 0.237 ± 0.013
3.533AspAsp: 3.533 ± 0.064
5.141AspGlu: 5.141 ± 0.076
3.341AspPhe: 3.341 ± 0.054
4.644AspGly: 4.644 ± 0.082
1.247AspHis: 1.247 ± 0.03
4.335AspIle: 4.335 ± 0.055
2.936AspLys: 2.936 ± 0.062
5.518AspLeu: 5.518 ± 0.064
1.377AspMet: 1.377 ± 0.032
2.527AspAsn: 2.527 ± 0.049
2.531AspPro: 2.531 ± 0.045
2.267AspGln: 2.267 ± 0.043
2.657AspArg: 2.657 ± 0.052
3.654AspSer: 3.654 ± 0.06
3.069AspThr: 3.069 ± 0.052
3.935AspVal: 3.935 ± 0.063
0.899AspTrp: 0.899 ± 0.029
2.622AspTyr: 2.622 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
5.796GluAla: 5.796 ± 0.084
0.314GluCys: 0.314 ± 0.017
4.639GluAsp: 4.639 ± 0.063
7.299GluGlu: 7.299 ± 0.113
3.147GluPhe: 3.147 ± 0.043
5.057GluGly: 5.057 ± 0.067
1.492GluHis: 1.492 ± 0.038
5.309GluIle: 5.309 ± 0.066
4.985GluLys: 4.985 ± 0.079
7.361GluLeu: 7.361 ± 0.093
2.014GluMet: 2.014 ± 0.035
3.893GluAsn: 3.893 ± 0.061
2.454GluPro: 2.454 ± 0.05
3.307GluGln: 3.307 ± 0.058
3.405GluArg: 3.405 ± 0.054
4.193GluSer: 4.193 ± 0.058
3.99GluThr: 3.99 ± 0.059
5.324GluVal: 5.324 ± 0.078
1.008GluTrp: 1.008 ± 0.031
2.779GluTyr: 2.779 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.084PheAla: 3.084 ± 0.054
0.317PheCys: 0.317 ± 0.016
3.225PheAsp: 3.225 ± 0.053
3.637PheGlu: 3.637 ± 0.058
2.265PhePhe: 2.265 ± 0.046
3.737PheGly: 3.737 ± 0.056
0.804PheHis: 0.804 ± 0.026
2.96PheIle: 2.96 ± 0.061
2.313PheLys: 2.313 ± 0.039
4.152PheLeu: 4.152 ± 0.061
1.139PheMet: 1.139 ± 0.034
2.38PheAsn: 2.38 ± 0.048
1.688PhePro: 1.688 ± 0.036
1.536PheGln: 1.536 ± 0.033
1.983PheArg: 1.983 ± 0.041
3.703PheSer: 3.703 ± 0.06
2.945PheThr: 2.945 ± 0.052
2.799PheVal: 2.799 ± 0.047
0.681PheTrp: 0.681 ± 0.021
1.849PheTyr: 1.849 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.769GlyAla: 4.769 ± 0.075
0.527GlyCys: 0.527 ± 0.022
4.155GlyAsp: 4.155 ± 0.061
5.081GlyGlu: 5.081 ± 0.064
3.699GlyPhe: 3.699 ± 0.053
5.332GlyGly: 5.332 ± 0.083
1.303GlyHis: 1.303 ± 0.031
5.362GlyIle: 5.362 ± 0.065
3.978GlyLys: 3.978 ± 0.062
6.554GlyLeu: 6.554 ± 0.078
2.026GlyMet: 2.026 ± 0.045
3.474GlyAsn: 3.474 ± 0.061
1.904GlyPro: 1.904 ± 0.043
2.405GlyGln: 2.405 ± 0.046
2.939GlyArg: 2.939 ± 0.05
4.784GlySer: 4.784 ± 0.074
4.358GlyThr: 4.358 ± 0.075
4.838GlyVal: 4.838 ± 0.063
1.151GlyTrp: 1.151 ± 0.032
3.007GlyTyr: 3.007 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.241HisAla: 1.241 ± 0.034
0.156HisCys: 0.156 ± 0.011
0.971HisAsp: 0.971 ± 0.027
1.288HisGlu: 1.288 ± 0.03
1.078HisPhe: 1.078 ± 0.03
1.232HisGly: 1.232 ± 0.031
0.6HisHis: 0.6 ± 0.023
1.345HisIle: 1.345 ± 0.033
0.987HisLys: 0.987 ± 0.027
1.824HisLeu: 1.824 ± 0.044
0.436HisMet: 0.436 ± 0.021
0.817HisAsn: 0.817 ± 0.027
1.176HisPro: 1.176 ± 0.032
0.795HisGln: 0.795 ± 0.026
0.912HisArg: 0.912 ± 0.028
1.243HisSer: 1.243 ± 0.03
1.039HisThr: 1.039 ± 0.026
1.115HisVal: 1.115 ± 0.026
0.299HisTrp: 0.299 ± 0.013
0.776HisTyr: 0.776 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
4.873IleAla: 4.873 ± 0.065
0.434IleCys: 0.434 ± 0.019
4.173IleAsp: 4.173 ± 0.059
5.165IleGlu: 5.165 ± 0.069
2.817IlePhe: 2.817 ± 0.054
4.754IleGly: 4.754 ± 0.062
1.33IleHis: 1.33 ± 0.034
4.212IleIle: 4.212 ± 0.066
3.515IleLys: 3.515 ± 0.058
5.589IleLeu: 5.589 ± 0.067
1.26IleMet: 1.26 ± 0.035
3.401IleAsn: 3.401 ± 0.051
3.228IlePro: 3.228 ± 0.052
2.424IleGln: 2.424 ± 0.046
3.156IleArg: 3.156 ± 0.053
5.114IleSer: 5.114 ± 0.071
4.376IleThr: 4.376 ± 0.064
3.793IleVal: 3.793 ± 0.07
0.752IleTrp: 0.752 ± 0.027
2.351IleTyr: 2.351 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.291LysAla: 4.291 ± 0.065
0.189LysCys: 0.189 ± 0.013
3.192LysAsp: 3.192 ± 0.053
5.189LysGlu: 5.189 ± 0.08
1.857LysPhe: 1.857 ± 0.034
3.36LysGly: 3.36 ± 0.052
1.097LysHis: 1.097 ± 0.03
3.503LysIle: 3.503 ± 0.056
4.356LysLys: 4.356 ± 0.07
5.017LysLeu: 5.017 ± 0.07
1.577LysMet: 1.577 ± 0.035
2.834LysAsn: 2.834 ± 0.048
2.134LysPro: 2.134 ± 0.036
2.135LysGln: 2.135 ± 0.043
2.532LysArg: 2.532 ± 0.05
3.253LysSer: 3.253 ± 0.058
3.112LysThr: 3.112 ± 0.057
3.814LysVal: 3.814 ± 0.057
0.666LysTrp: 0.666 ± 0.026
1.964LysTyr: 1.964 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
6.542LeuAla: 6.542 ± 0.078
0.541LeuCys: 0.541 ± 0.019
5.418LeuAsp: 5.418 ± 0.069
6.806LeuGlu: 6.806 ± 0.08
4.452LeuPhe: 4.452 ± 0.07
5.988LeuGly: 5.988 ± 0.083
1.669LeuHis: 1.669 ± 0.035
6.037LeuIle: 6.037 ± 0.08
5.592LeuLys: 5.592 ± 0.079
8.41LeuLeu: 8.41 ± 0.09
2.28LeuMet: 2.28 ± 0.046
4.745LeuAsn: 4.745 ± 0.063
3.868LeuPro: 3.868 ± 0.055
3.459LeuGln: 3.459 ± 0.05
4.094LeuArg: 4.094 ± 0.063
7.022LeuSer: 7.022 ± 0.086
5.16LeuThr: 5.16 ± 0.077
5.661LeuVal: 5.661 ± 0.074
1.026LeuTrp: 1.026 ± 0.031
3.056LeuTyr: 3.056 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.969MetAla: 1.969 ± 0.037
0.108MetCys: 0.108 ± 0.009
1.547MetAsp: 1.547 ± 0.038
1.827MetGlu: 1.827 ± 0.039
0.903MetPhe: 0.903 ± 0.032
1.672MetGly: 1.672 ± 0.038
0.455MetHis: 0.455 ± 0.02
1.532MetIle: 1.532 ± 0.037
1.788MetLys: 1.788 ± 0.043
2.223MetLeu: 2.223 ± 0.049
0.696MetMet: 0.696 ± 0.024
1.285MetAsn: 1.285 ± 0.027
1.032MetPro: 1.032 ± 0.031
0.93MetGln: 0.93 ± 0.026
1.043MetArg: 1.043 ± 0.029
1.523MetSer: 1.523 ± 0.037
1.134MetThr: 1.134 ± 0.033
1.58MetVal: 1.58 ± 0.039
0.211MetTrp: 0.211 ± 0.014
0.735MetTyr: 0.735 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.203AsnAla: 3.203 ± 0.043
0.252AsnCys: 0.252 ± 0.015
2.61AsnAsp: 2.61 ± 0.048
3.351AsnGlu: 3.351 ± 0.049
2.171AsnPhe: 2.171 ± 0.04
3.697AsnGly: 3.697 ± 0.072
0.954AsnHis: 0.954 ± 0.031
3.311AsnIle: 3.311 ± 0.048
2.423AsnLys: 2.423 ± 0.05
4.403AsnLeu: 4.403 ± 0.077
1.194AsnMet: 1.194 ± 0.031
2.353AsnAsn: 2.353 ± 0.062
2.867AsnPro: 2.867 ± 0.056
1.965AsnGln: 1.965 ± 0.045
2.404AsnArg: 2.404 ± 0.04
2.985AsnSer: 2.985 ± 0.058
2.707AsnThr: 2.707 ± 0.057
2.828AsnVal: 2.828 ± 0.053
0.738AsnTrp: 0.738 ± 0.026
2.165AsnTyr: 2.165 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.764ProAla: 2.764 ± 0.05
0.175ProCys: 0.175 ± 0.012
3.169ProAsp: 3.169 ± 0.054
4.055ProGlu: 4.055 ± 0.05
1.93ProPhe: 1.93 ± 0.043
2.97ProGly: 2.97 ± 0.054
0.725ProHis: 0.725 ± 0.027
2.295ProIle: 2.295 ± 0.044
2.03ProLys: 2.03 ± 0.042
3.249ProLeu: 3.249 ± 0.054
0.836ProMet: 0.836 ± 0.025
1.933ProAsn: 1.933 ± 0.041
1.286ProPro: 1.286 ± 0.034
1.347ProGln: 1.347 ± 0.033
1.331ProArg: 1.331 ± 0.035
2.353ProSer: 2.353 ± 0.045
1.918ProThr: 1.918 ± 0.04
3.238ProVal: 3.238 ± 0.048
0.471ProTrp: 0.471 ± 0.021
1.423ProTyr: 1.423 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.863GlnAla: 2.863 ± 0.05
0.13GlnCys: 0.13 ± 0.011
1.995GlnAsp: 1.995 ± 0.038
2.881GlnGlu: 2.881 ± 0.05
1.626GlnPhe: 1.626 ± 0.03
2.211GlnGly: 2.211 ± 0.045
0.724GlnHis: 0.724 ± 0.024
2.427GlnIle: 2.427 ± 0.047
2.513GlnLys: 2.513 ± 0.051
3.72GlnLeu: 3.72 ± 0.063
0.908GlnMet: 0.908 ± 0.028
2.074GlnAsn: 2.074 ± 0.036
1.497GlnPro: 1.497 ± 0.034
2.152GlnGln: 2.152 ± 0.051
1.723GlnArg: 1.723 ± 0.042
2.387GlnSer: 2.387 ± 0.046
2.131GlnThr: 2.131 ± 0.04
2.477GlnVal: 2.477 ± 0.036
0.489GlnTrp: 0.489 ± 0.018
1.357GlnTyr: 1.357 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.698ArgAla: 2.698 ± 0.053
0.202ArgCys: 0.202 ± 0.013
2.536ArgAsp: 2.536 ± 0.044
3.362ArgGlu: 3.362 ± 0.055
2.339ArgPhe: 2.339 ± 0.047
2.543ArgGly: 2.543 ± 0.05
0.833ArgHis: 0.833 ± 0.025
3.196ArgIle: 3.196 ± 0.052
2.781ArgLys: 2.781 ± 0.045
4.135ArgLeu: 4.135 ± 0.064
1.179ArgMet: 1.179 ± 0.032
2.233ArgAsn: 2.233 ± 0.043
1.518ArgPro: 1.518 ± 0.033
1.709ArgGln: 1.709 ± 0.039
2.018ArgArg: 2.018 ± 0.038
2.683ArgSer: 2.683 ± 0.051
2.251ArgThr: 2.251 ± 0.038
2.848ArgVal: 2.848 ± 0.049
0.616ArgTrp: 0.616 ± 0.022
2.033ArgTyr: 2.033 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.513SerAla: 4.513 ± 0.059
0.386SerCys: 0.386 ± 0.017
3.976SerAsp: 3.976 ± 0.062
4.614SerGlu: 4.614 ± 0.068
3.495SerPhe: 3.495 ± 0.056
5.614SerGly: 5.614 ± 0.085
1.131SerHis: 1.131 ± 0.027
4.456SerIle: 4.456 ± 0.071
3.293SerLys: 3.293 ± 0.057
6.332SerLeu: 6.332 ± 0.083
1.497SerMet: 1.497 ± 0.032
3.069SerAsn: 3.069 ± 0.063
2.5SerPro: 2.5 ± 0.054
2.229SerGln: 2.229 ± 0.046
2.852SerArg: 2.852 ± 0.057
4.864SerSer: 4.864 ± 0.085
3.667SerThr: 3.667 ± 0.064
4.429SerVal: 4.429 ± 0.057
0.901SerTrp: 0.901 ± 0.025
2.665SerTyr: 2.665 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.094ThrAla: 4.094 ± 0.073
0.265ThrCys: 0.265 ± 0.014
3.581ThrAsp: 3.581 ± 0.06
3.722ThrGlu: 3.722 ± 0.055
2.758ThrPhe: 2.758 ± 0.052
4.803ThrGly: 4.803 ± 0.07
1.069ThrHis: 1.069 ± 0.028
3.973ThrIle: 3.973 ± 0.062
2.523ThrLys: 2.523 ± 0.05
5.3ThrLeu: 5.3 ± 0.07
1.073ThrMet: 1.073 ± 0.03
2.533ThrAsn: 2.533 ± 0.066
2.529ThrPro: 2.529 ± 0.048
1.936ThrGln: 1.936 ± 0.04
2.089ThrArg: 2.089 ± 0.045
3.552ThrSer: 3.552 ± 0.066
3.297ThrThr: 3.297 ± 0.07
4.035ThrVal: 4.035 ± 0.063
0.649ThrTrp: 0.649 ± 0.023
2.077ThrTyr: 2.077 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
4.624ValAla: 4.624 ± 0.065
0.412ValCys: 0.412 ± 0.02
4.139ValAsp: 4.139 ± 0.065
4.859ValGlu: 4.859 ± 0.064
3.105ValPhe: 3.105 ± 0.05
4.117ValGly: 4.117 ± 0.071
1.294ValHis: 1.294 ± 0.029
4.476ValIle: 4.476 ± 0.071
3.334ValLys: 3.334 ± 0.056
6.058ValLeu: 6.058 ± 0.066
1.576ValMet: 1.576 ± 0.037
3.199ValAsn: 3.199 ± 0.051
2.589ValPro: 2.589 ± 0.037
2.468ValGln: 2.468 ± 0.05
2.863ValArg: 2.863 ± 0.045
4.646ValSer: 4.646 ± 0.062
3.751ValThr: 3.751 ± 0.068
4.391ValVal: 4.391 ± 0.066
0.731ValTrp: 0.731 ± 0.024
2.354ValTyr: 2.354 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.831TrpAla: 0.831 ± 0.027
0.076TrpCys: 0.076 ± 0.008
0.808TrpAsp: 0.808 ± 0.03
0.941TrpGlu: 0.941 ± 0.029
0.634TrpPhe: 0.634 ± 0.023
0.924TrpGly: 0.924 ± 0.031
0.305TrpHis: 0.305 ± 0.015
0.846TrpIle: 0.846 ± 0.031
0.758TrpLys: 0.758 ± 0.023
1.219TrpLeu: 1.219 ± 0.037
0.439TrpMet: 0.439 ± 0.018
0.684TrpAsn: 0.684 ± 0.023
0.405TrpPro: 0.405 ± 0.019
0.552TrpGln: 0.552 ± 0.021
0.538TrpArg: 0.538 ± 0.019
0.828TrpSer: 0.828 ± 0.024
0.67TrpThr: 0.67 ± 0.025
0.792TrpVal: 0.792 ± 0.028
0.226TrpTrp: 0.226 ± 0.015
0.5TrpTyr: 0.5 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.442TyrAla: 2.442 ± 0.041
0.255TyrCys: 0.255 ± 0.014
2.368TyrAsp: 2.368 ± 0.043
2.68TyrGlu: 2.68 ± 0.044
1.916TyrPhe: 1.916 ± 0.042
2.72TyrGly: 2.72 ± 0.056
0.86TyrHis: 0.86 ± 0.022
2.111TyrIle: 2.111 ± 0.047
1.967TyrLys: 1.967 ± 0.041
3.648TyrLeu: 3.648 ± 0.055
0.748TyrMet: 0.748 ± 0.024
1.779TyrAsn: 1.779 ± 0.043
1.702TyrPro: 1.702 ± 0.036
1.694TyrGln: 1.694 ± 0.042
1.949TyrArg: 1.949 ± 0.036
2.623TyrSer: 2.623 ± 0.05
2.251TyrThr: 2.251 ± 0.041
2.163TyrVal: 2.163 ± 0.045
0.541TyrTrp: 0.541 ± 0.021
1.747TyrTyr: 1.747 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3810 proteins (1339685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski