Amino acid dipepetide frequency for Orrella dioscoreae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.805AlaAla: 18.805 ± 0.166	1.432AlaCys: 1.432 ± 0.043	6.967AlaAsp: 6.967 ± 0.07	6.595AlaGlu: 6.595 ± 0.078	4.062AlaPhe: 4.062 ± 0.059	12.133AlaGly: 12.133 ± 0.15	2.744AlaHis: 2.744 ± 0.055	5.275AlaIle: 5.275 ± 0.07	2.98AlaLys: 2.98 ± 0.068	15.96AlaLeu: 15.96 ± 0.142	3.489AlaMet: 3.489 ± 0.055	2.747AlaAsn: 2.747 ± 0.044	6.903AlaPro: 6.903 ± 0.086	6.284AlaGln: 6.284 ± 0.075	10.966AlaArg: 10.966 ± 0.116	7.104AlaSer: 7.104 ± 0.083	6.084AlaThr: 6.084 ± 0.074	9.18AlaVal: 9.18 ± 0.085	2.27AlaTrp: 2.27 ± 0.05	2.727AlaTyr: 2.727 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.153CysAla: 1.153 ± 0.028	0.105CysCys: 0.105 ± 0.01	0.426CysAsp: 0.426 ± 0.016	0.435CysGlu: 0.435 ± 0.018	0.288CysPhe: 0.288 ± 0.015	0.908CysGly: 0.908 ± 0.029	0.219CysHis: 0.219 ± 0.014	0.316CysIle: 0.316 ± 0.015	0.167CysLys: 0.167 ± 0.011	0.884CysLeu: 0.884 ± 0.028	0.189CysMet: 0.189 ± 0.011	0.187CysAsn: 0.187 ± 0.013	0.447CysPro: 0.447 ± 0.018	0.254CysGln: 0.254 ± 0.015	0.595CysArg: 0.595 ± 0.021	0.352CysSer: 0.352 ± 0.014	0.411CysThr: 0.411 ± 0.018	0.725CysVal: 0.725 ± 0.026	0.11CysTrp: 0.11 ± 0.009	0.203CysTyr: 0.203 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.02AspAla: 8.02 ± 0.094	0.414AspCys: 0.414 ± 0.017	2.878AspAsp: 2.878 ± 0.049	2.943AspGlu: 2.943 ± 0.053	1.95AspPhe: 1.95 ± 0.036	4.846AspGly: 4.846 ± 0.07	1.039AspHis: 1.039 ± 0.028	2.654AspIle: 2.654 ± 0.045	1.396AspLys: 1.396 ± 0.034	5.641AspLeu: 5.641 ± 0.065	1.258AspMet: 1.258 ± 0.026	1.123AspAsn: 1.123 ± 0.032	3.215AspPro: 3.215 ± 0.048	1.582AspGln: 1.582 ± 0.035	3.439AspArg: 3.439 ± 0.052	2.252AspSer: 2.252 ± 0.041	3.15AspThr: 3.15 ± 0.049	4.355AspVal: 4.355 ± 0.053	1.019AspTrp: 1.019 ± 0.029	1.489AspTyr: 1.489 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.801GluAla: 6.801 ± 0.078	0.32GluCys: 0.32 ± 0.016	2.478GluAsp: 2.478 ± 0.04	2.374GluGlu: 2.374 ± 0.047	1.493GluPhe: 1.493 ± 0.037	3.825GluGly: 3.825 ± 0.059	1.196GluHis: 1.196 ± 0.031	2.645GluIle: 2.645 ± 0.043	1.531GluLys: 1.531 ± 0.036	5.065GluLeu: 5.065 ± 0.071	1.133GluMet: 1.133 ± 0.033	1.323GluAsn: 1.323 ± 0.034	2.449GluPro: 2.449 ± 0.046	2.423GluGln: 2.423 ± 0.048	4.239GluArg: 4.239 ± 0.059	2.467GluSer: 2.467 ± 0.043	2.737GluThr: 2.737 ± 0.043	3.534GluVal: 3.534 ± 0.054	0.626GluTrp: 0.626 ± 0.026	1.001GluTyr: 1.001 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.74PheAla: 3.74 ± 0.064	0.325PheCys: 0.325 ± 0.015	2.284PheAsp: 2.284 ± 0.041	1.708PheGlu: 1.708 ± 0.034	1.211PhePhe: 1.211 ± 0.034	3.108PheGly: 3.108 ± 0.046	0.744PheHis: 0.744 ± 0.022	1.387PheIle: 1.387 ± 0.032	0.884PheLys: 0.884 ± 0.026	3.255PheLeu: 3.255 ± 0.066	0.748PheMet: 0.748 ± 0.026	0.961PheAsn: 0.961 ± 0.028	1.494PhePro: 1.494 ± 0.033	1.11PheGln: 1.11 ± 0.032	1.751PheArg: 1.751 ± 0.034	2.117PheSer: 2.117 ± 0.04	1.725PheThr: 1.725 ± 0.037	2.52PheVal: 2.52 ± 0.048	0.487PheTrp: 0.487 ± 0.021	0.773PheTyr: 0.773 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.145GlyAla: 10.145 ± 0.108	0.784GlyCys: 0.784 ± 0.024	4.062GlyAsp: 4.062 ± 0.063	4.574GlyGlu: 4.574 ± 0.062	3.141GlyPhe: 3.141 ± 0.049	7.321GlyGly: 7.321 ± 0.119	1.936GlyHis: 1.936 ± 0.039	3.975GlyIle: 3.975 ± 0.056	3.156GlyLys: 3.156 ± 0.06	9.786GlyLeu: 9.786 ± 0.094	2.419GlyMet: 2.419 ± 0.038	2.124GlyAsn: 2.124 ± 0.053	3.299GlyPro: 3.299 ± 0.051	3.67GlyGln: 3.67 ± 0.052	6.009GlyArg: 6.009 ± 0.073	4.392GlySer: 4.392 ± 0.073	4.721GlyThr: 4.721 ± 0.074	6.854GlyVal: 6.854 ± 0.072	1.456GlyTrp: 1.456 ± 0.033	2.354GlyTyr: 2.354 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	3.232HisAla: 3.232 ± 0.056	0.235HisCys: 0.235 ± 0.012	1.345HisAsp: 1.345 ± 0.032	1.068HisGlu: 1.068 ± 0.03	0.771HisPhe: 0.771 ± 0.022	2.17HisGly: 2.17 ± 0.043	0.56HisHis: 0.56 ± 0.025	0.873HisIle: 0.873 ± 0.025	0.431HisLys: 0.431 ± 0.016	2.091HisLeu: 2.091 ± 0.041	0.444HisMet: 0.444 ± 0.016	0.428HisAsn: 0.428 ± 0.02	1.475HisPro: 1.475 ± 0.033	0.695HisGln: 0.695 ± 0.023	1.408HisArg: 1.408 ± 0.032	0.879HisSer: 0.879 ± 0.028	1.07HisThr: 1.07 ± 0.028	1.658HisVal: 1.658 ± 0.04	0.338HisTrp: 0.338 ± 0.016	0.627HisTyr: 0.627 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.961IleAla: 5.961 ± 0.074	0.329IleCys: 0.329 ± 0.015	2.943IleAsp: 2.943 ± 0.047	2.751IleGlu: 2.751 ± 0.051	1.219IlePhe: 1.219 ± 0.032	3.917IleGly: 3.917 ± 0.051	0.817IleHis: 0.817 ± 0.023	1.624IleIle: 1.624 ± 0.039	1.142IleLys: 1.142 ± 0.028	3.802IleLeu: 3.802 ± 0.06	0.786IleMet: 0.786 ± 0.024	1.25IleAsn: 1.25 ± 0.033	1.985IlePro: 1.985 ± 0.04	1.382IleGln: 1.382 ± 0.031	2.576IleArg: 2.576 ± 0.041	2.374IleSer: 2.374 ± 0.046	2.357IleThr: 2.357 ± 0.042	3.51IleVal: 3.51 ± 0.052	0.496IleTrp: 0.496 ± 0.016	0.885IleTyr: 0.885 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.109LysAla: 3.109 ± 0.069	0.109LysCys: 0.109 ± 0.008	1.33LysAsp: 1.33 ± 0.037	1.296LysGlu: 1.296 ± 0.035	0.663LysPhe: 0.663 ± 0.022	1.964LysGly: 1.964 ± 0.039	0.536LysHis: 0.536 ± 0.019	1.103LysIle: 1.103 ± 0.032	0.883LysLys: 0.883 ± 0.046	2.965LysLeu: 2.965 ± 0.056	0.591LysMet: 0.591 ± 0.02	0.627LysAsn: 0.627 ± 0.023	1.7LysPro: 1.7 ± 0.039	1.099LysGln: 1.099 ± 0.03	1.907LysArg: 1.907 ± 0.04	1.355LysSer: 1.355 ± 0.04	1.581LysThr: 1.581 ± 0.037	2.068LysVal: 2.068 ± 0.046	0.331LysTrp: 0.331 ± 0.015	0.498LysTyr: 0.498 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	17.013LeuAla: 17.013 ± 0.147	1.005LeuCys: 1.005 ± 0.026	6.563LeuAsp: 6.563 ± 0.075	4.776LeuGlu: 4.776 ± 0.066	3.385LeuPhe: 3.385 ± 0.06	9.358LeuGly: 9.358 ± 0.1	2.341LeuHis: 2.341 ± 0.047	4.266LeuIle: 4.266 ± 0.067	2.761LeuLys: 2.761 ± 0.051	11.586LeuLeu: 11.586 ± 0.148	2.344LeuMet: 2.344 ± 0.044	2.577LeuAsn: 2.577 ± 0.046	6.768LeuPro: 6.768 ± 0.076	3.793LeuGln: 3.793 ± 0.052	8.911LeuArg: 8.911 ± 0.1	6.676LeuSer: 6.676 ± 0.069	5.502LeuThr: 5.502 ± 0.069	7.827LeuVal: 7.827 ± 0.09	1.198LeuTrp: 1.198 ± 0.031	2.193LeuTyr: 2.193 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.942MetAla: 2.942 ± 0.055	0.136MetCys: 0.136 ± 0.01	1.081MetAsp: 1.081 ± 0.024	0.926MetGlu: 0.926 ± 0.029	0.653MetPhe: 0.653 ± 0.021	1.771MetGly: 1.771 ± 0.036	0.487MetHis: 0.487 ± 0.018	0.952MetIle: 0.952 ± 0.029	0.745MetLys: 0.745 ± 0.019	2.722MetLeu: 2.722 ± 0.046	0.582MetMet: 0.582 ± 0.022	0.693MetAsn: 0.693 ± 0.023	1.503MetPro: 1.503 ± 0.03	1.062MetGln: 1.062 ± 0.028	1.669MetArg: 1.669 ± 0.034	1.569MetSer: 1.569 ± 0.033	1.525MetThr: 1.525 ± 0.031	1.596MetVal: 1.596 ± 0.033	0.205MetTrp: 0.205 ± 0.012	0.34MetTyr: 0.34 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.034AsnAla: 3.034 ± 0.053	0.193AsnCys: 0.193 ± 0.012	1.25AsnAsp: 1.25 ± 0.028	1.015AsnGlu: 1.015 ± 0.031	0.786AsnPhe: 0.786 ± 0.026	2.05AsnGly: 2.05 ± 0.042	0.466AsnHis: 0.466 ± 0.018	1.13AsnIle: 1.13 ± 0.03	0.62AsnLys: 0.62 ± 0.021	2.591AsnLeu: 2.591 ± 0.045	0.523AsnMet: 0.523 ± 0.021	0.672AsnAsn: 0.672 ± 0.025	1.747AsnPro: 1.747 ± 0.039	0.793AsnGln: 0.793 ± 0.025	1.67AsnArg: 1.67 ± 0.038	0.987AsnSer: 0.987 ± 0.029	1.381AsnThr: 1.381 ± 0.032	1.963AsnVal: 1.963 ± 0.047	0.388AsnTrp: 0.388 ± 0.016	0.625AsnTyr: 0.625 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.334ProAla: 8.334 ± 0.107	0.36ProCys: 0.36 ± 0.019	3.705ProAsp: 3.705 ± 0.061	3.297ProGlu: 3.297 ± 0.052	1.779ProPhe: 1.779 ± 0.036	5.202ProGly: 5.202 ± 0.075	1.005ProHis: 1.005 ± 0.025	1.873ProIle: 1.873 ± 0.04	1.139ProLys: 1.139 ± 0.03	5.443ProLeu: 5.443 ± 0.071	1.21ProMet: 1.21 ± 0.028	1.132ProAsn: 1.132 ± 0.033	2.857ProPro: 2.857 ± 0.054	2.176ProGln: 2.176 ± 0.038	3.483ProArg: 3.483 ± 0.056	2.802ProSer: 2.802 ± 0.053	2.476ProThr: 2.476 ± 0.043	4.504ProVal: 4.504 ± 0.062	0.813ProTrp: 0.813 ± 0.025	1.247ProTyr: 1.247 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	7.053GlnAla: 7.053 ± 0.081	0.254GlnCys: 0.254 ± 0.013	2.007GlnAsp: 2.007 ± 0.039	1.702GlnGlu: 1.702 ± 0.039	1.072GlnPhe: 1.072 ± 0.028	3.665GlnGly: 3.665 ± 0.052	0.873GlnHis: 0.873 ± 0.025	1.649GlnIle: 1.649 ± 0.037	0.875GlnLys: 0.875 ± 0.031	3.663GlnLeu: 3.663 ± 0.058	0.902GlnMet: 0.902 ± 0.029	0.783GlnAsn: 0.783 ± 0.027	2.316GlnPro: 2.316 ± 0.04	1.792GlnGln: 1.792 ± 0.039	3.291GlnArg: 3.291 ± 0.06	1.929GlnSer: 1.929 ± 0.041	1.906GlnThr: 1.906 ± 0.038	3.091GlnVal: 3.091 ± 0.046	0.62GlnTrp: 0.62 ± 0.022	0.801GlnTyr: 0.801 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.017ArgAla: 9.017 ± 0.091	0.569ArgCys: 0.569 ± 0.021	4.17ArgAsp: 4.17 ± 0.063	4.358ArgGlu: 4.358 ± 0.062	2.332ArgPhe: 2.332 ± 0.038	5.23ArgGly: 5.23 ± 0.062	2.174ArgHis: 2.174 ± 0.041	3.635ArgIle: 3.635 ± 0.052	2.038ArgLys: 2.038 ± 0.041	8.565ArgLeu: 8.565 ± 0.103	1.853ArgMet: 1.853 ± 0.032	1.931ArgAsn: 1.931 ± 0.035	3.518ArgPro: 3.518 ± 0.06	3.489ArgGln: 3.489 ± 0.049	5.838ArgArg: 5.838 ± 0.093	3.267ArgSer: 3.267 ± 0.047	3.334ArgThr: 3.334 ± 0.046	5.528ArgVal: 5.528 ± 0.06	1.163ArgTrp: 1.163 ± 0.031	2.316ArgTyr: 2.316 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.446SerAla: 6.446 ± 0.082	0.395SerCys: 0.395 ± 0.02	2.596SerAsp: 2.596 ± 0.04	2.152SerGlu: 2.152 ± 0.037	1.84SerPhe: 1.84 ± 0.038	5.169SerGly: 5.169 ± 0.067	1.154SerHis: 1.154 ± 0.029	2.17SerIle: 2.17 ± 0.039	1.199SerLys: 1.199 ± 0.032	6.162SerLeu: 6.162 ± 0.072	1.149SerMet: 1.149 ± 0.029	1.259SerAsn: 1.259 ± 0.029	3.027SerPro: 3.027 ± 0.056	2.024SerGln: 2.024 ± 0.039	3.9SerArg: 3.9 ± 0.051	2.944SerSer: 2.944 ± 0.051	2.673SerThr: 2.673 ± 0.043	4.059SerVal: 4.059 ± 0.061	0.768SerTrp: 0.768 ± 0.024	1.252SerTyr: 1.252 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.856ThrAla: 5.856 ± 0.073	0.371ThrCys: 0.371 ± 0.017	2.547ThrAsp: 2.547 ± 0.044	2.215ThrGlu: 2.215 ± 0.038	1.588ThrPhe: 1.588 ± 0.038	4.747ThrGly: 4.747 ± 0.065	1.178ThrHis: 1.178 ± 0.031	1.984ThrIle: 1.984 ± 0.037	0.85ThrLys: 0.85 ± 0.024	7.253ThrLeu: 7.253 ± 0.09	0.959ThrMet: 0.959 ± 0.027	1.051ThrAsn: 1.051 ± 0.034	3.842ThrPro: 3.842 ± 0.057	2.004ThrGln: 2.004 ± 0.044	3.82ThrArg: 3.82 ± 0.053	2.458ThrSer: 2.458 ± 0.046	2.428ThrThr: 2.428 ± 0.049	4.332ThrVal: 4.332 ± 0.069	0.76ThrTrp: 0.76 ± 0.022	1.045ThrTyr: 1.045 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.656ValAla: 9.656 ± 0.089	0.694ValCys: 0.694 ± 0.021	4.022ValAsp: 4.022 ± 0.065	3.805ValGlu: 3.805 ± 0.043	2.708ValPhe: 2.708 ± 0.049	5.761ValGly: 5.761 ± 0.075	1.507ValHis: 1.507 ± 0.036	3.266ValIle: 3.266 ± 0.054	1.972ValLys: 1.972 ± 0.041	8.729ValLeu: 8.729 ± 0.099	1.791ValMet: 1.791 ± 0.037	2.039ValAsn: 2.039 ± 0.049	4.366ValPro: 4.366 ± 0.056	2.914ValGln: 2.914 ± 0.04	5.454ValArg: 5.454 ± 0.067	4.55ValSer: 4.55 ± 0.061	4.2ValThr: 4.2 ± 0.07	6.19ValVal: 6.19 ± 0.08	0.948ValTrp: 0.948 ± 0.024	1.564ValTyr: 1.564 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.351TrpAla: 1.351 ± 0.033	0.132TrpCys: 0.132 ± 0.01	0.615TrpAsp: 0.615 ± 0.021	0.588TrpGlu: 0.588 ± 0.019	0.526TrpPhe: 0.526 ± 0.019	0.94TrpGly: 0.94 ± 0.023	0.394TrpHis: 0.394 ± 0.017	0.589TrpIle: 0.589 ± 0.019	0.38TrpLys: 0.38 ± 0.017	2.208TrpLeu: 2.208 ± 0.047	0.389TrpMet: 0.389 ± 0.017	0.414TrpAsn: 0.414 ± 0.018	0.735TrpPro: 0.735 ± 0.025	0.85TrpGln: 0.85 ± 0.026	1.539TrpArg: 1.539 ± 0.034	0.704TrpSer: 0.704 ± 0.023	0.748TrpThr: 0.748 ± 0.023	0.961TrpVal: 0.961 ± 0.024	0.232TrpTrp: 0.232 ± 0.013	0.298TrpTyr: 0.298 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.037TyrAla: 3.037 ± 0.057	0.214TyrCys: 0.214 ± 0.013	1.394TyrAsp: 1.394 ± 0.034	1.084TyrGlu: 1.084 ± 0.03	0.864TyrPhe: 0.864 ± 0.025	2.094TyrGly: 2.094 ± 0.044	0.427TyrHis: 0.427 ± 0.018	0.737TyrIle: 0.737 ± 0.023	0.565TyrLys: 0.565 ± 0.022	2.476TyrLeu: 2.476 ± 0.039	0.398TyrMet: 0.398 ± 0.016	0.56TyrAsn: 0.56 ± 0.019	1.188TyrPro: 1.188 ± 0.027	0.849TyrGln: 0.849 ± 0.026	1.862TyrArg: 1.862 ± 0.041	1.163TyrSer: 1.163 ± 0.03	1.28TyrThr: 1.28 ± 0.034	1.68TyrVal: 1.68 ± 0.033	0.365TyrTrp: 0.365 ± 0.017	0.587TyrTyr: 0.587 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4379 proteins (1450914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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