Amino acid dipepetide frequency for Sulfuriferula sp. AH1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.081AlaAla: 14.081 ± 0.197
1.14AlaCys: 1.14 ± 0.036
6.356AlaAsp: 6.356 ± 0.093
6.518AlaGlu: 6.518 ± 0.092
3.62AlaPhe: 3.62 ± 0.062
8.695AlaGly: 8.695 ± 0.115
2.692AlaHis: 2.692 ± 0.057
6.396AlaIle: 6.396 ± 0.091
4.208AlaLys: 4.208 ± 0.071
12.301AlaLeu: 12.301 ± 0.146
3.359AlaMet: 3.359 ± 0.065
3.531AlaAsn: 3.531 ± 0.071
4.219AlaPro: 4.219 ± 0.085
5.14AlaGln: 5.14 ± 0.089
6.45AlaArg: 6.45 ± 0.092
5.727AlaSer: 5.727 ± 0.096
5.395AlaThr: 5.395 ± 0.091
7.816AlaVal: 7.816 ± 0.097
1.411AlaTrp: 1.411 ± 0.041
2.797AlaTyr: 2.797 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.941CysAla: 0.941 ± 0.031
0.131CysCys: 0.131 ± 0.014
0.576CysAsp: 0.576 ± 0.026
0.503CysGlu: 0.503 ± 0.025
0.303CysPhe: 0.303 ± 0.02
0.919CysGly: 0.919 ± 0.038
0.335CysHis: 0.335 ± 0.02
0.459CysIle: 0.459 ± 0.021
0.314CysLys: 0.314 ± 0.019
0.801CysLeu: 0.801 ± 0.03
0.219CysMet: 0.219 ± 0.015
0.33CysAsn: 0.33 ± 0.02
0.517CysPro: 0.517 ± 0.027
0.336CysGln: 0.336 ± 0.02
0.554CysArg: 0.554 ± 0.03
0.51CysSer: 0.51 ± 0.026
0.499CysThr: 0.499 ± 0.025
0.652CysVal: 0.652 ± 0.03
0.102CysTrp: 0.102 ± 0.01
0.279CysTyr: 0.279 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
6.209AspAla: 6.209 ± 0.096
0.498AspCys: 0.498 ± 0.023
2.767AspAsp: 2.767 ± 0.057
3.35AspGlu: 3.35 ± 0.06
2.284AspPhe: 2.284 ± 0.055
3.804AspGly: 3.804 ± 0.071
1.12AspHis: 1.12 ± 0.033
3.444AspIle: 3.444 ± 0.064
2.296AspLys: 2.296 ± 0.054
5.315AspLeu: 5.315 ± 0.089
1.631AspMet: 1.631 ± 0.045
1.791AspAsn: 1.791 ± 0.038
2.423AspPro: 2.423 ± 0.061
1.873AspGln: 1.873 ± 0.047
2.667AspArg: 2.667 ± 0.056
2.895AspSer: 2.895 ± 0.063
2.9AspThr: 2.9 ± 0.063
3.811AspVal: 3.811 ± 0.061
0.891AspTrp: 0.891 ± 0.03
1.88AspTyr: 1.88 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.816GluAla: 5.816 ± 0.1
0.431GluCys: 0.431 ± 0.025
2.322GluAsp: 2.322 ± 0.055
2.565GluGlu: 2.565 ± 0.066
2.107GluPhe: 2.107 ± 0.049
3.035GluGly: 3.035 ± 0.061
1.505GluHis: 1.505 ± 0.044
3.908GluIle: 3.908 ± 0.074
2.354GluLys: 2.354 ± 0.065
6.015GluLeu: 6.015 ± 0.089
1.581GluMet: 1.581 ± 0.039
1.827GluAsn: 1.827 ± 0.049
1.925GluPro: 1.925 ± 0.047
3.019GluGln: 3.019 ± 0.058
3.751GluArg: 3.751 ± 0.075
2.698GluSer: 2.698 ± 0.057
2.974GluThr: 2.974 ± 0.062
3.802GluVal: 3.802 ± 0.071
0.746GluTrp: 0.746 ± 0.032
1.525GluTyr: 1.525 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.908PheAla: 3.908 ± 0.071
0.375PheCys: 0.375 ± 0.017
2.436PheAsp: 2.436 ± 0.048
2.044PheGlu: 2.044 ± 0.046
1.407PhePhe: 1.407 ± 0.046
3.114PheGly: 3.114 ± 0.057
0.809PheHis: 0.809 ± 0.032
2.169PheIle: 2.169 ± 0.059
1.405PheLys: 1.405 ± 0.042
3.111PheLeu: 3.111 ± 0.068
0.956PheMet: 0.956 ± 0.036
1.48PheAsn: 1.48 ± 0.045
1.505PhePro: 1.505 ± 0.047
1.103PheGln: 1.103 ± 0.034
1.86PheArg: 1.86 ± 0.043
2.378PheSer: 2.378 ± 0.056
1.977PheThr: 1.977 ± 0.047
2.677PheVal: 2.677 ± 0.066
0.465PheTrp: 0.465 ± 0.025
1.094PheTyr: 1.094 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
6.816GlyAla: 6.816 ± 0.091
0.911GlyCys: 0.911 ± 0.036
3.628GlyAsp: 3.628 ± 0.071
4.167GlyGlu: 4.167 ± 0.074
3.142GlyPhe: 3.142 ± 0.064
5.403GlyGly: 5.403 ± 0.091
1.911GlyHis: 1.911 ± 0.044
4.77GlyIle: 4.77 ± 0.069
3.936GlyLys: 3.936 ± 0.062
7.682GlyLeu: 7.682 ± 0.093
2.575GlyMet: 2.575 ± 0.059
2.663GlyAsn: 2.663 ± 0.069
1.804GlyPro: 1.804 ± 0.046
2.893GlyGln: 2.893 ± 0.06
4.092GlyArg: 4.092 ± 0.067
3.934GlySer: 3.934 ± 0.073
3.877GlyThr: 3.877 ± 0.078
5.8GlyVal: 5.8 ± 0.079
1.19GlyTrp: 1.19 ± 0.043
2.524GlyTyr: 2.524 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.837HisAla: 2.837 ± 0.057
0.321HisCys: 0.321 ± 0.016
1.475HisAsp: 1.475 ± 0.044
1.346HisGlu: 1.346 ± 0.042
1.045HisPhe: 1.045 ± 0.038
2.093HisGly: 2.093 ± 0.056
0.769HisHis: 0.769 ± 0.029
1.428HisIle: 1.428 ± 0.043
0.85HisLys: 0.85 ± 0.029
2.545HisLeu: 2.545 ± 0.06
0.525HisMet: 0.525 ± 0.025
0.76HisAsn: 0.76 ± 0.032
1.653HisPro: 1.653 ± 0.051
1.059HisGln: 1.059 ± 0.033
1.297HisArg: 1.297 ± 0.037
1.222HisSer: 1.222 ± 0.037
1.301HisThr: 1.301 ± 0.039
1.562HisVal: 1.562 ± 0.043
0.4HisTrp: 0.4 ± 0.023
0.908HisTyr: 0.908 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
7.326IleAla: 7.326 ± 0.095
0.533IleCys: 0.533 ± 0.028
3.479IleAsp: 3.479 ± 0.068
3.575IleGlu: 3.575 ± 0.073
1.788IlePhe: 1.788 ± 0.05
4.676IleGly: 4.676 ± 0.084
1.34IleHis: 1.34 ± 0.036
3.118IleIle: 3.118 ± 0.062
2.524IleLys: 2.524 ± 0.062
5.128IleLeu: 5.128 ± 0.085
1.392IleMet: 1.392 ± 0.041
2.3IleAsn: 2.3 ± 0.049
2.85IlePro: 2.85 ± 0.052
2.022IleGln: 2.022 ± 0.047
3.265IleArg: 3.265 ± 0.061
3.609IleSer: 3.609 ± 0.065
3.332IleThr: 3.332 ± 0.062
4.069IleVal: 4.069 ± 0.083
0.642IleTrp: 0.642 ± 0.029
1.572IleTyr: 1.572 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
3.934LysAla: 3.934 ± 0.075
0.222LysCys: 0.222 ± 0.018
1.868LysAsp: 1.868 ± 0.048
1.82LysGlu: 1.82 ± 0.054
1.214LysPhe: 1.214 ± 0.04
2.504LysGly: 2.504 ± 0.057
1.02LysHis: 1.02 ± 0.036
2.552LysIle: 2.552 ± 0.059
1.742LysLys: 1.742 ± 0.049
4.546LysLeu: 4.546 ± 0.074
1.229LysMet: 1.229 ± 0.041
1.54LysAsn: 1.54 ± 0.04
2.159LysPro: 2.159 ± 0.06
2.071LysGln: 2.071 ± 0.052
2.348LysArg: 2.348 ± 0.059
2.334LysSer: 2.334 ± 0.058
2.5LysThr: 2.5 ± 0.047
2.715LysVal: 2.715 ± 0.058
0.465LysTrp: 0.465 ± 0.023
0.976LysTyr: 0.976 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
12.994LeuAla: 12.994 ± 0.158
0.876LeuCys: 0.876 ± 0.035
5.959LeuAsp: 5.959 ± 0.094
5.322LeuGlu: 5.322 ± 0.081
3.783LeuPhe: 3.783 ± 0.069
7.828LeuGly: 7.828 ± 0.103
2.665LeuHis: 2.665 ± 0.058
5.962LeuIle: 5.962 ± 0.091
4.283LeuLys: 4.283 ± 0.074
11.38LeuLeu: 11.38 ± 0.15
2.691LeuMet: 2.691 ± 0.054
3.796LeuAsn: 3.796 ± 0.069
5.809LeuPro: 5.809 ± 0.096
4.397LeuGln: 4.397 ± 0.079
6.269LeuArg: 6.269 ± 0.084
6.591LeuSer: 6.591 ± 0.087
6.118LeuThr: 6.118 ± 0.091
6.873LeuVal: 6.873 ± 0.1
1.251LeuTrp: 1.251 ± 0.046
2.429LeuTyr: 2.429 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.915MetAla: 2.915 ± 0.059
0.176MetCys: 0.176 ± 0.016
1.437MetAsp: 1.437 ± 0.043
1.298MetGlu: 1.298 ± 0.042
0.857MetPhe: 0.857 ± 0.031
1.853MetGly: 1.853 ± 0.045
0.715MetHis: 0.715 ± 0.031
1.361MetIle: 1.361 ± 0.046
1.194MetLys: 1.194 ± 0.04
3.206MetLeu: 3.206 ± 0.065
0.764MetMet: 0.764 ± 0.033
1.2MetAsn: 1.2 ± 0.037
1.547MetPro: 1.547 ± 0.042
1.475MetGln: 1.475 ± 0.042
1.707MetArg: 1.707 ± 0.043
1.827MetSer: 1.827 ± 0.043
1.608MetThr: 1.608 ± 0.037
1.828MetVal: 1.828 ± 0.045
0.21MetTrp: 0.21 ± 0.018
0.491MetTyr: 0.491 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.802AsnAla: 3.802 ± 0.062
0.318AsnCys: 0.318 ± 0.023
1.844AsnAsp: 1.844 ± 0.042
1.695AsnGlu: 1.695 ± 0.042
1.182AsnPhe: 1.182 ± 0.041
2.663AsnGly: 2.663 ± 0.067
0.836AsnHis: 0.836 ± 0.034
2.073AsnIle: 2.073 ± 0.055
1.397AsnLys: 1.397 ± 0.041
3.787AsnLeu: 3.787 ± 0.072
0.923AsnMet: 0.923 ± 0.033
1.23AsnAsn: 1.23 ± 0.042
2.248AsnPro: 2.248 ± 0.057
1.559AsnGln: 1.559 ± 0.046
2.101AsnArg: 2.101 ± 0.046
1.668AsnSer: 1.668 ± 0.054
1.879AsnThr: 1.879 ± 0.053
2.302AsnVal: 2.302 ± 0.053
0.475AsnTrp: 0.475 ± 0.024
0.931AsnTyr: 0.931 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
5.636ProAla: 5.636 ± 0.105
0.369ProCys: 0.369 ± 0.022
3.139ProAsp: 3.139 ± 0.065
3.095ProGlu: 3.095 ± 0.052
1.692ProPhe: 1.692 ± 0.046
3.532ProGly: 3.532 ± 0.071
1.119ProHis: 1.119 ± 0.033
2.258ProIle: 2.258 ± 0.051
1.605ProLys: 1.605 ± 0.043
4.774ProLeu: 4.774 ± 0.085
1.134ProMet: 1.134 ± 0.036
1.515ProAsn: 1.515 ± 0.039
1.894ProPro: 1.894 ± 0.055
2.03ProGln: 2.03 ± 0.048
2.109ProArg: 2.109 ± 0.059
2.2ProSer: 2.2 ± 0.052
2.066ProThr: 2.066 ± 0.049
3.932ProVal: 3.932 ± 0.081
0.617ProTrp: 0.617 ± 0.029
1.234ProTyr: 1.234 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
5.34GlnAla: 5.34 ± 0.086
0.326GlnCys: 0.326 ± 0.023
1.931GlnAsp: 1.931 ± 0.041
1.821GlnGlu: 1.821 ± 0.052
1.448GlnPhe: 1.448 ± 0.044
2.855GlnGly: 2.855 ± 0.058
1.405GlnHis: 1.405 ± 0.043
2.622GlnIle: 2.622 ± 0.055
1.479GlnLys: 1.479 ± 0.04
4.948GlnLeu: 4.948 ± 0.089
1.191GlnMet: 1.191 ± 0.034
1.385GlnAsn: 1.385 ± 0.039
2.198GlnPro: 2.198 ± 0.054
2.687GlnGln: 2.687 ± 0.08
3.047GlnArg: 3.047 ± 0.067
2.249GlnSer: 2.249 ± 0.056
2.338GlnThr: 2.338 ± 0.048
2.941GlnVal: 2.941 ± 0.067
0.532GlnTrp: 0.532 ± 0.029
1.104GlnTyr: 1.104 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
5.588ArgAla: 5.588 ± 0.094
0.486ArgCys: 0.486 ± 0.022
3.247ArgAsp: 3.247 ± 0.061
3.646ArgGlu: 3.646 ± 0.074
2.395ArgPhe: 2.395 ± 0.049
3.512ArgGly: 3.512 ± 0.077
1.723ArgHis: 1.723 ± 0.045
3.882ArgIle: 3.882 ± 0.074
2.266ArgLys: 2.266 ± 0.052
6.8ArgLeu: 6.8 ± 0.1
1.584ArgMet: 1.584 ± 0.043
2.198ArgAsn: 2.198 ± 0.05
2.445ArgPro: 2.445 ± 0.047
2.933ArgGln: 2.933 ± 0.062
3.598ArgArg: 3.598 ± 0.076
2.812ArgSer: 2.812 ± 0.052
2.726ArgThr: 2.726 ± 0.055
3.934ArgVal: 3.934 ± 0.072
0.801ArgTrp: 0.801 ± 0.033
2.082ArgTyr: 2.082 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.029SerAla: 6.029 ± 0.1
0.589SerCys: 0.589 ± 0.029
2.708SerAsp: 2.708 ± 0.061
2.711SerGlu: 2.711 ± 0.062
2.001SerPhe: 2.001 ± 0.047
5.049SerGly: 5.049 ± 0.075
1.376SerHis: 1.376 ± 0.039
3.142SerIle: 3.142 ± 0.066
2.034SerLys: 2.034 ± 0.048
5.772SerLeu: 5.772 ± 0.094
1.609SerMet: 1.609 ± 0.048
1.857SerAsn: 1.857 ± 0.056
2.452SerPro: 2.452 ± 0.061
2.14SerGln: 2.14 ± 0.053
3.403SerArg: 3.403 ± 0.065
3.108SerSer: 3.108 ± 0.076
2.762SerThr: 2.762 ± 0.064
3.864SerVal: 3.864 ± 0.068
0.724SerTrp: 0.724 ± 0.032
1.435SerTyr: 1.435 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.914ThrAla: 5.914 ± 0.09
0.458ThrCys: 0.458 ± 0.025
2.926ThrAsp: 2.926 ± 0.064
2.851ThrGlu: 2.851 ± 0.069
1.629ThrPhe: 1.629 ± 0.048
4.675ThrGly: 4.675 ± 0.086
1.378ThrHis: 1.378 ± 0.04
2.663ThrIle: 2.663 ± 0.058
1.53ThrLys: 1.53 ± 0.047
6.576ThrLeu: 6.576 ± 0.097
1.172ThrMet: 1.172 ± 0.036
1.562ThrAsn: 1.562 ± 0.05
3.212ThrPro: 3.212 ± 0.068
2.257ThrGln: 2.257 ± 0.055
3.137ThrArg: 3.137 ± 0.054
2.756ThrSer: 2.756 ± 0.06
2.892ThrThr: 2.892 ± 0.074
3.974ThrVal: 3.974 ± 0.07
0.531ThrTrp: 0.531 ± 0.027
1.278ThrTyr: 1.278 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
7.931ValAla: 7.931 ± 0.103
0.682ValCys: 0.682 ± 0.029
3.783ValAsp: 3.783 ± 0.075
3.823ValGlu: 3.823 ± 0.065
2.635ValPhe: 2.635 ± 0.07
4.633ValGly: 4.633 ± 0.083
1.514ValHis: 1.514 ± 0.044
4.305ValIle: 4.305 ± 0.071
2.951ValLys: 2.951 ± 0.062
7.527ValLeu: 7.527 ± 0.1
2.137ValMet: 2.137 ± 0.048
2.665ValAsn: 2.665 ± 0.052
3.145ValPro: 3.145 ± 0.062
2.452ValGln: 2.452 ± 0.059
4.032ValArg: 4.032 ± 0.068
4.165ValSer: 4.165 ± 0.062
4.233ValThr: 4.233 ± 0.075
5.349ValVal: 5.349 ± 0.094
0.886ValTrp: 0.886 ± 0.036
1.718ValTyr: 1.718 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.979TrpAla: 0.979 ± 0.038
0.14TrpCys: 0.14 ± 0.013
0.597TrpAsp: 0.597 ± 0.029
0.563TrpGlu: 0.563 ± 0.026
0.548TrpPhe: 0.548 ± 0.024
0.811TrpGly: 0.811 ± 0.032
0.439TrpHis: 0.439 ± 0.023
0.731TrpIle: 0.731 ± 0.031
0.476TrpLys: 0.476 ± 0.024
2.021TrpLeu: 2.021 ± 0.062
0.371TrpMet: 0.371 ± 0.022
0.412TrpAsn: 0.412 ± 0.02
0.49TrpPro: 0.49 ± 0.025
0.946TrpGln: 0.946 ± 0.034
0.967TrpArg: 0.967 ± 0.037
0.591TrpSer: 0.591 ± 0.029
0.482TrpThr: 0.482 ± 0.022
0.883TrpVal: 0.883 ± 0.029
0.214TrpTrp: 0.214 ± 0.017
0.306TrpTyr: 0.306 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.856TyrAla: 2.856 ± 0.057
0.298TyrCys: 0.298 ± 0.019
1.372TyrAsp: 1.372 ± 0.035
1.191TyrGlu: 1.191 ± 0.034
1.197TyrPhe: 1.197 ± 0.038
2.064TyrGly: 2.064 ± 0.048
0.725TyrHis: 0.725 ± 0.027
1.298TyrIle: 1.298 ± 0.042
0.916TyrLys: 0.916 ± 0.037
3.04TyrLeu: 3.04 ± 0.063
0.627TyrMet: 0.627 ± 0.031
0.871TyrAsn: 0.871 ± 0.036
1.455TyrPro: 1.455 ± 0.04
1.452TyrGln: 1.452 ± 0.04
2.004TyrArg: 2.004 ± 0.052
1.492TyrSer: 1.492 ± 0.04
1.511TyrThr: 1.511 ± 0.039
1.781TyrVal: 1.781 ± 0.049
0.415TyrTrp: 0.415 ± 0.023
0.879TyrTyr: 0.879 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2803 proteins (864869 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski