Amino acid dipepetide frequency for [Clostridium] cocleatum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.115AlaAla: 3.115 ± 0.076	0.756AlaCys: 0.756 ± 0.034	2.702AlaAsp: 2.702 ± 0.063	2.416AlaGlu: 2.416 ± 0.073	2.386AlaPhe: 2.386 ± 0.061	3.782AlaGly: 3.782 ± 0.083	0.854AlaHis: 0.854 ± 0.029	5.392AlaIle: 5.392 ± 0.078	5.042AlaLys: 5.042 ± 0.082	5.825AlaLeu: 5.825 ± 0.09	1.695AlaMet: 1.695 ± 0.043	3.403AlaAsn: 3.403 ± 0.069	1.408AlaPro: 1.408 ± 0.054	1.419AlaGln: 1.419 ± 0.042	1.908AlaArg: 1.908 ± 0.049	3.519AlaSer: 3.519 ± 0.083	3.147AlaThr: 3.147 ± 0.082	3.857AlaVal: 3.857 ± 0.085	0.424AlaTrp: 0.424 ± 0.025	2.355AlaTyr: 2.355 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.591CysAla: 0.591 ± 0.031	0.202CysCys: 0.202 ± 0.017	0.784CysAsp: 0.784 ± 0.033	0.598CysGlu: 0.598 ± 0.027	0.678CysPhe: 0.678 ± 0.033	1.065CysGly: 1.065 ± 0.042	0.269CysHis: 0.269 ± 0.016	1.229CysIle: 1.229 ± 0.038	0.988CysLys: 0.988 ± 0.039	1.292CysLeu: 1.292 ± 0.042	0.288CysMet: 0.288 ± 0.018	0.757CysAsn: 0.757 ± 0.035	0.474CysPro: 0.474 ± 0.027	0.417CysGln: 0.417 ± 0.024	0.401CysArg: 0.401 ± 0.024	0.832CysSer: 0.832 ± 0.032	0.611CysThr: 0.611 ± 0.025	0.73CysVal: 0.73 ± 0.027	0.098CysTrp: 0.098 ± 0.011	0.634CysTyr: 0.634 ± 0.032	0.0CysXaa: 0.0 ± 0.0
Asp	2.997AspAla: 2.997 ± 0.062	0.786AspCys: 0.786 ± 0.031	3.746AspAsp: 3.746 ± 0.076	5.069AspGlu: 5.069 ± 0.085	3.026AspPhe: 3.026 ± 0.064	3.781AspGly: 3.781 ± 0.086	0.94AspHis: 0.94 ± 0.033	5.799AspIle: 5.799 ± 0.091	5.105AspLys: 5.105 ± 0.089	5.749AspLeu: 5.749 ± 0.09	1.521AspMet: 1.521 ± 0.046	3.993AspAsn: 3.993 ± 0.074	1.433AspPro: 1.433 ± 0.038	1.693AspGln: 1.693 ± 0.044	1.745AspArg: 1.745 ± 0.055	3.289AspSer: 3.289 ± 0.062	2.833AspThr: 2.833 ± 0.065	3.855AspVal: 3.855 ± 0.069	0.444AspTrp: 0.444 ± 0.026	3.684AspTyr: 3.684 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	4.152GluAla: 4.152 ± 0.076	0.762GluCys: 0.762 ± 0.029	3.655GluAsp: 3.655 ± 0.068	5.1GluGlu: 5.1 ± 0.098	2.971GluPhe: 2.971 ± 0.054	3.301GluGly: 3.301 ± 0.063	1.078GluHis: 1.078 ± 0.038	6.804GluIle: 6.804 ± 0.093	6.003GluLys: 6.003 ± 0.093	6.682GluLeu: 6.682 ± 0.103	2.024GluMet: 2.024 ± 0.051	4.889GluAsn: 4.889 ± 0.074	1.293GluPro: 1.293 ± 0.038	2.224GluGln: 2.224 ± 0.056	2.215GluArg: 2.215 ± 0.062	3.176GluSer: 3.176 ± 0.062	3.335GluThr: 3.335 ± 0.069	4.798GluVal: 4.798 ± 0.088	0.47GluTrp: 0.47 ± 0.022	3.43GluTyr: 3.43 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.253PheAla: 2.253 ± 0.057	0.547PheCys: 0.547 ± 0.027	3.246PheAsp: 3.246 ± 0.061	3.018PheGlu: 3.018 ± 0.067	1.684PhePhe: 1.684 ± 0.052	2.588PheGly: 2.588 ± 0.062	0.612PheHis: 0.612 ± 0.027	4.439PheIle: 4.439 ± 0.089	3.705PheLys: 3.705 ± 0.076	3.395PheLeu: 3.395 ± 0.071	1.105PheMet: 1.105 ± 0.036	3.103PheAsn: 3.103 ± 0.064	0.987PhePro: 0.987 ± 0.043	0.982PheGln: 0.982 ± 0.036	1.167PheArg: 1.167 ± 0.041	3.004PheSer: 3.004 ± 0.059	2.273PheThr: 2.273 ± 0.058	2.807PheVal: 2.807 ± 0.051	0.277PheTrp: 0.277 ± 0.022	1.991PheTyr: 1.991 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.506GlyAla: 3.506 ± 0.082	0.893GlyCys: 0.893 ± 0.035	3.213GlyAsp: 3.213 ± 0.069	3.319GlyGlu: 3.319 ± 0.065	2.765GlyPhe: 2.765 ± 0.057	3.618GlyGly: 3.618 ± 0.083	1.038GlyHis: 1.038 ± 0.035	6.01GlyIle: 6.01 ± 0.092	4.863GlyLys: 4.863 ± 0.072	5.361GlyLeu: 5.361 ± 0.09	1.772GlyMet: 1.772 ± 0.046	3.462GlyAsn: 3.462 ± 0.074	1.012GlyPro: 1.012 ± 0.046	1.589GlyGln: 1.589 ± 0.046	1.878GlyArg: 1.878 ± 0.049	3.46GlySer: 3.46 ± 0.068	3.371GlyThr: 3.371 ± 0.086	3.892GlyVal: 3.892 ± 0.077	0.508GlyTrp: 0.508 ± 0.03	3.352GlyTyr: 3.352 ± 0.082	0.0GlyXaa: 0.0 ± 0.0
His	0.739HisAla: 0.739 ± 0.032	0.282HisCys: 0.282 ± 0.019	1.105HisAsp: 1.105 ± 0.034	0.981HisGlu: 0.981 ± 0.035	0.716HisPhe: 0.716 ± 0.029	1.13HisGly: 1.13 ± 0.041	0.476HisHis: 0.476 ± 0.025	1.41HisIle: 1.41 ± 0.041	1.03HisLys: 1.03 ± 0.036	1.484HisLeu: 1.484 ± 0.044	0.45HisMet: 0.45 ± 0.021	0.94HisAsn: 0.94 ± 0.039	0.699HisPro: 0.699 ± 0.031	0.644HisGln: 0.644 ± 0.027	0.576HisArg: 0.576 ± 0.028	0.957HisSer: 0.957 ± 0.031	0.767HisThr: 0.767 ± 0.032	0.916HisVal: 0.916 ± 0.035	0.118HisTrp: 0.118 ± 0.011	0.744HisTyr: 0.744 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.309IleAla: 5.309 ± 0.095	1.38IleCys: 1.38 ± 0.043	6.572IleAsp: 6.572 ± 0.086	6.922IleGlu: 6.922 ± 0.104	3.921IlePhe: 3.921 ± 0.077	5.359IleGly: 5.359 ± 0.09	1.273IleHis: 1.273 ± 0.041	9.59IleIle: 9.59 ± 0.147	8.375IleLys: 8.375 ± 0.101	8.005IleLeu: 8.005 ± 0.107	2.201IleMet: 2.201 ± 0.049	6.87IleAsn: 6.87 ± 0.113	2.852IlePro: 2.852 ± 0.062	2.32IleGln: 2.32 ± 0.056	2.722IleArg: 2.722 ± 0.058	6.037IleSer: 6.037 ± 0.106	4.901IleThr: 4.901 ± 0.074	5.93IleVal: 5.93 ± 0.092	0.535IleTrp: 0.535 ± 0.026	4.014IleTyr: 4.014 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	4.786LysAla: 4.786 ± 0.081	0.866LysCys: 0.866 ± 0.033	5.612LysAsp: 5.612 ± 0.082	7.526LysGlu: 7.526 ± 0.109	2.706LysPhe: 2.706 ± 0.058	3.971LysGly: 3.971 ± 0.066	1.398LysHis: 1.398 ± 0.04	7.71LysIle: 7.71 ± 0.104	7.513LysLys: 7.513 ± 0.108	7.141LysLeu: 7.141 ± 0.11	2.534LysMet: 2.534 ± 0.061	5.546LysAsn: 5.546 ± 0.091	2.002LysPro: 2.002 ± 0.044	3.213LysGln: 3.213 ± 0.067	3.182LysArg: 3.182 ± 0.068	4.034LysSer: 4.034 ± 0.078	4.339LysThr: 4.339 ± 0.067	5.274LysVal: 5.274 ± 0.082	0.595LysTrp: 0.595 ± 0.023	4.388LysTyr: 4.388 ± 0.084	0.0LysXaa: 0.0 ± 0.0
Leu	5.474LeuAla: 5.474 ± 0.086	1.161LeuCys: 1.161 ± 0.036	5.799LeuAsp: 5.799 ± 0.091	6.586LeuGlu: 6.586 ± 0.095	3.89LeuPhe: 3.89 ± 0.084	5.379LeuGly: 5.379 ± 0.089	1.257LeuHis: 1.257 ± 0.037	8.217LeuIle: 8.217 ± 0.13	8.151LeuLys: 8.151 ± 0.108	8.167LeuLeu: 8.167 ± 0.119	2.352LeuMet: 2.352 ± 0.052	6.129LeuAsn: 6.129 ± 0.105	2.744LeuPro: 2.744 ± 0.061	2.739LeuGln: 2.739 ± 0.059	2.766LeuArg: 2.766 ± 0.065	6.118LeuSer: 6.118 ± 0.09	4.737LeuThr: 4.737 ± 0.096	5.894LeuVal: 5.894 ± 0.081	0.52LeuTrp: 0.52 ± 0.029	3.551LeuTyr: 3.551 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	1.686MetAla: 1.686 ± 0.049	0.273MetCys: 0.273 ± 0.018	1.43MetAsp: 1.43 ± 0.042	1.634MetGlu: 1.634 ± 0.044	1.124MetPhe: 1.124 ± 0.042	1.367MetGly: 1.367 ± 0.045	0.418MetHis: 0.418 ± 0.023	2.722MetIle: 2.722 ± 0.06	2.545MetLys: 2.545 ± 0.048	2.447MetLeu: 2.447 ± 0.055	0.881MetMet: 0.881 ± 0.038	1.748MetAsn: 1.748 ± 0.046	0.779MetPro: 0.779 ± 0.025	0.845MetGln: 0.845 ± 0.031	0.724MetArg: 0.724 ± 0.027	1.703MetSer: 1.703 ± 0.049	1.231MetThr: 1.231 ± 0.039	1.579MetVal: 1.579 ± 0.041	0.179MetTrp: 0.179 ± 0.012	1.005MetTyr: 1.005 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.45AsnAla: 3.45 ± 0.082	0.836AsnCys: 0.836 ± 0.03	4.269AsnAsp: 4.269 ± 0.089	4.938AsnGlu: 4.938 ± 0.083	2.382AsnPhe: 2.382 ± 0.061	4.077AsnGly: 4.077 ± 0.081	1.185AsnHis: 1.185 ± 0.04	6.097AsnIle: 6.097 ± 0.099	5.748AsnLys: 5.748 ± 0.097	5.363AsnLeu: 5.363 ± 0.092	1.503AsnMet: 1.503 ± 0.037	4.981AsnAsn: 4.981 ± 0.094	2.068AsnPro: 2.068 ± 0.051	2.496AsnGln: 2.496 ± 0.058	2.111AsnArg: 2.111 ± 0.048	3.79AsnSer: 3.79 ± 0.072	3.118AsnThr: 3.118 ± 0.057	3.726AsnVal: 3.726 ± 0.077	0.478AsnTrp: 0.478 ± 0.026	3.524AsnTyr: 3.524 ± 0.082	0.0AsnXaa: 0.0 ± 0.0
Pro	1.458ProAla: 1.458 ± 0.048	0.337ProCys: 0.337 ± 0.021	1.575ProAsp: 1.575 ± 0.044	2.003ProGlu: 2.003 ± 0.057	1.298ProPhe: 1.298 ± 0.04	1.577ProGly: 1.577 ± 0.044	0.487ProHis: 0.487 ± 0.022	2.382ProIle: 2.382 ± 0.052	1.845ProLys: 1.845 ± 0.053	2.298ProLeu: 2.298 ± 0.058	0.647ProMet: 0.647 ± 0.025	1.628ProAsn: 1.628 ± 0.045	0.42ProPro: 0.42 ± 0.025	0.78ProGln: 0.78 ± 0.029	0.803ProArg: 0.803 ± 0.029	1.573ProSer: 1.573 ± 0.046	1.517ProThr: 1.517 ± 0.046	2.012ProVal: 2.012 ± 0.052	0.225ProTrp: 0.225 ± 0.016	1.316ProTyr: 1.316 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.896GlnAla: 1.896 ± 0.052	0.322GlnCys: 0.322 ± 0.019	1.636GlnAsp: 1.636 ± 0.044	2.447GlnGlu: 2.447 ± 0.053	1.235GlnPhe: 1.235 ± 0.036	1.762GlnGly: 1.762 ± 0.044	0.454GlnHis: 0.454 ± 0.023	2.957GlnIle: 2.957 ± 0.059	2.426GlnLys: 2.426 ± 0.048	3.047GlnLeu: 3.047 ± 0.064	0.851GlnMet: 0.851 ± 0.033	1.867GlnAsn: 1.867 ± 0.046	0.678GlnPro: 0.678 ± 0.029	1.031GlnGln: 1.031 ± 0.038	1.185GlnArg: 1.185 ± 0.039	1.58GlnSer: 1.58 ± 0.045	1.622GlnThr: 1.622 ± 0.042	1.92GlnVal: 1.92 ± 0.055	0.279GlnTrp: 0.279 ± 0.019	1.491GlnTyr: 1.491 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	1.6ArgAla: 1.6 ± 0.044	0.472ArgCys: 0.472 ± 0.026	1.872ArgAsp: 1.872 ± 0.052	2.051ArgGlu: 2.051 ± 0.052	1.581ArgPhe: 1.581 ± 0.046	1.705ArgGly: 1.705 ± 0.049	0.535ArgHis: 0.535 ± 0.024	2.959ArgIle: 2.959 ± 0.059	2.883ArgLys: 2.883 ± 0.054	3.153ArgLeu: 3.153 ± 0.066	0.966ArgMet: 0.966 ± 0.032	2.001ArgAsn: 2.001 ± 0.055	0.906ArgPro: 0.906 ± 0.037	1.059ArgGln: 1.059 ± 0.037	1.228ArgArg: 1.228 ± 0.045	1.554ArgSer: 1.554 ± 0.045	1.394ArgThr: 1.394 ± 0.041	2.015ArgVal: 2.015 ± 0.051	0.268ArgTrp: 0.268 ± 0.018	1.792ArgTyr: 1.792 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.006SerAla: 3.006 ± 0.065	0.695SerCys: 0.695 ± 0.034	3.418SerAsp: 3.418 ± 0.059	3.418SerGlu: 3.418 ± 0.069	3.007SerPhe: 3.007 ± 0.063	3.971SerGly: 3.971 ± 0.081	0.965SerHis: 0.965 ± 0.035	5.452SerIle: 5.452 ± 0.091	5.085SerLys: 5.085 ± 0.081	5.921SerLeu: 5.921 ± 0.083	1.504SerMet: 1.504 ± 0.048	3.978SerAsn: 3.978 ± 0.083	1.28SerPro: 1.28 ± 0.037	1.715SerGln: 1.715 ± 0.05	1.997SerArg: 1.997 ± 0.045	4.137SerSer: 4.137 ± 0.084	3.044SerThr: 3.044 ± 0.071	3.686SerVal: 3.686 ± 0.068	0.563SerTrp: 0.563 ± 0.025	2.881SerTyr: 2.881 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	2.862ThrAla: 2.862 ± 0.075	0.56ThrCys: 0.56 ± 0.027	2.813ThrAsp: 2.813 ± 0.072	2.436ThrGlu: 2.436 ± 0.064	2.291ThrPhe: 2.291 ± 0.047	3.587ThrGly: 3.587 ± 0.087	0.805ThrHis: 0.805 ± 0.032	5.191ThrIle: 5.191 ± 0.083	4.08ThrLys: 4.08 ± 0.066	4.577ThrLeu: 4.577 ± 0.078	1.215ThrMet: 1.215 ± 0.034	3.35ThrAsn: 3.35 ± 0.07	1.765ThrPro: 1.765 ± 0.049	1.341ThrGln: 1.341 ± 0.051	1.575ThrArg: 1.575 ± 0.05	3.378ThrSer: 3.378 ± 0.074	2.964ThrThr: 2.964 ± 0.072	3.751ThrVal: 3.751 ± 0.073	0.455ThrTrp: 0.455 ± 0.025	2.374ThrTyr: 2.374 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	3.814ValAla: 3.814 ± 0.071	0.955ValCys: 0.955 ± 0.034	4.344ValAsp: 4.344 ± 0.088	4.617ValGlu: 4.617 ± 0.075	2.84ValPhe: 2.84 ± 0.063	3.607ValGly: 3.607 ± 0.071	0.918ValHis: 0.918 ± 0.035	6.087ValIle: 6.087 ± 0.091	5.092ValLys: 5.092 ± 0.084	5.948ValLeu: 5.948 ± 0.087	1.591ValMet: 1.591 ± 0.045	3.958ValAsn: 3.958 ± 0.071	1.741ValPro: 1.741 ± 0.048	1.43ValGln: 1.43 ± 0.046	1.859ValArg: 1.859 ± 0.044	4.201ValSer: 4.201 ± 0.072	3.475ValThr: 3.475 ± 0.077	4.549ValVal: 4.549 ± 0.089	0.439ValTrp: 0.439 ± 0.024	2.885ValTyr: 2.885 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.429TrpAla: 0.429 ± 0.023	0.119TrpCys: 0.119 ± 0.01	0.404TrpAsp: 0.404 ± 0.025	0.343TrpGlu: 0.343 ± 0.022	0.358TrpPhe: 0.358 ± 0.023	0.476TrpGly: 0.476 ± 0.026	0.142TrpHis: 0.142 ± 0.014	0.656TrpIle: 0.656 ± 0.033	0.514TrpLys: 0.514 ± 0.028	0.819TrpLeu: 0.819 ± 0.03	0.195TrpMet: 0.195 ± 0.016	0.501TrpAsn: 0.501 ± 0.026	0.154TrpPro: 0.154 ± 0.012	0.366TrpGln: 0.366 ± 0.022	0.201TrpArg: 0.201 ± 0.016	0.45TrpSer: 0.45 ± 0.025	0.332TrpThr: 0.332 ± 0.023	0.426TrpVal: 0.426 ± 0.023	0.085TrpTrp: 0.085 ± 0.01	0.369TrpTyr: 0.369 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.284TyrAla: 2.284 ± 0.049	0.734TyrCys: 0.734 ± 0.031	3.293TyrAsp: 3.293 ± 0.064	2.941TyrGlu: 2.941 ± 0.065	2.324TyrPhe: 2.324 ± 0.057	2.779TyrGly: 2.779 ± 0.062	1.062TyrHis: 1.062 ± 0.033	3.984TyrIle: 3.984 ± 0.075	3.346TyrLys: 3.346 ± 0.064	4.957TyrLeu: 4.957 ± 0.087	1.025TyrMet: 1.025 ± 0.04	3.035TyrAsn: 3.035 ± 0.073	1.486TyrPro: 1.486 ± 0.04	2.382TyrGln: 2.382 ± 0.058	1.75TyrArg: 1.75 ± 0.046	2.925TyrSer: 2.925 ± 0.064	2.357TyrThr: 2.357 ± 0.065	2.735TyrVal: 2.735 ± 0.057	0.38TyrTrp: 0.38 ± 0.02	2.642TyrTyr: 2.642 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2756 proteins (839769 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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