Amino acid dipepetide frequency for Corallincola sp. C4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.701AlaAla: 9.701 ± 0.123	1.037AlaCys: 1.037 ± 0.032	5.82AlaAsp: 5.82 ± 0.083	6.781AlaGlu: 6.781 ± 0.097	3.349AlaPhe: 3.349 ± 0.059	6.797AlaGly: 6.797 ± 0.088	1.85AlaHis: 1.85 ± 0.045	5.696AlaIle: 5.696 ± 0.07	4.739AlaLys: 4.739 ± 0.078	11.026AlaLeu: 11.026 ± 0.122	2.764AlaMet: 2.764 ± 0.064	3.574AlaAsn: 3.574 ± 0.056	3.636AlaPro: 3.636 ± 0.061	4.121AlaGln: 4.121 ± 0.067	4.116AlaArg: 4.116 ± 0.054	5.68AlaSer: 5.68 ± 0.072	4.865AlaThr: 4.865 ± 0.071	6.727AlaVal: 6.727 ± 0.07	1.14AlaTrp: 1.14 ± 0.036	2.531AlaTyr: 2.531 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.901CysAla: 0.901 ± 0.026	0.23CysCys: 0.23 ± 0.016	0.672CysAsp: 0.672 ± 0.027	0.628CysGlu: 0.628 ± 0.026	0.483CysPhe: 0.483 ± 0.021	0.978CysGly: 0.978 ± 0.027	0.42CysHis: 0.42 ± 0.023	0.516CysIle: 0.516 ± 0.02	0.36CysLys: 0.36 ± 0.017	1.038CysLeu: 1.038 ± 0.034	0.201CysMet: 0.201 ± 0.012	0.317CysAsn: 0.317 ± 0.016	0.485CysPro: 0.485 ± 0.022	0.549CysGln: 0.549 ± 0.021	0.617CysArg: 0.617 ± 0.023	0.767CysSer: 0.767 ± 0.027	0.429CysThr: 0.429 ± 0.017	0.65CysVal: 0.65 ± 0.022	0.171CysTrp: 0.171 ± 0.012	0.378CysTyr: 0.378 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.342AspAla: 5.342 ± 0.067	0.554AspCys: 0.554 ± 0.021	3.666AspAsp: 3.666 ± 0.077	4.005AspGlu: 4.005 ± 0.062	2.318AspPhe: 2.318 ± 0.052	4.513AspGly: 4.513 ± 0.105	1.158AspHis: 1.158 ± 0.031	3.468AspIle: 3.468 ± 0.058	2.819AspLys: 2.819 ± 0.044	5.371AspLeu: 5.371 ± 0.067	1.375AspMet: 1.375 ± 0.035	2.347AspAsn: 2.347 ± 0.05	2.532AspPro: 2.532 ± 0.045	2.167AspGln: 2.167 ± 0.047	2.601AspArg: 2.601 ± 0.043	3.401AspSer: 3.401 ± 0.055	2.852AspThr: 2.852 ± 0.054	3.908AspVal: 3.908 ± 0.075	0.948AspTrp: 0.948 ± 0.031	2.106AspTyr: 2.106 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.656GluAla: 5.656 ± 0.08	0.493GluCys: 0.493 ± 0.02	2.72GluAsp: 2.72 ± 0.053	3.478GluGlu: 3.478 ± 0.062	2.223GluPhe: 2.223 ± 0.047	3.688GluGly: 3.688 ± 0.056	1.505GluHis: 1.505 ± 0.038	3.518GluIle: 3.518 ± 0.05	3.139GluLys: 3.139 ± 0.065	7.645GluLeu: 7.645 ± 0.097	1.725GluMet: 1.725 ± 0.035	2.079GluAsn: 2.079 ± 0.039	2.231GluPro: 2.231 ± 0.05	4.68GluGln: 4.68 ± 0.074	3.548GluArg: 3.548 ± 0.056	3.437GluSer: 3.437 ± 0.06	2.974GluThr: 2.974 ± 0.049	4.477GluVal: 4.477 ± 0.071	0.764GluTrp: 0.764 ± 0.026	1.643GluTyr: 1.643 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.77PheAla: 3.77 ± 0.055	0.511PheCys: 0.511 ± 0.018	2.705PheAsp: 2.705 ± 0.054	2.447PheGlu: 2.447 ± 0.045	1.652PhePhe: 1.652 ± 0.039	3.102PheGly: 3.102 ± 0.052	0.831PheHis: 0.831 ± 0.026	2.259PheIle: 2.259 ± 0.05	1.681PheLys: 1.681 ± 0.041	3.194PheLeu: 3.194 ± 0.058	0.864PheMet: 0.864 ± 0.032	1.832PheAsn: 1.832 ± 0.042	1.43PhePro: 1.43 ± 0.037	1.304PheGln: 1.304 ± 0.03	1.718PheArg: 1.718 ± 0.037	3.278PheSer: 3.278 ± 0.06	2.136PheThr: 2.136 ± 0.04	2.705PheVal: 2.705 ± 0.048	0.562PheTrp: 0.562 ± 0.025	1.24PheTyr: 1.24 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.81GlyAla: 5.81 ± 0.076	0.983GlyCys: 0.983 ± 0.032	4.378GlyAsp: 4.378 ± 0.074	4.758GlyGlu: 4.758 ± 0.064	3.18GlyPhe: 3.18 ± 0.054	5.253GlyGly: 5.253 ± 0.088	1.706GlyHis: 1.706 ± 0.043	4.293GlyIle: 4.293 ± 0.062	3.57GlyLys: 3.57 ± 0.059	7.264GlyLeu: 7.264 ± 0.081	1.952GlyMet: 1.952 ± 0.049	2.389GlyAsn: 2.389 ± 0.051	1.765GlyPro: 1.765 ± 0.038	3.003GlyGln: 3.003 ± 0.056	3.43GlyArg: 3.43 ± 0.052	4.283GlySer: 4.283 ± 0.074	3.417GlyThr: 3.417 ± 0.062	5.449GlyVal: 5.449 ± 0.069	1.163GlyTrp: 1.163 ± 0.035	2.661GlyTyr: 2.661 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.777HisAla: 1.777 ± 0.04	0.37HisCys: 0.37 ± 0.017	1.132HisAsp: 1.132 ± 0.033	1.157HisGlu: 1.157 ± 0.034	0.96HisPhe: 0.96 ± 0.024	1.777HisGly: 1.777 ± 0.042	0.709HisHis: 0.709 ± 0.027	1.232HisIle: 1.232 ± 0.033	0.905HisLys: 0.905 ± 0.029	2.413HisLeu: 2.413 ± 0.044	0.483HisMet: 0.483 ± 0.019	0.731HisAsn: 0.731 ± 0.023	1.261HisPro: 1.261 ± 0.034	1.312HisGln: 1.312 ± 0.038	1.242HisArg: 1.242 ± 0.032	1.456HisSer: 1.456 ± 0.039	1.038HisThr: 1.038 ± 0.028	1.225HisVal: 1.225 ± 0.029	0.465HisTrp: 0.465 ± 0.019	0.89HisTyr: 0.89 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.073IleAla: 6.073 ± 0.078	0.7IleCys: 0.7 ± 0.024	4.119IleAsp: 4.119 ± 0.062	4.014IleGlu: 4.014 ± 0.057	1.858IlePhe: 1.858 ± 0.042	4.254IleGly: 4.254 ± 0.063	1.091IleHis: 1.091 ± 0.028	2.672IleIle: 2.672 ± 0.043	2.565IleLys: 2.565 ± 0.05	4.422IleLeu: 4.422 ± 0.072	1.045IleMet: 1.045 ± 0.03	2.446IleAsn: 2.446 ± 0.048	2.299IlePro: 2.299 ± 0.044	1.899IleGln: 1.899 ± 0.039	2.726IleArg: 2.726 ± 0.047	4.165IleSer: 4.165 ± 0.068	3.233IleThr: 3.233 ± 0.054	3.605IleVal: 3.605 ± 0.061	0.644IleTrp: 0.644 ± 0.026	1.651IleTyr: 1.651 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.482LysAla: 4.482 ± 0.074	0.324LysCys: 0.324 ± 0.019	2.146LysAsp: 2.146 ± 0.044	2.56LysGlu: 2.56 ± 0.053	1.453LysPhe: 1.453 ± 0.037	2.959LysGly: 2.959 ± 0.055	1.032LysHis: 1.032 ± 0.028	2.254LysIle: 2.254 ± 0.047	2.149LysLys: 2.149 ± 0.053	4.992LysLeu: 4.992 ± 0.067	1.147LysMet: 1.147 ± 0.035	1.41LysAsn: 1.41 ± 0.031	2.219LysPro: 2.219 ± 0.049	2.95LysGln: 2.95 ± 0.063	2.831LysArg: 2.831 ± 0.053	2.605LysSer: 2.605 ± 0.052	2.174LysThr: 2.174 ± 0.044	3.363LysVal: 3.363 ± 0.054	0.438LysTrp: 0.438 ± 0.018	1.141LysTyr: 1.141 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.643LeuAla: 11.643 ± 0.131	1.158LeuCys: 1.158 ± 0.031	5.833LeuAsp: 5.833 ± 0.065	5.795LeuGlu: 5.795 ± 0.075	4.418LeuPhe: 4.418 ± 0.077	7.146LeuGly: 7.146 ± 0.086	2.183LeuHis: 2.183 ± 0.046	5.904LeuIle: 5.904 ± 0.088	5.052LeuLys: 5.052 ± 0.074	12.543LeuLeu: 12.543 ± 0.164	2.727LeuMet: 2.727 ± 0.053	4.165LeuAsn: 4.165 ± 0.056	5.458LeuPro: 5.458 ± 0.07	4.671LeuGln: 4.671 ± 0.073	5.078LeuArg: 5.078 ± 0.065	7.842LeuSer: 7.842 ± 0.085	6.159LeuThr: 6.159 ± 0.073	7.47LeuVal: 7.47 ± 0.078	1.267LeuTrp: 1.267 ± 0.038	2.83LeuTyr: 2.83 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.802MetAla: 2.802 ± 0.051	0.179MetCys: 0.179 ± 0.011	1.231MetAsp: 1.231 ± 0.035	1.293MetGlu: 1.293 ± 0.03	0.834MetPhe: 0.834 ± 0.028	1.718MetGly: 1.718 ± 0.043	0.473MetHis: 0.473 ± 0.019	1.258MetIle: 1.258 ± 0.033	1.191MetLys: 1.191 ± 0.031	2.826MetLeu: 2.826 ± 0.056	0.727MetMet: 0.727 ± 0.026	0.915MetAsn: 0.915 ± 0.029	1.281MetPro: 1.281 ± 0.035	1.124MetGln: 1.124 ± 0.03	1.293MetArg: 1.293 ± 0.034	1.769MetSer: 1.769 ± 0.038	1.523MetThr: 1.523 ± 0.035	1.819MetVal: 1.819 ± 0.043	0.193MetTrp: 0.193 ± 0.012	0.437MetTyr: 0.437 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.239AsnAla: 3.239 ± 0.055	0.386AsnCys: 0.386 ± 0.02	2.204AsnAsp: 2.204 ± 0.047	2.188AsnGlu: 2.188 ± 0.04	1.344AsnPhe: 1.344 ± 0.034	2.819AsnGly: 2.819 ± 0.057	0.878AsnHis: 0.878 ± 0.03	2.053AsnIle: 2.053 ± 0.042	1.587AsnLys: 1.587 ± 0.04	3.505AsnLeu: 3.505 ± 0.055	0.867AsnMet: 0.867 ± 0.027	1.443AsnAsn: 1.443 ± 0.037	1.79AsnPro: 1.79 ± 0.037	1.81AsnGln: 1.81 ± 0.043	1.967AsnArg: 1.967 ± 0.05	2.272AsnSer: 2.272 ± 0.043	1.832AsnThr: 1.832 ± 0.037	2.204AsnVal: 2.204 ± 0.047	0.552AsnTrp: 0.552 ± 0.02	1.216AsnTyr: 1.216 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.125ProAla: 4.125 ± 0.077	0.395ProCys: 0.395 ± 0.018	2.738ProAsp: 2.738 ± 0.052	3.448ProGlu: 3.448 ± 0.062	1.722ProPhe: 1.722 ± 0.036	2.813ProGly: 2.813 ± 0.053	0.89ProHis: 0.89 ± 0.023	2.292ProIle: 2.292 ± 0.046	1.843ProLys: 1.843 ± 0.04	4.739ProLeu: 4.739 ± 0.074	1.073ProMet: 1.073 ± 0.03	1.626ProAsn: 1.626 ± 0.029	1.539ProPro: 1.539 ± 0.044	1.798ProGln: 1.798 ± 0.039	1.619ProArg: 1.619 ± 0.039	2.569ProSer: 2.569 ± 0.047	2.259ProThr: 2.259 ± 0.041	3.386ProVal: 3.386 ± 0.051	0.6ProTrp: 0.6 ± 0.026	1.18ProTyr: 1.18 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.932GlnAla: 4.932 ± 0.077	0.446GlnCys: 0.446 ± 0.022	1.871GlnAsp: 1.871 ± 0.037	2.243GlnGlu: 2.243 ± 0.048	1.835GlnPhe: 1.835 ± 0.039	3.198GlnGly: 3.198 ± 0.061	1.33GlnHis: 1.33 ± 0.04	2.56GlnIle: 2.56 ± 0.047	1.751GlnLys: 1.751 ± 0.043	6.478GlnLeu: 6.478 ± 0.084	1.212GlnMet: 1.212 ± 0.031	1.277GlnAsn: 1.277 ± 0.031	2.302GlnPro: 2.302 ± 0.044	4.135GlnGln: 4.135 ± 0.098	3.106GlnArg: 3.106 ± 0.064	2.79GlnSer: 2.79 ± 0.058	2.265GlnThr: 2.265 ± 0.046	3.425GlnVal: 3.425 ± 0.051	0.783GlnTrp: 0.783 ± 0.029	1.242GlnTyr: 1.242 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.962ArgAla: 3.962 ± 0.055	0.57ArgCys: 0.57 ± 0.023	2.642ArgAsp: 2.642 ± 0.05	3.016ArgGlu: 3.016 ± 0.054	2.491ArgPhe: 2.491 ± 0.044	2.997ArgGly: 2.997 ± 0.055	1.345ArgHis: 1.345 ± 0.033	2.923ArgIle: 2.923 ± 0.05	2.169ArgLys: 2.169 ± 0.05	5.863ArgLeu: 5.863 ± 0.086	1.288ArgMet: 1.288 ± 0.033	1.762ArgAsn: 1.762 ± 0.037	1.99ArgPro: 1.99 ± 0.036	2.815ArgGln: 2.815 ± 0.057	2.843ArgArg: 2.843 ± 0.049	2.918ArgSer: 2.918 ± 0.058	2.123ArgThr: 2.123 ± 0.041	3.461ArgVal: 3.461 ± 0.056	0.871ArgTrp: 0.871 ± 0.032	2.038ArgTyr: 2.038 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.14SerAla: 6.14 ± 0.073	0.689SerCys: 0.689 ± 0.026	3.811SerAsp: 3.811 ± 0.061	3.932SerGlu: 3.932 ± 0.058	2.768SerPhe: 2.768 ± 0.048	5.142SerGly: 5.142 ± 0.071	1.632SerHis: 1.632 ± 0.037	3.228SerIle: 3.228 ± 0.054	2.587SerLys: 2.587 ± 0.044	7.105SerLeu: 7.105 ± 0.089	1.523SerMet: 1.523 ± 0.032	2.204SerAsn: 2.204 ± 0.046	2.64SerPro: 2.64 ± 0.052	2.96SerGln: 2.96 ± 0.054	3.143SerArg: 3.143 ± 0.051	4.119SerSer: 4.119 ± 0.068	2.928SerThr: 2.928 ± 0.053	4.483SerVal: 4.483 ± 0.08	0.938SerTrp: 0.938 ± 0.028	2.148SerTyr: 2.148 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.052ThrAla: 5.052 ± 0.062	0.473ThrCys: 0.473 ± 0.017	3.03ThrAsp: 3.03 ± 0.067	3.249ThrGlu: 3.249 ± 0.052	1.828ThrPhe: 1.828 ± 0.038	3.857ThrGly: 3.857 ± 0.066	1.049ThrHis: 1.049 ± 0.032	2.874ThrIle: 2.874 ± 0.057	1.83ThrLys: 1.83 ± 0.036	6.347ThrLeu: 6.347 ± 0.079	1.084ThrMet: 1.084 ± 0.029	1.618ThrAsn: 1.618 ± 0.041	2.856ThrPro: 2.856 ± 0.049	2.178ThrGln: 2.178 ± 0.041	2.191ThrArg: 2.191 ± 0.043	3.056ThrSer: 3.056 ± 0.054	2.752ThrThr: 2.752 ± 0.046	3.86ThrVal: 3.86 ± 0.065	0.547ThrTrp: 0.547 ± 0.024	1.39ThrTyr: 1.39 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.264ValAla: 7.264 ± 0.076	0.732ValCys: 0.732 ± 0.023	4.417ValAsp: 4.417 ± 0.073	4.542ValGlu: 4.542 ± 0.076	2.572ValPhe: 2.572 ± 0.05	4.741ValGly: 4.741 ± 0.063	1.257ValHis: 1.257 ± 0.031	4.443ValIle: 4.443 ± 0.061	3.197ValLys: 3.197 ± 0.06	6.94ValLeu: 6.94 ± 0.072	1.87ValMet: 1.87 ± 0.042	2.699ValAsn: 2.699 ± 0.045	2.906ValPro: 2.906 ± 0.053	2.263ValGln: 2.263 ± 0.034	3.114ValArg: 3.114 ± 0.056	5.004ValSer: 5.004 ± 0.083	4.321ValThr: 4.321 ± 0.085	5.629ValVal: 5.629 ± 0.085	0.825ValTrp: 0.825 ± 0.024	1.774ValTyr: 1.774 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.874TrpAla: 0.874 ± 0.03	0.192TrpCys: 0.192 ± 0.014	0.644TrpAsp: 0.644 ± 0.024	0.533TrpGlu: 0.533 ± 0.023	0.596TrpPhe: 0.596 ± 0.024	0.832TrpGly: 0.832 ± 0.031	0.398TrpHis: 0.398 ± 0.02	0.644TrpIle: 0.644 ± 0.025	0.433TrpLys: 0.433 ± 0.021	2.087TrpLeu: 2.087 ± 0.049	0.311TrpMet: 0.311 ± 0.018	0.369TrpAsn: 0.369 ± 0.019	0.602TrpPro: 0.602 ± 0.022	1.324TrpGln: 1.324 ± 0.04	0.915TrpArg: 0.915 ± 0.031	0.801TrpSer: 0.801 ± 0.027	0.514TrpThr: 0.514 ± 0.02	0.886TrpVal: 0.886 ± 0.027	0.241TrpTrp: 0.241 ± 0.016	0.42TrpTyr: 0.42 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.403TyrAla: 2.403 ± 0.043	0.369TyrCys: 0.369 ± 0.019	1.671TyrAsp: 1.671 ± 0.04	1.558TyrGlu: 1.558 ± 0.037	1.338TyrPhe: 1.338 ± 0.036	2.124TyrGly: 2.124 ± 0.044	0.798TyrHis: 0.798 ± 0.028	1.396TyrIle: 1.396 ± 0.035	1.063TyrLys: 1.063 ± 0.03	3.544TyrLeu: 3.544 ± 0.059	0.645TyrMet: 0.645 ± 0.023	0.954TyrAsn: 0.954 ± 0.031	1.431TyrPro: 1.431 ± 0.034	2.116TyrGln: 2.116 ± 0.039	1.988TyrArg: 1.988 ± 0.044	1.907TyrSer: 1.907 ± 0.042	1.327TyrThr: 1.327 ± 0.039	1.78TyrVal: 1.78 ± 0.038	0.503TyrTrp: 0.503 ± 0.023	1.026TyrTyr: 1.026 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3747 proteins (1271560 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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