Amino acid dipepetide frequency for Ilumatobacter fluminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.42AlaAla: 17.42 ± 0.184
1.075AlaCys: 1.075 ± 0.028
9.873AlaAsp: 9.873 ± 0.097
7.536AlaGlu: 7.536 ± 0.091
3.611AlaPhe: 3.611 ± 0.051
10.933AlaGly: 10.933 ± 0.111
2.159AlaHis: 2.159 ± 0.048
5.724AlaIle: 5.724 ± 0.068
2.179AlaLys: 2.179 ± 0.057
11.079AlaLeu: 11.079 ± 0.115
2.82AlaMet: 2.82 ± 0.047
2.419AlaAsn: 2.419 ± 0.044
5.995AlaPro: 5.995 ± 0.091
2.737AlaGln: 2.737 ± 0.042
7.438AlaArg: 7.438 ± 0.091
6.394AlaSer: 6.394 ± 0.073
7.812AlaThr: 7.812 ± 0.091
10.792AlaVal: 10.792 ± 0.106
1.726AlaTrp: 1.726 ± 0.052
2.078AlaTyr: 2.078 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.834CysAla: 0.834 ± 0.025
0.09CysCys: 0.09 ± 0.008
0.668CysAsp: 0.668 ± 0.025
0.484CysGlu: 0.484 ± 0.019
0.247CysPhe: 0.247 ± 0.014
0.967CysGly: 0.967 ± 0.027
0.219CysHis: 0.219 ± 0.011
0.306CysIle: 0.306 ± 0.017
0.101CysLys: 0.101 ± 0.008
0.604CysLeu: 0.604 ± 0.02
0.121CysMet: 0.121 ± 0.009
0.196CysAsn: 0.196 ± 0.012
0.472CysPro: 0.472 ± 0.018
0.176CysGln: 0.176 ± 0.012
0.565CysArg: 0.565 ± 0.023
0.534CysSer: 0.534 ± 0.018
0.516CysThr: 0.516 ± 0.021
0.636CysVal: 0.636 ± 0.021
0.153CysTrp: 0.153 ± 0.013
0.157CysTyr: 0.157 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
9.269AspAla: 9.269 ± 0.1
0.464AspCys: 0.464 ± 0.02
8.145AspAsp: 8.145 ± 0.115
6.279AspGlu: 6.279 ± 0.079
1.784AspPhe: 1.784 ± 0.034
8.33AspGly: 8.33 ± 0.105
1.827AspHis: 1.827 ± 0.036
2.69AspIle: 2.69 ± 0.046
0.866AspLys: 0.866 ± 0.031
7.153AspLeu: 7.153 ± 0.072
1.089AspMet: 1.089 ± 0.031
1.171AspAsn: 1.171 ± 0.037
5.182AspPro: 5.182 ± 0.082
2.091AspGln: 2.091 ± 0.035
6.007AspArg: 6.007 ± 0.084
2.849AspSer: 2.849 ± 0.05
4.064AspThr: 4.064 ± 0.065
6.935AspVal: 6.935 ± 0.072
1.094AspTrp: 1.094 ± 0.031
1.224AspTyr: 1.224 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
6.78GluAla: 6.78 ± 0.075
0.413GluCys: 0.413 ± 0.017
2.024GluAsp: 2.024 ± 0.043
2.491GluGlu: 2.491 ± 0.056
2.14GluPhe: 2.14 ± 0.039
3.808GluGly: 3.808 ± 0.061
1.713GluHis: 1.713 ± 0.038
3.273GluIle: 3.273 ± 0.051
0.791GluLys: 0.791 ± 0.032
7.038GluLeu: 7.038 ± 0.07
1.279GluMet: 1.279 ± 0.033
1.021GluAsn: 1.021 ± 0.029
3.967GluPro: 3.967 ± 0.074
2.454GluGln: 2.454 ± 0.045
5.966GluArg: 5.966 ± 0.079
3.005GluSer: 3.005 ± 0.05
3.262GluThr: 3.262 ± 0.062
5.029GluVal: 5.029 ± 0.063
0.974GluTrp: 0.974 ± 0.027
1.266GluTyr: 1.266 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.847PheAla: 3.847 ± 0.052
0.298PheCys: 0.298 ± 0.015
3.085PheAsp: 3.085 ± 0.05
2.118PheGlu: 2.118 ± 0.038
0.971PhePhe: 0.971 ± 0.032
3.441PheGly: 3.441 ± 0.052
0.654PheHis: 0.654 ± 0.022
0.994PheIle: 0.994 ± 0.027
0.407PheLys: 0.407 ± 0.019
2.429PheLeu: 2.429 ± 0.046
0.46PheMet: 0.46 ± 0.019
0.649PheAsn: 0.649 ± 0.02
1.49PhePro: 1.49 ± 0.029
0.72PheGln: 0.72 ± 0.024
1.885PheArg: 1.885 ± 0.033
1.599PheSer: 1.599 ± 0.036
2.021PheThr: 2.021 ± 0.041
3.361PheVal: 3.361 ± 0.047
0.433PheTrp: 0.433 ± 0.018
0.563PheTyr: 0.563 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
9.752GlyAla: 9.752 ± 0.099
0.806GlyCys: 0.806 ± 0.021
7.051GlyAsp: 7.051 ± 0.093
5.072GlyGlu: 5.072 ± 0.062
3.191GlyPhe: 3.191 ± 0.048
7.908GlyGly: 7.908 ± 0.094
1.905GlyHis: 1.905 ± 0.042
3.932GlyIle: 3.932 ± 0.053
1.762GlyLys: 1.762 ± 0.043
8.149GlyLeu: 8.149 ± 0.089
1.994GlyMet: 1.994 ± 0.042
1.94GlyAsn: 1.94 ± 0.047
4.215GlyPro: 4.215 ± 0.052
2.364GlyGln: 2.364 ± 0.046
6.412GlyArg: 6.412 ± 0.073
5.491GlySer: 5.491 ± 0.081
5.708GlyThr: 5.708 ± 0.085
7.893GlyVal: 7.893 ± 0.078
1.768GlyTrp: 1.768 ± 0.037
2.118GlyTyr: 2.118 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.259HisAla: 2.259 ± 0.041
0.188HisCys: 0.188 ± 0.011
1.876HisAsp: 1.876 ± 0.046
1.316HisGlu: 1.316 ± 0.034
0.593HisPhe: 0.593 ± 0.019
2.082HisGly: 2.082 ± 0.041
0.75HisHis: 0.75 ± 0.028
0.716HisIle: 0.716 ± 0.023
0.26HisLys: 0.26 ± 0.013
2.181HisLeu: 2.181 ± 0.043
0.328HisMet: 0.328 ± 0.015
0.376HisAsn: 0.376 ± 0.019
1.519HisPro: 1.519 ± 0.034
0.581HisGln: 0.581 ± 0.021
1.825HisArg: 1.825 ± 0.041
0.823HisSer: 0.823 ± 0.025
1.064HisThr: 1.064 ± 0.03
1.934HisVal: 1.934 ± 0.038
0.293HisTrp: 0.293 ± 0.014
0.445HisTyr: 0.445 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.268IleAla: 6.268 ± 0.076
0.336IleCys: 0.336 ± 0.015
4.611IleAsp: 4.611 ± 0.051
3.46IleGlu: 3.46 ± 0.048
0.95IlePhe: 0.95 ± 0.032
4.771IleGly: 4.771 ± 0.06
0.775IleHis: 0.775 ± 0.024
1.474IleIle: 1.474 ± 0.032
0.591IleLys: 0.591 ± 0.021
2.613IleLeu: 2.613 ± 0.052
0.61IleMet: 0.61 ± 0.021
0.932IleAsn: 0.932 ± 0.022
2.069IlePro: 2.069 ± 0.04
0.889IleGln: 0.889 ± 0.027
2.574IleArg: 2.574 ± 0.044
2.128IleSer: 2.128 ± 0.043
2.892IleThr: 2.892 ± 0.061
4.925IleVal: 4.925 ± 0.063
0.507IleTrp: 0.507 ± 0.02
0.722IleTyr: 0.722 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
1.945LysAla: 1.945 ± 0.05
0.098LysCys: 0.098 ± 0.008
0.698LysAsp: 0.698 ± 0.025
0.744LysGlu: 0.744 ± 0.026
0.464LysPhe: 0.464 ± 0.018
1.23LysGly: 1.23 ± 0.033
0.355LysHis: 0.355 ± 0.017
0.784LysIle: 0.784 ± 0.027
0.575LysLys: 0.575 ± 0.042
1.598LysLeu: 1.598 ± 0.043
0.35LysMet: 0.35 ± 0.018
0.382LysAsn: 0.382 ± 0.019
0.971LysPro: 0.971 ± 0.027
0.603LysGln: 0.603 ± 0.025
1.405LysArg: 1.405 ± 0.035
0.925LysSer: 0.925 ± 0.031
0.927LysThr: 0.927 ± 0.025
1.422LysVal: 1.422 ± 0.035
0.223LysTrp: 0.223 ± 0.013
0.354LysTyr: 0.354 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
12.468LeuAla: 12.468 ± 0.122
0.679LeuCys: 0.679 ± 0.02
7.99LeuAsp: 7.99 ± 0.09
4.887LeuGlu: 4.887 ± 0.063
2.683LeuPhe: 2.683 ± 0.051
8.417LeuGly: 8.417 ± 0.081
1.862LeuHis: 1.862 ± 0.034
3.782LeuIle: 3.782 ± 0.055
1.238LeuLys: 1.238 ± 0.037
8.267LeuLeu: 8.267 ± 0.108
1.567LeuMet: 1.567 ± 0.037
1.701LeuAsn: 1.701 ± 0.041
5.084LeuPro: 5.084 ± 0.068
2.078LeuGln: 2.078 ± 0.036
6.39LeuArg: 6.39 ± 0.089
4.83LeuSer: 4.83 ± 0.062
5.77LeuThr: 5.77 ± 0.072
9.087LeuVal: 9.087 ± 0.086
1.089LeuTrp: 1.089 ± 0.031
1.507LeuTyr: 1.507 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.435MetAla: 2.435 ± 0.047
0.169MetCys: 0.169 ± 0.011
0.801MetAsp: 0.801 ± 0.028
0.85MetGlu: 0.85 ± 0.028
0.591MetPhe: 0.591 ± 0.023
1.522MetGly: 1.522 ± 0.034
0.403MetHis: 0.403 ± 0.016
1.001MetIle: 1.001 ± 0.024
0.42MetLys: 0.42 ± 0.019
1.875MetLeu: 1.875 ± 0.043
0.411MetMet: 0.411 ± 0.019
0.523MetAsn: 0.523 ± 0.018
1.166MetPro: 1.166 ± 0.028
0.571MetGln: 0.571 ± 0.023
1.462MetArg: 1.462 ± 0.036
1.587MetSer: 1.587 ± 0.034
1.667MetThr: 1.667 ± 0.036
1.623MetVal: 1.623 ± 0.037
0.262MetTrp: 0.262 ± 0.013
0.343MetTyr: 0.343 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.315AsnAla: 2.315 ± 0.042
0.189AsnCys: 0.189 ± 0.011
1.579AsnAsp: 1.579 ± 0.038
1.226AsnGlu: 1.226 ± 0.025
0.601AsnPhe: 0.601 ± 0.021
2.199AsnGly: 2.199 ± 0.05
0.437AsnHis: 0.437 ± 0.018
0.843AsnIle: 0.843 ± 0.027
0.359AsnLys: 0.359 ± 0.016
1.795AsnLeu: 1.795 ± 0.035
0.338AsnMet: 0.338 ± 0.017
0.508AsnAsn: 0.508 ± 0.024
1.495AsnPro: 1.495 ± 0.033
0.597AsnGln: 0.597 ± 0.019
1.495AsnArg: 1.495 ± 0.03
1.009AsnSer: 1.009 ± 0.032
1.243AsnThr: 1.243 ± 0.041
1.893AsnVal: 1.893 ± 0.04
0.322AsnTrp: 0.322 ± 0.015
0.506AsnTyr: 0.506 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.593ProAla: 6.593 ± 0.092
0.37ProCys: 0.37 ± 0.018
5.61ProAsp: 5.61 ± 0.081
3.58ProGlu: 3.58 ± 0.056
1.789ProPhe: 1.789 ± 0.035
5.078ProGly: 5.078 ± 0.071
1.111ProHis: 1.111 ± 0.028
2.614ProIle: 2.614 ± 0.047
0.984ProLys: 0.984 ± 0.03
4.352ProLeu: 4.352 ± 0.058
1.129ProMet: 1.129 ± 0.031
1.432ProAsn: 1.432 ± 0.034
3.094ProPro: 3.094 ± 0.06
1.167ProGln: 1.167 ± 0.031
2.637ProArg: 2.637 ± 0.042
3.436ProSer: 3.436 ± 0.053
4.287ProThr: 4.287 ± 0.069
4.788ProVal: 4.788 ± 0.067
0.862ProTrp: 0.862 ± 0.03
1.088ProTyr: 1.088 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
2.976GlnAla: 2.976 ± 0.052
0.186GlnCys: 0.186 ± 0.012
0.997GlnAsp: 0.997 ± 0.027
1.071GlnGlu: 1.071 ± 0.026
0.901GlnPhe: 0.901 ± 0.026
1.774GlnGly: 1.774 ± 0.038
0.663GlnHis: 0.663 ± 0.02
1.331GlnIle: 1.331 ± 0.033
0.422GlnLys: 0.422 ± 0.021
3.004GlnLeu: 3.004 ± 0.052
0.6GlnMet: 0.6 ± 0.021
0.554GlnAsn: 0.554 ± 0.022
1.623GlnPro: 1.623 ± 0.038
1.02GlnGln: 1.02 ± 0.028
2.391GlnArg: 2.391 ± 0.047
1.253GlnSer: 1.253 ± 0.027
1.343GlnThr: 1.343 ± 0.029
2.294GlnVal: 2.294 ± 0.046
0.46GlnTrp: 0.46 ± 0.02
0.599GlnTyr: 0.599 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
7.518ArgAla: 7.518 ± 0.096
0.611ArgCys: 0.611 ± 0.022
4.247ArgAsp: 4.247 ± 0.062
3.483ArgGlu: 3.483 ± 0.055
2.746ArgPhe: 2.746 ± 0.042
4.546ArgGly: 4.546 ± 0.068
1.806ArgHis: 1.806 ± 0.036
3.266ArgIle: 3.266 ± 0.05
1.159ArgLys: 1.159 ± 0.031
7.435ArgLeu: 7.435 ± 0.091
1.556ArgMet: 1.556 ± 0.037
1.556ArgAsn: 1.556 ± 0.035
4.119ArgPro: 4.119 ± 0.057
1.985ArgGln: 1.985 ± 0.043
6.911ArgArg: 6.911 ± 0.111
4.663ArgSer: 4.663 ± 0.068
4.145ArgThr: 4.145 ± 0.048
5.509ArgVal: 5.509 ± 0.067
1.481ArgTrp: 1.481 ± 0.034
1.628ArgTyr: 1.628 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.02SerAla: 6.02 ± 0.056
0.449SerCys: 0.449 ± 0.021
3.788SerAsp: 3.788 ± 0.056
2.643SerGlu: 2.643 ± 0.043
1.962SerPhe: 1.962 ± 0.04
5.664SerGly: 5.664 ± 0.071
1.012SerHis: 1.012 ± 0.027
2.8SerIle: 2.8 ± 0.047
1.015SerLys: 1.015 ± 0.026
4.858SerLeu: 4.858 ± 0.056
1.391SerMet: 1.391 ± 0.031
1.356SerAsn: 1.356 ± 0.035
2.919SerPro: 2.919 ± 0.055
1.23SerGln: 1.23 ± 0.033
3.018SerArg: 3.018 ± 0.056
3.592SerSer: 3.592 ± 0.083
4.036SerThr: 4.036 ± 0.076
4.857SerVal: 4.857 ± 0.067
0.908SerTrp: 0.908 ± 0.026
1.158SerTyr: 1.158 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
7.405ThrAla: 7.405 ± 0.083
0.504ThrCys: 0.504 ± 0.025
4.92ThrAsp: 4.92 ± 0.068
3.464ThrGlu: 3.464 ± 0.054
2.118ThrPhe: 2.118 ± 0.045
5.817ThrGly: 5.817 ± 0.078
1.133ThrHis: 1.133 ± 0.025
3.368ThrIle: 3.368 ± 0.061
1.029ThrLys: 1.029 ± 0.032
5.419ThrLeu: 5.419 ± 0.076
1.366ThrMet: 1.366 ± 0.035
1.456ThrAsn: 1.456 ± 0.043
3.881ThrPro: 3.881 ± 0.06
1.217ThrGln: 1.217 ± 0.032
3.355ThrArg: 3.355 ± 0.053
3.698ThrSer: 3.698 ± 0.059
5.808ThrThr: 5.808 ± 0.127
6.425ThrVal: 6.425 ± 0.111
0.934ThrTrp: 0.934 ± 0.027
1.331ThrTyr: 1.331 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
12.085ValAla: 12.085 ± 0.106
0.754ValCys: 0.754 ± 0.023
7.987ValAsp: 7.987 ± 0.091
5.93ValGlu: 5.93 ± 0.073
2.727ValPhe: 2.727 ± 0.049
7.908ValGly: 7.908 ± 0.081
1.808ValHis: 1.808 ± 0.038
3.929ValIle: 3.929 ± 0.054
1.294ValLys: 1.294 ± 0.031
8.12ValLeu: 8.12 ± 0.095
1.661ValMet: 1.661 ± 0.035
1.928ValAsn: 1.928 ± 0.039
4.947ValPro: 4.947 ± 0.065
1.928ValGln: 1.928 ± 0.036
5.776ValArg: 5.776 ± 0.079
4.825ValSer: 4.825 ± 0.061
5.962ValThr: 5.962 ± 0.113
10.143ValVal: 10.143 ± 0.109
1.239ValTrp: 1.239 ± 0.03
1.526ValTyr: 1.526 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.606TrpAla: 1.606 ± 0.035
0.178TrpCys: 0.178 ± 0.011
0.906TrpAsp: 0.906 ± 0.023
0.721TrpGlu: 0.721 ± 0.024
0.698TrpPhe: 0.698 ± 0.024
1.088TrpGly: 1.088 ± 0.027
0.378TrpHis: 0.378 ± 0.018
0.704TrpIle: 0.704 ± 0.021
0.318TrpLys: 0.318 ± 0.015
1.533TrpLeu: 1.533 ± 0.032
0.348TrpMet: 0.348 ± 0.016
0.468TrpAsn: 0.468 ± 0.021
0.747TrpPro: 0.747 ± 0.022
0.496TrpGln: 0.496 ± 0.018
1.217TrpArg: 1.217 ± 0.032
1.085TrpSer: 1.085 ± 0.032
0.994TrpThr: 0.994 ± 0.029
1.221TrpVal: 1.221 ± 0.027
0.426TrpTrp: 0.426 ± 0.019
0.361TrpTyr: 0.361 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.006TyrAla: 2.006 ± 0.041
0.186TyrCys: 0.186 ± 0.011
1.659TyrAsp: 1.659 ± 0.04
1.339TyrGlu: 1.339 ± 0.031
0.658TyrPhe: 0.658 ± 0.02
1.949TyrGly: 1.949 ± 0.04
0.436TyrHis: 0.436 ± 0.019
0.566TyrIle: 0.566 ± 0.021
0.285TyrLys: 0.285 ± 0.016
1.875TyrLeu: 1.875 ± 0.045
0.261TyrMet: 0.261 ± 0.015
0.383TyrAsn: 0.383 ± 0.018
1.043TyrPro: 1.043 ± 0.028
0.559TyrGln: 0.559 ± 0.021
1.644TyrArg: 1.644 ± 0.033
0.948TyrSer: 0.948 ± 0.026
1.129TyrThr: 1.129 ± 0.035
1.714TyrVal: 1.714 ± 0.039
0.336TyrTrp: 0.336 ± 0.016
0.426TyrTyr: 0.426 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4258 proteins (1475297 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski