Amino acid dipepetide frequency for Streptomyces katsurahamanus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.428AlaAla: 21.428 ± 0.739
0.939AlaCys: 0.939 ± 0.125
8.354AlaAsp: 8.354 ± 0.365
8.952AlaGlu: 8.952 ± 0.412
3.497AlaPhe: 3.497 ± 0.235
13.768AlaGly: 13.768 ± 0.509
2.911AlaHis: 2.911 ± 0.18
3.537AlaIle: 3.537 ± 0.218
2.231AlaLys: 2.231 ± 0.191
15.741AlaLeu: 15.741 ± 0.51
2.544AlaMet: 2.544 ± 0.189
2.041AlaAsn: 2.041 ± 0.162
6.966AlaPro: 6.966 ± 0.37
3.66AlaGln: 3.66 ± 0.259
11.197AlaArg: 11.197 ± 0.418
6.149AlaSer: 6.149 ± 0.29
6.435AlaThr: 6.435 ± 0.26
12.666AlaVal: 12.666 ± 0.5
1.456AlaTrp: 1.456 ± 0.134
2.762AlaTyr: 2.762 ± 0.215
0.0AlaXaa: 0.0 ± 0.0
Cys
1.116CysAla: 1.116 ± 0.123
0.068CysCys: 0.068 ± 0.026
0.571CysAsp: 0.571 ± 0.089
0.517CysGlu: 0.517 ± 0.078
0.19CysPhe: 0.19 ± 0.061
1.034CysGly: 1.034 ± 0.112
0.19CysHis: 0.19 ± 0.043
0.286CysIle: 0.286 ± 0.054
0.082CysLys: 0.082 ± 0.036
0.925CysLeu: 0.925 ± 0.142
0.109CysMet: 0.109 ± 0.043
0.19CysAsn: 0.19 ± 0.05
0.585CysPro: 0.585 ± 0.101
0.136CysGln: 0.136 ± 0.037
0.667CysArg: 0.667 ± 0.083
0.435CysSer: 0.435 ± 0.082
0.476CysThr: 0.476 ± 0.082
0.83CysVal: 0.83 ± 0.115
0.163CysTrp: 0.163 ± 0.045
0.163CysTyr: 0.163 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
7.456AspAla: 7.456 ± 0.342
0.612AspCys: 0.612 ± 0.099
3.292AspAsp: 3.292 ± 0.221
3.769AspGlu: 3.769 ± 0.216
1.646AspPhe: 1.646 ± 0.16
6.571AspGly: 6.571 ± 0.353
1.388AspHis: 1.388 ± 0.139
2.258AspIle: 2.258 ± 0.171
0.884AspLys: 0.884 ± 0.113
5.755AspLeu: 5.755 ± 0.254
0.639AspMet: 0.639 ± 0.104
0.803AspAsn: 0.803 ± 0.102
4.558AspPro: 4.558 ± 0.268
1.415AspGln: 1.415 ± 0.138
5.279AspArg: 5.279 ± 0.258
2.707AspSer: 2.707 ± 0.208
3.17AspThr: 3.17 ± 0.217
4.0AspVal: 4.0 ± 0.204
1.02AspTrp: 1.02 ± 0.106
1.102AspTyr: 1.102 ± 0.147
0.0AspXaa: 0.0 ± 0.0
Glu
6.49GluAla: 6.49 ± 0.357
0.435GluCys: 0.435 ± 0.076
2.966GluAsp: 2.966 ± 0.221
2.939GluGlu: 2.939 ± 0.212
1.401GluPhe: 1.401 ± 0.151
3.877GluGly: 3.877 ± 0.228
1.333GluHis: 1.333 ± 0.122
2.204GluIle: 2.204 ± 0.174
1.211GluLys: 1.211 ± 0.131
7.469GluLeu: 7.469 ± 0.38
0.748GluMet: 0.748 ± 0.093
1.048GluAsn: 1.048 ± 0.111
3.428GluPro: 3.428 ± 0.223
2.286GluGln: 2.286 ± 0.204
5.755GluArg: 5.755 ± 0.297
2.748GluSer: 2.748 ± 0.18
3.061GluThr: 3.061 ± 0.195
4.204GluVal: 4.204 ± 0.268
0.898GluTrp: 0.898 ± 0.105
1.143GluTyr: 1.143 ± 0.13
0.0GluXaa: 0.0 ± 0.0
Phe
3.673PheAla: 3.673 ± 0.23
0.327PheCys: 0.327 ± 0.066
2.326PheAsp: 2.326 ± 0.201
1.265PheGlu: 1.265 ± 0.131
0.912PhePhe: 0.912 ± 0.123
2.367PheGly: 2.367 ± 0.192
0.898PheHis: 0.898 ± 0.111
0.694PheIle: 0.694 ± 0.103
0.34PheLys: 0.34 ± 0.071
2.571PheLeu: 2.571 ± 0.178
0.34PheMet: 0.34 ± 0.065
0.476PheAsn: 0.476 ± 0.083
1.238PhePro: 1.238 ± 0.129
0.639PheGln: 0.639 ± 0.089
1.891PheArg: 1.891 ± 0.144
1.456PheSer: 1.456 ± 0.146
1.864PheThr: 1.864 ± 0.167
2.19PheVal: 2.19 ± 0.169
0.354PheTrp: 0.354 ± 0.074
0.585PheTyr: 0.585 ± 0.102
0.0PheXaa: 0.0 ± 0.0
Gly
11.224GlyAla: 11.224 ± 0.431
0.844GlyCys: 0.844 ± 0.109
5.292GlyAsp: 5.292 ± 0.301
5.184GlyGlu: 5.184 ± 0.288
2.871GlyPhe: 2.871 ± 0.165
8.707GlyGly: 8.707 ± 0.442
2.571GlyHis: 2.571 ± 0.208
3.102GlyIle: 3.102 ± 0.195
1.714GlyLys: 1.714 ± 0.16
9.741GlyLeu: 9.741 ± 0.389
2.014GlyMet: 2.014 ± 0.16
1.769GlyAsn: 1.769 ± 0.152
5.741GlyPro: 5.741 ± 0.301
2.612GlyGln: 2.612 ± 0.183
8.68GlyArg: 8.68 ± 0.363
5.728GlySer: 5.728 ± 0.297
5.551GlyThr: 5.551 ± 0.269
7.837GlyVal: 7.837 ± 0.387
1.551GlyTrp: 1.551 ± 0.149
2.231GlyTyr: 2.231 ± 0.192
0.0GlyXaa: 0.0 ± 0.0
His
2.639HisAla: 2.639 ± 0.211
0.354HisCys: 0.354 ± 0.073
1.578HisAsp: 1.578 ± 0.136
1.17HisGlu: 1.17 ± 0.129
0.68HisPhe: 0.68 ± 0.089
2.422HisGly: 2.422 ± 0.192
0.775HisHis: 0.775 ± 0.102
0.721HisIle: 0.721 ± 0.091
0.19HisLys: 0.19 ± 0.041
2.367HisLeu: 2.367 ± 0.184
0.367HisMet: 0.367 ± 0.07
0.367HisAsn: 0.367 ± 0.07
2.0HisPro: 2.0 ± 0.168
0.68HisGln: 0.68 ± 0.094
2.449HisArg: 2.449 ± 0.185
1.17HisSer: 1.17 ± 0.127
1.728HisThr: 1.728 ± 0.142
1.646HisVal: 1.646 ± 0.146
0.435HisTrp: 0.435 ± 0.081
0.544HisTyr: 0.544 ± 0.093
0.0HisXaa: 0.0 ± 0.0
Ile
5.646IleAla: 5.646 ± 0.313
0.286IleCys: 0.286 ± 0.059
2.136IleAsp: 2.136 ± 0.169
1.782IleGlu: 1.782 ± 0.166
0.571IlePhe: 0.571 ± 0.103
3.714IleGly: 3.714 ± 0.22
0.735IleHis: 0.735 ± 0.103
0.912IleIle: 0.912 ± 0.115
0.571IleLys: 0.571 ± 0.094
2.326IleLeu: 2.326 ± 0.165
0.395IleMet: 0.395 ± 0.084
0.558IleAsn: 0.558 ± 0.09
2.054IlePro: 2.054 ± 0.19
0.476IleGln: 0.476 ± 0.08
2.571IleArg: 2.571 ± 0.178
1.741IleSer: 1.741 ± 0.143
2.014IleThr: 2.014 ± 0.174
2.898IleVal: 2.898 ± 0.227
0.367IleTrp: 0.367 ± 0.07
0.408IleTyr: 0.408 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
2.15LysAla: 2.15 ± 0.191
0.15LysCys: 0.15 ± 0.044
1.061LysAsp: 1.061 ± 0.151
0.966LysGlu: 0.966 ± 0.119
0.258LysPhe: 0.258 ± 0.066
1.456LysGly: 1.456 ± 0.129
0.395LysHis: 0.395 ± 0.08
0.612LysIle: 0.612 ± 0.101
0.599LysLys: 0.599 ± 0.119
1.592LysLeu: 1.592 ± 0.147
0.272LysMet: 0.272 ± 0.069
0.435LysAsn: 0.435 ± 0.087
1.211LysPro: 1.211 ± 0.143
0.639LysGln: 0.639 ± 0.093
1.292LysArg: 1.292 ± 0.14
0.857LysSer: 0.857 ± 0.122
1.075LysThr: 1.075 ± 0.121
1.238LysVal: 1.238 ± 0.145
0.231LysTrp: 0.231 ± 0.061
0.408LysTyr: 0.408 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
15.972LeuAla: 15.972 ± 0.613
0.98LeuCys: 0.98 ± 0.134
6.571LeuAsp: 6.571 ± 0.259
4.789LeuGlu: 4.789 ± 0.276
2.721LeuPhe: 2.721 ± 0.216
9.156LeuGly: 9.156 ± 0.402
2.517LeuHis: 2.517 ± 0.19
3.796LeuIle: 3.796 ± 0.248
1.687LeuLys: 1.687 ± 0.144
11.782LeuLeu: 11.782 ± 0.48
1.809LeuMet: 1.809 ± 0.18
1.51LeuAsn: 1.51 ± 0.139
6.748LeuPro: 6.748 ± 0.266
1.932LeuGln: 1.932 ± 0.149
9.592LeuArg: 9.592 ± 0.409
5.891LeuSer: 5.891 ± 0.291
6.979LeuThr: 6.979 ± 0.314
8.476LeuVal: 8.476 ± 0.409
1.279LeuTrp: 1.279 ± 0.139
1.755LeuTyr: 1.755 ± 0.157
0.0LeuXaa: 0.0 ± 0.0
Met
2.326MetAla: 2.326 ± 0.181
0.136MetCys: 0.136 ± 0.038
0.748MetAsp: 0.748 ± 0.096
0.707MetGlu: 0.707 ± 0.104
0.395MetPhe: 0.395 ± 0.079
1.306MetGly: 1.306 ± 0.119
0.408MetHis: 0.408 ± 0.082
0.775MetIle: 0.775 ± 0.099
0.286MetLys: 0.286 ± 0.076
1.877MetLeu: 1.877 ± 0.182
0.313MetMet: 0.313 ± 0.079
0.354MetAsn: 0.354 ± 0.067
0.98MetPro: 0.98 ± 0.116
0.313MetGln: 0.313 ± 0.068
1.537MetArg: 1.537 ± 0.156
1.048MetSer: 1.048 ± 0.118
1.592MetThr: 1.592 ± 0.138
1.347MetVal: 1.347 ± 0.17
0.231MetTrp: 0.231 ± 0.068
0.327MetTyr: 0.327 ± 0.068
0.0MetXaa: 0.0 ± 0.0
Asn
2.014AsnAla: 2.014 ± 0.161
0.299AsnCys: 0.299 ± 0.07
0.871AsnAsp: 0.871 ± 0.112
0.83AsnGlu: 0.83 ± 0.107
0.286AsnPhe: 0.286 ± 0.072
1.932AsnGly: 1.932 ± 0.178
0.422AsnHis: 0.422 ± 0.078
0.612AsnIle: 0.612 ± 0.097
0.204AsnLys: 0.204 ± 0.05
1.388AsnLeu: 1.388 ± 0.136
0.258AsnMet: 0.258 ± 0.066
0.395AsnAsn: 0.395 ± 0.065
1.415AsnPro: 1.415 ± 0.13
0.313AsnGln: 0.313 ± 0.06
1.224AsnArg: 1.224 ± 0.142
1.007AsnSer: 1.007 ± 0.141
1.129AsnThr: 1.129 ± 0.126
1.32AsnVal: 1.32 ± 0.132
0.258AsnTrp: 0.258 ± 0.062
0.408AsnTyr: 0.408 ± 0.076
0.0AsnXaa: 0.0 ± 0.0
Pro
8.884ProAla: 8.884 ± 0.418
0.408ProCys: 0.408 ± 0.069
4.122ProAsp: 4.122 ± 0.26
4.0ProGlu: 4.0 ± 0.243
1.374ProPhe: 1.374 ± 0.131
7.837ProGly: 7.837 ± 0.383
1.347ProHis: 1.347 ± 0.143
1.211ProIle: 1.211 ± 0.11
1.02ProLys: 1.02 ± 0.173
6.245ProLeu: 6.245 ± 0.319
0.707ProMet: 0.707 ± 0.105
0.762ProAsn: 0.762 ± 0.099
3.537ProPro: 3.537 ± 0.221
1.292ProGln: 1.292 ± 0.145
5.034ProArg: 5.034 ± 0.284
3.048ProSer: 3.048 ± 0.21
2.925ProThr: 2.925 ± 0.172
5.469ProVal: 5.469 ± 0.272
0.844ProTrp: 0.844 ± 0.095
1.646ProTyr: 1.646 ± 0.17
0.0ProXaa: 0.0 ± 0.0
Gln
2.599GlnAla: 2.599 ± 0.221
0.258GlnCys: 0.258 ± 0.059
1.401GlnAsp: 1.401 ± 0.147
1.497GlnGlu: 1.497 ± 0.14
0.599GlnPhe: 0.599 ± 0.087
2.136GlnGly: 2.136 ± 0.213
0.517GlnHis: 0.517 ± 0.094
1.088GlnIle: 1.088 ± 0.104
0.463GlnLys: 0.463 ± 0.088
2.694GlnLeu: 2.694 ± 0.218
0.463GlnMet: 0.463 ± 0.091
0.503GlnAsn: 0.503 ± 0.078
1.456GlnPro: 1.456 ± 0.167
1.17GlnGln: 1.17 ± 0.178
2.599GlnArg: 2.599 ± 0.197
1.483GlnSer: 1.483 ± 0.138
1.442GlnThr: 1.442 ± 0.147
2.19GlnVal: 2.19 ± 0.144
0.395GlnTrp: 0.395 ± 0.095
0.544GlnTyr: 0.544 ± 0.089
0.0GlnXaa: 0.0 ± 0.0
Arg
10.993ArgAla: 10.993 ± 0.413
0.571ArgCys: 0.571 ± 0.096
4.462ArgAsp: 4.462 ± 0.292
5.211ArgGlu: 5.211 ± 0.32
2.463ArgPhe: 2.463 ± 0.172
6.313ArgGly: 6.313 ± 0.323
2.313ArgHis: 2.313 ± 0.163
3.374ArgIle: 3.374 ± 0.188
1.565ArgLys: 1.565 ± 0.146
9.333ArgLeu: 9.333 ± 0.414
2.095ArgMet: 2.095 ± 0.167
1.374ArgAsn: 1.374 ± 0.122
5.496ArgPro: 5.496 ± 0.271
2.503ArgGln: 2.503 ± 0.195
8.53ArgArg: 8.53 ± 0.399
4.707ArgSer: 4.707 ± 0.227
6.53ArgThr: 6.53 ± 0.294
6.299ArgVal: 6.299 ± 0.281
1.605ArgTrp: 1.605 ± 0.164
1.864ArgTyr: 1.864 ± 0.145
0.0ArgXaa: 0.0 ± 0.0
Ser
7.741SerAla: 7.741 ± 0.352
0.463SerCys: 0.463 ± 0.074
2.558SerAsp: 2.558 ± 0.191
2.408SerGlu: 2.408 ± 0.186
1.456SerPhe: 1.456 ± 0.14
6.476SerGly: 6.476 ± 0.352
1.32SerHis: 1.32 ± 0.123
1.401SerIle: 1.401 ± 0.148
0.993SerLys: 0.993 ± 0.128
5.415SerLeu: 5.415 ± 0.235
0.789SerMet: 0.789 ± 0.096
0.925SerAsn: 0.925 ± 0.107
3.02SerPro: 3.02 ± 0.222
1.088SerGln: 1.088 ± 0.122
3.959SerArg: 3.959 ± 0.246
3.088SerSer: 3.088 ± 0.211
2.816SerThr: 2.816 ± 0.188
4.258SerVal: 4.258 ± 0.229
1.02SerTrp: 1.02 ± 0.146
1.497SerTyr: 1.497 ± 0.139
0.0SerXaa: 0.0 ± 0.0
Thr
10.122ThrAla: 10.122 ± 0.408
0.476ThrCys: 0.476 ± 0.079
3.238ThrAsp: 3.238 ± 0.203
3.17ThrGlu: 3.17 ± 0.231
1.388ThrPhe: 1.388 ± 0.153
6.49ThrGly: 6.49 ± 0.307
0.952ThrHis: 0.952 ± 0.12
1.66ThrIle: 1.66 ± 0.153
0.789ThrLys: 0.789 ± 0.125
5.605ThrLeu: 5.605 ± 0.275
1.02ThrMet: 1.02 ± 0.105
0.816ThrAsn: 0.816 ± 0.102
4.041ThrPro: 4.041 ± 0.243
0.952ThrGln: 0.952 ± 0.108
3.932ThrArg: 3.932 ± 0.241
3.075ThrSer: 3.075 ± 0.226
3.238ThrThr: 3.238 ± 0.229
6.476ThrVal: 6.476 ± 0.336
0.898ThrTrp: 0.898 ± 0.105
1.129ThrTyr: 1.129 ± 0.131
0.0ThrXaa: 0.0 ± 0.0
Val
10.054ValAla: 10.054 ± 0.434
0.762ValCys: 0.762 ± 0.101
4.558ValAsp: 4.558 ± 0.235
4.68ValGlu: 4.68 ± 0.263
2.585ValPhe: 2.585 ± 0.18
5.823ValGly: 5.823 ± 0.331
2.394ValHis: 2.394 ± 0.176
2.667ValIle: 2.667 ± 0.191
1.429ValLys: 1.429 ± 0.15
9.442ValLeu: 9.442 ± 0.48
1.592ValMet: 1.592 ± 0.129
1.524ValAsn: 1.524 ± 0.176
5.36ValPro: 5.36 ± 0.249
2.0ValGln: 2.0 ± 0.174
8.19ValArg: 8.19 ± 0.376
4.476ValSer: 4.476 ± 0.242
5.415ValThr: 5.415 ± 0.298
7.469ValVal: 7.469 ± 0.354
1.156ValTrp: 1.156 ± 0.123
1.442ValTyr: 1.442 ± 0.139
0.0ValXaa: 0.0 ± 0.0
Trp
1.755TrpAla: 1.755 ± 0.151
0.204TrpCys: 0.204 ± 0.055
0.952TrpAsp: 0.952 ± 0.123
0.735TrpGlu: 0.735 ± 0.113
0.449TrpPhe: 0.449 ± 0.099
1.116TrpGly: 1.116 ± 0.127
0.449TrpHis: 0.449 ± 0.086
0.612TrpIle: 0.612 ± 0.092
0.245TrpLys: 0.245 ± 0.062
1.592TrpLeu: 1.592 ± 0.165
0.272TrpMet: 0.272 ± 0.068
0.354TrpAsn: 0.354 ± 0.071
0.748TrpPro: 0.748 ± 0.105
0.544TrpGln: 0.544 ± 0.096
1.469TrpArg: 1.469 ± 0.15
0.884TrpSer: 0.884 ± 0.122
0.912TrpThr: 0.912 ± 0.106
0.884TrpVal: 0.884 ± 0.123
0.327TrpTrp: 0.327 ± 0.069
0.463TrpTyr: 0.463 ± 0.091
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.952TyrAla: 2.952 ± 0.189
0.163TyrCys: 0.163 ± 0.039
1.265TyrAsp: 1.265 ± 0.157
1.075TyrGlu: 1.075 ± 0.125
0.667TyrPhe: 0.667 ± 0.086
2.463TyrGly: 2.463 ± 0.199
0.449TyrHis: 0.449 ± 0.077
0.639TyrIle: 0.639 ± 0.085
0.395TyrLys: 0.395 ± 0.072
2.082TyrLeu: 2.082 ± 0.147
0.245TyrMet: 0.245 ± 0.058
0.381TyrAsn: 0.381 ± 0.073
1.129TyrPro: 1.129 ± 0.124
0.844TyrGln: 0.844 ± 0.104
1.769TyrArg: 1.769 ± 0.151
0.993TyrSer: 0.993 ± 0.102
1.116TyrThr: 1.116 ± 0.108
1.32TyrVal: 1.32 ± 0.143
0.476TyrTrp: 0.476 ± 0.082
0.435TyrTyr: 0.435 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 319 proteins (73503 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski