Amino acid dipepetide frequency for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.731AlaAla: 3.731 ± 0.063	0.568AlaCys: 0.568 ± 0.015	2.322AlaAsp: 2.322 ± 0.032	2.777AlaGlu: 2.777 ± 0.044	2.033AlaPhe: 2.033 ± 0.03	2.785AlaGly: 2.785 ± 0.046	0.884AlaHis: 0.884 ± 0.018	3.768AlaIle: 3.768 ± 0.042	3.761AlaLys: 3.761 ± 0.048	4.553AlaLeu: 4.553 ± 0.046	1.005AlaMet: 1.005 ± 0.017	3.171AlaAsn: 3.171 ± 0.034	2.276AlaPro: 2.276 ± 0.042	1.845AlaGln: 1.845 ± 0.029	2.011AlaArg: 2.011 ± 0.029	4.432AlaSer: 4.432 ± 0.055	3.722AlaThr: 3.722 ± 0.054	2.856AlaVal: 2.856 ± 0.038	0.424AlaTrp: 0.424 ± 0.014	1.567AlaTyr: 1.567 ± 0.024	0.002AlaXaa: 0.002 ± 0.001
Cys	0.497CysAla: 0.497 ± 0.014	0.236CysCys: 0.236 ± 0.011	0.63CysAsp: 0.63 ± 0.017	0.513CysGlu: 0.513 ± 0.013	0.577CysPhe: 0.577 ± 0.016	0.755CysGly: 0.755 ± 0.019	0.295CysHis: 0.295 ± 0.011	0.829CysIle: 0.829 ± 0.017	0.649CysLys: 0.649 ± 0.017	1.127CysLeu: 1.127 ± 0.02	0.209CysMet: 0.209 ± 0.008	0.569CysAsn: 0.569 ± 0.013	0.445CysPro: 0.445 ± 0.012	0.442CysGln: 0.442 ± 0.012	0.416CysArg: 0.416 ± 0.012	0.817CysSer: 0.817 ± 0.017	0.518CysThr: 0.518 ± 0.012	0.6CysVal: 0.6 ± 0.014	0.142CysTrp: 0.142 ± 0.007	0.408CysTyr: 0.408 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	2.668AspAla: 2.668 ± 0.038	0.56AspCys: 0.56 ± 0.016	5.28AspAsp: 5.28 ± 0.077	5.162AspGlu: 5.162 ± 0.061	2.666AspPhe: 2.666 ± 0.033	2.789AspGly: 2.789 ± 0.036	1.093AspHis: 1.093 ± 0.021	4.28AspIle: 4.28 ± 0.046	4.007AspLys: 4.007 ± 0.044	5.545AspLeu: 5.545 ± 0.046	0.986AspMet: 0.986 ± 0.02	3.931AspAsn: 3.931 ± 0.043	2.321AspPro: 2.321 ± 0.028	2.102AspGln: 2.102 ± 0.029	1.797AspArg: 1.797 ± 0.027	4.775AspSer: 4.775 ± 0.048	2.881AspThr: 2.881 ± 0.032	3.16AspVal: 3.16 ± 0.038	0.61AspTrp: 0.61 ± 0.014	2.432AspTyr: 2.432 ± 0.032	0.002AspXaa: 0.002 ± 0.001
Glu	2.943GluAla: 2.943 ± 0.048	0.556GluCys: 0.556 ± 0.017	4.285GluAsp: 4.285 ± 0.051	6.526GluGlu: 6.526 ± 0.1	2.894GluPhe: 2.894 ± 0.037	2.435GluGly: 2.435 ± 0.036	1.084GluHis: 1.084 ± 0.022	4.825GluIle: 4.825 ± 0.049	5.052GluLys: 5.052 ± 0.059	6.518GluLeu: 6.518 ± 0.056	1.194GluMet: 1.194 ± 0.023	4.235GluAsn: 4.235 ± 0.045	2.025GluPro: 2.025 ± 0.034	2.722GluGln: 2.722 ± 0.035	2.342GluArg: 2.342 ± 0.034	5.208GluSer: 5.208 ± 0.067	3.632GluThr: 3.632 ± 0.048	3.304GluVal: 3.304 ± 0.046	0.562GluTrp: 0.562 ± 0.014	2.318GluTyr: 2.318 ± 0.037	0.003GluXaa: 0.003 ± 0.001
Phe	2.375PheAla: 2.375 ± 0.034	0.5PheCys: 0.5 ± 0.012	2.905PheAsp: 2.905 ± 0.031	2.802PheGlu: 2.802 ± 0.034	1.986PhePhe: 1.986 ± 0.038	2.675PheGly: 2.675 ± 0.044	0.951PheHis: 0.951 ± 0.02	3.297PheIle: 3.297 ± 0.041	3.253PheLys: 3.253 ± 0.034	3.754PheLeu: 3.754 ± 0.041	0.851PheMet: 0.851 ± 0.017	2.985PheAsn: 2.985 ± 0.036	1.802PhePro: 1.802 ± 0.031	1.873PheGln: 1.873 ± 0.025	1.469PheArg: 1.469 ± 0.024	3.318PheSer: 3.318 ± 0.037	2.521PheThr: 2.521 ± 0.032	2.569PheVal: 2.569 ± 0.037	0.512PheTrp: 0.512 ± 0.016	1.565PheTyr: 1.565 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	2.794GlyAla: 2.794 ± 0.052	0.645GlyCys: 0.645 ± 0.016	2.911GlyAsp: 2.911 ± 0.032	2.779GlyGlu: 2.779 ± 0.036	2.469GlyPhe: 2.469 ± 0.033	4.026GlyGly: 4.026 ± 0.069	1.049GlyHis: 1.049 ± 0.02	3.592GlyIle: 3.592 ± 0.041	3.646GlyLys: 3.646 ± 0.046	4.489GlyLeu: 4.489 ± 0.047	0.872GlyMet: 0.872 ± 0.019	3.2GlyAsn: 3.2 ± 0.043	1.514GlyPro: 1.514 ± 0.026	1.619GlyGln: 1.619 ± 0.026	1.842GlyArg: 1.842 ± 0.032	4.609GlySer: 4.609 ± 0.07	2.948GlyThr: 2.948 ± 0.039	3.172GlyVal: 3.172 ± 0.041	0.585GlyTrp: 0.585 ± 0.016	2.023GlyTyr: 2.023 ± 0.034	0.002GlyXaa: 0.002 ± 0.001
His	0.894HisAla: 0.894 ± 0.018	0.263HisCys: 0.263 ± 0.01	1.202HisAsp: 1.202 ± 0.019	1.284HisGlu: 1.284 ± 0.024	0.877HisPhe: 0.877 ± 0.017	1.088HisGly: 1.088 ± 0.021	0.922HisHis: 0.922 ± 0.03	1.335HisIle: 1.335 ± 0.021	1.399HisLys: 1.399 ± 0.021	1.956HisLeu: 1.956 ± 0.029	0.331HisMet: 0.331 ± 0.011	1.362HisAsn: 1.362 ± 0.025	1.09HisPro: 1.09 ± 0.024	1.237HisGln: 1.237 ± 0.022	0.889HisArg: 0.889 ± 0.017	1.714HisSer: 1.714 ± 0.029	1.035HisThr: 1.035 ± 0.02	1.004HisVal: 1.004 ± 0.02	0.214HisTrp: 0.214 ± 0.008	0.808HisTyr: 0.808 ± 0.014	0.001HisXaa: 0.001 ± 0.001
Ile	3.716IleAla: 3.716 ± 0.039	0.814IleCys: 0.814 ± 0.016	4.864IleAsp: 4.864 ± 0.043	4.622IleGlu: 4.622 ± 0.046	2.998IlePhe: 2.998 ± 0.036	3.501IleGly: 3.501 ± 0.041	1.486IleHis: 1.486 ± 0.024	5.218IleIle: 5.218 ± 0.059	5.189IleLys: 5.189 ± 0.047	6.343IleLeu: 6.343 ± 0.058	1.323IleMet: 1.323 ± 0.026	4.97IleAsn: 4.97 ± 0.058	3.558IlePro: 3.558 ± 0.043	2.645IleGln: 2.645 ± 0.034	2.614IleArg: 2.614 ± 0.037	5.901IleSer: 5.901 ± 0.051	4.189IleThr: 4.189 ± 0.041	4.033IleVal: 4.033 ± 0.045	0.746IleTrp: 0.746 ± 0.016	2.411IleTyr: 2.411 ± 0.031	0.002IleXaa: 0.002 ± 0.001
Lys	3.207LysAla: 3.207 ± 0.041	0.739LysCys: 0.739 ± 0.018	4.014LysAsp: 4.014 ± 0.04	4.902LysGlu: 4.902 ± 0.057	3.451LysPhe: 3.451 ± 0.039	2.749LysGly: 2.749 ± 0.042	1.563LysHis: 1.563 ± 0.022	5.017LysIle: 5.017 ± 0.05	6.446LysLys: 6.446 ± 0.068	7.906LysLeu: 7.906 ± 0.061	1.26LysMet: 1.26 ± 0.024	4.405LysAsn: 4.405 ± 0.042	3.139LysPro: 3.139 ± 0.04	3.487LysGln: 3.487 ± 0.034	3.411LysArg: 3.411 ± 0.041	6.315LysSer: 6.315 ± 0.053	3.941LysThr: 3.941 ± 0.041	3.853LysVal: 3.853 ± 0.038	0.695LysTrp: 0.695 ± 0.015	2.978LysTyr: 2.978 ± 0.032	0.005LysXaa: 0.005 ± 0.002
Leu	5.0LeuAla: 5.0 ± 0.048	1.032LeuCys: 1.032 ± 0.02	5.17LeuAsp: 5.17 ± 0.045	5.609LeuGlu: 5.609 ± 0.057	3.925LeuPhe: 3.925 ± 0.045	4.402LeuGly: 4.402 ± 0.046	1.9LeuHis: 1.9 ± 0.027	6.788LeuIle: 6.788 ± 0.07	7.067LeuLys: 7.067 ± 0.058	8.563LeuLeu: 8.563 ± 0.072	1.724LeuMet: 1.724 ± 0.025	6.064LeuAsn: 6.064 ± 0.06	4.506LeuPro: 4.506 ± 0.041	4.268LeuGln: 4.268 ± 0.05	3.609LeuArg: 3.609 ± 0.044	8.103LeuSer: 8.103 ± 0.063	5.37LeuThr: 5.37 ± 0.045	5.133LeuVal: 5.133 ± 0.046	0.758LeuTrp: 0.758 ± 0.015	3.094LeuTyr: 3.094 ± 0.035	0.002LeuXaa: 0.002 ± 0.001
Met	1.096MetAla: 1.096 ± 0.02	0.193MetCys: 0.193 ± 0.008	0.983MetAsp: 0.983 ± 0.021	1.033MetGlu: 1.033 ± 0.02	0.774MetPhe: 0.774 ± 0.016	1.024MetGly: 1.024 ± 0.02	0.274MetHis: 0.274 ± 0.009	1.298MetIle: 1.298 ± 0.022	1.369MetLys: 1.369 ± 0.024	1.476MetLeu: 1.476 ± 0.026	0.445MetMet: 0.445 ± 0.012	1.173MetAsn: 1.173 ± 0.021	0.693MetPro: 0.693 ± 0.016	0.608MetGln: 0.608 ± 0.016	0.607MetArg: 0.607 ± 0.015	1.875MetSer: 1.875 ± 0.024	1.091MetThr: 1.091 ± 0.02	1.052MetVal: 1.052 ± 0.021	0.161MetTrp: 0.161 ± 0.008	0.594MetTyr: 0.594 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.807AsnAla: 2.807 ± 0.03	0.675AsnCys: 0.675 ± 0.018	4.366AsnAsp: 4.366 ± 0.046	4.328AsnGlu: 4.328 ± 0.046	2.725AsnPhe: 2.725 ± 0.034	3.713AsnGly: 3.713 ± 0.05	1.515AsnHis: 1.515 ± 0.03	4.17AsnIle: 4.17 ± 0.039	4.752AsnLys: 4.752 ± 0.052	5.881AsnLeu: 5.881 ± 0.054	1.014AsnMet: 1.014 ± 0.019	6.696AsnAsn: 6.696 ± 0.117	2.752AsnPro: 2.752 ± 0.039	2.989AsnGln: 2.989 ± 0.04	2.132AsnArg: 2.132 ± 0.03	6.107AsnSer: 6.107 ± 0.076	3.734AsnThr: 3.734 ± 0.045	3.236AsnVal: 3.236 ± 0.037	0.716AsnTrp: 0.716 ± 0.018	2.601AsnTyr: 2.601 ± 0.032	0.002AsnXaa: 0.002 ± 0.001
Pro	2.173ProAla: 2.173 ± 0.036	0.325ProCys: 0.325 ± 0.012	2.141ProAsp: 2.141 ± 0.029	2.983ProGlu: 2.983 ± 0.035	1.803ProPhe: 1.803 ± 0.027	1.969ProGly: 1.969 ± 0.03	0.946ProHis: 0.946 ± 0.021	3.318ProIle: 3.318 ± 0.038	3.138ProLys: 3.138 ± 0.032	3.631ProLeu: 3.631 ± 0.039	0.747ProMet: 0.747 ± 0.015	2.723ProAsn: 2.723 ± 0.036	3.242ProPro: 3.242 ± 0.079	2.369ProGln: 2.369 ± 0.046	1.55ProArg: 1.55 ± 0.025	4.142ProSer: 4.142 ± 0.059	3.184ProThr: 3.184 ± 0.043	2.593ProVal: 2.593 ± 0.034	0.362ProTrp: 0.362 ± 0.013	1.392ProTyr: 1.392 ± 0.023	0.001ProXaa: 0.001 ± 0.0
Gln	2.023GlnAla: 2.023 ± 0.029	0.407GlnCys: 0.407 ± 0.013	2.195GlnAsp: 2.195 ± 0.025	3.041GlnGlu: 3.041 ± 0.038	2.026GlnPhe: 2.026 ± 0.027	1.772GlnGly: 1.772 ± 0.029	1.082GlnHis: 1.082 ± 0.024	2.77GlnIle: 2.77 ± 0.035	2.709GlnLys: 2.709 ± 0.037	4.439GlnLeu: 4.439 ± 0.045	0.78GlnMet: 0.78 ± 0.018	2.4GlnAsn: 2.4 ± 0.036	2.22GlnPro: 2.22 ± 0.041	5.366GlnGln: 5.366 ± 0.164	1.714GlnArg: 1.714 ± 0.023	3.658GlnSer: 3.658 ± 0.047	2.182GlnThr: 2.182 ± 0.027	2.143GlnVal: 2.143 ± 0.027	0.377GlnTrp: 0.377 ± 0.012	1.623GlnTyr: 1.623 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	1.91ArgAla: 1.91 ± 0.029	0.4ArgCys: 0.4 ± 0.011	2.044ArgAsp: 2.044 ± 0.026	2.31ArgGlu: 2.31 ± 0.037	1.777ArgPhe: 1.777 ± 0.031	1.857ArgGly: 1.857 ± 0.029	0.835ArgHis: 0.835 ± 0.018	2.625ArgIle: 2.625 ± 0.033	3.227ArgLys: 3.227 ± 0.038	3.647ArgLeu: 3.647 ± 0.037	0.699ArgMet: 0.699 ± 0.017	2.328ArgAsn: 2.328 ± 0.032	1.429ArgPro: 1.429 ± 0.025	1.694ArgGln: 1.694 ± 0.026	2.178ArgArg: 2.178 ± 0.039	3.068ArgSer: 3.068 ± 0.034	1.873ArgThr: 1.873 ± 0.027	1.999ArgVal: 1.999 ± 0.029	0.375ArgTrp: 0.375 ± 0.011	1.36ArgTyr: 1.36 ± 0.026	0.001ArgXaa: 0.001 ± 0.001
Ser	4.109SerAla: 4.109 ± 0.051	0.808SerCys: 0.808 ± 0.017	4.559SerAsp: 4.559 ± 0.048	4.581SerGlu: 4.581 ± 0.069	3.819SerPhe: 3.819 ± 0.044	4.628SerGly: 4.628 ± 0.062	1.768SerHis: 1.768 ± 0.021	6.658SerIle: 6.658 ± 0.057	6.391SerLys: 6.391 ± 0.054	7.807SerLeu: 7.807 ± 0.066	1.574SerMet: 1.574 ± 0.022	6.24SerAsn: 6.24 ± 0.067	4.013SerPro: 4.013 ± 0.057	3.731SerGln: 3.731 ± 0.048	3.284SerArg: 3.284 ± 0.038	11.313SerSer: 11.313 ± 0.184	6.559SerThr: 6.559 ± 0.065	4.461SerVal: 4.461 ± 0.044	0.777SerTrp: 0.777 ± 0.02	2.678SerTyr: 2.678 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	3.236ThrAla: 3.236 ± 0.045	0.603ThrCys: 0.603 ± 0.016	2.917ThrAsp: 2.917 ± 0.035	3.216ThrGlu: 3.216 ± 0.043	2.434ThrPhe: 2.434 ± 0.032	3.278ThrGly: 3.278 ± 0.042	1.123ThrHis: 1.123 ± 0.021	4.464ThrIle: 4.464 ± 0.04	4.462ThrLys: 4.462 ± 0.043	4.837ThrLeu: 4.837 ± 0.044	0.971ThrMet: 0.971 ± 0.019	4.316ThrAsn: 4.316 ± 0.05	3.378ThrPro: 3.378 ± 0.039	2.027ThrGln: 2.027 ± 0.028	2.139ThrArg: 2.139 ± 0.026	6.082ThrSer: 6.082 ± 0.072	6.49ThrThr: 6.49 ± 0.144	3.241ThrVal: 3.241 ± 0.057	0.526ThrTrp: 0.526 ± 0.014	1.718ThrTyr: 1.718 ± 0.03	0.002ThrXaa: 0.002 ± 0.001
Val	3.273ValAla: 3.273 ± 0.043	0.629ValCys: 0.629 ± 0.015	3.448ValAsp: 3.448 ± 0.036	3.591ValGlu: 3.591 ± 0.047	2.457ValPhe: 2.457 ± 0.032	2.903ValGly: 2.903 ± 0.037	1.054ValHis: 1.054 ± 0.02	3.767ValIle: 3.767 ± 0.035	3.766ValLys: 3.766 ± 0.04	5.01ValLeu: 5.01 ± 0.051	1.004ValMet: 1.004 ± 0.018	3.133ValAsn: 3.133 ± 0.034	2.578ValPro: 2.578 ± 0.033	1.844ValGln: 1.844 ± 0.023	1.87ValArg: 1.87 ± 0.025	4.737ValSer: 4.737 ± 0.056	3.268ValThr: 3.268 ± 0.056	3.539ValVal: 3.539 ± 0.05	0.522ValTrp: 0.522 ± 0.013	1.899ValTyr: 1.899 ± 0.028	0.001ValXaa: 0.001 ± 0.001
Trp	0.449TrpAla: 0.449 ± 0.012	0.201TrpCys: 0.201 ± 0.009	0.589TrpAsp: 0.589 ± 0.016	0.545TrpGlu: 0.545 ± 0.015	0.504TrpPhe: 0.504 ± 0.013	0.526TrpGly: 0.526 ± 0.014	0.189TrpHis: 0.189 ± 0.008	0.689TrpIle: 0.689 ± 0.016	0.778TrpLys: 0.778 ± 0.02	0.957TrpLeu: 0.957 ± 0.019	0.193TrpMet: 0.193 ± 0.008	0.625TrpAsn: 0.625 ± 0.016	0.285TrpPro: 0.285 ± 0.009	0.349TrpGln: 0.349 ± 0.011	0.412TrpArg: 0.412 ± 0.013	0.8TrpSer: 0.8 ± 0.026	0.503TrpThr: 0.503 ± 0.015	0.533TrpVal: 0.533 ± 0.015	0.169TrpTrp: 0.169 ± 0.009	0.391TrpTyr: 0.391 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.59TyrAla: 1.59 ± 0.031	0.522TyrCys: 0.522 ± 0.014	2.222TyrAsp: 2.222 ± 0.03	2.06TyrGlu: 2.06 ± 0.026	1.766TyrPhe: 1.766 ± 0.029	1.913TyrGly: 1.913 ± 0.028	0.892TyrHis: 0.892 ± 0.018	2.427TyrIle: 2.427 ± 0.029	2.421TyrLys: 2.421 ± 0.028	3.642TyrLeu: 3.642 ± 0.041	0.635TyrMet: 0.635 ± 0.014	2.379TyrAsn: 2.379 ± 0.03	1.468TyrPro: 1.468 ± 0.026	1.709TyrGln: 1.709 ± 0.023	1.347TyrArg: 1.347 ± 0.022	2.782TyrSer: 2.782 ± 0.036	1.816TyrThr: 1.816 ± 0.027	1.812TyrVal: 1.812 ± 0.025	0.455TyrTrp: 0.455 ± 0.021	1.639TyrTyr: 1.639 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.003XaaIle: 0.003 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.003XaaLeu: 0.003 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.004XaaAsn: 0.004 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.014XaaXaa: 0.014 ± 0.008

Statistics based on 6036 proteins (2982981 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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