Amino acid dipepetide frequency for Xanthomonas phage Pagan

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.412AlaAla: 15.412 ± 1.683
1.389AlaCys: 1.389 ± 0.64
6.457AlaAsp: 6.457 ± 0.828
6.873AlaGlu: 6.873 ± 0.619
3.124AlaPhe: 3.124 ± 0.494
7.984AlaGly: 7.984 ± 0.981
1.527AlaHis: 1.527 ± 0.287
4.721AlaIle: 4.721 ± 0.528
5.276AlaLys: 5.276 ± 0.67
8.748AlaLeu: 8.748 ± 0.805
3.888AlaMet: 3.888 ± 0.648
3.957AlaAsn: 3.957 ± 0.568
4.721AlaPro: 4.721 ± 0.952
4.929AlaGln: 4.929 ± 0.714
6.109AlaArg: 6.109 ± 0.627
5.415AlaSer: 5.415 ± 0.53
6.179AlaThr: 6.179 ± 0.736
6.665AlaVal: 6.665 ± 0.66
2.222AlaTrp: 2.222 ± 0.453
2.777AlaTyr: 2.777 ± 0.465
0.0AlaXaa: 0.0 ± 0.0
Cys
1.041CysAla: 1.041 ± 0.443
0.069CysCys: 0.069 ± 0.076
0.555CysAsp: 0.555 ± 0.239
0.417CysGlu: 0.417 ± 0.184
0.347CysPhe: 0.347 ± 0.181
0.833CysGly: 0.833 ± 0.295
0.069CysHis: 0.069 ± 0.071
0.694CysIle: 0.694 ± 0.232
0.347CysLys: 0.347 ± 0.151
0.903CysLeu: 0.903 ± 0.233
0.417CysMet: 0.417 ± 0.167
0.625CysAsn: 0.625 ± 0.222
0.208CysPro: 0.208 ± 0.112
0.417CysGln: 0.417 ± 0.231
0.625CysArg: 0.625 ± 0.259
0.208CysSer: 0.208 ± 0.141
1.111CysThr: 1.111 ± 0.343
0.625CysVal: 0.625 ± 0.249
0.0CysTrp: 0.0 ± 0.0
0.486CysTyr: 0.486 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
6.457AspAla: 6.457 ± 0.58
0.486AspCys: 0.486 ± 0.159
4.443AspAsp: 4.443 ± 0.659
3.541AspGlu: 3.541 ± 0.358
2.985AspPhe: 2.985 ± 0.432
5.068AspGly: 5.068 ± 0.502
0.972AspHis: 0.972 ± 0.292
3.332AspIle: 3.332 ± 0.368
2.985AspLys: 2.985 ± 0.449
3.818AspLeu: 3.818 ± 0.483
1.319AspMet: 1.319 ± 0.323
2.777AspAsn: 2.777 ± 0.411
2.569AspPro: 2.569 ± 0.388
2.569AspGln: 2.569 ± 0.416
3.957AspArg: 3.957 ± 0.426
3.818AspSer: 3.818 ± 0.524
3.818AspThr: 3.818 ± 0.474
4.235AspVal: 4.235 ± 0.567
1.111AspTrp: 1.111 ± 0.291
2.083AspTyr: 2.083 ± 0.483
0.0AspXaa: 0.0 ± 0.0
Glu
6.109GluAla: 6.109 ± 0.566
0.417GluCys: 0.417 ± 0.2
2.846GluAsp: 2.846 ± 0.317
3.957GluGlu: 3.957 ± 0.607
2.43GluPhe: 2.43 ± 0.434
4.304GluGly: 4.304 ± 0.47
1.666GluHis: 1.666 ± 0.301
1.805GluIle: 1.805 ± 0.302
2.846GluLys: 2.846 ± 0.485
6.248GluLeu: 6.248 ± 0.68
1.597GluMet: 1.597 ± 0.284
1.944GluAsn: 1.944 ± 0.397
2.152GluPro: 2.152 ± 0.434
2.708GluGln: 2.708 ± 0.401
2.985GluArg: 2.985 ± 0.557
2.638GluSer: 2.638 ± 0.44
2.916GluThr: 2.916 ± 0.302
3.541GluVal: 3.541 ± 0.556
1.458GluTrp: 1.458 ± 0.415
2.43GluTyr: 2.43 ± 0.441
0.0GluXaa: 0.0 ± 0.0
Phe
3.749PheAla: 3.749 ± 0.483
0.486PheCys: 0.486 ± 0.205
2.846PheAsp: 2.846 ± 0.54
1.597PheGlu: 1.597 ± 0.413
0.625PhePhe: 0.625 ± 0.166
2.708PheGly: 2.708 ± 0.386
0.764PheHis: 0.764 ± 0.205
1.25PheIle: 1.25 ± 0.285
1.111PheLys: 1.111 ± 0.297
2.222PheLeu: 2.222 ± 0.354
0.694PheMet: 0.694 ± 0.207
1.805PheAsn: 1.805 ± 0.395
1.666PhePro: 1.666 ± 0.296
1.25PheGln: 1.25 ± 0.262
1.389PheArg: 1.389 ± 0.25
1.805PheSer: 1.805 ± 0.287
1.944PheThr: 1.944 ± 0.43
2.499PheVal: 2.499 ± 0.56
0.347PheTrp: 0.347 ± 0.161
1.736PheTyr: 1.736 ± 0.302
0.0PheXaa: 0.0 ± 0.0
Gly
7.984GlyAla: 7.984 ± 0.854
0.625GlyCys: 0.625 ± 0.228
5.623GlyAsp: 5.623 ± 0.623
4.235GlyGlu: 4.235 ± 0.402
2.569GlyPhe: 2.569 ± 0.327
7.29GlyGly: 7.29 ± 0.882
0.972GlyHis: 0.972 ± 0.334
3.402GlyIle: 3.402 ± 0.48
5.068GlyLys: 5.068 ± 0.582
5.693GlyLeu: 5.693 ± 0.445
2.708GlyMet: 2.708 ± 0.406
3.332GlyAsn: 3.332 ± 0.458
2.36GlyPro: 2.36 ± 0.365
2.985GlyGln: 2.985 ± 0.43
5.068GlyArg: 5.068 ± 0.629
5.346GlySer: 5.346 ± 0.638
5.276GlyThr: 5.276 ± 0.652
6.179GlyVal: 6.179 ± 0.586
1.458GlyTrp: 1.458 ± 0.315
2.846GlyTyr: 2.846 ± 0.353
0.0GlyXaa: 0.0 ± 0.0
His
1.736HisAla: 1.736 ± 0.299
0.139HisCys: 0.139 ± 0.108
1.319HisAsp: 1.319 ± 0.362
1.25HisGlu: 1.25 ± 0.248
0.417HisPhe: 0.417 ± 0.164
1.389HisGly: 1.389 ± 0.314
0.833HisHis: 0.833 ± 0.264
1.319HisIle: 1.319 ± 0.229
1.041HisLys: 1.041 ± 0.351
0.972HisLeu: 0.972 ± 0.262
0.347HisMet: 0.347 ± 0.132
0.764HisAsn: 0.764 ± 0.242
1.527HisPro: 1.527 ± 0.349
0.555HisGln: 0.555 ± 0.248
1.319HisArg: 1.319 ± 0.323
1.041HisSer: 1.041 ± 0.293
0.833HisThr: 0.833 ± 0.269
1.389HisVal: 1.389 ± 0.455
0.347HisTrp: 0.347 ± 0.125
0.764HisTyr: 0.764 ± 0.242
0.0HisXaa: 0.0 ± 0.0
Ile
5.415IleAla: 5.415 ± 0.595
0.417IleCys: 0.417 ± 0.143
3.263IleAsp: 3.263 ± 0.309
2.985IleGlu: 2.985 ± 0.417
1.319IlePhe: 1.319 ± 0.323
3.124IleGly: 3.124 ± 0.406
1.041IleHis: 1.041 ± 0.276
1.944IleIle: 1.944 ± 0.426
2.43IleLys: 2.43 ± 0.393
2.777IleLeu: 2.777 ± 0.443
0.972IleMet: 0.972 ± 0.176
2.36IleAsn: 2.36 ± 0.395
2.985IlePro: 2.985 ± 0.398
1.527IleGln: 1.527 ± 0.313
2.916IleArg: 2.916 ± 0.444
1.597IleSer: 1.597 ± 0.286
3.194IleThr: 3.194 ± 0.422
2.846IleVal: 2.846 ± 0.386
0.417IleTrp: 0.417 ± 0.165
0.972IleTyr: 0.972 ± 0.251
0.0IleXaa: 0.0 ± 0.0
Lys
6.457LysAla: 6.457 ± 0.771
0.208LysCys: 0.208 ± 0.104
3.124LysAsp: 3.124 ± 0.44
2.708LysGlu: 2.708 ± 0.452
1.527LysPhe: 1.527 ± 0.24
3.61LysGly: 3.61 ± 0.521
1.18LysHis: 1.18 ± 0.236
1.805LysIle: 1.805 ± 0.29
1.597LysLys: 1.597 ± 0.387
5.485LysLeu: 5.485 ± 0.772
0.972LysMet: 0.972 ± 0.272
1.597LysAsn: 1.597 ± 0.35
2.569LysPro: 2.569 ± 0.376
2.43LysGln: 2.43 ± 0.398
4.096LysArg: 4.096 ± 0.687
1.666LysSer: 1.666 ± 0.397
2.43LysThr: 2.43 ± 0.408
3.263LysVal: 3.263 ± 0.494
1.111LysTrp: 1.111 ± 0.232
2.152LysTyr: 2.152 ± 0.337
0.0LysXaa: 0.0 ± 0.0
Leu
7.428LeuAla: 7.428 ± 0.811
1.319LeuCys: 1.319 ± 0.318
5.623LeuAsp: 5.623 ± 0.456
4.86LeuGlu: 4.86 ± 0.758
1.111LeuPhe: 1.111 ± 0.245
5.623LeuGly: 5.623 ± 0.574
1.666LeuHis: 1.666 ± 0.434
3.471LeuIle: 3.471 ± 0.422
4.235LeuLys: 4.235 ± 0.583
7.22LeuLeu: 7.22 ± 0.631
2.083LeuMet: 2.083 ± 0.251
3.541LeuAsn: 3.541 ± 0.413
3.957LeuPro: 3.957 ± 0.583
3.471LeuGln: 3.471 ± 0.635
6.873LeuArg: 6.873 ± 0.679
5.207LeuSer: 5.207 ± 0.563
5.346LeuThr: 5.346 ± 0.506
4.374LeuVal: 4.374 ± 0.629
1.18LeuTrp: 1.18 ± 0.268
2.499LeuTyr: 2.499 ± 0.42
0.0LeuXaa: 0.0 ± 0.0
Met
2.916MetAla: 2.916 ± 0.442
0.069MetCys: 0.069 ± 0.069
2.291MetAsp: 2.291 ± 0.395
1.458MetGlu: 1.458 ± 0.363
0.972MetPhe: 0.972 ± 0.263
1.944MetGly: 1.944 ± 0.402
0.417MetHis: 0.417 ± 0.14
0.903MetIle: 0.903 ± 0.256
1.111MetLys: 1.111 ± 0.278
2.291MetLeu: 2.291 ± 0.313
0.417MetMet: 0.417 ± 0.187
0.625MetAsn: 0.625 ± 0.196
0.694MetPro: 0.694 ± 0.195
1.527MetGln: 1.527 ± 0.292
2.152MetArg: 2.152 ± 0.526
2.916MetSer: 2.916 ± 0.365
1.319MetThr: 1.319 ± 0.272
1.458MetVal: 1.458 ± 0.294
0.139MetTrp: 0.139 ± 0.094
0.903MetTyr: 0.903 ± 0.248
0.0MetXaa: 0.0 ± 0.0
Asn
4.166AsnAla: 4.166 ± 0.605
0.347AsnCys: 0.347 ± 0.17
2.083AsnAsp: 2.083 ± 0.398
1.944AsnGlu: 1.944 ± 0.309
1.319AsnPhe: 1.319 ± 0.348
4.443AsnGly: 4.443 ± 0.52
0.972AsnHis: 0.972 ± 0.257
1.944AsnIle: 1.944 ± 0.54
2.638AsnLys: 2.638 ± 0.381
2.985AsnLeu: 2.985 ± 0.437
1.041AsnMet: 1.041 ± 0.273
1.805AsnAsn: 1.805 ± 0.451
2.083AsnPro: 2.083 ± 0.285
1.666AsnGln: 1.666 ± 0.358
2.569AsnArg: 2.569 ± 0.453
2.36AsnSer: 2.36 ± 0.415
2.846AsnThr: 2.846 ± 0.647
2.222AsnVal: 2.222 ± 0.346
0.833AsnTrp: 0.833 ± 0.206
1.389AsnTyr: 1.389 ± 0.303
0.0AsnXaa: 0.0 ± 0.0
Pro
4.79ProAla: 4.79 ± 1.221
0.417ProCys: 0.417 ± 0.173
2.846ProAsp: 2.846 ± 0.432
2.846ProGlu: 2.846 ± 0.401
1.041ProPhe: 1.041 ± 0.27
3.541ProGly: 3.541 ± 0.578
0.972ProHis: 0.972 ± 0.261
1.25ProIle: 1.25 ± 0.32
1.805ProLys: 1.805 ± 0.333
3.332ProLeu: 3.332 ± 0.51
1.389ProMet: 1.389 ± 0.279
2.222ProAsn: 2.222 ± 0.318
1.805ProPro: 1.805 ± 0.396
1.458ProGln: 1.458 ± 0.259
1.805ProArg: 1.805 ± 0.273
2.222ProSer: 2.222 ± 0.346
3.194ProThr: 3.194 ± 0.471
4.027ProVal: 4.027 ± 0.651
0.764ProTrp: 0.764 ± 0.2
0.972ProTyr: 0.972 ± 0.276
0.0ProXaa: 0.0 ± 0.0
Gln
5.346GlnAla: 5.346 ± 0.785
0.486GlnCys: 0.486 ± 0.206
1.736GlnAsp: 1.736 ± 0.341
2.083GlnGlu: 2.083 ± 0.433
1.874GlnPhe: 1.874 ± 0.237
3.194GlnGly: 3.194 ± 0.404
0.694GlnHis: 0.694 ± 0.199
1.805GlnIle: 1.805 ± 0.286
1.319GlnLys: 1.319 ± 0.262
3.749GlnLeu: 3.749 ± 0.466
1.25GlnMet: 1.25 ± 0.289
1.319GlnAsn: 1.319 ± 0.293
1.597GlnPro: 1.597 ± 0.395
2.846GlnGln: 2.846 ± 0.679
3.402GlnArg: 3.402 ± 0.613
2.36GlnSer: 2.36 ± 0.488
2.777GlnThr: 2.777 ± 0.539
2.708GlnVal: 2.708 ± 0.48
0.833GlnTrp: 0.833 ± 0.248
1.389GlnTyr: 1.389 ± 0.309
0.0GlnXaa: 0.0 ± 0.0
Arg
6.109ArgAla: 6.109 ± 0.691
0.972ArgCys: 0.972 ± 0.303
3.68ArgAsp: 3.68 ± 0.549
3.402ArgGlu: 3.402 ± 0.597
2.43ArgPhe: 2.43 ± 0.404
4.86ArgGly: 4.86 ± 0.642
1.25ArgHis: 1.25 ± 0.308
3.263ArgIle: 3.263 ± 0.584
5.068ArgLys: 5.068 ± 0.599
4.651ArgLeu: 4.651 ± 0.626
1.805ArgMet: 1.805 ± 0.311
2.846ArgAsn: 2.846 ± 0.397
1.736ArgPro: 1.736 ± 0.388
2.43ArgGln: 2.43 ± 0.392
3.332ArgArg: 3.332 ± 0.512
3.541ArgSer: 3.541 ± 0.485
3.194ArgThr: 3.194 ± 0.51
5.137ArgVal: 5.137 ± 0.585
0.903ArgTrp: 0.903 ± 0.295
2.152ArgTyr: 2.152 ± 0.333
0.0ArgXaa: 0.0 ± 0.0
Ser
5.485SerAla: 5.485 ± 0.578
0.555SerCys: 0.555 ± 0.196
3.055SerAsp: 3.055 ± 0.495
2.846SerGlu: 2.846 ± 0.354
2.291SerPhe: 2.291 ± 0.685
5.068SerGly: 5.068 ± 0.658
0.833SerHis: 0.833 ± 0.226
3.749SerIle: 3.749 ± 0.603
2.291SerLys: 2.291 ± 0.455
4.929SerLeu: 4.929 ± 0.384
1.458SerMet: 1.458 ± 0.249
2.36SerAsn: 2.36 ± 0.403
1.805SerPro: 1.805 ± 0.342
2.152SerGln: 2.152 ± 0.472
3.61SerArg: 3.61 ± 0.491
3.402SerSer: 3.402 ± 0.805
3.402SerThr: 3.402 ± 0.389
3.957SerVal: 3.957 ± 0.486
1.041SerTrp: 1.041 ± 0.294
1.805SerTyr: 1.805 ± 0.394
0.0SerXaa: 0.0 ± 0.0
Thr
7.012ThrAla: 7.012 ± 0.653
0.417ThrCys: 0.417 ± 0.177
3.61ThrAsp: 3.61 ± 0.483
3.402ThrGlu: 3.402 ± 0.521
1.874ThrPhe: 1.874 ± 0.349
6.804ThrGly: 6.804 ± 0.576
0.833ThrHis: 0.833 ± 0.195
2.222ThrIle: 2.222 ± 0.358
3.124ThrLys: 3.124 ± 0.499
4.027ThrLeu: 4.027 ± 0.424
1.041ThrMet: 1.041 ± 0.339
2.43ThrAsn: 2.43 ± 0.454
2.708ThrPro: 2.708 ± 0.421
3.055ThrGln: 3.055 ± 0.459
2.985ThrArg: 2.985 ± 0.43
3.471ThrSer: 3.471 ± 0.584
4.86ThrThr: 4.86 ± 0.764
4.651ThrVal: 4.651 ± 0.599
1.041ThrTrp: 1.041 ± 0.252
2.36ThrTyr: 2.36 ± 0.446
0.0ThrXaa: 0.0 ± 0.0
Val
6.04ValAla: 6.04 ± 0.672
0.625ValCys: 0.625 ± 0.216
3.957ValAsp: 3.957 ± 0.586
3.749ValGlu: 3.749 ± 0.528
2.152ValPhe: 2.152 ± 0.395
5.623ValGly: 5.623 ± 0.611
1.389ValHis: 1.389 ± 0.39
3.055ValIle: 3.055 ± 0.366
3.124ValLys: 3.124 ± 0.397
6.595ValLeu: 6.595 ± 0.599
1.874ValMet: 1.874 ± 0.399
3.055ValAsn: 3.055 ± 0.618
3.957ValPro: 3.957 ± 0.548
2.499ValGln: 2.499 ± 0.382
4.235ValArg: 4.235 ± 0.508
4.166ValSer: 4.166 ± 0.548
4.79ValThr: 4.79 ± 0.674
4.096ValVal: 4.096 ± 0.564
1.041ValTrp: 1.041 ± 0.239
2.291ValTyr: 2.291 ± 0.368
0.0ValXaa: 0.0 ± 0.0
Trp
1.319TrpAla: 1.319 ± 0.307
0.347TrpCys: 0.347 ± 0.17
0.486TrpAsp: 0.486 ± 0.181
0.903TrpGlu: 0.903 ± 0.208
0.903TrpPhe: 0.903 ± 0.218
0.833TrpGly: 0.833 ± 0.197
0.833TrpHis: 0.833 ± 0.222
0.903TrpIle: 0.903 ± 0.255
1.041TrpLys: 1.041 ± 0.249
1.874TrpLeu: 1.874 ± 0.347
0.625TrpMet: 0.625 ± 0.258
0.625TrpAsn: 0.625 ± 0.21
0.625TrpPro: 0.625 ± 0.184
0.833TrpGln: 0.833 ± 0.23
0.625TrpArg: 0.625 ± 0.185
0.903TrpSer: 0.903 ± 0.289
0.625TrpThr: 0.625 ± 0.189
1.736TrpVal: 1.736 ± 0.38
0.208TrpTrp: 0.208 ± 0.094
0.972TrpTyr: 0.972 ± 0.247
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.402TyrAla: 3.402 ± 0.446
0.208TyrCys: 0.208 ± 0.122
2.499TyrAsp: 2.499 ± 0.293
1.944TyrGlu: 1.944 ± 0.313
1.18TyrPhe: 1.18 ± 0.26
2.777TyrGly: 2.777 ± 0.452
0.417TyrHis: 0.417 ± 0.19
1.666TyrIle: 1.666 ± 0.418
1.527TyrLys: 1.527 ± 0.344
2.569TyrLeu: 2.569 ± 0.449
0.555TyrMet: 0.555 ± 0.219
1.666TyrAsn: 1.666 ± 0.362
1.041TyrPro: 1.041 ± 0.276
1.458TyrGln: 1.458 ± 0.306
2.708TyrArg: 2.708 ± 0.403
2.013TyrSer: 2.013 ± 0.35
1.874TyrThr: 1.874 ± 0.361
2.708TyrVal: 2.708 ± 0.45
0.764TyrTrp: 0.764 ± 0.26
0.972TyrTyr: 0.972 ± 0.268
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (14405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski