Amino acid dipepetide frequency for Collinsella stercoris DSM 13279

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.738AlaAla: 14.738 ± 0.235	2.254AlaCys: 2.254 ± 0.073	6.641AlaAsp: 6.641 ± 0.113	7.554AlaGlu: 7.554 ± 0.14	4.067AlaPhe: 4.067 ± 0.085	9.642AlaGly: 9.642 ± 0.136	2.501AlaHis: 2.501 ± 0.063	5.665AlaIle: 5.665 ± 0.125	4.058AlaLys: 4.058 ± 0.102	11.555AlaLeu: 11.555 ± 0.163	3.157AlaMet: 3.157 ± 0.069	3.062AlaAsn: 3.062 ± 0.082	4.99AlaPro: 4.99 ± 0.1	3.852AlaGln: 3.852 ± 0.09	8.022AlaArg: 8.022 ± 0.144	7.116AlaSer: 7.116 ± 0.104	5.502AlaThr: 5.502 ± 0.099	8.477AlaVal: 8.477 ± 0.134	1.34AlaTrp: 1.34 ± 0.044	3.055AlaTyr: 3.055 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.991CysAla: 1.991 ± 0.059	0.287CysCys: 0.287 ± 0.021	1.104CysAsp: 1.104 ± 0.039	0.993CysGlu: 0.993 ± 0.037	0.493CysPhe: 0.493 ± 0.027	1.735CysGly: 1.735 ± 0.058	0.348CysHis: 0.348 ± 0.027	0.719CysIle: 0.719 ± 0.034	0.404CysLys: 0.404 ± 0.026	1.252CysLeu: 1.252 ± 0.047	0.418CysMet: 0.418 ± 0.026	0.369CysAsn: 0.369 ± 0.025	0.789CysPro: 0.789 ± 0.035	0.413CysGln: 0.413 ± 0.023	1.063CysArg: 1.063 ± 0.041	0.889CysSer: 0.889 ± 0.039	0.816CysThr: 0.816 ± 0.037	1.267CysVal: 1.267 ± 0.048	0.152CysTrp: 0.152 ± 0.015	0.401CysTyr: 0.401 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	8.402AspAla: 8.402 ± 0.139	0.806AspCys: 0.806 ± 0.038	3.491AspAsp: 3.491 ± 0.092	5.094AspGlu: 5.094 ± 0.093	2.312AspPhe: 2.312 ± 0.063	5.608AspGly: 5.608 ± 0.113	1.134AspHis: 1.134 ± 0.041	3.2AspIle: 3.2 ± 0.071	1.911AspLys: 1.911 ± 0.062	5.526AspLeu: 5.526 ± 0.09	1.657AspMet: 1.657 ± 0.047	1.444AspAsn: 1.444 ± 0.05	3.149AspPro: 3.149 ± 0.071	1.417AspGln: 1.417 ± 0.044	3.663AspArg: 3.663 ± 0.079	2.769AspSer: 2.769 ± 0.069	2.725AspThr: 2.725 ± 0.063	5.029AspVal: 5.029 ± 0.089	0.746AspTrp: 0.746 ± 0.029	1.816AspTyr: 1.816 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	7.221GluAla: 7.221 ± 0.118	0.787GluCys: 0.787 ± 0.041	3.851GluAsp: 3.851 ± 0.088	4.277GluGlu: 4.277 ± 0.092	2.18GluPhe: 2.18 ± 0.054	5.421GluGly: 5.421 ± 0.113	1.677GluHis: 1.677 ± 0.052	3.017GluIle: 3.017 ± 0.07	2.383GluLys: 2.383 ± 0.076	7.109GluLeu: 7.109 ± 0.11	1.827GluMet: 1.827 ± 0.048	2.012GluAsn: 2.012 ± 0.058	2.779GluPro: 2.779 ± 0.067	2.575GluGln: 2.575 ± 0.065	5.844GluArg: 5.844 ± 0.122	3.088GluSer: 3.088 ± 0.065	2.883GluThr: 2.883 ± 0.061	4.828GluVal: 4.828 ± 0.086	0.642GluTrp: 0.642 ± 0.027	1.579GluTyr: 1.579 ± 0.048	0.001GluXaa: 0.001 ± 0.001
Phe	4.16PheAla: 4.16 ± 0.084	0.675PheCys: 0.675 ± 0.033	2.882PheAsp: 2.882 ± 0.064	2.508PheGlu: 2.508 ± 0.059	1.415PhePhe: 1.415 ± 0.052	3.414PheGly: 3.414 ± 0.066	0.628PheHis: 0.628 ± 0.031	1.769PheIle: 1.769 ± 0.057	1.134PheLys: 1.134 ± 0.04	2.921PheLeu: 2.921 ± 0.085	0.966PheMet: 0.966 ± 0.037	1.067PheAsn: 1.067 ± 0.041	1.297PhePro: 1.297 ± 0.044	0.833PheGln: 0.833 ± 0.035	1.657PheArg: 1.657 ± 0.052	2.349PheSer: 2.349 ± 0.071	2.202PheThr: 2.202 ± 0.067	2.794PheVal: 2.794 ± 0.071	0.396PheTrp: 0.396 ± 0.023	1.049PheTyr: 1.049 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	9.379GlyAla: 9.379 ± 0.131	1.562GlyCys: 1.562 ± 0.059	4.707GlyAsp: 4.707 ± 0.095	5.263GlyGlu: 5.263 ± 0.097	3.197GlyPhe: 3.197 ± 0.075	6.661GlyGly: 6.661 ± 0.123	1.668GlyHis: 1.668 ± 0.051	4.845GlyIle: 4.845 ± 0.102	3.534GlyLys: 3.534 ± 0.082	7.171GlyLeu: 7.171 ± 0.106	2.614GlyMet: 2.614 ± 0.06	2.481GlyAsn: 2.481 ± 0.07	2.407GlyPro: 2.407 ± 0.066	2.163GlyGln: 2.163 ± 0.055	5.202GlyArg: 5.202 ± 0.112	5.169GlySer: 5.169 ± 0.115	4.754GlyThr: 4.754 ± 0.091	6.808GlyVal: 6.808 ± 0.094	1.063GlyTrp: 1.063 ± 0.049	2.592GlyTyr: 2.592 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	2.369HisAla: 2.369 ± 0.067	0.332HisCys: 0.332 ± 0.022	1.31HisAsp: 1.31 ± 0.039	1.38HisGlu: 1.38 ± 0.051	0.691HisPhe: 0.691 ± 0.035	1.894HisGly: 1.894 ± 0.054	0.459HisHis: 0.459 ± 0.03	1.113HisIle: 1.113 ± 0.045	0.597HisLys: 0.597 ± 0.032	1.712HisLeu: 1.712 ± 0.052	0.544HisMet: 0.544 ± 0.028	0.534HisAsn: 0.534 ± 0.028	1.123HisPro: 1.123 ± 0.043	0.509HisGln: 0.509 ± 0.029	1.196HisArg: 1.196 ± 0.046	0.899HisSer: 0.899 ± 0.038	0.943HisThr: 0.943 ± 0.042	1.84HisVal: 1.84 ± 0.052	0.199HisTrp: 0.199 ± 0.016	0.574HisTyr: 0.574 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.881IleAla: 6.881 ± 0.102	0.843IleCys: 0.843 ± 0.036	4.098IleAsp: 4.098 ± 0.085	3.981IleGlu: 3.981 ± 0.078	1.522IlePhe: 1.522 ± 0.056	3.917IleGly: 3.917 ± 0.079	0.857IleHis: 0.857 ± 0.039	2.354IleIle: 2.354 ± 0.08	1.779IleLys: 1.779 ± 0.049	3.744IleLeu: 3.744 ± 0.095	1.272IleMet: 1.272 ± 0.046	1.5IleAsn: 1.5 ± 0.045	2.386IlePro: 2.386 ± 0.063	1.15IleGln: 1.15 ± 0.041	2.637IleArg: 2.637 ± 0.066	2.931IleSer: 2.931 ± 0.069	2.653IleThr: 2.653 ± 0.069	4.133IleVal: 4.133 ± 0.084	0.462IleTrp: 0.462 ± 0.027	1.145IleTyr: 1.145 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.701LysAla: 3.701 ± 0.098	0.317LysCys: 0.317 ± 0.022	2.002LysAsp: 2.002 ± 0.063	2.018LysGlu: 2.018 ± 0.06	0.936LysPhe: 0.936 ± 0.044	2.727LysGly: 2.727 ± 0.071	0.624LysHis: 0.624 ± 0.032	1.702LysIle: 1.702 ± 0.052	1.897LysLys: 1.897 ± 0.066	3.304LysLeu: 3.304 ± 0.077	1.029LysMet: 1.029 ± 0.043	1.391LysAsn: 1.391 ± 0.05	1.785LysPro: 1.785 ± 0.059	1.172LysGln: 1.172 ± 0.051	2.839LysArg: 2.839 ± 0.066	1.928LysSer: 1.928 ± 0.067	2.316LysThr: 2.316 ± 0.061	2.525LysVal: 2.525 ± 0.075	0.304LysTrp: 0.304 ± 0.022	0.943LysTyr: 0.943 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	11.183LeuAla: 11.183 ± 0.16	1.395LeuCys: 1.395 ± 0.047	6.202LeuAsp: 6.202 ± 0.104	5.617LeuGlu: 5.617 ± 0.101	3.343LeuPhe: 3.343 ± 0.084	7.559LeuGly: 7.559 ± 0.113	1.711LeuHis: 1.711 ± 0.048	4.305LeuIle: 4.305 ± 0.094	3.223LeuLys: 3.223 ± 0.085	8.025LeuLeu: 8.025 ± 0.16	2.666LeuMet: 2.666 ± 0.067	2.514LeuAsn: 2.514 ± 0.059	4.321LeuPro: 4.321 ± 0.085	2.12LeuGln: 2.12 ± 0.051	5.422LeuArg: 5.422 ± 0.099	5.945LeuSer: 5.945 ± 0.109	5.175LeuThr: 5.175 ± 0.089	7.181LeuVal: 7.181 ± 0.105	0.818LeuTrp: 0.818 ± 0.035	2.261LeuTyr: 2.261 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	3.125MetAla: 3.125 ± 0.065	0.408MetCys: 0.408 ± 0.026	1.589MetAsp: 1.589 ± 0.053	1.468MetGlu: 1.468 ± 0.046	0.854MetPhe: 0.854 ± 0.038	2.441MetGly: 2.441 ± 0.064	0.591MetHis: 0.591 ± 0.028	1.219MetIle: 1.219 ± 0.045	0.993MetLys: 0.993 ± 0.04	2.694MetLeu: 2.694 ± 0.073	0.679MetMet: 0.679 ± 0.034	0.934MetAsn: 0.934 ± 0.039	1.549MetPro: 1.549 ± 0.042	0.881MetGln: 0.881 ± 0.04	2.099MetArg: 2.099 ± 0.055	1.869MetSer: 1.869 ± 0.051	1.556MetThr: 1.556 ± 0.045	1.911MetVal: 1.911 ± 0.054	0.254MetTrp: 0.254 ± 0.019	0.591MetTyr: 0.591 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.227AsnAla: 3.227 ± 0.08	0.361AsnCys: 0.361 ± 0.025	1.719AsnAsp: 1.719 ± 0.057	1.78AsnGlu: 1.78 ± 0.057	0.878AsnPhe: 0.878 ± 0.04	2.74AsnGly: 2.74 ± 0.081	0.534AsnHis: 0.534 ± 0.029	1.59AsnIle: 1.59 ± 0.048	1.08AsnLys: 1.08 ± 0.047	2.616AsnLeu: 2.616 ± 0.061	0.826AsnMet: 0.826 ± 0.034	0.889AsnAsn: 0.889 ± 0.044	1.759AsnPro: 1.759 ± 0.058	0.763AsnGln: 0.763 ± 0.033	1.758AsnArg: 1.758 ± 0.051	1.408AsnSer: 1.408 ± 0.049	1.424AsnThr: 1.424 ± 0.044	2.261AsnVal: 2.261 ± 0.054	0.33AsnTrp: 0.33 ± 0.024	0.78AsnTyr: 0.78 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.284ProAla: 5.284 ± 0.105	0.666ProCys: 0.666 ± 0.037	2.731ProAsp: 2.731 ± 0.068	3.522ProGlu: 3.522 ± 0.085	1.789ProPhe: 1.789 ± 0.054	3.467ProGly: 3.467 ± 0.074	1.0ProHis: 1.0 ± 0.04	2.062ProIle: 2.062 ± 0.056	1.462ProLys: 1.462 ± 0.045	3.788ProLeu: 3.788 ± 0.075	1.083ProMet: 1.083 ± 0.039	1.272ProAsn: 1.272 ± 0.053	1.26ProPro: 1.26 ± 0.049	1.489ProGln: 1.489 ± 0.049	2.614ProArg: 2.614 ± 0.066	2.897ProSer: 2.897 ± 0.075	2.345ProThr: 2.345 ± 0.055	3.814ProVal: 3.814 ± 0.068	0.568ProTrp: 0.568 ± 0.032	1.272ProTyr: 1.272 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.366GlnAla: 3.366 ± 0.089	0.304GlnCys: 0.304 ± 0.026	1.482GlnAsp: 1.482 ± 0.054	1.623GlnGlu: 1.623 ± 0.057	0.945GlnPhe: 0.945 ± 0.039	2.367GlnGly: 2.367 ± 0.064	0.54GlnHis: 0.54 ± 0.027	1.635GlnIle: 1.635 ± 0.043	1.111GlnLys: 1.111 ± 0.038	2.784GlnLeu: 2.784 ± 0.073	0.898GlnMet: 0.898 ± 0.038	0.948GlnAsn: 0.948 ± 0.036	1.184GlnPro: 1.184 ± 0.042	1.113GlnGln: 1.113 ± 0.047	1.972GlnArg: 1.972 ± 0.057	1.454GlnSer: 1.454 ± 0.048	1.591GlnThr: 1.591 ± 0.052	2.183GlnVal: 2.183 ± 0.06	0.291GlnTrp: 0.291 ± 0.02	0.696GlnTyr: 0.696 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.754ArgAla: 7.754 ± 0.126	1.002ArgCys: 1.002 ± 0.037	3.895ArgAsp: 3.895 ± 0.082	4.918ArgGlu: 4.918 ± 0.101	2.357ArgPhe: 2.357 ± 0.064	4.73ArgGly: 4.73 ± 0.098	1.418ArgHis: 1.418 ± 0.047	3.447ArgIle: 3.447 ± 0.067	2.237ArgLys: 2.237 ± 0.053	5.6ArgLeu: 5.6 ± 0.111	2.134ArgMet: 2.134 ± 0.058	1.606ArgAsn: 1.606 ± 0.053	2.801ArgPro: 2.801 ± 0.069	1.755ArgGln: 1.755 ± 0.057	5.188ArgArg: 5.188 ± 0.13	3.645ArgSer: 3.645 ± 0.088	3.348ArgThr: 3.348 ± 0.074	5.128ArgVal: 5.128 ± 0.094	0.703ArgTrp: 0.703 ± 0.03	1.998ArgTyr: 1.998 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	6.45SerAla: 6.45 ± 0.124	0.988SerCys: 0.988 ± 0.035	3.463SerAsp: 3.463 ± 0.087	3.289SerGlu: 3.289 ± 0.075	2.481SerPhe: 2.481 ± 0.063	5.277SerGly: 5.277 ± 0.087	1.186SerHis: 1.186 ± 0.046	3.15SerIle: 3.15 ± 0.064	2.036SerLys: 2.036 ± 0.07	5.196SerLeu: 5.196 ± 0.104	1.635SerMet: 1.635 ± 0.053	1.709SerAsn: 1.709 ± 0.062	2.406SerPro: 2.406 ± 0.065	1.664SerGln: 1.664 ± 0.051	3.576SerArg: 3.576 ± 0.075	3.774SerSer: 3.774 ± 0.084	3.24SerThr: 3.24 ± 0.066	4.453SerVal: 4.453 ± 0.088	0.747SerTrp: 0.747 ± 0.039	1.77SerTyr: 1.77 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	5.488ThrAla: 5.488 ± 0.1	1.01ThrCys: 1.01 ± 0.039	2.994ThrAsp: 2.994 ± 0.073	2.72ThrGlu: 2.72 ± 0.064	2.225ThrPhe: 2.225 ± 0.064	4.811ThrGly: 4.811 ± 0.095	1.107ThrHis: 1.107 ± 0.041	2.684ThrIle: 2.684 ± 0.075	1.692ThrLys: 1.692 ± 0.054	4.948ThrLeu: 4.948 ± 0.085	1.255ThrMet: 1.255 ± 0.048	1.458ThrAsn: 1.458 ± 0.048	2.947ThrPro: 2.947 ± 0.063	1.444ThrGln: 1.444 ± 0.046	3.059ThrArg: 3.059 ± 0.062	3.206ThrSer: 3.206 ± 0.064	2.776ThrThr: 2.776 ± 0.069	4.548ThrVal: 4.548 ± 0.076	0.638ThrTrp: 0.638 ± 0.035	1.677ThrTyr: 1.677 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	8.699ValAla: 8.699 ± 0.127	1.348ValCys: 1.348 ± 0.049	5.223ValAsp: 5.223 ± 0.099	5.367ValGlu: 5.367 ± 0.092	2.965ValPhe: 2.965 ± 0.072	5.617ValGly: 5.617 ± 0.099	1.482ValHis: 1.482 ± 0.053	4.02ValIle: 4.02 ± 0.08	2.684ValLys: 2.684 ± 0.085	7.285ValLeu: 7.285 ± 0.127	2.045ValMet: 2.045 ± 0.066	2.381ValAsn: 2.381 ± 0.062	3.798ValPro: 3.798 ± 0.088	1.917ValGln: 1.917 ± 0.056	5.03ValArg: 5.03 ± 0.087	5.04ValSer: 5.04 ± 0.083	4.338ValThr: 4.338 ± 0.074	6.278ValVal: 6.278 ± 0.106	0.767ValTrp: 0.767 ± 0.033	1.972ValTyr: 1.972 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.99TrpAla: 0.99 ± 0.038	0.18TrpCys: 0.18 ± 0.016	0.672TrpAsp: 0.672 ± 0.038	0.682TrpGlu: 0.682 ± 0.032	0.438TrpPhe: 0.438 ± 0.029	0.914TrpGly: 0.914 ± 0.039	0.243TrpHis: 0.243 ± 0.017	0.526TrpIle: 0.526 ± 0.029	0.395TrpLys: 0.395 ± 0.024	1.073TrpLeu: 1.073 ± 0.041	0.334TrpMet: 0.334 ± 0.023	0.396TrpAsn: 0.396 ± 0.026	0.438TrpPro: 0.438 ± 0.024	0.389TrpGln: 0.389 ± 0.024	0.743TrpArg: 0.743 ± 0.032	0.712TrpSer: 0.712 ± 0.044	0.566TrpThr: 0.566 ± 0.032	0.755TrpVal: 0.755 ± 0.038	0.173TrpTrp: 0.173 ± 0.017	0.328TrpTyr: 0.328 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.84TyrAla: 2.84 ± 0.071	0.378TyrCys: 0.378 ± 0.023	1.842TyrAsp: 1.842 ± 0.051	1.927TyrGlu: 1.927 ± 0.056	1.029TyrPhe: 1.029 ± 0.036	2.298TyrGly: 2.298 ± 0.06	0.51TyrHis: 0.51 ± 0.03	1.225TyrIle: 1.225 ± 0.04	0.851TyrLys: 0.851 ± 0.041	2.684TyrLeu: 2.684 ± 0.064	0.664TyrMet: 0.664 ± 0.034	0.755TyrAsn: 0.755 ± 0.037	1.221TyrPro: 1.221 ± 0.042	0.87TyrGln: 0.87 ± 0.036	2.075TyrArg: 2.075 ± 0.057	1.404TyrSer: 1.404 ± 0.051	1.533TyrThr: 1.533 ± 0.056	2.045TyrVal: 2.045 ± 0.058	0.351TyrTrp: 0.351 ± 0.022	0.858TyrTyr: 0.858 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2527 proteins (703773 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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