Amino acid dipepetide frequency for Meiothermus phage MMP7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.902AlaAla: 14.902 ± 1.496
0.779AlaCys: 0.779 ± 0.296
5.844AlaAsp: 5.844 ± 0.824
6.721AlaGlu: 6.721 ± 0.992
3.019AlaPhe: 3.019 ± 0.517
9.643AlaGly: 9.643 ± 1.085
1.851AlaHis: 1.851 ± 0.503
5.844AlaIle: 5.844 ± 0.807
3.409AlaLys: 3.409 ± 0.585
17.045AlaLeu: 17.045 ± 1.428
1.656AlaMet: 1.656 ± 0.287
2.532AlaAsn: 2.532 ± 0.343
5.649AlaPro: 5.649 ± 0.643
4.48AlaGln: 4.48 ± 0.623
11.006AlaArg: 11.006 ± 1.261
4.773AlaSer: 4.773 ± 0.656
6.526AlaThr: 6.526 ± 0.897
8.182AlaVal: 8.182 ± 0.982
3.409AlaTrp: 3.409 ± 0.693
3.701AlaTyr: 3.701 ± 0.49
0.0AlaXaa: 0.0 ± 0.0
Cys
0.292CysAla: 0.292 ± 0.198
0.097CysCys: 0.097 ± 0.095
0.682CysAsp: 0.682 ± 0.323
1.071CysGlu: 1.071 ± 0.319
0.0CysPhe: 0.0 ± 0.0
1.266CysGly: 1.266 ± 0.451
0.195CysHis: 0.195 ± 0.186
0.0CysIle: 0.0 ± 0.0
0.195CysLys: 0.195 ± 0.175
0.292CysLeu: 0.292 ± 0.178
0.0CysMet: 0.0 ± 0.0
0.195CysAsn: 0.195 ± 0.184
0.779CysPro: 0.779 ± 0.384
0.487CysGln: 0.487 ± 0.261
1.169CysArg: 1.169 ± 0.308
0.195CysSer: 0.195 ± 0.143
0.39CysThr: 0.39 ± 0.246
0.097CysVal: 0.097 ± 0.113
0.195CysTrp: 0.195 ± 0.111
0.195CysTyr: 0.195 ± 0.128
0.0CysXaa: 0.0 ± 0.0
Asp
5.454AspAla: 5.454 ± 0.627
0.39AspCys: 0.39 ± 0.174
2.338AspAsp: 2.338 ± 0.481
3.993AspGlu: 3.993 ± 0.634
1.071AspPhe: 1.071 ± 0.249
3.993AspGly: 3.993 ± 0.784
0.584AspHis: 0.584 ± 0.253
1.948AspIle: 1.948 ± 0.422
0.974AspLys: 0.974 ± 0.261
5.941AspLeu: 5.941 ± 0.697
0.682AspMet: 0.682 ± 0.312
1.461AspAsn: 1.461 ± 0.38
3.896AspPro: 3.896 ± 0.704
0.779AspGln: 0.779 ± 0.276
3.117AspArg: 3.117 ± 0.624
1.753AspSer: 1.753 ± 0.365
2.338AspThr: 2.338 ± 0.372
2.435AspVal: 2.435 ± 0.545
2.63AspTrp: 2.63 ± 0.462
1.266AspTyr: 1.266 ± 0.373
0.0AspXaa: 0.0 ± 0.0
Glu
11.591GluAla: 11.591 ± 1.276
0.974GluCys: 0.974 ± 0.436
2.143GluAsp: 2.143 ± 0.456
4.87GluGlu: 4.87 ± 0.912
1.753GluPhe: 1.753 ± 0.427
5.941GluGly: 5.941 ± 1.001
1.656GluHis: 1.656 ± 0.43
3.312GluIle: 3.312 ± 0.443
1.558GluLys: 1.558 ± 0.395
6.818GluLeu: 6.818 ± 1.044
1.266GluMet: 1.266 ± 0.349
1.558GluAsn: 1.558 ± 0.416
4.48GluPro: 4.48 ± 0.502
3.214GluGln: 3.214 ± 0.547
8.669GluArg: 8.669 ± 1.085
2.338GluSer: 2.338 ± 0.508
3.019GluThr: 3.019 ± 0.409
4.967GluVal: 4.967 ± 0.789
2.045GluTrp: 2.045 ± 0.582
1.558GluTyr: 1.558 ± 0.36
0.0GluXaa: 0.0 ± 0.0
Phe
2.825PheAla: 2.825 ± 0.595
0.0PheCys: 0.0 ± 0.0
1.461PheAsp: 1.461 ± 0.33
1.558PheGlu: 1.558 ± 0.368
0.487PhePhe: 0.487 ± 0.202
2.045PheGly: 2.045 ± 0.531
0.292PheHis: 0.292 ± 0.155
1.071PheIle: 1.071 ± 0.38
0.779PheLys: 0.779 ± 0.226
1.753PheLeu: 1.753 ± 0.439
0.097PheMet: 0.097 ± 0.095
1.364PheAsn: 1.364 ± 0.363
1.364PhePro: 1.364 ± 0.407
0.487PheGln: 0.487 ± 0.297
2.045PheArg: 2.045 ± 0.462
1.558PheSer: 1.558 ± 0.348
1.753PheThr: 1.753 ± 0.366
1.558PheVal: 1.558 ± 0.328
0.487PheTrp: 0.487 ± 0.21
0.779PheTyr: 0.779 ± 0.231
0.0PheXaa: 0.0 ± 0.0
Gly
8.084GlyAla: 8.084 ± 1.141
0.584GlyCys: 0.584 ± 0.232
5.065GlyAsp: 5.065 ± 0.76
4.286GlyGlu: 4.286 ± 0.715
2.922GlyPhe: 2.922 ± 0.556
6.623GlyGly: 6.623 ± 1.209
1.364GlyHis: 1.364 ± 0.479
3.506GlyIle: 3.506 ± 0.479
3.019GlyLys: 3.019 ± 0.531
9.448GlyLeu: 9.448 ± 1.228
2.143GlyMet: 2.143 ± 0.38
2.338GlyAsn: 2.338 ± 0.476
3.214GlyPro: 3.214 ± 0.386
2.532GlyGln: 2.532 ± 0.541
7.695GlyArg: 7.695 ± 0.792
3.993GlySer: 3.993 ± 0.616
4.967GlyThr: 4.967 ± 0.817
4.773GlyVal: 4.773 ± 0.581
2.63GlyTrp: 2.63 ± 0.546
3.214GlyTyr: 3.214 ± 0.537
0.0GlyXaa: 0.0 ± 0.0
His
1.851HisAla: 1.851 ± 0.447
0.195HisCys: 0.195 ± 0.186
0.877HisAsp: 0.877 ± 0.251
0.877HisGlu: 0.877 ± 0.242
0.39HisPhe: 0.39 ± 0.179
1.169HisGly: 1.169 ± 0.342
0.195HisHis: 0.195 ± 0.148
0.487HisIle: 0.487 ± 0.213
0.292HisLys: 0.292 ± 0.145
1.656HisLeu: 1.656 ± 0.408
0.195HisMet: 0.195 ± 0.137
0.292HisAsn: 0.292 ± 0.154
1.461HisPro: 1.461 ± 0.376
0.974HisGln: 0.974 ± 0.29
0.974HisArg: 0.974 ± 0.334
1.364HisSer: 1.364 ± 0.402
0.584HisThr: 0.584 ± 0.214
0.779HisVal: 0.779 ± 0.226
0.292HisTrp: 0.292 ± 0.154
0.39HisTyr: 0.39 ± 0.175
0.0HisXaa: 0.0 ± 0.0
Ile
5.065IleAla: 5.065 ± 0.904
0.195IleCys: 0.195 ± 0.124
1.266IleAsp: 1.266 ± 0.335
3.604IleGlu: 3.604 ± 0.471
0.39IlePhe: 0.39 ± 0.186
3.409IleGly: 3.409 ± 0.889
0.779IleHis: 0.779 ± 0.256
1.948IleIle: 1.948 ± 0.386
1.461IleLys: 1.461 ± 0.322
3.701IleLeu: 3.701 ± 0.541
0.487IleMet: 0.487 ± 0.193
1.753IleAsn: 1.753 ± 0.339
2.922IlePro: 2.922 ± 0.537
1.851IleGln: 1.851 ± 0.406
2.143IleArg: 2.143 ± 0.486
2.338IleSer: 2.338 ± 0.556
3.214IleThr: 3.214 ± 0.836
2.63IleVal: 2.63 ± 0.667
0.682IleTrp: 0.682 ± 0.263
1.169IleTyr: 1.169 ± 0.279
0.0IleXaa: 0.0 ± 0.0
Lys
2.63LysAla: 2.63 ± 0.51
0.0LysCys: 0.0 ± 0.0
0.682LysAsp: 0.682 ± 0.22
1.558LysGlu: 1.558 ± 0.52
0.682LysPhe: 0.682 ± 0.222
1.851LysGly: 1.851 ± 0.361
0.39LysHis: 0.39 ± 0.181
0.974LysIle: 0.974 ± 0.315
1.071LysLys: 1.071 ± 0.611
3.117LysLeu: 3.117 ± 0.722
0.487LysMet: 0.487 ± 0.19
0.584LysAsn: 0.584 ± 0.202
1.461LysPro: 1.461 ± 0.31
1.656LysGln: 1.656 ± 0.397
2.435LysArg: 2.435 ± 0.446
1.266LysSer: 1.266 ± 0.388
2.825LysThr: 2.825 ± 0.487
2.143LysVal: 2.143 ± 0.451
0.292LysTrp: 0.292 ± 0.171
0.39LysTyr: 0.39 ± 0.189
0.0LysXaa: 0.0 ± 0.0
Leu
15.097LeuAla: 15.097 ± 1.678
0.584LeuCys: 0.584 ± 0.225
5.552LeuAsp: 5.552 ± 0.538
12.857LeuGlu: 12.857 ± 1.237
1.851LeuPhe: 1.851 ± 0.365
9.74LeuGly: 9.74 ± 1.226
1.948LeuHis: 1.948 ± 0.369
3.701LeuIle: 3.701 ± 0.524
2.922LeuLys: 2.922 ± 0.504
9.837LeuLeu: 9.837 ± 1.185
1.266LeuMet: 1.266 ± 0.32
2.24LeuAsn: 2.24 ± 0.53
6.721LeuPro: 6.721 ± 0.75
3.312LeuGln: 3.312 ± 0.578
8.961LeuArg: 8.961 ± 0.929
5.649LeuSer: 5.649 ± 0.524
6.428LeuThr: 6.428 ± 0.89
6.526LeuVal: 6.526 ± 0.673
2.532LeuTrp: 2.532 ± 0.367
3.312LeuTyr: 3.312 ± 0.507
0.0LeuXaa: 0.0 ± 0.0
Met
2.825MetAla: 2.825 ± 0.509
0.292MetCys: 0.292 ± 0.151
0.584MetAsp: 0.584 ± 0.22
0.487MetGlu: 0.487 ± 0.167
0.292MetPhe: 0.292 ± 0.149
1.071MetGly: 1.071 ± 0.321
0.0MetHis: 0.0 ± 0.0
0.584MetIle: 0.584 ± 0.19
0.487MetLys: 0.487 ± 0.238
1.558MetLeu: 1.558 ± 0.475
0.097MetMet: 0.097 ± 0.085
0.39MetAsn: 0.39 ± 0.167
1.461MetPro: 1.461 ± 0.379
0.39MetGln: 0.39 ± 0.188
1.558MetArg: 1.558 ± 0.301
0.584MetSer: 0.584 ± 0.182
1.558MetThr: 1.558 ± 0.395
0.682MetVal: 0.682 ± 0.25
0.292MetTrp: 0.292 ± 0.143
0.39MetTyr: 0.39 ± 0.232
0.0MetXaa: 0.0 ± 0.0
Asn
2.045AsnAla: 2.045 ± 0.52
0.195AsnCys: 0.195 ± 0.125
1.071AsnAsp: 1.071 ± 0.318
1.364AsnGlu: 1.364 ± 0.388
0.487AsnPhe: 0.487 ± 0.223
2.24AsnGly: 2.24 ± 0.461
0.195AsnHis: 0.195 ± 0.14
1.169AsnIle: 1.169 ± 0.307
0.974AsnLys: 0.974 ± 0.277
3.993AsnLeu: 3.993 ± 0.528
0.584AsnMet: 0.584 ± 0.192
0.584AsnAsn: 0.584 ± 0.22
2.338AsnPro: 2.338 ± 0.598
1.071AsnGln: 1.071 ± 0.292
2.532AsnArg: 2.532 ± 0.347
1.169AsnSer: 1.169 ± 0.349
2.045AsnThr: 2.045 ± 0.497
1.461AsnVal: 1.461 ± 0.387
0.487AsnTrp: 0.487 ± 0.201
0.779AsnTyr: 0.779 ± 0.249
0.0AsnXaa: 0.0 ± 0.0
Pro
7.208ProAla: 7.208 ± 0.785
0.584ProCys: 0.584 ± 0.335
3.019ProAsp: 3.019 ± 0.489
5.941ProGlu: 5.941 ± 0.969
1.169ProPhe: 1.169 ± 0.327
5.454ProGly: 5.454 ± 0.655
0.487ProHis: 0.487 ± 0.244
2.143ProIle: 2.143 ± 0.495
1.266ProLys: 1.266 ± 0.328
6.428ProLeu: 6.428 ± 0.696
0.779ProMet: 0.779 ± 0.222
1.558ProAsn: 1.558 ± 0.345
4.188ProPro: 4.188 ± 0.837
3.214ProGln: 3.214 ± 0.49
3.799ProArg: 3.799 ± 0.693
2.825ProSer: 2.825 ± 0.496
3.409ProThr: 3.409 ± 0.535
3.214ProVal: 3.214 ± 0.537
1.753ProTrp: 1.753 ± 0.411
2.045ProTyr: 2.045 ± 0.447
0.0ProXaa: 0.0 ± 0.0
Gln
5.357GlnAla: 5.357 ± 0.718
0.195GlnCys: 0.195 ± 0.135
1.851GlnAsp: 1.851 ± 0.382
2.435GlnGlu: 2.435 ± 0.476
0.682GlnPhe: 0.682 ± 0.244
3.019GlnGly: 3.019 ± 0.517
0.877GlnHis: 0.877 ± 0.306
1.753GlnIle: 1.753 ± 0.475
0.779GlnLys: 0.779 ± 0.221
3.312GlnLeu: 3.312 ± 0.534
0.779GlnMet: 0.779 ± 0.302
0.779GlnAsn: 0.779 ± 0.321
1.851GlnPro: 1.851 ± 0.395
1.558GlnGln: 1.558 ± 0.378
3.701GlnArg: 3.701 ± 0.562
1.169GlnSer: 1.169 ± 0.239
2.338GlnThr: 2.338 ± 0.445
3.019GlnVal: 3.019 ± 0.547
0.974GlnTrp: 0.974 ± 0.265
1.071GlnTyr: 1.071 ± 0.379
0.0GlnXaa: 0.0 ± 0.0
Arg
10.13ArgAla: 10.13 ± 1.013
1.169ArgCys: 1.169 ± 0.365
3.312ArgAsp: 3.312 ± 0.455
7.11ArgGlu: 7.11 ± 1.188
2.532ArgPhe: 2.532 ± 0.47
5.941ArgGly: 5.941 ± 0.73
1.071ArgHis: 1.071 ± 0.328
3.701ArgIle: 3.701 ± 0.435
1.753ArgLys: 1.753 ± 0.433
11.201ArgLeu: 11.201 ± 1.063
1.948ArgMet: 1.948 ± 0.552
2.24ArgAsn: 2.24 ± 0.457
4.87ArgPro: 4.87 ± 0.797
2.63ArgGln: 2.63 ± 0.496
6.039ArgArg: 6.039 ± 0.672
3.896ArgSer: 3.896 ± 0.61
3.409ArgThr: 3.409 ± 0.464
6.428ArgVal: 6.428 ± 0.951
3.117ArgTrp: 3.117 ± 0.584
4.188ArgTyr: 4.188 ± 0.688
0.0ArgXaa: 0.0 ± 0.0
Ser
4.286SerAla: 4.286 ± 0.572
0.292SerCys: 0.292 ± 0.212
2.532SerAsp: 2.532 ± 0.472
3.117SerGlu: 3.117 ± 0.514
1.753SerPhe: 1.753 ± 0.386
5.065SerGly: 5.065 ± 0.771
0.487SerHis: 0.487 ± 0.244
2.045SerIle: 2.045 ± 0.3
0.974SerLys: 0.974 ± 0.301
4.967SerLeu: 4.967 ± 0.565
0.779SerMet: 0.779 ± 0.254
1.071SerAsn: 1.071 ± 0.332
3.214SerPro: 3.214 ± 0.441
1.656SerGln: 1.656 ± 0.518
3.019SerArg: 3.019 ± 0.566
1.851SerSer: 1.851 ± 0.436
2.045SerThr: 2.045 ± 0.484
3.506SerVal: 3.506 ± 0.551
0.779SerTrp: 0.779 ± 0.235
1.364SerTyr: 1.364 ± 0.488
0.0SerXaa: 0.0 ± 0.0
Thr
5.941ThrAla: 5.941 ± 0.99
0.195ThrCys: 0.195 ± 0.14
3.214ThrAsp: 3.214 ± 0.571
2.727ThrGlu: 2.727 ± 0.408
1.266ThrPhe: 1.266 ± 0.298
4.383ThrGly: 4.383 ± 0.744
0.779ThrHis: 0.779 ± 0.225
2.727ThrIle: 2.727 ± 0.667
1.558ThrLys: 1.558 ± 0.446
7.013ThrLeu: 7.013 ± 0.719
0.195ThrMet: 0.195 ± 0.146
2.045ThrAsn: 2.045 ± 0.506
4.188ThrPro: 4.188 ± 0.611
2.045ThrGln: 2.045 ± 0.392
4.773ThrArg: 4.773 ± 0.582
2.143ThrSer: 2.143 ± 0.338
3.312ThrThr: 3.312 ± 0.695
5.357ThrVal: 5.357 ± 0.858
1.071ThrTrp: 1.071 ± 0.293
1.266ThrTyr: 1.266 ± 0.309
0.0ThrXaa: 0.0 ± 0.0
Val
8.182ValAla: 8.182 ± 0.918
0.584ValCys: 0.584 ± 0.22
3.312ValAsp: 3.312 ± 0.542
4.967ValGlu: 4.967 ± 0.847
1.266ValPhe: 1.266 ± 0.343
5.162ValGly: 5.162 ± 0.722
1.169ValHis: 1.169 ± 0.31
2.143ValIle: 2.143 ± 0.42
2.338ValLys: 2.338 ± 0.422
6.526ValLeu: 6.526 ± 0.739
0.779ValMet: 0.779 ± 0.249
1.851ValAsn: 1.851 ± 0.46
2.63ValPro: 2.63 ± 0.673
2.825ValGln: 2.825 ± 0.514
6.526ValArg: 6.526 ± 0.769
3.506ValSer: 3.506 ± 0.688
3.701ValThr: 3.701 ± 0.634
3.896ValVal: 3.896 ± 0.623
2.143ValTrp: 2.143 ± 0.359
1.656ValTyr: 1.656 ± 0.401
0.0ValXaa: 0.0 ± 0.0
Trp
3.701TrpAla: 3.701 ± 0.685
0.292TrpCys: 0.292 ± 0.137
0.682TrpAsp: 0.682 ± 0.22
1.948TrpGlu: 1.948 ± 0.344
0.877TrpPhe: 0.877 ± 0.24
2.24TrpGly: 2.24 ± 0.486
0.584TrpHis: 0.584 ± 0.274
0.779TrpIle: 0.779 ± 0.328
0.487TrpLys: 0.487 ± 0.246
3.506TrpLeu: 3.506 ± 0.635
0.877TrpMet: 0.877 ± 0.295
0.877TrpAsn: 0.877 ± 0.286
2.24TrpPro: 2.24 ± 0.389
1.169TrpGln: 1.169 ± 0.322
3.019TrpArg: 3.019 ± 0.506
1.071TrpSer: 1.071 ± 0.272
0.682TrpThr: 0.682 ± 0.278
1.266TrpVal: 1.266 ± 0.433
0.39TrpTrp: 0.39 ± 0.173
0.39TrpTyr: 0.39 ± 0.191
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.506TyrAla: 3.506 ± 0.534
0.195TyrCys: 0.195 ± 0.146
1.558TyrAsp: 1.558 ± 0.419
2.24TyrGlu: 2.24 ± 0.589
0.877TyrPhe: 0.877 ± 0.32
2.143TyrGly: 2.143 ± 0.364
0.39TyrHis: 0.39 ± 0.25
1.169TyrIle: 1.169 ± 0.273
0.195TyrLys: 0.195 ± 0.127
2.922TyrLeu: 2.922 ± 0.552
0.39TyrMet: 0.39 ± 0.168
1.071TyrAsn: 1.071 ± 0.259
1.558TyrPro: 1.558 ± 0.376
1.266TyrGln: 1.266 ± 0.378
3.506TyrArg: 3.506 ± 0.537
1.364TyrSer: 1.364 ± 0.418
1.656TyrThr: 1.656 ± 0.435
2.24TyrVal: 2.24 ± 0.448
0.877TyrTrp: 0.877 ± 0.265
1.071TyrTyr: 1.071 ± 0.277
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (10268 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski