Amino acid dipepetide frequency for Blastococcus sp. CCUG 61487

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.04AlaAla: 23.04 ± 0.257
0.936AlaCys: 0.936 ± 0.029
9.123AlaAsp: 9.123 ± 0.115
9.461AlaGlu: 9.461 ± 0.107
3.332AlaPhe: 3.332 ± 0.063
13.934AlaGly: 13.934 ± 0.13
2.47AlaHis: 2.47 ± 0.06
3.989AlaIle: 3.989 ± 0.073
2.018AlaLys: 2.018 ± 0.052
14.952AlaLeu: 14.952 ± 0.155
2.575AlaMet: 2.575 ± 0.049
1.808AlaAsn: 1.808 ± 0.044
6.985AlaPro: 6.985 ± 0.086
3.729AlaGln: 3.729 ± 0.065
10.722AlaArg: 10.722 ± 0.111
5.625AlaSer: 5.625 ± 0.077
7.427AlaThr: 7.427 ± 0.08
13.563AlaVal: 13.563 ± 0.131
1.938AlaTrp: 1.938 ± 0.041
2.29AlaTyr: 2.29 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.846CysAla: 0.846 ± 0.028
0.088CysCys: 0.088 ± 0.009
0.439CysAsp: 0.439 ± 0.019
0.32CysGlu: 0.32 ± 0.015
0.184CysPhe: 0.184 ± 0.013
0.87CysGly: 0.87 ± 0.03
0.165CysHis: 0.165 ± 0.013
0.192CysIle: 0.192 ± 0.013
0.08CysLys: 0.08 ± 0.009
0.651CysLeu: 0.651 ± 0.023
0.095CysMet: 0.095 ± 0.008
0.107CysAsn: 0.107 ± 0.009
0.5CysPro: 0.5 ± 0.02
0.151CysGln: 0.151 ± 0.012
0.592CysArg: 0.592 ± 0.023
0.364CysSer: 0.364 ± 0.016
0.442CysThr: 0.442 ± 0.021
0.563CysVal: 0.563 ± 0.024
0.093CysTrp: 0.093 ± 0.01
0.122CysTyr: 0.122 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.561AspAla: 8.561 ± 0.098
0.356AspCys: 0.356 ± 0.018
4.734AspAsp: 4.734 ± 0.084
4.578AspGlu: 4.578 ± 0.065
1.392AspPhe: 1.392 ± 0.035
6.738AspGly: 6.738 ± 0.09
1.251AspHis: 1.251 ± 0.029
1.625AspIle: 1.625 ± 0.041
0.795AspLys: 0.795 ± 0.028
7.051AspLeu: 7.051 ± 0.086
0.785AspMet: 0.785 ± 0.026
0.685AspAsn: 0.685 ± 0.028
4.812AspPro: 4.812 ± 0.07
1.631AspGln: 1.631 ± 0.041
5.342AspArg: 5.342 ± 0.074
2.28AspSer: 2.28 ± 0.051
2.774AspThr: 2.774 ± 0.051
6.514AspVal: 6.514 ± 0.081
0.959AspTrp: 0.959 ± 0.031
1.058AspTyr: 1.058 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.44GluAla: 7.44 ± 0.086
0.314GluCys: 0.314 ± 0.02
3.125GluAsp: 3.125 ± 0.063
3.65GluGlu: 3.65 ± 0.056
1.595GluPhe: 1.595 ± 0.037
4.349GluGly: 4.349 ± 0.058
1.685GluHis: 1.685 ± 0.04
2.246GluIle: 2.246 ± 0.044
1.126GluLys: 1.126 ± 0.038
7.389GluLeu: 7.389 ± 0.083
0.886GluMet: 0.886 ± 0.029
0.929GluAsn: 0.929 ± 0.032
3.54GluPro: 3.54 ± 0.059
2.711GluGln: 2.711 ± 0.054
5.583GluArg: 5.583 ± 0.081
2.442GluSer: 2.442 ± 0.038
2.828GluThr: 2.828 ± 0.048
5.493GluVal: 5.493 ± 0.069
0.867GluTrp: 0.867 ± 0.028
0.998GluTyr: 0.998 ± 0.033
0.001GluXaa: 0.001 ± 0.001
Phe
3.556PheAla: 3.556 ± 0.058
0.233PheCys: 0.233 ± 0.016
1.996PheAsp: 1.996 ± 0.042
1.366PheGlu: 1.366 ± 0.04
0.841PhePhe: 0.841 ± 0.028
2.892PheGly: 2.892 ± 0.054
0.487PheHis: 0.487 ± 0.022
0.66PheIle: 0.66 ± 0.025
0.356PheLys: 0.356 ± 0.017
2.569PheLeu: 2.569 ± 0.055
0.316PheMet: 0.316 ± 0.015
0.433PheAsn: 0.433 ± 0.022
1.347PhePro: 1.347 ± 0.037
0.616PheGln: 0.616 ± 0.021
1.732PheArg: 1.732 ± 0.039
1.344PheSer: 1.344 ± 0.043
1.745PheThr: 1.745 ± 0.038
2.448PheVal: 2.448 ± 0.05
0.423PheTrp: 0.423 ± 0.019
0.515PheTyr: 0.515 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
11.064GlyAla: 11.064 ± 0.117
0.789GlyCys: 0.789 ± 0.029
5.582GlyAsp: 5.582 ± 0.077
5.481GlyGlu: 5.481 ± 0.065
2.769GlyPhe: 2.769 ± 0.054
8.523GlyGly: 8.523 ± 0.109
1.94GlyHis: 1.94 ± 0.042
3.448GlyIle: 3.448 ± 0.057
1.726GlyLys: 1.726 ± 0.044
9.842GlyLeu: 9.842 ± 0.11
2.075GlyMet: 2.075 ± 0.046
1.484GlyAsn: 1.484 ± 0.037
5.077GlyPro: 5.077 ± 0.082
2.736GlyGln: 2.736 ± 0.054
8.048GlyArg: 8.048 ± 0.1
5.266GlySer: 5.266 ± 0.072
5.783GlyThr: 5.783 ± 0.072
8.136GlyVal: 8.136 ± 0.097
1.824GlyTrp: 1.824 ± 0.047
2.124GlyTyr: 2.124 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.437HisAla: 2.437 ± 0.052
0.193HisCys: 0.193 ± 0.014
1.228HisAsp: 1.228 ± 0.029
1.146HisGlu: 1.146 ± 0.033
0.511HisPhe: 0.511 ± 0.021
2.155HisGly: 2.155 ± 0.048
0.583HisHis: 0.583 ± 0.024
0.455HisIle: 0.455 ± 0.02
0.237HisLys: 0.237 ± 0.014
2.374HisLeu: 2.374 ± 0.055
0.236HisMet: 0.236 ± 0.014
0.275HisAsn: 0.275 ± 0.014
1.599HisPro: 1.599 ± 0.033
0.487HisGln: 0.487 ± 0.021
1.899HisArg: 1.899 ± 0.045
0.815HisSer: 0.815 ± 0.026
0.987HisThr: 0.987 ± 0.03
1.818HisVal: 1.818 ± 0.04
0.307HisTrp: 0.307 ± 0.016
0.396HisTyr: 0.396 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.854IleAla: 4.854 ± 0.078
0.249IleCys: 0.249 ± 0.014
2.512IleAsp: 2.512 ± 0.054
1.996IleGlu: 1.996 ± 0.043
0.651IlePhe: 0.651 ± 0.023
3.546IleGly: 3.546 ± 0.061
0.446IleHis: 0.446 ± 0.021
0.823IleIle: 0.823 ± 0.036
0.505IleLys: 0.505 ± 0.024
2.052IleLeu: 2.052 ± 0.048
0.354IleMet: 0.354 ± 0.019
0.621IleAsn: 0.621 ± 0.023
1.664IlePro: 1.664 ± 0.039
0.663IleGln: 0.663 ± 0.026
2.181IleArg: 2.181 ± 0.042
1.753IleSer: 1.753 ± 0.044
2.021IleThr: 2.021 ± 0.043
2.754IleVal: 2.754 ± 0.049
0.364IleTrp: 0.364 ± 0.019
0.543IleTyr: 0.543 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.096LysAla: 2.096 ± 0.047
0.067LysCys: 0.067 ± 0.008
0.87LysAsp: 0.87 ± 0.031
0.788LysGlu: 0.788 ± 0.029
0.347LysPhe: 0.347 ± 0.018
1.179LysGly: 1.179 ± 0.036
0.34LysHis: 0.34 ± 0.016
0.566LysIle: 0.566 ± 0.026
0.523LysLys: 0.523 ± 0.031
1.516LysLeu: 1.516 ± 0.043
0.284LysMet: 0.284 ± 0.016
0.345LysAsn: 0.345 ± 0.02
0.966LysPro: 0.966 ± 0.032
0.511LysGln: 0.511 ± 0.023
1.189LysArg: 1.189 ± 0.031
0.769LysSer: 0.769 ± 0.025
0.958LysThr: 0.958 ± 0.031
1.384LysVal: 1.384 ± 0.038
0.194LysTrp: 0.194 ± 0.014
0.295LysTyr: 0.295 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
16.857LeuAla: 16.857 ± 0.138
0.679LeuCys: 0.679 ± 0.023
7.159LeuAsp: 7.159 ± 0.101
5.324LeuGlu: 5.324 ± 0.07
2.523LeuPhe: 2.523 ± 0.049
9.753LeuGly: 9.753 ± 0.103
2.113LeuHis: 2.113 ± 0.046
2.839LeuIle: 2.839 ± 0.059
1.352LeuLys: 1.352 ± 0.04
12.03LeuLeu: 12.03 ± 0.154
1.441LeuMet: 1.441 ± 0.035
1.384LeuAsn: 1.384 ± 0.037
6.866LeuPro: 6.866 ± 0.085
2.654LeuGln: 2.654 ± 0.049
8.746LeuArg: 8.746 ± 0.106
5.072LeuSer: 5.072 ± 0.077
6.644LeuThr: 6.644 ± 0.076
10.753LeuVal: 10.753 ± 0.121
1.193LeuTrp: 1.193 ± 0.032
1.521LeuTyr: 1.521 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.301MetAla: 2.301 ± 0.049
0.125MetCys: 0.125 ± 0.011
0.859MetAsp: 0.859 ± 0.028
0.712MetGlu: 0.712 ± 0.024
0.392MetPhe: 0.392 ± 0.02
1.307MetGly: 1.307 ± 0.04
0.345MetHis: 0.345 ± 0.018
0.557MetIle: 0.557 ± 0.019
0.32MetLys: 0.32 ± 0.017
1.613MetLeu: 1.613 ± 0.036
0.216MetMet: 0.216 ± 0.014
0.337MetAsn: 0.337 ± 0.017
1.09MetPro: 1.09 ± 0.03
0.502MetGln: 0.502 ± 0.021
1.366MetArg: 1.366 ± 0.036
1.295MetSer: 1.295 ± 0.036
1.601MetThr: 1.601 ± 0.031
1.313MetVal: 1.313 ± 0.034
0.185MetTrp: 0.185 ± 0.014
0.236MetTyr: 0.236 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
1.944AsnAla: 1.944 ± 0.041
0.125AsnCys: 0.125 ± 0.012
0.796AsnAsp: 0.796 ± 0.028
0.735AsnGlu: 0.735 ± 0.028
0.404AsnPhe: 0.404 ± 0.018
1.442AsnGly: 1.442 ± 0.042
0.304AsnHis: 0.304 ± 0.016
0.517AsnIle: 0.517 ± 0.021
0.264AsnLys: 0.264 ± 0.015
1.576AsnLeu: 1.576 ± 0.044
0.284AsnMet: 0.284 ± 0.016
0.322AsnAsn: 0.322 ± 0.02
1.176AsnPro: 1.176 ± 0.035
0.417AsnGln: 0.417 ± 0.018
1.195AsnArg: 1.195 ± 0.031
0.723AsnSer: 0.723 ± 0.027
0.881AsnThr: 0.881 ± 0.03
1.3AsnVal: 1.3 ± 0.038
0.228AsnTrp: 0.228 ± 0.014
0.326AsnTyr: 0.326 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
8.646ProAla: 8.646 ± 0.098
0.296ProCys: 0.296 ± 0.016
4.897ProAsp: 4.897 ± 0.072
4.464ProGlu: 4.464 ± 0.066
1.503ProPhe: 1.503 ± 0.039
6.574ProGly: 6.574 ± 0.086
1.181ProHis: 1.181 ± 0.033
1.511ProIle: 1.511 ± 0.038
0.863ProLys: 0.863 ± 0.033
5.468ProLeu: 5.468 ± 0.074
1.011ProMet: 1.011 ± 0.031
0.8ProAsn: 0.8 ± 0.03
3.858ProPro: 3.858 ± 0.094
1.419ProGln: 1.419 ± 0.038
4.089ProArg: 4.089 ± 0.07
2.984ProSer: 2.984 ± 0.06
3.481ProThr: 3.481 ± 0.055
5.849ProVal: 5.849 ± 0.07
0.95ProTrp: 0.95 ± 0.03
1.015ProTyr: 1.015 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.841GlnAla: 3.841 ± 0.06
0.144GlnCys: 0.144 ± 0.012
1.207GlnAsp: 1.207 ± 0.033
1.444GlnGlu: 1.444 ± 0.037
0.71GlnPhe: 0.71 ± 0.023
1.973GlnGly: 1.973 ± 0.043
0.61GlnHis: 0.61 ± 0.023
1.083GlnIle: 1.083 ± 0.034
0.478GlnLys: 0.478 ± 0.022
3.454GlnLeu: 3.454 ± 0.066
0.511GlnMet: 0.511 ± 0.021
0.424GlnAsn: 0.424 ± 0.022
1.707GlnPro: 1.707 ± 0.036
1.179GlnGln: 1.179 ± 0.039
2.727GlnArg: 2.727 ± 0.053
1.083GlnSer: 1.083 ± 0.035
1.314GlnThr: 1.314 ± 0.036
2.818GlnVal: 2.818 ± 0.051
0.422GlnTrp: 0.422 ± 0.021
0.512GlnTyr: 0.512 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
10.441ArgAla: 10.441 ± 0.114
0.588ArgCys: 0.588 ± 0.025
4.531ArgAsp: 4.531 ± 0.061
4.627ArgGlu: 4.627 ± 0.058
2.288ArgPhe: 2.288 ± 0.049
6.075ArgGly: 6.075 ± 0.068
1.779ArgHis: 1.779 ± 0.042
2.957ArgIle: 2.957 ± 0.051
1.208ArgLys: 1.208 ± 0.039
9.107ArgLeu: 9.107 ± 0.09
1.849ArgMet: 1.849 ± 0.042
1.267ArgAsn: 1.267 ± 0.04
5.385ArgPro: 5.385 ± 0.076
2.433ArgGln: 2.433 ± 0.047
8.424ArgArg: 8.424 ± 0.114
4.422ArgSer: 4.422 ± 0.073
4.962ArgThr: 4.962 ± 0.063
6.461ArgVal: 6.461 ± 0.074
1.562ArgTrp: 1.562 ± 0.037
1.776ArgTyr: 1.776 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.439SerAla: 6.439 ± 0.079
0.344SerCys: 0.344 ± 0.019
2.697SerAsp: 2.697 ± 0.05
2.368SerGlu: 2.368 ± 0.047
1.418SerPhe: 1.418 ± 0.039
5.381SerGly: 5.381 ± 0.071
0.83SerHis: 0.83 ± 0.026
1.611SerIle: 1.611 ± 0.037
0.71SerLys: 0.71 ± 0.024
4.65SerLeu: 4.65 ± 0.067
1.097SerMet: 1.097 ± 0.028
0.779SerAsn: 0.779 ± 0.027
3.055SerPro: 3.055 ± 0.057
1.136SerGln: 1.136 ± 0.035
3.764SerArg: 3.764 ± 0.063
2.909SerSer: 2.909 ± 0.058
3.18SerThr: 3.18 ± 0.06
4.141SerVal: 4.141 ± 0.059
0.861SerTrp: 0.861 ± 0.027
0.992SerTyr: 0.992 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
8.503ThrAla: 8.503 ± 0.104
0.385ThrCys: 0.385 ± 0.02
3.677ThrAsp: 3.677 ± 0.06
3.206ThrGlu: 3.206 ± 0.055
1.57ThrPhe: 1.57 ± 0.037
6.289ThrGly: 6.289 ± 0.076
0.991ThrHis: 0.991 ± 0.03
1.808ThrIle: 1.808 ± 0.046
0.862ThrLys: 0.862 ± 0.029
5.44ThrLeu: 5.44 ± 0.072
0.905ThrMet: 0.905 ± 0.03
0.909ThrAsn: 0.909 ± 0.031
3.834ThrPro: 3.834 ± 0.06
1.284ThrGln: 1.284 ± 0.034
4.009ThrArg: 4.009 ± 0.057
3.062ThrSer: 3.062 ± 0.053
3.841ThrThr: 3.841 ± 0.067
6.175ThrVal: 6.175 ± 0.071
0.957ThrTrp: 0.957 ± 0.029
1.111ThrTyr: 1.111 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
12.996ValAla: 12.996 ± 0.128
0.662ValCys: 0.662 ± 0.028
6.317ValAsp: 6.317 ± 0.083
5.703ValGlu: 5.703 ± 0.083
2.405ValPhe: 2.405 ± 0.047
7.869ValGly: 7.869 ± 0.075
1.987ValHis: 1.987 ± 0.042
2.791ValIle: 2.791 ± 0.054
1.262ValLys: 1.262 ± 0.041
11.251ValLeu: 11.251 ± 0.12
1.296ValMet: 1.296 ± 0.036
1.486ValAsn: 1.486 ± 0.038
5.651ValPro: 5.651 ± 0.077
2.326ValGln: 2.326 ± 0.039
7.474ValArg: 7.474 ± 0.088
4.327ValSer: 4.327 ± 0.064
5.975ValThr: 5.975 ± 0.08
10.917ValVal: 10.917 ± 0.131
1.125ValTrp: 1.125 ± 0.037
1.434ValTyr: 1.434 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.738TrpAla: 1.738 ± 0.046
0.137TrpCys: 0.137 ± 0.012
0.796TrpAsp: 0.796 ± 0.027
0.707TrpGlu: 0.707 ± 0.026
0.508TrpPhe: 0.508 ± 0.025
1.034TrpGly: 1.034 ± 0.032
0.34TrpHis: 0.34 ± 0.017
0.461TrpIle: 0.461 ± 0.021
0.236TrpLys: 0.236 ± 0.015
1.885TrpLeu: 1.885 ± 0.036
0.256TrpMet: 0.256 ± 0.016
0.284TrpAsn: 0.284 ± 0.018
0.841TrpPro: 0.841 ± 0.027
0.575TrpGln: 0.575 ± 0.022
1.428TrpArg: 1.428 ± 0.04
0.989TrpSer: 0.989 ± 0.032
1.048TrpThr: 1.048 ± 0.032
1.186TrpVal: 1.186 ± 0.031
0.368TrpTrp: 0.368 ± 0.019
0.288TrpTyr: 0.288 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.32TyrAla: 2.32 ± 0.048
0.151TyrCys: 0.151 ± 0.012
1.373TyrAsp: 1.373 ± 0.037
1.119TyrGlu: 1.119 ± 0.036
0.53TyrPhe: 0.53 ± 0.021
1.832TyrGly: 1.832 ± 0.044
0.29TyrHis: 0.29 ± 0.015
0.415TyrIle: 0.415 ± 0.021
0.268TyrLys: 0.268 ± 0.018
2.035TyrLeu: 2.035 ± 0.041
0.199TyrMet: 0.199 ± 0.014
0.28TyrAsn: 0.28 ± 0.018
0.906TyrPro: 0.906 ± 0.025
0.481TyrGln: 0.481 ± 0.022
1.632TyrArg: 1.632 ± 0.045
0.837TyrSer: 0.837 ± 0.025
0.928TyrThr: 0.928 ± 0.027
1.671TyrVal: 1.671 ± 0.04
0.286TyrTrp: 0.286 ± 0.019
0.358TyrTyr: 0.358 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 3688 proteins (1142701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski