Amino acid dipepetide frequency for Pedobacter cryoconitis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.498AlaAla: 6.498 ± 0.089	0.613AlaCys: 0.613 ± 0.018	4.336AlaAsp: 4.336 ± 0.055	4.575AlaGlu: 4.575 ± 0.059	3.345AlaPhe: 3.345 ± 0.044	5.765AlaGly: 5.765 ± 0.063	1.313AlaHis: 1.313 ± 0.028	5.673AlaIle: 5.673 ± 0.071	4.796AlaLys: 4.796 ± 0.06	6.912AlaLeu: 6.912 ± 0.076	1.707AlaMet: 1.707 ± 0.036	3.627AlaAsn: 3.627 ± 0.052	2.216AlaPro: 2.216 ± 0.037	2.946AlaGln: 2.946 ± 0.049	2.294AlaArg: 2.294 ± 0.038	4.266AlaSer: 4.266 ± 0.057	3.913AlaThr: 3.913 ± 0.068	4.945AlaVal: 4.945 ± 0.065	0.686AlaTrp: 0.686 ± 0.018	3.045AlaTyr: 3.045 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.513CysAla: 0.513 ± 0.02	0.125CysCys: 0.125 ± 0.008	0.365CysAsp: 0.365 ± 0.013	0.379CysGlu: 0.379 ± 0.015	0.434CysPhe: 0.434 ± 0.018	0.583CysGly: 0.583 ± 0.02	0.19CysHis: 0.19 ± 0.011	0.65CysIle: 0.65 ± 0.027	0.54CysLys: 0.54 ± 0.017	0.795CysLeu: 0.795 ± 0.026	0.187CysMet: 0.187 ± 0.01	0.366CysAsn: 0.366 ± 0.016	0.29CysPro: 0.29 ± 0.012	0.251CysGln: 0.251 ± 0.018	0.273CysArg: 0.273 ± 0.012	0.492CysSer: 0.492 ± 0.017	0.44CysThr: 0.44 ± 0.017	0.446CysVal: 0.446 ± 0.018	0.088CysTrp: 0.088 ± 0.008	0.311CysTyr: 0.311 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.606AspAla: 3.606 ± 0.047	0.34AspCys: 0.34 ± 0.015	2.33AspAsp: 2.33 ± 0.042	3.176AspGlu: 3.176 ± 0.049	3.292AspPhe: 3.292 ± 0.05	3.554AspGly: 3.554 ± 0.055	1.124AspHis: 1.124 ± 0.028	3.912AspIle: 3.912 ± 0.052	3.722AspLys: 3.722 ± 0.051	5.292AspLeu: 5.292 ± 0.061	1.088AspMet: 1.088 ± 0.027	2.596AspAsn: 2.596 ± 0.038	2.142AspPro: 2.142 ± 0.035	2.331AspGln: 2.331 ± 0.043	2.032AspArg: 2.032 ± 0.034	2.892AspSer: 2.892 ± 0.046	2.53AspThr: 2.53 ± 0.043	3.133AspVal: 3.133 ± 0.047	0.709AspTrp: 0.709 ± 0.02	2.551AspTyr: 2.551 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.057GluAla: 4.057 ± 0.057	0.325GluCys: 0.325 ± 0.014	2.906GluAsp: 2.906 ± 0.046	4.044GluGlu: 4.044 ± 0.073	2.57GluPhe: 2.57 ± 0.043	3.244GluGly: 3.244 ± 0.05	1.124GluHis: 1.124 ± 0.027	4.762GluIle: 4.762 ± 0.062	4.941GluLys: 4.941 ± 0.062	6.373GluLeu: 6.373 ± 0.093	1.444GluMet: 1.444 ± 0.027	3.554GluAsn: 3.554 ± 0.05	1.475GluPro: 1.475 ± 0.032	2.598GluGln: 2.598 ± 0.055	2.455GluArg: 2.455 ± 0.044	2.954GluSer: 2.954 ± 0.044	3.084GluThr: 3.084 ± 0.037	3.733GluVal: 3.733 ± 0.049	0.624GluTrp: 0.624 ± 0.018	1.989GluTyr: 1.989 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.163PheAla: 3.163 ± 0.046	0.468PheCys: 0.468 ± 0.017	2.944PheAsp: 2.944 ± 0.042	2.874PheGlu: 2.874 ± 0.045	2.5PhePhe: 2.5 ± 0.052	3.263PheGly: 3.263 ± 0.043	0.89PheHis: 0.89 ± 0.023	3.749PheIle: 3.749 ± 0.056	3.526PheLys: 3.526 ± 0.053	4.499PheLeu: 4.499 ± 0.06	1.07PheMet: 1.07 ± 0.023	3.08PheAsn: 3.08 ± 0.046	1.687PhePro: 1.687 ± 0.032	1.441PheGln: 1.441 ± 0.026	1.791PheArg: 1.791 ± 0.035	3.869PheSer: 3.869 ± 0.053	3.035PheThr: 3.035 ± 0.048	2.749PheVal: 2.749 ± 0.046	0.541PheTrp: 0.541 ± 0.018	2.112PheTyr: 2.112 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.536GlyAla: 4.536 ± 0.059	0.599GlyCys: 0.599 ± 0.021	3.19GlyAsp: 3.19 ± 0.048	3.382GlyGlu: 3.382 ± 0.054	3.551GlyPhe: 3.551 ± 0.045	4.697GlyGly: 4.697 ± 0.077	1.231GlyHis: 1.231 ± 0.029	5.501GlyIle: 5.501 ± 0.066	5.288GlyLys: 5.288 ± 0.059	6.418GlyLeu: 6.418 ± 0.051	1.705GlyMet: 1.705 ± 0.037	3.708GlyAsn: 3.708 ± 0.068	1.516GlyPro: 1.516 ± 0.029	2.329GlyGln: 2.329 ± 0.045	2.445GlyArg: 2.445 ± 0.04	4.39GlySer: 4.39 ± 0.062	4.12GlyThr: 4.12 ± 0.085	4.298GlyVal: 4.298 ± 0.061	0.873GlyTrp: 0.873 ± 0.023	3.087GlyTyr: 3.087 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.129HisAla: 1.129 ± 0.028	0.197HisCys: 0.197 ± 0.011	0.856HisAsp: 0.856 ± 0.025	1.011HisGlu: 1.011 ± 0.027	1.099HisPhe: 1.099 ± 0.022	1.109HisGly: 1.109 ± 0.028	0.562HisHis: 0.562 ± 0.021	1.429HisIle: 1.429 ± 0.03	1.076HisLys: 1.076 ± 0.027	1.944HisLeu: 1.944 ± 0.038	0.378HisMet: 0.378 ± 0.014	0.873HisAsn: 0.873 ± 0.026	0.972HisPro: 0.972 ± 0.026	0.953HisGln: 0.953 ± 0.026	0.729HisArg: 0.729 ± 0.02	1.151HisSer: 1.151 ± 0.029	1.055HisThr: 1.055 ± 0.027	0.931HisVal: 0.931 ± 0.022	0.229HisTrp: 0.229 ± 0.013	0.892HisTyr: 0.892 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.127IleAla: 6.127 ± 0.066	0.766IleCys: 0.766 ± 0.023	4.286IleAsp: 4.286 ± 0.056	4.375IleGlu: 4.375 ± 0.058	3.306IlePhe: 3.306 ± 0.055	5.09IleGly: 5.09 ± 0.054	1.367IleHis: 1.367 ± 0.033	5.373IleIle: 5.373 ± 0.075	5.318IleLys: 5.318 ± 0.062	6.901IleLeu: 6.901 ± 0.072	1.351IleMet: 1.351 ± 0.031	4.514IleAsn: 4.514 ± 0.056	3.31IlePro: 3.31 ± 0.05	2.63IleGln: 2.63 ± 0.042	2.931IleArg: 2.931 ± 0.046	5.573IleSer: 5.573 ± 0.056	4.714IleThr: 4.714 ± 0.073	4.373IleVal: 4.373 ± 0.054	0.724IleTrp: 0.724 ± 0.023	2.822IleTyr: 2.822 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	5.12LysAla: 5.12 ± 0.05	0.32LysCys: 0.32 ± 0.014	4.307LysAsp: 4.307 ± 0.051	5.038LysGlu: 5.038 ± 0.069	2.758LysPhe: 2.758 ± 0.041	4.58LysGly: 4.58 ± 0.05	1.319LysHis: 1.319 ± 0.03	5.572LysIle: 5.572 ± 0.07	5.583LysLys: 5.583 ± 0.073	6.441LysLeu: 6.441 ± 0.068	1.88LysMet: 1.88 ± 0.038	4.378LysAsn: 4.378 ± 0.058	2.632LysPro: 2.632 ± 0.044	2.826LysGln: 2.826 ± 0.041	2.742LysArg: 2.742 ± 0.047	4.347LysSer: 4.347 ± 0.058	4.325LysThr: 4.325 ± 0.053	4.53LysVal: 4.53 ± 0.053	0.79LysTrp: 0.79 ± 0.026	2.875LysTyr: 2.875 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	6.943LeuAla: 6.943 ± 0.078	0.851LeuCys: 0.851 ± 0.025	4.795LeuAsp: 4.795 ± 0.058	5.152LeuGlu: 5.152 ± 0.072	4.882LeuPhe: 4.882 ± 0.069	5.788LeuGly: 5.788 ± 0.062	1.742LeuHis: 1.742 ± 0.038	7.385LeuIle: 7.385 ± 0.091	7.922LeuLys: 7.922 ± 0.077	9.976LeuLeu: 9.976 ± 0.12	2.315LeuMet: 2.315 ± 0.039	6.09LeuAsn: 6.09 ± 0.064	4.186LeuPro: 4.186 ± 0.052	3.654LeuGln: 3.654 ± 0.055	3.568LeuArg: 3.568 ± 0.049	7.405LeuSer: 7.405 ± 0.074	5.796LeuThr: 5.796 ± 0.078	5.49LeuVal: 5.49 ± 0.062	0.868LeuTrp: 0.868 ± 0.025	3.349LeuTyr: 3.349 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.758MetAla: 1.758 ± 0.033	0.133MetCys: 0.133 ± 0.008	1.214MetAsp: 1.214 ± 0.03	1.496MetGlu: 1.496 ± 0.032	0.788MetPhe: 0.788 ± 0.022	1.471MetGly: 1.471 ± 0.034	0.43MetHis: 0.43 ± 0.018	1.649MetIle: 1.649 ± 0.034	1.934MetLys: 1.934 ± 0.038	2.19MetLeu: 2.19 ± 0.038	0.591MetMet: 0.591 ± 0.023	1.352MetAsn: 1.352 ± 0.032	0.958MetPro: 0.958 ± 0.024	0.888MetGln: 0.888 ± 0.022	0.909MetArg: 0.909 ± 0.023	1.368MetSer: 1.368 ± 0.033	1.149MetThr: 1.149 ± 0.028	1.404MetVal: 1.404 ± 0.029	0.158MetTrp: 0.158 ± 0.009	0.646MetTyr: 0.646 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.858AsnAla: 3.858 ± 0.05	0.41AsnCys: 0.41 ± 0.018	2.698AsnAsp: 2.698 ± 0.043	3.062AsnGlu: 3.062 ± 0.045	2.745AsnPhe: 2.745 ± 0.051	3.943AsnGly: 3.943 ± 0.059	1.019AsnHis: 1.019 ± 0.024	4.304AsnIle: 4.304 ± 0.052	3.874AsnLys: 3.874 ± 0.051	5.354AsnLeu: 5.354 ± 0.065	1.164AsnMet: 1.164 ± 0.028	3.183AsnAsn: 3.183 ± 0.06	2.725AsnPro: 2.725 ± 0.045	2.288AsnGln: 2.288 ± 0.038	2.187AsnArg: 2.187 ± 0.036	3.552AsnSer: 3.552 ± 0.056	3.441AsnThr: 3.441 ± 0.052	3.036AsnVal: 3.036 ± 0.046	0.7AsnTrp: 0.7 ± 0.023	2.743AsnTyr: 2.743 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.271ProAla: 3.271 ± 0.058	0.204ProCys: 0.204 ± 0.012	2.553ProAsp: 2.553 ± 0.038	2.933ProGlu: 2.933 ± 0.046	1.869ProPhe: 1.869 ± 0.032	2.811ProGly: 2.811 ± 0.04	0.595ProHis: 0.595 ± 0.018	2.33ProIle: 2.33 ± 0.034	2.219ProLys: 2.219 ± 0.037	3.473ProLeu: 3.473 ± 0.051	0.738ProMet: 0.738 ± 0.019	1.738ProAsn: 1.738 ± 0.036	0.907ProPro: 0.907 ± 0.027	1.307ProGln: 1.307 ± 0.026	0.983ProArg: 0.983 ± 0.023	2.154ProSer: 2.154 ± 0.035	1.671ProThr: 1.671 ± 0.034	3.431ProVal: 3.431 ± 0.051	0.37ProTrp: 0.37 ± 0.016	1.482ProTyr: 1.482 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.673GlnAla: 2.673 ± 0.037	0.196GlnCys: 0.196 ± 0.011	1.775GlnAsp: 1.775 ± 0.04	2.302GlnGlu: 2.302 ± 0.05	1.706GlnPhe: 1.706 ± 0.031	2.073GlnGly: 2.073 ± 0.042	0.831GlnHis: 0.831 ± 0.029	2.665GlnIle: 2.665 ± 0.04	2.743GlnLys: 2.743 ± 0.049	4.346GlnLeu: 4.346 ± 0.062	0.901GlnMet: 0.901 ± 0.024	2.014GlnAsn: 2.014 ± 0.038	1.333GlnPro: 1.333 ± 0.033	2.225GlnGln: 2.225 ± 0.058	1.55GlnArg: 1.55 ± 0.035	2.241GlnSer: 2.241 ± 0.037	2.227GlnThr: 2.227 ± 0.036	2.436GlnVal: 2.436 ± 0.044	0.423GlnTrp: 0.423 ± 0.017	1.575GlnTyr: 1.575 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.312ArgAla: 2.312 ± 0.041	0.233ArgCys: 0.233 ± 0.013	1.783ArgAsp: 1.783 ± 0.036	2.157ArgGlu: 2.157 ± 0.043	2.009ArgPhe: 2.009 ± 0.037	2.058ArgGly: 2.058 ± 0.034	0.638ArgHis: 0.638 ± 0.02	3.152ArgIle: 3.152 ± 0.052	2.961ArgLys: 2.961 ± 0.046	3.813ArgLeu: 3.813 ± 0.053	1.009ArgMet: 1.009 ± 0.023	2.191ArgAsn: 2.191 ± 0.04	1.278ArgPro: 1.278 ± 0.028	1.301ArgGln: 1.301 ± 0.029	1.402ArgArg: 1.402 ± 0.032	2.248ArgSer: 2.248 ± 0.037	2.03ArgThr: 2.03 ± 0.034	2.177ArgVal: 2.177 ± 0.034	0.452ArgTrp: 0.452 ± 0.015	1.644ArgTyr: 1.644 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.951SerAla: 4.951 ± 0.058	0.622SerCys: 0.622 ± 0.02	3.043SerAsp: 3.043 ± 0.04	3.063SerGlu: 3.063 ± 0.048	3.788SerPhe: 3.788 ± 0.051	5.232SerGly: 5.232 ± 0.075	1.088SerHis: 1.088 ± 0.023	5.007SerIle: 5.007 ± 0.053	4.16SerLys: 4.16 ± 0.049	6.625SerLeu: 6.625 ± 0.066	1.375SerMet: 1.375 ± 0.03	3.271SerAsn: 3.271 ± 0.05	2.377SerPro: 2.377 ± 0.041	1.998SerGln: 1.998 ± 0.037	2.479SerArg: 2.479 ± 0.037	4.416SerSer: 4.416 ± 0.064	3.578SerThr: 3.578 ± 0.049	4.025SerVal: 4.025 ± 0.047	0.737SerTrp: 0.737 ± 0.024	2.93SerTyr: 2.93 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.893ThrAla: 4.893 ± 0.071	0.341ThrCys: 0.341 ± 0.014	3.175ThrAsp: 3.175 ± 0.04	3.175ThrGlu: 3.175 ± 0.046	2.671ThrPhe: 2.671 ± 0.046	4.784ThrGly: 4.784 ± 0.079	0.993ThrHis: 0.993 ± 0.026	4.436ThrIle: 4.436 ± 0.071	3.362ThrLys: 3.362 ± 0.049	5.477ThrLeu: 5.477 ± 0.056	1.012ThrMet: 1.012 ± 0.024	2.907ThrAsn: 2.907 ± 0.05	2.52ThrPro: 2.52 ± 0.048	1.872ThrGln: 1.872 ± 0.032	1.828ThrArg: 1.828 ± 0.037	3.582ThrSer: 3.582 ± 0.051	3.505ThrThr: 3.505 ± 0.061	4.028ThrVal: 4.028 ± 0.077	0.546ThrTrp: 0.546 ± 0.019	2.424ThrTyr: 2.424 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.539ValAla: 4.539 ± 0.068	0.524ValCys: 0.524 ± 0.016	3.088ValAsp: 3.088 ± 0.044	3.394ValGlu: 3.394 ± 0.047	3.167ValPhe: 3.167 ± 0.046	3.411ValGly: 3.411 ± 0.051	1.044ValHis: 1.044 ± 0.025	4.869ValIle: 4.869 ± 0.06	4.719ValLys: 4.719 ± 0.057	6.13ValLeu: 6.13 ± 0.066	1.477ValMet: 1.477 ± 0.03	3.693ValAsn: 3.693 ± 0.055	2.488ValPro: 2.488 ± 0.044	2.097ValGln: 2.097 ± 0.037	2.11ValArg: 2.11 ± 0.04	4.469ValSer: 4.469 ± 0.065	3.708ValThr: 3.708 ± 0.062	4.007ValVal: 4.007 ± 0.057	0.63ValTrp: 0.63 ± 0.016	2.454ValTyr: 2.454 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.707TrpAla: 0.707 ± 0.023	0.108TrpCys: 0.108 ± 0.008	0.564TrpAsp: 0.564 ± 0.021	0.651TrpGlu: 0.651 ± 0.02	0.548TrpPhe: 0.548 ± 0.019	0.725TrpGly: 0.725 ± 0.019	0.205TrpHis: 0.205 ± 0.011	0.771TrpIle: 0.771 ± 0.023	0.852TrpLys: 0.852 ± 0.024	1.096TrpLeu: 1.096 ± 0.027	0.325TrpMet: 0.325 ± 0.015	0.625TrpAsn: 0.625 ± 0.02	0.307TrpPro: 0.307 ± 0.015	0.45TrpGln: 0.45 ± 0.015	0.426TrpArg: 0.426 ± 0.016	0.668TrpSer: 0.668 ± 0.02	0.565TrpThr: 0.565 ± 0.018	0.635TrpVal: 0.635 ± 0.02	0.166TrpTrp: 0.166 ± 0.009	0.424TrpTyr: 0.424 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.817TyrAla: 2.817 ± 0.04	0.344TyrCys: 0.344 ± 0.014	2.146TyrAsp: 2.146 ± 0.042	2.016TyrGlu: 2.016 ± 0.034	2.222TyrPhe: 2.222 ± 0.037	2.681TyrGly: 2.681 ± 0.05	0.869TyrHis: 0.869 ± 0.023	2.663TyrIle: 2.663 ± 0.047	2.825TyrLys: 2.825 ± 0.041	4.102TyrLeu: 4.102 ± 0.059	0.766TyrMet: 0.766 ± 0.023	2.528TyrAsn: 2.528 ± 0.047	1.724TyrPro: 1.724 ± 0.038	1.855TyrGln: 1.855 ± 0.041	1.713TyrArg: 1.713 ± 0.034	2.726TyrSer: 2.726 ± 0.045	2.645TyrThr: 2.645 ± 0.045	2.209TyrVal: 2.209 ± 0.038	0.506TyrTrp: 0.506 ± 0.019	1.756TyrTyr: 1.756 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4911 proteins (1755082 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---