Amino acid dipepetide frequency for Absidia glauca (Pin mould)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.999AlaAla: 5.999 ± 0.046	0.925AlaCys: 0.925 ± 0.012	3.382AlaAsp: 3.382 ± 0.021	3.059AlaGlu: 3.059 ± 0.021	2.603AlaPhe: 2.603 ± 0.023	3.591AlaGly: 3.591 ± 0.031	1.744AlaHis: 1.744 ± 0.018	3.984AlaIle: 3.984 ± 0.026	3.815AlaLys: 3.815 ± 0.03	6.993AlaLeu: 6.993 ± 0.039	1.938AlaMet: 1.938 ± 0.02	2.916AlaAsn: 2.916 ± 0.02	3.684AlaPro: 3.684 ± 0.035	2.843AlaGln: 2.843 ± 0.023	3.215AlaArg: 3.215 ± 0.02	6.195AlaSer: 6.195 ± 0.036	5.408AlaThr: 5.408 ± 0.033	4.011AlaVal: 4.011 ± 0.032	0.755AlaTrp: 0.755 ± 0.01	2.094AlaTyr: 2.094 ± 0.017	0.003AlaXaa: 0.003 ± 0.001
Cys	0.862CysAla: 0.862 ± 0.013	0.295CysCys: 0.295 ± 0.008	0.759CysAsp: 0.759 ± 0.012	0.542CysGlu: 0.542 ± 0.009	0.62CysPhe: 0.62 ± 0.01	0.971CysGly: 0.971 ± 0.015	0.518CysHis: 0.518 ± 0.01	0.811CysIle: 0.811 ± 0.013	0.653CysLys: 0.653 ± 0.01	1.492CysLeu: 1.492 ± 0.015	0.341CysMet: 0.341 ± 0.006	0.517CysAsn: 0.517 ± 0.009	0.744CysPro: 0.744 ± 0.013	0.637CysGln: 0.637 ± 0.009	0.751CysArg: 0.751 ± 0.011	0.961CysSer: 0.961 ± 0.013	0.79CysThr: 0.79 ± 0.012	0.844CysVal: 0.844 ± 0.011	0.17CysTrp: 0.17 ± 0.005	0.498CysTyr: 0.498 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.862AspAla: 3.862 ± 0.029	0.696AspCys: 0.696 ± 0.012	6.689AspAsp: 6.689 ± 0.068	4.11AspGlu: 4.11 ± 0.036	2.153AspPhe: 2.153 ± 0.018	3.489AspGly: 3.489 ± 0.028	1.913AspHis: 1.913 ± 0.021	3.429AspIle: 3.429 ± 0.025	2.881AspLys: 2.881 ± 0.023	5.63AspLeu: 5.63 ± 0.033	1.644AspMet: 1.644 ± 0.016	2.819AspAsn: 2.819 ± 0.023	3.137AspPro: 3.137 ± 0.028	2.978AspGln: 2.978 ± 0.024	2.926AspArg: 2.926 ± 0.023	4.391AspSer: 4.391 ± 0.03	3.87AspThr: 3.87 ± 0.027	3.243AspVal: 3.243 ± 0.025	0.76AspTrp: 0.76 ± 0.012	2.116AspTyr: 2.116 ± 0.018	0.002AspXaa: 0.002 ± 0.001
Glu	3.559GluAla: 3.559 ± 0.03	0.621GluCys: 0.621 ± 0.01	3.589GluAsp: 3.589 ± 0.028	4.145GluGlu: 4.145 ± 0.042	1.615GluPhe: 1.615 ± 0.02	2.416GluGly: 2.416 ± 0.022	1.423GluHis: 1.423 ± 0.017	2.479GluIle: 2.479 ± 0.023	3.38GluLys: 3.38 ± 0.03	4.683GluLeu: 4.683 ± 0.032	1.382GluMet: 1.382 ± 0.017	2.161GluAsn: 2.161 ± 0.018	1.998GluPro: 1.998 ± 0.022	2.944GluGln: 2.944 ± 0.026	3.037GluArg: 3.037 ± 0.026	3.448GluSer: 3.448 ± 0.022	3.188GluThr: 3.188 ± 0.026	2.475GluVal: 2.475 ± 0.025	0.747GluTrp: 0.747 ± 0.01	1.53GluTyr: 1.53 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.54PheAla: 2.54 ± 0.021	0.649PheCys: 0.649 ± 0.012	2.502PheAsp: 2.502 ± 0.022	1.949PheGlu: 1.949 ± 0.02	1.682PhePhe: 1.682 ± 0.022	2.656PheGly: 2.656 ± 0.027	0.897PheHis: 0.897 ± 0.012	1.914PheIle: 1.914 ± 0.018	1.769PheLys: 1.769 ± 0.014	3.379PheLeu: 3.379 ± 0.025	0.994PheMet: 0.994 ± 0.013	1.473PheAsn: 1.473 ± 0.015	1.651PhePro: 1.651 ± 0.019	1.386PheGln: 1.386 ± 0.015	1.586PheArg: 1.586 ± 0.016	2.89PheSer: 2.89 ± 0.022	2.192PheThr: 2.192 ± 0.021	2.484PheVal: 2.484 ± 0.022	0.526PheTrp: 0.526 ± 0.009	1.398PheTyr: 1.398 ± 0.017	0.001PheXaa: 0.001 ± 0.0
Gly	3.657GlyAla: 3.657 ± 0.031	0.815GlyCys: 0.815 ± 0.013	3.285GlyAsp: 3.285 ± 0.027	2.336GlyGlu: 2.336 ± 0.021	2.328GlyPhe: 2.328 ± 0.023	4.169GlyGly: 4.169 ± 0.048	1.546GlyHis: 1.546 ± 0.015	3.043GlyIle: 3.043 ± 0.022	3.121GlyLys: 3.121 ± 0.025	4.897GlyLeu: 4.897 ± 0.027	1.359GlyMet: 1.359 ± 0.015	2.549GlyAsn: 2.549 ± 0.02	2.076GlyPro: 2.076 ± 0.018	2.229GlyGln: 2.229 ± 0.02	2.784GlyArg: 2.784 ± 0.025	4.52GlySer: 4.52 ± 0.031	3.318GlyThr: 3.318 ± 0.025	3.314GlyVal: 3.314 ± 0.029	0.779GlyTrp: 0.779 ± 0.012	1.993GlyTyr: 1.993 ± 0.02	0.001GlyXaa: 0.001 ± 0.0
His	1.693HisAla: 1.693 ± 0.018	0.46HisCys: 0.46 ± 0.009	1.729HisAsp: 1.729 ± 0.017	1.21HisGlu: 1.21 ± 0.015	1.119HisPhe: 1.119 ± 0.015	1.652HisGly: 1.652 ± 0.017	2.072HisHis: 2.072 ± 0.032	1.524HisIle: 1.524 ± 0.014	1.142HisLys: 1.142 ± 0.016	2.932HisLeu: 2.932 ± 0.023	0.625HisMet: 0.625 ± 0.01	1.094HisAsn: 1.094 ± 0.014	1.994HisPro: 1.994 ± 0.018	2.135HisGln: 2.135 ± 0.022	1.852HisArg: 1.852 ± 0.021	2.447HisSer: 2.447 ± 0.022	1.736HisThr: 1.736 ± 0.019	1.546HisVal: 1.546 ± 0.016	0.385HisTrp: 0.385 ± 0.008	1.184HisTyr: 1.184 ± 0.014	0.001HisXaa: 0.001 ± 0.0
Ile	3.369IleAla: 3.369 ± 0.03	0.809IleCys: 0.809 ± 0.01	3.244IleAsp: 3.244 ± 0.022	2.576IleGlu: 2.576 ± 0.025	1.831IlePhe: 1.831 ± 0.02	2.954IleGly: 2.954 ± 0.024	1.601IleHis: 1.601 ± 0.016	2.653IleIle: 2.653 ± 0.024	3.042IleLys: 3.042 ± 0.022	4.812IleLeu: 4.812 ± 0.035	1.284IleMet: 1.284 ± 0.014	2.393IleAsn: 2.393 ± 0.021	3.022IlePro: 3.022 ± 0.024	2.602IleGln: 2.602 ± 0.021	2.803IleArg: 2.803 ± 0.021	3.916IleSer: 3.916 ± 0.023	3.121IleThr: 3.121 ± 0.027	3.091IleVal: 3.091 ± 0.024	0.605IleTrp: 0.605 ± 0.01	1.682IleTyr: 1.682 ± 0.015	0.001IleXaa: 0.001 ± 0.0
Lys	3.879LysAla: 3.879 ± 0.027	0.62LysCys: 0.62 ± 0.01	3.308LysAsp: 3.308 ± 0.028	3.348LysGlu: 3.348 ± 0.03	1.4LysPhe: 1.4 ± 0.017	2.467LysGly: 2.467 ± 0.02	1.477LysHis: 1.477 ± 0.016	2.486LysIle: 2.486 ± 0.019	4.395LysLys: 4.395 ± 0.042	4.506LysLeu: 4.506 ± 0.03	1.272LysMet: 1.272 ± 0.014	2.245LysAsn: 2.245 ± 0.019	2.547LysPro: 2.547 ± 0.023	2.824LysGln: 2.824 ± 0.024	3.636LysArg: 3.636 ± 0.026	3.869LysSer: 3.869 ± 0.025	3.332LysThr: 3.332 ± 0.028	3.259LysVal: 3.259 ± 0.026	0.621LysTrp: 0.621 ± 0.011	1.654LysTyr: 1.654 ± 0.014	0.002LysXaa: 0.002 ± 0.001
Leu	7.035LeuAla: 7.035 ± 0.039	1.505LeuCys: 1.505 ± 0.016	6.191LeuAsp: 6.191 ± 0.033	5.185LeuGlu: 5.185 ± 0.036	3.679LeuPhe: 3.679 ± 0.031	4.971LeuGly: 4.971 ± 0.029	2.607LeuHis: 2.607 ± 0.022	4.273LeuIle: 4.273 ± 0.03	4.778LeuLys: 4.778 ± 0.031	9.242LeuLeu: 9.242 ± 0.052	2.265LeuMet: 2.265 ± 0.02	3.61LeuAsn: 3.61 ± 0.021	5.474LeuPro: 5.474 ± 0.032	4.493LeuGln: 4.493 ± 0.029	4.549LeuArg: 4.549 ± 0.03	7.677LeuSer: 7.677 ± 0.038	5.648LeuThr: 5.648 ± 0.029	5.922LeuVal: 5.922 ± 0.034	1.099LeuTrp: 1.099 ± 0.015	2.976LeuTyr: 2.976 ± 0.023	0.002LeuXaa: 0.002 ± 0.001
Met	2.406MetAla: 2.406 ± 0.021	0.261MetCys: 0.261 ± 0.007	2.161MetAsp: 2.161 ± 0.019	1.756MetGlu: 1.756 ± 0.017	0.774MetPhe: 0.774 ± 0.012	1.308MetGly: 1.308 ± 0.014	0.604MetHis: 0.604 ± 0.01	1.385MetIle: 1.385 ± 0.016	1.351MetLys: 1.351 ± 0.017	1.947MetLeu: 1.947 ± 0.021	0.951MetMet: 0.951 ± 0.013	1.178MetAsn: 1.178 ± 0.013	1.095MetPro: 1.095 ± 0.015	0.957MetGln: 0.957 ± 0.013	0.994MetArg: 0.994 ± 0.015	1.69MetSer: 1.69 ± 0.017	1.811MetThr: 1.811 ± 0.017	1.789MetVal: 1.789 ± 0.018	0.221MetTrp: 0.221 ± 0.006	0.746MetTyr: 0.746 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	2.887AsnAla: 2.887 ± 0.024	0.539AsnCys: 0.539 ± 0.01	3.267AsnAsp: 3.267 ± 0.029	2.287AsnGlu: 2.287 ± 0.023	1.271AsnPhe: 1.271 ± 0.016	2.881AsnGly: 2.881 ± 0.024	1.293AsnHis: 1.293 ± 0.014	2.202AsnIle: 2.202 ± 0.019	2.485AsnLys: 2.485 ± 0.023	3.365AsnLeu: 3.365 ± 0.025	1.077AsnMet: 1.077 ± 0.012	2.907AsnAsn: 2.907 ± 0.032	2.211AsnPro: 2.211 ± 0.019	1.954AsnGln: 1.954 ± 0.018	1.994AsnArg: 1.994 ± 0.016	3.273AsnSer: 3.273 ± 0.027	2.911AsnThr: 2.911 ± 0.024	2.629AsnVal: 2.629 ± 0.024	0.485AsnTrp: 0.485 ± 0.01	1.308AsnTyr: 1.308 ± 0.017	0.001AsnXaa: 0.001 ± 0.0
Pro	3.831ProAla: 3.831 ± 0.03	0.63ProCys: 0.63 ± 0.011	2.731ProAsp: 2.731 ± 0.02	2.395ProGlu: 2.395 ± 0.021	2.071ProPhe: 2.071 ± 0.021	2.53ProGly: 2.53 ± 0.022	1.545ProHis: 1.545 ± 0.017	2.745ProIle: 2.745 ± 0.022	2.318ProLys: 2.318 ± 0.022	5.211ProLeu: 5.211 ± 0.033	1.262ProMet: 1.262 ± 0.016	1.98ProAsn: 1.98 ± 0.021	5.568ProPro: 5.568 ± 0.06	2.32ProGln: 2.32 ± 0.025	2.491ProArg: 2.491 ± 0.022	6.865ProSer: 6.865 ± 0.053	4.672ProThr: 4.672 ± 0.03	3.009ProVal: 3.009 ± 0.027	0.57ProTrp: 0.57 ± 0.01	1.601ProTyr: 1.601 ± 0.017	0.003ProXaa: 0.003 ± 0.001
Gln	3.227GlnAla: 3.227 ± 0.027	0.642GlnCys: 0.642 ± 0.011	2.741GlnAsp: 2.741 ± 0.022	2.677GlnGlu: 2.677 ± 0.024	1.407GlnPhe: 1.407 ± 0.015	2.291GlnGly: 2.291 ± 0.023	2.364GlnHis: 2.364 ± 0.023	1.958GlnIle: 1.958 ± 0.019	2.381GlnLys: 2.381 ± 0.022	4.662GlnLeu: 4.662 ± 0.031	1.049GlnMet: 1.049 ± 0.014	1.55GlnAsn: 1.55 ± 0.016	2.95GlnPro: 2.95 ± 0.026	7.733GlnGln: 7.733 ± 0.125	3.071GlnArg: 3.071 ± 0.026	3.403GlnSer: 3.403 ± 0.023	2.432GlnThr: 2.432 ± 0.021	2.827GlnVal: 2.827 ± 0.024	0.67GlnTrp: 0.67 ± 0.011	1.476GlnTyr: 1.476 ± 0.017	0.002GlnXaa: 0.002 ± 0.001
Arg	2.919ArgAla: 2.919 ± 0.023	0.714ArgCys: 0.714 ± 0.011	2.362ArgAsp: 2.362 ± 0.017	2.242ArgGlu: 2.242 ± 0.022	2.047ArgPhe: 2.047 ± 0.02	2.344ArgGly: 2.344 ± 0.022	1.953ArgHis: 1.953 ± 0.02	2.638ArgIle: 2.638 ± 0.022	3.098ArgLys: 3.098 ± 0.026	5.351ArgLeu: 5.351 ± 0.032	1.319ArgMet: 1.319 ± 0.015	2.122ArgAsn: 2.122 ± 0.02	2.745ArgPro: 2.745 ± 0.023	3.185ArgGln: 3.185 ± 0.025	4.235ArgArg: 4.235 ± 0.037	4.34ArgSer: 4.34 ± 0.033	3.0ArgThr: 3.0 ± 0.02	2.483ArgVal: 2.483 ± 0.022	0.759ArgTrp: 0.759 ± 0.012	1.771ArgTyr: 1.771 ± 0.017	0.001ArgXaa: 0.001 ± 0.0
Ser	5.547SerAla: 5.547 ± 0.033	1.017SerCys: 1.017 ± 0.014	4.466SerAsp: 4.466 ± 0.032	2.944SerGlu: 2.944 ± 0.024	3.272SerPhe: 3.272 ± 0.027	4.231SerGly: 4.231 ± 0.029	2.262SerHis: 2.262 ± 0.017	4.482SerIle: 4.482 ± 0.023	3.866SerLys: 3.866 ± 0.026	7.956SerLeu: 7.956 ± 0.038	2.097SerMet: 2.097 ± 0.019	4.0SerAsn: 4.0 ± 0.029	5.999SerPro: 5.999 ± 0.048	3.189SerGln: 3.189 ± 0.023	3.806SerArg: 3.806 ± 0.026	12.683SerSer: 12.683 ± 0.11	7.144SerThr: 7.144 ± 0.046	4.42SerVal: 4.42 ± 0.028	0.901SerTrp: 0.901 ± 0.011	2.347SerTyr: 2.347 ± 0.021	0.001SerXaa: 0.001 ± 0.001
Thr	4.804ThrAla: 4.804 ± 0.032	0.871ThrCys: 0.871 ± 0.013	3.498ThrAsp: 3.498 ± 0.023	2.802ThrGlu: 2.802 ± 0.025	2.456ThrPhe: 2.456 ± 0.021	3.44ThrGly: 3.44 ± 0.026	1.818ThrHis: 1.818 ± 0.017	3.783ThrIle: 3.783 ± 0.024	3.41ThrLys: 3.41 ± 0.028	6.345ThrLeu: 6.345 ± 0.031	1.81ThrMet: 1.81 ± 0.016	3.139ThrAsn: 3.139 ± 0.027	4.461ThrPro: 4.461 ± 0.03	2.518ThrGln: 2.518 ± 0.023	2.813ThrArg: 2.813 ± 0.021	6.466ThrSer: 6.466 ± 0.044	7.122ThrThr: 7.122 ± 0.061	3.667ThrVal: 3.667 ± 0.026	0.755ThrTrp: 0.755 ± 0.012	1.808ThrTyr: 1.808 ± 0.018	0.002ThrXaa: 0.002 ± 0.001
Val	4.352ValAla: 4.352 ± 0.032	0.942ValCys: 0.942 ± 0.013	4.058ValAsp: 4.058 ± 0.029	3.151ValGlu: 3.151 ± 0.027	2.349ValPhe: 2.349 ± 0.022	3.168ValGly: 3.168 ± 0.028	1.389ValHis: 1.389 ± 0.016	3.256ValIle: 3.256 ± 0.028	3.078ValLys: 3.078 ± 0.024	5.386ValLeu: 5.386 ± 0.034	1.565ValMet: 1.565 ± 0.015	2.458ValAsn: 2.458 ± 0.021	2.977ValPro: 2.977 ± 0.022	2.246ValGln: 2.246 ± 0.021	2.627ValArg: 2.627 ± 0.022	4.303ValSer: 4.303 ± 0.03	3.408ValThr: 3.408 ± 0.03	4.139ValVal: 4.139 ± 0.034	0.701ValTrp: 0.701 ± 0.012	1.954ValTyr: 1.954 ± 0.02	0.002ValXaa: 0.002 ± 0.001
Trp	0.748TrpAla: 0.748 ± 0.011	0.206TrpCys: 0.206 ± 0.006	0.708TrpAsp: 0.708 ± 0.012	0.565TrpGlu: 0.565 ± 0.011	0.508TrpPhe: 0.508 ± 0.01	0.562TrpGly: 0.562 ± 0.011	0.365TrpHis: 0.365 ± 0.008	0.767TrpIle: 0.767 ± 0.011	0.742TrpLys: 0.742 ± 0.011	1.139TrpLeu: 1.139 ± 0.014	0.384TrpMet: 0.384 ± 0.008	0.651TrpAsn: 0.651 ± 0.01	0.429TrpPro: 0.429 ± 0.008	0.597TrpGln: 0.597 ± 0.01	0.705TrpArg: 0.705 ± 0.011	0.965TrpSer: 0.965 ± 0.013	0.832TrpThr: 0.832 ± 0.011	0.635TrpVal: 0.635 ± 0.01	0.213TrpTrp: 0.213 ± 0.006	0.405TrpTyr: 0.405 ± 0.009	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.982TyrAla: 1.982 ± 0.018	0.555TyrCys: 0.555 ± 0.01	2.066TyrAsp: 2.066 ± 0.019	1.537TyrGlu: 1.537 ± 0.016	1.335TyrPhe: 1.335 ± 0.016	2.024TyrGly: 2.024 ± 0.018	1.143TyrHis: 1.143 ± 0.014	1.594TyrIle: 1.594 ± 0.018	1.442TyrLys: 1.442 ± 0.015	3.251TyrLeu: 3.251 ± 0.024	0.767TyrMet: 0.767 ± 0.012	1.466TyrAsn: 1.466 ± 0.017	1.584TyrPro: 1.584 ± 0.02	1.739TyrGln: 1.739 ± 0.018	1.753TyrArg: 1.753 ± 0.018	2.327TyrSer: 2.327 ± 0.019	1.85TyrThr: 1.85 ± 0.02	1.721TyrVal: 1.721 ± 0.017	0.404TyrTrp: 0.404 ± 0.009	1.282TyrTyr: 1.282 ± 0.016	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.001XaaArg: 0.001 ± 0.0	0.002XaaSer: 0.002 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.002XaaVal: 0.002 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.586XaaXaa: 0.586 ± 0.089

Statistics based on 14825 proteins (6549974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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