Amino acid dipepetide frequency for Kitasatospora sp. OK780

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	26.442AlaAla: 26.442 ± 0.207	1.106AlaCys: 1.106 ± 0.023	9.293AlaAsp: 9.293 ± 0.066	9.033AlaGlu: 9.033 ± 0.089	3.638AlaPhe: 3.638 ± 0.039	15.022AlaGly: 15.022 ± 0.092	2.913AlaHis: 2.913 ± 0.032	3.314AlaIle: 3.314 ± 0.041	2.518AlaLys: 2.518 ± 0.044	15.483AlaLeu: 15.483 ± 0.109	2.432AlaMet: 2.432 ± 0.035	2.017AlaAsn: 2.017 ± 0.032	8.198AlaPro: 8.198 ± 0.087	3.938AlaGln: 3.938 ± 0.042	10.606AlaArg: 10.606 ± 0.088	5.711AlaSer: 5.711 ± 0.051	7.469AlaThr: 7.469 ± 0.064	13.667AlaVal: 13.667 ± 0.088	2.005AlaTrp: 2.005 ± 0.031	2.602AlaTyr: 2.602 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.1CysAla: 1.1 ± 0.022	0.107CysCys: 0.107 ± 0.007	0.455CysAsp: 0.455 ± 0.014	0.336CysGlu: 0.336 ± 0.012	0.217CysPhe: 0.217 ± 0.01	0.953CysGly: 0.953 ± 0.023	0.204CysHis: 0.204 ± 0.011	0.18CysIle: 0.18 ± 0.008	0.09CysLys: 0.09 ± 0.006	0.818CysLeu: 0.818 ± 0.019	0.12CysMet: 0.12 ± 0.007	0.145CysAsn: 0.145 ± 0.009	0.544CysPro: 0.544 ± 0.016	0.162CysGln: 0.162 ± 0.008	0.623CysArg: 0.623 ± 0.016	0.489CysSer: 0.489 ± 0.015	0.601CysThr: 0.601 ± 0.017	0.545CysVal: 0.545 ± 0.015	0.144CysTrp: 0.144 ± 0.008	0.165CysTyr: 0.165 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.579AspAla: 7.579 ± 0.064	0.445AspCys: 0.445 ± 0.015	3.25AspAsp: 3.25 ± 0.041	3.437AspGlu: 3.437 ± 0.044	1.563AspPhe: 1.563 ± 0.025	6.736AspGly: 6.736 ± 0.052	1.451AspHis: 1.451 ± 0.027	1.58AspIle: 1.58 ± 0.03	0.875AspLys: 0.875 ± 0.025	6.615AspLeu: 6.615 ± 0.054	0.668AspMet: 0.668 ± 0.017	0.917AspAsn: 0.917 ± 0.022	4.61AspPro: 4.61 ± 0.043	1.499AspGln: 1.499 ± 0.028	5.197AspArg: 5.197 ± 0.055	2.323AspSer: 2.323 ± 0.034	3.26AspThr: 3.26 ± 0.037	4.23AspVal: 4.23 ± 0.041	0.995AspTrp: 0.995 ± 0.022	1.067AspTyr: 1.067 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.914GluAla: 6.914 ± 0.075	0.331GluCys: 0.331 ± 0.011	2.493GluAsp: 2.493 ± 0.035	2.877GluGlu: 2.877 ± 0.042	1.348GluPhe: 1.348 ± 0.027	3.628GluGly: 3.628 ± 0.052	1.518GluHis: 1.518 ± 0.026	2.071GluIle: 2.071 ± 0.032	0.992GluLys: 0.992 ± 0.023	6.54GluLeu: 6.54 ± 0.07	0.717GluMet: 0.717 ± 0.02	0.876GluAsn: 0.876 ± 0.018	3.213GluPro: 3.213 ± 0.041	2.36GluGln: 2.36 ± 0.035	5.012GluArg: 5.012 ± 0.051	2.245GluSer: 2.245 ± 0.031	2.408GluThr: 2.408 ± 0.036	4.171GluVal: 4.171 ± 0.057	0.66GluTrp: 0.66 ± 0.015	0.976GluTyr: 0.976 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.737PheAla: 3.737 ± 0.046	0.284PheCys: 0.284 ± 0.012	1.883PheAsp: 1.883 ± 0.029	1.285PheGlu: 1.285 ± 0.025	0.801PhePhe: 0.801 ± 0.023	3.007PheGly: 3.007 ± 0.042	0.625PheHis: 0.625 ± 0.016	0.586PheIle: 0.586 ± 0.015	0.436PheLys: 0.436 ± 0.013	2.48PheLeu: 2.48 ± 0.038	0.342PheMet: 0.342 ± 0.011	0.547PheAsn: 0.547 ± 0.019	1.376PhePro: 1.376 ± 0.025	0.67PheGln: 0.67 ± 0.018	1.793PheArg: 1.793 ± 0.027	1.306PheSer: 1.306 ± 0.026	1.973PheThr: 1.973 ± 0.029	2.068PheVal: 2.068 ± 0.03	0.415PheTrp: 0.415 ± 0.014	0.532PheTyr: 0.532 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	12.028GlyAla: 12.028 ± 0.098	0.886GlyCys: 0.886 ± 0.019	4.943GlyAsp: 4.943 ± 0.046	4.58GlyGlu: 4.58 ± 0.048	2.815GlyPhe: 2.815 ± 0.033	9.343GlyGly: 9.343 ± 0.101	2.439GlyHis: 2.439 ± 0.031	3.304GlyIle: 3.304 ± 0.044	1.908GlyLys: 1.908 ± 0.031	10.123GlyLeu: 10.123 ± 0.08	1.942GlyMet: 1.942 ± 0.03	1.751GlyAsn: 1.751 ± 0.034	6.077GlyPro: 6.077 ± 0.063	2.715GlyGln: 2.715 ± 0.044	8.706GlyArg: 8.706 ± 0.078	5.639GlySer: 5.639 ± 0.055	6.689GlyThr: 6.689 ± 0.073	7.299GlyVal: 7.299 ± 0.064	1.845GlyTrp: 1.845 ± 0.029	2.37GlyTyr: 2.37 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.728HisAla: 2.728 ± 0.038	0.226HisCys: 0.226 ± 0.009	1.286HisAsp: 1.286 ± 0.025	1.057HisGlu: 1.057 ± 0.018	0.606HisPhe: 0.606 ± 0.015	2.553HisGly: 2.553 ± 0.035	0.726HisHis: 0.726 ± 0.019	0.57HisIle: 0.57 ± 0.016	0.276HisLys: 0.276 ± 0.013	2.66HisLeu: 2.66 ± 0.035	0.297HisMet: 0.297 ± 0.012	0.384HisAsn: 0.384 ± 0.014	1.957HisPro: 1.957 ± 0.03	0.663HisGln: 0.663 ± 0.018	2.454HisArg: 2.454 ± 0.035	0.972HisSer: 0.972 ± 0.02	1.306HisThr: 1.306 ± 0.022	1.602HisVal: 1.602 ± 0.027	0.42HisTrp: 0.42 ± 0.012	0.473HisTyr: 0.473 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.64IleAla: 4.64 ± 0.048	0.277IleCys: 0.277 ± 0.011	2.078IleAsp: 2.078 ± 0.033	1.714IleGlu: 1.714 ± 0.03	0.61IlePhe: 0.61 ± 0.018	3.536IleGly: 3.536 ± 0.037	0.591IleHis: 0.591 ± 0.015	0.733IleIle: 0.733 ± 0.022	0.591IleLys: 0.591 ± 0.018	2.254IleLeu: 2.254 ± 0.035	0.384IleMet: 0.384 ± 0.013	0.646IleAsn: 0.646 ± 0.017	1.69IlePro: 1.69 ± 0.028	0.664IleGln: 0.664 ± 0.018	2.15IleArg: 2.15 ± 0.029	1.519IleSer: 1.519 ± 0.026	2.116IleThr: 2.116 ± 0.03	2.477IleVal: 2.477 ± 0.032	0.37IleTrp: 0.37 ± 0.013	0.459IleTyr: 0.459 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.536LysAla: 2.536 ± 0.047	0.087LysCys: 0.087 ± 0.007	1.043LysAsp: 1.043 ± 0.026	0.869LysGlu: 0.869 ± 0.022	0.368LysPhe: 0.368 ± 0.014	1.43LysGly: 1.43 ± 0.028	0.363LysHis: 0.363 ± 0.013	0.717LysIle: 0.717 ± 0.021	0.53LysLys: 0.53 ± 0.021	1.591LysLeu: 1.591 ± 0.031	0.275LysMet: 0.275 ± 0.013	0.403LysAsn: 0.403 ± 0.015	1.095LysPro: 1.095 ± 0.023	0.601LysGln: 0.601 ± 0.018	1.129LysArg: 1.129 ± 0.024	0.923LysSer: 0.923 ± 0.024	1.024LysThr: 1.024 ± 0.022	1.572LysVal: 1.572 ± 0.034	0.204LysTrp: 0.204 ± 0.011	0.38LysTyr: 0.38 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	17.028LeuAla: 17.028 ± 0.122	0.845LeuCys: 0.845 ± 0.02	6.789LeuAsp: 6.789 ± 0.059	4.321LeuGlu: 4.321 ± 0.055	2.543LeuPhe: 2.543 ± 0.035	9.807LeuGly: 9.807 ± 0.074	2.463LeuHis: 2.463 ± 0.034	3.089LeuIle: 3.089 ± 0.045	1.667LeuLys: 1.667 ± 0.031	12.163LeuLeu: 12.163 ± 0.109	1.5LeuMet: 1.5 ± 0.024	1.614LeuAsn: 1.614 ± 0.031	7.1LeuPro: 7.1 ± 0.06	2.427LeuGln: 2.427 ± 0.033	8.85LeuArg: 8.85 ± 0.08	4.941LeuSer: 4.941 ± 0.055	6.897LeuThr: 6.897 ± 0.053	9.077LeuVal: 9.077 ± 0.066	1.333LeuTrp: 1.333 ± 0.026	1.745LeuTyr: 1.745 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.204MetAla: 2.204 ± 0.033	0.119MetCys: 0.119 ± 0.007	0.778MetAsp: 0.778 ± 0.017	0.602MetGlu: 0.602 ± 0.018	0.408MetPhe: 0.408 ± 0.015	1.169MetGly: 1.169 ± 0.025	0.355MetHis: 0.355 ± 0.011	0.57MetIle: 0.57 ± 0.016	0.319MetLys: 0.319 ± 0.01	1.592MetLeu: 1.592 ± 0.028	0.247MetMet: 0.247 ± 0.01	0.393MetAsn: 0.393 ± 0.013	1.106MetPro: 1.106 ± 0.022	0.417MetGln: 0.417 ± 0.015	1.229MetArg: 1.229 ± 0.021	1.193MetSer: 1.193 ± 0.021	1.453MetThr: 1.453 ± 0.023	1.193MetVal: 1.193 ± 0.024	0.171MetTrp: 0.171 ± 0.008	0.27MetTyr: 0.27 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.2AsnAla: 2.2 ± 0.031	0.16AsnCys: 0.16 ± 0.009	0.863AsnAsp: 0.863 ± 0.021	0.712AsnGlu: 0.712 ± 0.016	0.465AsnPhe: 0.465 ± 0.014	1.944AsnGly: 1.944 ± 0.04	0.392AsnHis: 0.392 ± 0.011	0.56AsnIle: 0.56 ± 0.017	0.294AsnLys: 0.294 ± 0.012	1.718AsnLeu: 1.718 ± 0.029	0.247AsnMet: 0.247 ± 0.01	0.418AsnAsn: 0.418 ± 0.015	1.349AsnPro: 1.349 ± 0.028	0.508AsnGln: 0.508 ± 0.017	1.241AsnArg: 1.241 ± 0.024	0.917AsnSer: 0.917 ± 0.023	1.148AsnThr: 1.148 ± 0.03	1.25AsnVal: 1.25 ± 0.024	0.273AsnTrp: 0.273 ± 0.013	0.389AsnTyr: 0.389 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.954ProAla: 10.954 ± 0.1	0.373ProCys: 0.373 ± 0.012	4.601ProAsp: 4.601 ± 0.048	3.969ProGlu: 3.969 ± 0.046	1.54ProPhe: 1.54 ± 0.026	7.364ProGly: 7.364 ± 0.065	1.381ProHis: 1.381 ± 0.027	1.357ProIle: 1.357 ± 0.023	0.989ProLys: 0.989 ± 0.023	5.513ProLeu: 5.513 ± 0.053	0.964ProMet: 0.964 ± 0.021	0.925ProAsn: 0.925 ± 0.021	3.827ProPro: 3.827 ± 0.064	1.977ProGln: 1.977 ± 0.034	3.885ProArg: 3.885 ± 0.041	3.265ProSer: 3.265 ± 0.046	3.476ProThr: 3.476 ± 0.041	5.789ProVal: 5.789 ± 0.054	0.942ProTrp: 0.942 ± 0.02	1.38ProTyr: 1.38 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.132GlnAla: 4.132 ± 0.047	0.17GlnCys: 0.17 ± 0.008	1.451GlnAsp: 1.451 ± 0.025	1.318GlnGlu: 1.318 ± 0.025	0.648GlnPhe: 0.648 ± 0.016	2.267GlnGly: 2.267 ± 0.034	0.702GlnHis: 0.702 ± 0.016	1.028GlnIle: 1.028 ± 0.023	0.52GlnLys: 0.52 ± 0.017	3.214GlnLeu: 3.214 ± 0.039	0.427GlnMet: 0.427 ± 0.014	0.512GlnAsn: 0.512 ± 0.014	1.85GlnPro: 1.85 ± 0.033	1.476GlnGln: 1.476 ± 0.041	2.363GlnArg: 2.363 ± 0.037	1.317GlnSer: 1.317 ± 0.025	1.347GlnThr: 1.347 ± 0.029	2.524GlnVal: 2.524 ± 0.031	0.487GlnTrp: 0.487 ± 0.016	0.622GlnTyr: 0.622 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.421ArgAla: 10.421 ± 0.088	0.628ArgCys: 0.628 ± 0.018	3.889ArgAsp: 3.889 ± 0.041	4.222ArgGlu: 4.222 ± 0.049	2.176ArgPhe: 2.176 ± 0.03	5.66ArgGly: 5.66 ± 0.054	2.19ArgHis: 2.19 ± 0.031	3.421ArgIle: 3.421 ± 0.042	1.308ArgLys: 1.308 ± 0.026	9.303ArgLeu: 9.303 ± 0.089	1.676ArgMet: 1.676 ± 0.03	1.28ArgAsn: 1.28 ± 0.025	5.723ArgPro: 5.723 ± 0.066	2.298ArgGln: 2.298 ± 0.036	8.28ArgArg: 8.28 ± 0.083	4.221ArgSer: 4.221 ± 0.046	5.601ArgThr: 5.601 ± 0.055	5.429ArgVal: 5.429 ± 0.047	1.485ArgTrp: 1.485 ± 0.026	1.782ArgTyr: 1.782 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	7.067SerAla: 7.067 ± 0.066	0.438SerCys: 0.438 ± 0.014	2.465SerAsp: 2.465 ± 0.031	2.016SerGlu: 2.016 ± 0.034	1.45SerPhe: 1.45 ± 0.024	5.864SerGly: 5.864 ± 0.061	0.963SerHis: 0.963 ± 0.022	1.376SerIle: 1.376 ± 0.026	0.824SerLys: 0.824 ± 0.021	4.459SerLeu: 4.459 ± 0.041	0.947SerMet: 0.947 ± 0.018	0.859SerAsn: 0.859 ± 0.022	3.193SerPro: 3.193 ± 0.044	1.181SerGln: 1.181 ± 0.026	3.423SerArg: 3.423 ± 0.041	2.74SerSer: 2.74 ± 0.043	3.104SerThr: 3.104 ± 0.039	3.997SerVal: 3.997 ± 0.039	0.904SerTrp: 0.904 ± 0.021	1.132SerTyr: 1.132 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	10.225ThrAla: 10.225 ± 0.077	0.446ThrCys: 0.446 ± 0.014	3.648ThrAsp: 3.648 ± 0.044	2.888ThrGlu: 2.888 ± 0.033	1.503ThrPhe: 1.503 ± 0.027	7.159ThrGly: 7.159 ± 0.075	1.078ThrHis: 1.078 ± 0.021	1.553ThrIle: 1.553 ± 0.03	0.932ThrLys: 0.932 ± 0.022	5.556ThrLeu: 5.556 ± 0.053	0.857ThrMet: 0.857 ± 0.019	0.948ThrAsn: 0.948 ± 0.021	4.164ThrPro: 4.164 ± 0.044	1.234ThrGln: 1.234 ± 0.028	3.757ThrArg: 3.757 ± 0.039	2.9ThrSer: 2.9 ± 0.043	3.981ThrThr: 3.981 ± 0.06	6.52ThrVal: 6.52 ± 0.057	0.913ThrTrp: 0.913 ± 0.02	1.149ThrTyr: 1.149 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.107ValAla: 11.107 ± 0.076	0.732ValCys: 0.732 ± 0.019	4.943ValAsp: 4.943 ± 0.048	4.429ValGlu: 4.429 ± 0.053	2.324ValPhe: 2.324 ± 0.035	6.725ValGly: 6.725 ± 0.054	2.086ValHis: 2.086 ± 0.033	2.536ValIle: 2.536 ± 0.035	1.454ValLys: 1.454 ± 0.028	10.063ValLeu: 10.063 ± 0.083	1.258ValMet: 1.258 ± 0.023	1.614ValAsn: 1.614 ± 0.026	5.447ValPro: 5.447 ± 0.048	2.224ValGln: 2.224 ± 0.03	7.013ValArg: 7.013 ± 0.058	3.931ValSer: 3.931 ± 0.047	5.335ValThr: 5.335 ± 0.048	7.869ValVal: 7.869 ± 0.076	1.087ValTrp: 1.087 ± 0.022	1.513ValTyr: 1.513 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.798TrpAla: 1.798 ± 0.027	0.163TrpCys: 0.163 ± 0.007	0.81TrpAsp: 0.81 ± 0.022	0.681TrpGlu: 0.681 ± 0.016	0.519TrpPhe: 0.519 ± 0.016	1.042TrpGly: 1.042 ± 0.02	0.393TrpHis: 0.393 ± 0.012	0.538TrpIle: 0.538 ± 0.016	0.309TrpLys: 0.309 ± 0.011	1.8TrpLeu: 1.8 ± 0.033	0.283TrpMet: 0.283 ± 0.01	0.375TrpAsn: 0.375 ± 0.015	0.852TrpPro: 0.852 ± 0.02	0.697TrpGln: 0.697 ± 0.017	1.371TrpArg: 1.371 ± 0.026	0.925TrpSer: 0.925 ± 0.02	1.086TrpThr: 1.086 ± 0.023	0.968TrpVal: 0.968 ± 0.02	0.347TrpTrp: 0.347 ± 0.012	0.386TrpTyr: 0.386 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.569TyrAla: 2.569 ± 0.039	0.18TyrCys: 0.18 ± 0.009	1.336TyrAsp: 1.336 ± 0.029	1.002TyrGlu: 1.002 ± 0.022	0.602TyrPhe: 0.602 ± 0.015	2.194TyrGly: 2.194 ± 0.036	0.383TyrHis: 0.383 ± 0.011	0.416TyrIle: 0.416 ± 0.013	0.307TyrLys: 0.307 ± 0.013	2.255TyrLeu: 2.255 ± 0.031	0.204TyrMet: 0.204 ± 0.01	0.425TyrAsn: 0.425 ± 0.015	1.101TyrPro: 1.101 ± 0.023	0.664TyrGln: 0.664 ± 0.017	1.911TyrArg: 1.911 ± 0.026	0.925TyrSer: 0.925 ± 0.021	1.136TyrThr: 1.136 ± 0.028	1.439TyrVal: 1.439 ± 0.025	0.344TyrTrp: 0.344 ± 0.013	0.439TyrTyr: 0.439 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7543 proteins (2465880 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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