Amino acid dipepetide frequency for Macaca mulatta papillomavirus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.031AlaAla: 4.031 ± 0.676
0.403AlaCys: 0.403 ± 0.365
3.628AlaAsp: 3.628 ± 1.304
5.24AlaGlu: 5.24 ± 2.139
2.821AlaPhe: 2.821 ± 0.525
4.031AlaGly: 4.031 ± 1.385
0.403AlaHis: 0.403 ± 0.345
2.821AlaIle: 2.821 ± 0.603
3.628AlaLys: 3.628 ± 0.771
6.046AlaLeu: 6.046 ± 2.311
0.403AlaMet: 0.403 ± 0.347
1.612AlaAsn: 1.612 ± 0.889
3.628AlaPro: 3.628 ± 0.936
3.225AlaGln: 3.225 ± 0.476
3.628AlaArg: 3.628 ± 1.026
5.643AlaSer: 5.643 ± 1.253
2.821AlaThr: 2.821 ± 0.926
2.821AlaVal: 2.821 ± 1.217
1.209AlaTrp: 1.209 ± 0.698
1.612AlaTyr: 1.612 ± 0.385
0.0AlaXaa: 0.0 ± 0.0
Cys
2.015CysAla: 2.015 ± 0.771
0.403CysCys: 0.403 ± 0.347
0.806CysAsp: 0.806 ± 0.388
1.209CysGlu: 1.209 ± 1.042
0.806CysPhe: 0.806 ± 0.695
0.403CysGly: 0.403 ± 0.413
0.403CysHis: 0.403 ± 0.413
1.612CysIle: 1.612 ± 1.036
0.806CysLys: 0.806 ± 0.398
2.418CysLeu: 2.418 ± 2.104
0.0CysMet: 0.0 ± 0.0
0.806CysAsn: 0.806 ± 0.577
1.612CysPro: 1.612 ± 0.544
1.612CysGln: 1.612 ± 1.0
0.403CysArg: 0.403 ± 0.556
2.418CysSer: 2.418 ± 1.245
2.418CysThr: 2.418 ± 1.119
0.0CysVal: 0.0 ± 0.0
0.806CysTrp: 0.806 ± 0.435
0.806CysTyr: 0.806 ± 0.577
0.0CysXaa: 0.0 ± 0.0
Asp
3.225AspAla: 3.225 ± 0.733
1.612AspCys: 1.612 ± 0.719
3.225AspAsp: 3.225 ± 0.813
4.434AspGlu: 4.434 ± 0.899
2.821AspPhe: 2.821 ± 0.898
2.821AspGly: 2.821 ± 0.833
0.806AspHis: 0.806 ± 0.497
5.643AspIle: 5.643 ± 1.762
1.612AspLys: 1.612 ± 0.966
4.434AspLeu: 4.434 ± 1.229
0.403AspMet: 0.403 ± 0.345
4.031AspAsn: 4.031 ± 0.829
5.24AspPro: 5.24 ± 2.214
0.806AspGln: 0.806 ± 0.483
2.418AspArg: 2.418 ± 0.868
5.24AspSer: 5.24 ± 1.865
5.643AspThr: 5.643 ± 1.086
5.24AspVal: 5.24 ± 1.572
1.209AspTrp: 1.209 ± 0.651
2.418AspTyr: 2.418 ± 1.348
0.0AspXaa: 0.0 ± 0.0
Glu
5.24GluAla: 5.24 ± 1.415
1.612GluCys: 1.612 ± 1.39
5.643GluAsp: 5.643 ± 1.35
8.464GluGlu: 8.464 ± 1.839
1.209GluPhe: 1.209 ± 0.655
4.434GluGly: 4.434 ± 1.547
1.612GluHis: 1.612 ± 0.642
2.821GluIle: 2.821 ± 1.061
3.628GluLys: 3.628 ± 1.229
4.031GluLeu: 4.031 ± 1.284
0.806GluMet: 0.806 ± 0.545
3.628GluAsn: 3.628 ± 0.858
4.434GluPro: 4.434 ± 1.68
1.209GluGln: 1.209 ± 0.407
2.418GluArg: 2.418 ± 0.938
3.225GluSer: 3.225 ± 1.388
5.643GluThr: 5.643 ± 0.999
2.821GluVal: 2.821 ± 0.694
1.209GluTrp: 1.209 ± 0.481
1.209GluTyr: 1.209 ± 0.418
0.0GluXaa: 0.0 ± 0.0
Phe
2.015PheAla: 2.015 ± 0.764
1.612PheCys: 1.612 ± 0.812
2.015PheAsp: 2.015 ± 0.724
4.434PheGlu: 4.434 ± 1.176
4.031PhePhe: 4.031 ± 2.017
2.821PheGly: 2.821 ± 0.958
0.806PheHis: 0.806 ± 0.577
2.015PheIle: 2.015 ± 0.635
2.418PheLys: 2.418 ± 1.64
2.821PheLeu: 2.821 ± 0.48
0.806PheMet: 0.806 ± 0.397
1.612PheAsn: 1.612 ± 1.034
2.418PhePro: 2.418 ± 0.748
2.015PheGln: 2.015 ± 1.028
0.806PheArg: 0.806 ± 0.388
2.418PheSer: 2.418 ± 0.594
2.418PheThr: 2.418 ± 0.862
2.418PheVal: 2.418 ± 1.061
0.806PheTrp: 0.806 ± 0.388
1.209PheTyr: 1.209 ± 0.676
0.0PheXaa: 0.0 ± 0.0
Gly
3.628GlyAla: 3.628 ± 1.673
1.209GlyCys: 1.209 ± 0.418
4.031GlyAsp: 4.031 ± 0.92
2.418GlyGlu: 2.418 ± 0.969
1.612GlyPhe: 1.612 ± 0.534
5.643GlyGly: 5.643 ± 1.99
2.821GlyHis: 2.821 ± 1.222
3.628GlyIle: 3.628 ± 0.367
3.225GlyLys: 3.225 ± 0.966
2.821GlyLeu: 2.821 ± 1.2
0.403GlyMet: 0.403 ± 0.345
2.821GlyAsn: 2.821 ± 0.857
4.434GlyPro: 4.434 ± 1.4
3.628GlyGln: 3.628 ± 0.787
7.658GlyArg: 7.658 ± 2.789
6.046GlySer: 6.046 ± 1.773
4.434GlyThr: 4.434 ± 0.907
2.821GlyVal: 2.821 ± 0.526
0.806GlyTrp: 0.806 ± 0.695
0.806GlyTyr: 0.806 ± 0.664
0.0GlyXaa: 0.0 ± 0.0
His
1.209HisAla: 1.209 ± 0.541
0.403HisCys: 0.403 ± 0.347
0.403HisAsp: 0.403 ± 0.36
0.0HisGlu: 0.0 ± 0.0
0.806HisPhe: 0.806 ± 0.421
0.403HisGly: 0.403 ± 0.413
0.0HisHis: 0.0 ± 0.0
1.209HisIle: 1.209 ± 0.672
0.806HisLys: 0.806 ± 0.435
2.821HisLeu: 2.821 ± 0.783
0.0HisMet: 0.0 ± 0.0
1.209HisAsn: 1.209 ± 0.788
2.015HisPro: 2.015 ± 1.044
0.806HisGln: 0.806 ± 0.577
1.209HisArg: 1.209 ± 0.705
1.612HisSer: 1.612 ± 0.961
1.612HisThr: 1.612 ± 0.663
1.209HisVal: 1.209 ± 0.67
0.806HisTrp: 0.806 ± 0.456
0.806HisTyr: 0.806 ± 0.456
0.0HisXaa: 0.0 ± 0.0
Ile
2.418IleAla: 2.418 ± 0.85
0.0IleCys: 0.0 ± 0.0
5.24IleAsp: 5.24 ± 0.958
4.031IleGlu: 4.031 ± 1.727
1.612IlePhe: 1.612 ± 0.626
2.015IleGly: 2.015 ± 0.914
0.403IleHis: 0.403 ± 0.345
0.806IleIle: 0.806 ± 0.731
2.015IleLys: 2.015 ± 0.844
4.031IleLeu: 4.031 ± 1.305
0.806IleMet: 0.806 ± 0.719
0.806IleAsn: 0.806 ± 0.413
4.434IlePro: 4.434 ± 1.791
1.209IleGln: 1.209 ± 0.655
3.628IleArg: 3.628 ± 1.631
5.24IleSer: 5.24 ± 0.999
1.612IleThr: 1.612 ± 1.0
2.821IleVal: 2.821 ± 0.872
0.806IleTrp: 0.806 ± 0.435
2.015IleTyr: 2.015 ± 0.718
0.0IleXaa: 0.0 ± 0.0
Lys
1.612LysAla: 1.612 ± 0.682
1.209LysCys: 1.209 ± 0.481
2.015LysAsp: 2.015 ± 0.69
4.031LysGlu: 4.031 ± 0.956
1.209LysPhe: 1.209 ± 0.698
4.031LysGly: 4.031 ± 1.305
0.806LysHis: 0.806 ± 0.388
1.612LysIle: 1.612 ± 0.836
2.015LysLys: 2.015 ± 0.718
6.046LysLeu: 6.046 ± 1.432
1.612LysMet: 1.612 ± 0.61
3.225LysAsn: 3.225 ± 1.455
1.209LysPro: 1.209 ± 0.646
3.225LysGln: 3.225 ± 0.919
7.255LysArg: 7.255 ± 1.017
4.031LysSer: 4.031 ± 1.781
2.418LysThr: 2.418 ± 0.86
3.225LysVal: 3.225 ± 0.754
0.403LysTrp: 0.403 ± 0.345
3.225LysTyr: 3.225 ± 1.708
0.0LysXaa: 0.0 ± 0.0
Leu
4.434LeuAla: 4.434 ± 1.063
2.821LeuCys: 2.821 ± 1.25
3.628LeuAsp: 3.628 ± 1.07
4.434LeuGlu: 4.434 ± 0.9
5.24LeuPhe: 5.24 ± 0.721
6.449LeuGly: 6.449 ± 1.97
2.015LeuHis: 2.015 ± 0.656
2.821LeuIle: 2.821 ± 0.503
7.255LeuLys: 7.255 ± 1.829
10.883LeuLeu: 10.883 ± 2.642
0.806LeuMet: 0.806 ± 0.418
2.418LeuAsn: 2.418 ± 1.049
4.837LeuPro: 4.837 ± 0.847
6.449LeuGln: 6.449 ± 1.142
3.628LeuArg: 3.628 ± 1.162
6.852LeuSer: 6.852 ± 1.374
6.046LeuThr: 6.046 ± 0.765
5.24LeuVal: 5.24 ± 1.643
0.806LeuTrp: 0.806 ± 0.637
3.628LeuTyr: 3.628 ± 1.215
0.0LeuXaa: 0.0 ± 0.0
Met
0.806MetAla: 0.806 ± 0.388
0.403MetCys: 0.403 ± 0.345
2.418MetAsp: 2.418 ± 1.02
1.209MetGlu: 1.209 ± 0.418
0.403MetPhe: 0.403 ± 0.345
0.403MetGly: 0.403 ± 0.347
0.403MetHis: 0.403 ± 0.354
0.403MetIle: 0.403 ± 0.347
0.806MetLys: 0.806 ± 0.422
0.806MetLeu: 0.806 ± 0.435
0.403MetMet: 0.403 ± 0.36
0.806MetAsn: 0.806 ± 0.422
0.403MetPro: 0.403 ± 0.347
0.806MetGln: 0.806 ± 0.422
1.612MetArg: 1.612 ± 1.058
1.612MetSer: 1.612 ± 0.719
0.403MetThr: 0.403 ± 0.36
1.209MetVal: 1.209 ± 0.698
0.0MetTrp: 0.0 ± 0.0
1.209MetTyr: 1.209 ± 0.651
0.0MetXaa: 0.0 ± 0.0
Asn
2.821AsnAla: 2.821 ± 1.026
1.209AsnCys: 1.209 ± 0.397
0.806AsnAsp: 0.806 ± 0.731
2.418AsnGlu: 2.418 ± 0.922
1.209AsnPhe: 1.209 ± 0.86
1.612AsnGly: 1.612 ± 0.815
0.806AsnHis: 0.806 ± 0.388
4.031AsnIle: 4.031 ± 0.757
2.015AsnLys: 2.015 ± 0.635
3.628AsnLeu: 3.628 ± 1.51
0.403AsnMet: 0.403 ± 0.36
3.225AsnAsn: 3.225 ± 1.005
2.015AsnPro: 2.015 ± 0.561
2.821AsnGln: 2.821 ± 1.141
2.015AsnArg: 2.015 ± 0.684
2.418AsnSer: 2.418 ± 1.244
1.612AsnThr: 1.612 ± 0.618
3.225AsnVal: 3.225 ± 1.213
0.0AsnTrp: 0.0 ± 0.0
2.418AsnTyr: 2.418 ± 1.241
0.0AsnXaa: 0.0 ± 0.0
Pro
4.837ProAla: 4.837 ± 1.576
1.612ProCys: 1.612 ± 1.273
4.837ProAsp: 4.837 ± 0.858
3.225ProGlu: 3.225 ± 1.475
2.821ProPhe: 2.821 ± 0.889
2.821ProGly: 2.821 ± 0.971
0.806ProHis: 0.806 ± 0.497
2.015ProIle: 2.015 ± 1.351
4.031ProLys: 4.031 ± 1.555
6.449ProLeu: 6.449 ± 1.97
1.209ProMet: 1.209 ± 1.042
2.015ProAsn: 2.015 ± 0.765
7.255ProPro: 7.255 ± 1.641
2.418ProGln: 2.418 ± 0.797
4.837ProArg: 4.837 ± 0.709
7.255ProSer: 7.255 ± 1.79
2.821ProThr: 2.821 ± 1.003
3.628ProVal: 3.628 ± 1.007
0.0ProTrp: 0.0 ± 0.0
1.209ProTyr: 1.209 ± 0.407
0.0ProXaa: 0.0 ± 0.0
Gln
3.225GlnAla: 3.225 ± 0.725
1.209GlnCys: 1.209 ± 0.625
3.628GlnAsp: 3.628 ± 1.098
2.015GlnGlu: 2.015 ± 0.718
1.612GlnPhe: 1.612 ± 0.558
2.821GlnGly: 2.821 ± 0.863
2.015GlnHis: 2.015 ± 0.645
1.612GlnIle: 1.612 ± 0.614
1.209GlnLys: 1.209 ± 0.795
5.24GlnLeu: 5.24 ± 0.935
1.612GlnMet: 1.612 ± 0.775
1.612GlnAsn: 1.612 ± 0.423
2.418GlnPro: 2.418 ± 0.592
2.418GlnGln: 2.418 ± 0.794
2.418GlnArg: 2.418 ± 1.167
2.015GlnSer: 2.015 ± 0.473
3.225GlnThr: 3.225 ± 1.017
1.612GlnVal: 1.612 ± 0.826
0.806GlnTrp: 0.806 ± 0.577
1.612GlnTyr: 1.612 ± 0.63
0.0GlnXaa: 0.0 ± 0.0
Arg
6.046ArgAla: 6.046 ± 1.185
1.209ArgCys: 1.209 ± 0.583
2.821ArgAsp: 2.821 ± 0.848
2.821ArgGlu: 2.821 ± 0.525
2.418ArgPhe: 2.418 ± 1.029
5.643ArgGly: 5.643 ± 2.063
1.612ArgHis: 1.612 ± 0.889
1.612ArgIle: 1.612 ± 0.612
4.434ArgLys: 4.434 ± 0.919
6.449ArgLeu: 6.449 ± 1.287
0.806ArgMet: 0.806 ± 0.584
2.015ArgAsn: 2.015 ± 0.918
3.628ArgPro: 3.628 ± 1.229
2.015ArgGln: 2.015 ± 0.274
6.852ArgArg: 6.852 ± 2.475
3.225ArgSer: 3.225 ± 0.864
2.418ArgThr: 2.418 ± 1.377
2.821ArgVal: 2.821 ± 1.087
0.806ArgTrp: 0.806 ± 0.602
2.418ArgTyr: 2.418 ± 0.797
0.0ArgXaa: 0.0 ± 0.0
Ser
2.821SerAla: 2.821 ± 0.603
1.209SerCys: 1.209 ± 0.749
5.24SerAsp: 5.24 ± 1.803
5.24SerGlu: 5.24 ± 0.871
5.24SerPhe: 5.24 ± 1.953
5.24SerGly: 5.24 ± 0.99
1.612SerHis: 1.612 ± 0.739
3.628SerIle: 3.628 ± 1.058
4.031SerLys: 4.031 ± 1.475
8.061SerLeu: 8.061 ± 1.267
1.612SerMet: 1.612 ± 0.646
3.628SerAsn: 3.628 ± 1.65
3.628SerPro: 3.628 ± 1.276
2.821SerGln: 2.821 ± 0.745
4.031SerArg: 4.031 ± 0.937
6.449SerSer: 6.449 ± 1.649
5.643SerThr: 5.643 ± 1.366
6.449SerVal: 6.449 ± 0.9
0.0SerTrp: 0.0 ± 0.0
1.612SerTyr: 1.612 ± 0.616
0.0SerXaa: 0.0 ± 0.0
Thr
1.612ThrAla: 1.612 ± 0.724
1.612ThrCys: 1.612 ± 0.618
6.046ThrAsp: 6.046 ± 0.982
3.225ThrGlu: 3.225 ± 0.76
2.821ThrPhe: 2.821 ± 0.69
5.643ThrGly: 5.643 ± 1.681
0.403ThrHis: 0.403 ± 0.345
2.418ThrIle: 2.418 ± 1.439
2.418ThrLys: 2.418 ± 0.864
5.643ThrLeu: 5.643 ± 0.521
0.806ThrMet: 0.806 ± 0.422
2.015ThrAsn: 2.015 ± 0.926
5.24ThrPro: 5.24 ± 0.941
1.612ThrGln: 1.612 ± 0.618
3.225ThrArg: 3.225 ± 0.78
4.434ThrSer: 4.434 ± 0.93
2.821ThrThr: 2.821 ± 0.558
5.643ThrVal: 5.643 ± 1.539
0.403ThrTrp: 0.403 ± 0.365
1.209ThrTyr: 1.209 ± 0.721
0.0ThrXaa: 0.0 ± 0.0
Val
4.837ValAla: 4.837 ± 1.183
0.403ValCys: 0.403 ± 0.556
4.434ValAsp: 4.434 ± 2.059
4.031ValGlu: 4.031 ± 1.05
2.418ValPhe: 2.418 ± 0.497
4.434ValGly: 4.434 ± 1.572
1.209ValHis: 1.209 ± 0.705
2.821ValIle: 2.821 ± 1.099
2.418ValLys: 2.418 ± 0.694
2.821ValLeu: 2.821 ± 1.217
0.806ValMet: 0.806 ± 0.388
0.806ValAsn: 0.806 ± 0.497
6.046ValPro: 6.046 ± 1.386
4.031ValGln: 4.031 ± 1.033
2.418ValArg: 2.418 ± 0.535
4.837ValSer: 4.837 ± 0.798
2.418ValThr: 2.418 ± 0.758
2.418ValVal: 2.418 ± 1.252
1.209ValTrp: 1.209 ± 0.86
2.821ValTyr: 2.821 ± 1.141
0.0ValXaa: 0.0 ± 0.0
Trp
0.403TrpAla: 0.403 ± 0.347
0.403TrpCys: 0.403 ± 0.556
0.806TrpAsp: 0.806 ± 0.483
0.806TrpGlu: 0.806 ± 0.731
0.0TrpPhe: 0.0 ± 0.0
0.403TrpGly: 0.403 ± 0.345
0.0TrpHis: 0.0 ± 0.0
0.403TrpIle: 0.403 ± 0.347
2.418TrpLys: 2.418 ± 0.866
1.612TrpLeu: 1.612 ± 0.775
0.403TrpMet: 0.403 ± 0.347
0.806TrpAsn: 0.806 ± 0.456
0.403TrpPro: 0.403 ± 0.345
0.0TrpGln: 0.0 ± 0.0
0.806TrpArg: 0.806 ± 0.602
0.403TrpSer: 0.403 ± 0.347
1.209TrpThr: 1.209 ± 0.751
0.806TrpVal: 0.806 ± 0.577
0.0TrpTrp: 0.0 ± 0.0
0.403TrpTyr: 0.403 ± 0.347
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.418TyrAla: 2.418 ± 0.936
1.209TyrCys: 1.209 ± 1.667
1.612TyrAsp: 1.612 ± 0.663
1.612TyrGlu: 1.612 ± 0.761
0.806TyrPhe: 0.806 ± 0.398
2.821TyrGly: 2.821 ± 1.081
0.403TyrHis: 0.403 ± 0.556
2.015TyrIle: 2.015 ± 0.58
3.628TyrLys: 3.628 ± 1.204
3.628TyrLeu: 3.628 ± 1.347
2.015TyrMet: 2.015 ± 1.362
1.612TyrAsn: 1.612 ± 0.573
0.806TyrPro: 0.806 ± 0.398
1.209TyrGln: 1.209 ± 0.583
0.806TyrArg: 0.806 ± 0.69
2.821TyrSer: 2.821 ± 0.734
1.612TyrThr: 1.612 ± 0.755
1.209TyrVal: 1.209 ± 0.338
0.403TyrTrp: 0.403 ± 0.345
2.821TyrTyr: 2.821 ± 1.329
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2482 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski