Amino acid dipepetide frequency for Bosea thiooxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.221AlaAla: 20.221 ± 0.173
1.185AlaCys: 1.185 ± 0.029
6.427AlaAsp: 6.427 ± 0.068
8.361AlaGlu: 8.361 ± 0.087
4.994AlaPhe: 4.994 ± 0.069
12.221AlaGly: 12.221 ± 0.104
2.187AlaHis: 2.187 ± 0.04
7.102AlaIle: 7.102 ± 0.072
4.309AlaLys: 4.309 ± 0.071
15.59AlaLeu: 15.59 ± 0.124
3.795AlaMet: 3.795 ± 0.047
2.762AlaAsn: 2.762 ± 0.043
6.119AlaPro: 6.119 ± 0.079
4.265AlaGln: 4.265 ± 0.056
9.797AlaArg: 9.797 ± 0.098
6.601AlaSer: 6.601 ± 0.07
6.371AlaThr: 6.371 ± 0.074
9.497AlaVal: 9.497 ± 0.087
1.586AlaTrp: 1.586 ± 0.032
2.643AlaTyr: 2.643 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.97CysAla: 0.97 ± 0.025
0.105CysCys: 0.105 ± 0.009
0.477CysAsp: 0.477 ± 0.018
0.427CysGlu: 0.427 ± 0.015
0.303CysPhe: 0.303 ± 0.015
0.94CysGly: 0.94 ± 0.025
0.21CysHis: 0.21 ± 0.011
0.393CysIle: 0.393 ± 0.016
0.166CysLys: 0.166 ± 0.011
0.816CysLeu: 0.816 ± 0.023
0.13CysMet: 0.13 ± 0.009
0.177CysAsn: 0.177 ± 0.012
0.412CysPro: 0.412 ± 0.019
0.19CysGln: 0.19 ± 0.011
0.616CysArg: 0.616 ± 0.023
0.411CysSer: 0.411 ± 0.016
0.354CysThr: 0.354 ± 0.015
0.592CysVal: 0.592 ± 0.023
0.108CysTrp: 0.108 ± 0.009
0.174CysTyr: 0.174 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.641AspAla: 6.641 ± 0.071
0.42AspCys: 0.42 ± 0.018
2.646AspAsp: 2.646 ± 0.044
3.226AspGlu: 3.226 ± 0.053
2.018AspPhe: 2.018 ± 0.034
5.049AspGly: 5.049 ± 0.062
1.131AspHis: 1.131 ± 0.03
2.803AspIle: 2.803 ± 0.04
1.642AspLys: 1.642 ± 0.04
5.635AspLeu: 5.635 ± 0.074
1.127AspMet: 1.127 ± 0.029
1.005AspAsn: 1.005 ± 0.025
3.474AspPro: 3.474 ± 0.048
1.447AspGln: 1.447 ± 0.03
3.976AspArg: 3.976 ± 0.052
1.915AspSer: 1.915 ± 0.03
2.118AspThr: 2.118 ± 0.038
3.803AspVal: 3.803 ± 0.051
0.899AspTrp: 0.899 ± 0.022
1.323AspTyr: 1.323 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
8.688GluAla: 8.688 ± 0.087
0.306GluCys: 0.306 ± 0.015
2.358GluAsp: 2.358 ± 0.042
2.967GluGlu: 2.967 ± 0.049
1.579GluPhe: 1.579 ± 0.033
4.27GluGly: 4.27 ± 0.058
1.124GluHis: 1.124 ± 0.027
3.495GluIle: 3.495 ± 0.056
2.104GluLys: 2.104 ± 0.041
5.35GluLeu: 5.35 ± 0.066
1.387GluMet: 1.387 ± 0.031
1.34GluAsn: 1.34 ± 0.032
2.973GluPro: 2.973 ± 0.042
1.942GluGln: 1.942 ± 0.038
5.424GluArg: 5.424 ± 0.071
2.216GluSer: 2.216 ± 0.044
3.388GluThr: 3.388 ± 0.044
3.607GluVal: 3.607 ± 0.044
0.629GluTrp: 0.629 ± 0.018
0.782GluTyr: 0.782 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
5.043PheAla: 5.043 ± 0.068
0.385PheCys: 0.385 ± 0.016
2.461PheAsp: 2.461 ± 0.042
2.077PheGlu: 2.077 ± 0.035
1.393PhePhe: 1.393 ± 0.033
3.851PheGly: 3.851 ± 0.049
0.738PheHis: 0.738 ± 0.024
1.63PheIle: 1.63 ± 0.035
0.992PheLys: 0.992 ± 0.026
3.388PheLeu: 3.388 ± 0.05
0.81PheMet: 0.81 ± 0.019
0.933PheAsn: 0.933 ± 0.026
1.666PhePro: 1.666 ± 0.033
0.981PheGln: 0.981 ± 0.028
2.368PheArg: 2.368 ± 0.043
2.037PheSer: 2.037 ± 0.038
1.872PheThr: 1.872 ± 0.039
3.035PheVal: 3.035 ± 0.049
0.585PheTrp: 0.585 ± 0.021
0.839PheTyr: 0.839 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.225GlyAla: 10.225 ± 0.094
0.852GlyCys: 0.852 ± 0.024
4.167GlyAsp: 4.167 ± 0.051
5.051GlyGlu: 5.051 ± 0.056
3.926GlyPhe: 3.926 ± 0.054
7.675GlyGly: 7.675 ± 0.108
1.988GlyHis: 1.988 ± 0.046
4.655GlyIle: 4.655 ± 0.054
3.298GlyLys: 3.298 ± 0.051
10.09GlyLeu: 10.09 ± 0.086
2.24GlyMet: 2.24 ± 0.038
1.986GlyAsn: 1.986 ± 0.034
3.878GlyPro: 3.878 ± 0.058
2.966GlyGln: 2.966 ± 0.044
6.872GlyArg: 6.872 ± 0.064
4.683GlySer: 4.683 ± 0.054
4.579GlyThr: 4.579 ± 0.068
6.108GlyVal: 6.108 ± 0.062
1.509GlyTrp: 1.509 ± 0.031
2.286GlyTyr: 2.286 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.379HisAla: 2.379 ± 0.042
0.208HisCys: 0.208 ± 0.013
1.207HisAsp: 1.207 ± 0.028
0.983HisGlu: 0.983 ± 0.023
0.768HisPhe: 0.768 ± 0.025
2.023HisGly: 2.023 ± 0.039
0.557HisHis: 0.557 ± 0.024
0.85HisIle: 0.85 ± 0.026
0.458HisLys: 0.458 ± 0.019
1.993HisLeu: 1.993 ± 0.036
0.411HisMet: 0.411 ± 0.017
0.395HisAsn: 0.395 ± 0.015
1.272HisPro: 1.272 ± 0.031
0.485HisGln: 0.485 ± 0.021
1.38HisArg: 1.38 ± 0.031
0.817HisSer: 0.817 ± 0.022
0.65HisThr: 0.65 ± 0.024
1.506HisVal: 1.506 ± 0.029
0.351HisTrp: 0.351 ± 0.014
0.486HisTyr: 0.486 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
8.1IleAla: 8.1 ± 0.076
0.5IleCys: 0.5 ± 0.018
3.27IleAsp: 3.27 ± 0.046
3.37IleGlu: 3.37 ± 0.047
1.587IlePhe: 1.587 ± 0.036
5.503IleGly: 5.503 ± 0.059
0.878IleHis: 0.878 ± 0.023
2.047IleIle: 2.047 ± 0.039
1.309IleLys: 1.309 ± 0.038
4.588IleLeu: 4.588 ± 0.055
0.932IleMet: 0.932 ± 0.026
1.155IleAsn: 1.155 ± 0.027
2.331IlePro: 2.331 ± 0.049
1.139IleGln: 1.139 ± 0.031
3.235IleArg: 3.235 ± 0.042
2.461IleSer: 2.461 ± 0.043
2.423IleThr: 2.423 ± 0.041
4.596IleVal: 4.596 ± 0.059
0.594IleTrp: 0.594 ± 0.02
1.06IleTyr: 1.06 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
4.698LysAla: 4.698 ± 0.065
0.124LysCys: 0.124 ± 0.01
1.565LysAsp: 1.565 ± 0.036
1.513LysGlu: 1.513 ± 0.03
0.774LysPhe: 0.774 ± 0.026
2.702LysGly: 2.702 ± 0.052
0.561LysHis: 0.561 ± 0.017
1.516LysIle: 1.516 ± 0.032
1.077LysLys: 1.077 ± 0.033
3.548LysLeu: 3.548 ± 0.057
0.63LysMet: 0.63 ± 0.023
0.736LysAsn: 0.736 ± 0.023
2.3LysPro: 2.3 ± 0.042
0.993LysGln: 0.993 ± 0.025
2.379LysArg: 2.379 ± 0.042
1.55LysSer: 1.55 ± 0.033
1.737LysThr: 1.737 ± 0.035
2.43LysVal: 2.43 ± 0.042
0.295LysTrp: 0.295 ± 0.016
0.474LysTyr: 0.474 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
16.083LeuAla: 16.083 ± 0.122
0.876LeuCys: 0.876 ± 0.026
6.199LeuAsp: 6.199 ± 0.071
4.878LeuGlu: 4.878 ± 0.064
3.707LeuPhe: 3.707 ± 0.053
9.313LeuGly: 9.313 ± 0.09
1.756LeuHis: 1.756 ± 0.033
5.191LeuIle: 5.191 ± 0.062
3.792LeuLys: 3.792 ± 0.053
10.437LeuLeu: 10.437 ± 0.113
2.349LeuMet: 2.349 ± 0.04
2.347LeuAsn: 2.347 ± 0.038
6.008LeuPro: 6.008 ± 0.075
2.715LeuGln: 2.715 ± 0.04
7.311LeuArg: 7.311 ± 0.079
6.435LeuSer: 6.435 ± 0.071
5.488LeuThr: 5.488 ± 0.067
8.274LeuVal: 8.274 ± 0.083
1.264LeuTrp: 1.264 ± 0.03
1.988LeuTyr: 1.988 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.21MetAla: 3.21 ± 0.048
0.137MetCys: 0.137 ± 0.009
0.964MetAsp: 0.964 ± 0.026
0.962MetGlu: 0.962 ± 0.025
0.623MetPhe: 0.623 ± 0.019
1.692MetGly: 1.692 ± 0.034
0.375MetHis: 0.375 ± 0.015
1.249MetIle: 1.249 ± 0.03
0.905MetLys: 0.905 ± 0.025
2.628MetLeu: 2.628 ± 0.045
0.62MetMet: 0.62 ± 0.022
0.699MetAsn: 0.699 ± 0.022
1.545MetPro: 1.545 ± 0.032
0.766MetGln: 0.766 ± 0.025
1.841MetArg: 1.841 ± 0.035
1.541MetSer: 1.541 ± 0.034
1.786MetThr: 1.786 ± 0.031
1.668MetVal: 1.668 ± 0.034
0.171MetTrp: 0.171 ± 0.009
0.256MetTyr: 0.256 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.999AsnAla: 2.999 ± 0.048
0.203AsnCys: 0.203 ± 0.012
1.165AsnAsp: 1.165 ± 0.03
1.114AsnGlu: 1.114 ± 0.027
0.822AsnPhe: 0.822 ± 0.021
2.165AsnGly: 2.165 ± 0.043
0.405AsnHis: 0.405 ± 0.016
1.152AsnIle: 1.152 ± 0.028
0.607AsnLys: 0.607 ± 0.019
2.432AsnLeu: 2.432 ± 0.046
0.494AsnMet: 0.494 ± 0.02
0.583AsnAsn: 0.583 ± 0.02
1.705AsnPro: 1.705 ± 0.033
0.639AsnGln: 0.639 ± 0.019
1.65AsnArg: 1.65 ± 0.036
0.991AsnSer: 0.991 ± 0.025
1.066AsnThr: 1.066 ± 0.027
1.677AsnVal: 1.677 ± 0.03
0.394AsnTrp: 0.394 ± 0.016
0.592AsnTyr: 0.592 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.357ProAla: 7.357 ± 0.08
0.301ProCys: 0.301 ± 0.014
3.405ProAsp: 3.405 ± 0.048
3.816ProGlu: 3.816 ± 0.048
2.118ProPhe: 2.118 ± 0.041
4.943ProGly: 4.943 ± 0.059
1.078ProHis: 1.078 ± 0.028
2.349ProIle: 2.349 ± 0.037
1.674ProLys: 1.674 ± 0.042
5.081ProLeu: 5.081 ± 0.065
1.256ProMet: 1.256 ± 0.029
1.285ProAsn: 1.285 ± 0.035
2.737ProPro: 2.737 ± 0.055
1.844ProGln: 1.844 ± 0.039
3.269ProArg: 3.269 ± 0.053
2.752ProSer: 2.752 ± 0.044
2.447ProThr: 2.447 ± 0.043
4.305ProVal: 4.305 ± 0.055
0.692ProTrp: 0.692 ± 0.024
1.193ProTyr: 1.193 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.423GlnAla: 4.423 ± 0.063
0.146GlnCys: 0.146 ± 0.011
1.354GlnAsp: 1.354 ± 0.03
1.401GlnGlu: 1.401 ± 0.027
0.95GlnPhe: 0.95 ± 0.022
2.569GlnGly: 2.569 ± 0.041
0.576GlnHis: 0.576 ± 0.021
1.764GlnIle: 1.764 ± 0.032
0.955GlnLys: 0.955 ± 0.026
2.784GlnLeu: 2.784 ± 0.042
0.748GlnMet: 0.748 ± 0.024
0.797GlnAsn: 0.797 ± 0.026
1.919GlnPro: 1.919 ± 0.04
1.137GlnGln: 1.137 ± 0.037
2.586GlnArg: 2.586 ± 0.055
1.55GlnSer: 1.55 ± 0.03
1.509GlnThr: 1.509 ± 0.033
2.111GlnVal: 2.111 ± 0.039
0.338GlnTrp: 0.338 ± 0.014
0.51GlnTyr: 0.51 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
8.445ArgAla: 8.445 ± 0.086
0.511ArgCys: 0.511 ± 0.02
4.034ArgAsp: 4.034 ± 0.052
4.471ArgGlu: 4.471 ± 0.06
3.106ArgPhe: 3.106 ± 0.046
5.062ArgGly: 5.062 ± 0.059
1.708ArgHis: 1.708 ± 0.034
4.257ArgIle: 4.257 ± 0.053
2.271ArgLys: 2.271 ± 0.04
8.713ArgLeu: 8.713 ± 0.097
1.831ArgMet: 1.831 ± 0.033
1.766ArgAsn: 1.766 ± 0.033
3.924ArgPro: 3.924 ± 0.057
2.606ArgGln: 2.606 ± 0.045
6.145ArgArg: 6.145 ± 0.087
3.891ArgSer: 3.891 ± 0.045
3.162ArgThr: 3.162 ± 0.048
4.704ArgVal: 4.704 ± 0.065
1.038ArgTrp: 1.038 ± 0.03
1.708ArgTyr: 1.708 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.124SerAla: 6.124 ± 0.077
0.441SerCys: 0.441 ± 0.019
2.518SerAsp: 2.518 ± 0.04
2.638SerGlu: 2.638 ± 0.044
2.392SerPhe: 2.392 ± 0.039
5.339SerGly: 5.339 ± 0.06
1.013SerHis: 1.013 ± 0.027
2.506SerIle: 2.506 ± 0.045
1.382SerLys: 1.382 ± 0.033
5.607SerLeu: 5.607 ± 0.06
1.181SerMet: 1.181 ± 0.028
1.138SerAsn: 1.138 ± 0.027
2.735SerPro: 2.735 ± 0.045
1.532SerGln: 1.532 ± 0.033
3.65SerArg: 3.65 ± 0.052
2.585SerSer: 2.585 ± 0.048
2.389SerThr: 2.389 ± 0.038
3.717SerVal: 3.717 ± 0.047
0.84SerTrp: 0.84 ± 0.024
1.26SerTyr: 1.26 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
6.344ThrAla: 6.344 ± 0.064
0.387ThrCys: 0.387 ± 0.015
2.329ThrAsp: 2.329 ± 0.038
2.42ThrGlu: 2.42 ± 0.04
1.801ThrPhe: 1.801 ± 0.039
4.944ThrGly: 4.944 ± 0.066
0.916ThrHis: 0.916 ± 0.024
2.857ThrIle: 2.857 ± 0.044
1.296ThrLys: 1.296 ± 0.037
5.906ThrLeu: 5.906 ± 0.077
1.113ThrMet: 1.113 ± 0.028
1.078ThrAsn: 1.078 ± 0.028
3.08ThrPro: 3.08 ± 0.042
1.354ThrGln: 1.354 ± 0.03
3.245ThrArg: 3.245 ± 0.05
2.505ThrSer: 2.505 ± 0.042
2.634ThrThr: 2.634 ± 0.05
4.242ThrVal: 4.242 ± 0.056
0.551ThrTrp: 0.551 ± 0.02
1.025ThrTyr: 1.025 ± 0.026
0.0ThrXaa: 0.0 ± 0.0
Val
10.318ValAla: 10.318 ± 0.091
0.558ValCys: 0.558 ± 0.019
3.826ValAsp: 3.826 ± 0.056
4.57ValGlu: 4.57 ± 0.061
2.863ValPhe: 2.863 ± 0.05
5.727ValGly: 5.727 ± 0.061
1.247ValHis: 1.247 ± 0.028
3.876ValIle: 3.876 ± 0.055
2.369ValLys: 2.369 ± 0.045
7.808ValLeu: 7.808 ± 0.08
1.884ValMet: 1.884 ± 0.033
1.756ValAsn: 1.756 ± 0.039
3.965ValPro: 3.965 ± 0.058
1.977ValGln: 1.977 ± 0.035
4.664ValArg: 4.664 ± 0.062
4.216ValSer: 4.216 ± 0.052
4.39ValThr: 4.39 ± 0.057
6.262ValVal: 6.262 ± 0.076
0.839ValTrp: 0.839 ± 0.026
1.349ValTyr: 1.349 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.238TrpAla: 1.238 ± 0.031
0.13TrpCys: 0.13 ± 0.008
0.562TrpAsp: 0.562 ± 0.023
0.548TrpGlu: 0.548 ± 0.021
0.556TrpPhe: 0.556 ± 0.018
0.932TrpGly: 0.932 ± 0.023
0.316TrpHis: 0.316 ± 0.016
0.625TrpIle: 0.625 ± 0.018
0.44TrpLys: 0.44 ± 0.019
1.842TrpLeu: 1.842 ± 0.044
0.326TrpMet: 0.326 ± 0.013
0.414TrpAsn: 0.414 ± 0.016
0.752TrpPro: 0.752 ± 0.021
0.552TrpGln: 0.552 ± 0.022
1.209TrpArg: 1.209 ± 0.029
0.85TrpSer: 0.85 ± 0.024
0.732TrpThr: 0.732 ± 0.023
0.739TrpVal: 0.739 ± 0.021
0.24TrpTrp: 0.24 ± 0.013
0.274TrpTyr: 0.274 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.526TyrAla: 2.526 ± 0.042
0.195TyrCys: 0.195 ± 0.011
1.364TyrAsp: 1.364 ± 0.027
1.137TyrGlu: 1.137 ± 0.029
0.802TyrPhe: 0.802 ± 0.023
2.114TyrGly: 2.114 ± 0.038
0.415TyrHis: 0.415 ± 0.018
0.757TyrIle: 0.757 ± 0.027
0.557TyrLys: 0.557 ± 0.021
2.173TyrLeu: 2.173 ± 0.036
0.375TyrMet: 0.375 ± 0.015
0.502TyrAsn: 0.502 ± 0.017
1.108TyrPro: 1.108 ± 0.03
0.601TyrGln: 0.601 ± 0.019
1.737TyrArg: 1.737 ± 0.032
0.981TyrSer: 0.981 ± 0.027
0.933TyrThr: 0.933 ± 0.025
1.59TyrVal: 1.59 ± 0.037
0.357TyrTrp: 0.357 ± 0.016
0.518TyrTyr: 0.518 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4956 proteins (1551163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski