Amino acid dipepetide frequency for Rhodobacter sp. LPB0142

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.437AlaAla: 22.437 ± 0.273	1.176AlaCys: 1.176 ± 0.037	6.703AlaAsp: 6.703 ± 0.081	10.695AlaGlu: 10.695 ± 0.128	4.45AlaPhe: 4.45 ± 0.068	12.953AlaGly: 12.953 ± 0.142	2.478AlaHis: 2.478 ± 0.048	5.854AlaIle: 5.854 ± 0.077	3.967AlaLys: 3.967 ± 0.065	16.51AlaLeu: 16.51 ± 0.18	3.884AlaMet: 3.884 ± 0.069	2.543AlaAsn: 2.543 ± 0.05	8.357AlaPro: 8.357 ± 0.152	4.927AlaGln: 4.927 ± 0.075	12.126AlaArg: 12.126 ± 0.151	5.687AlaSer: 5.687 ± 0.064	6.222AlaThr: 6.222 ± 0.081	8.943AlaVal: 8.943 ± 0.114	1.666AlaTrp: 1.666 ± 0.047	2.501AlaTyr: 2.501 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.143CysAla: 1.143 ± 0.04	0.086CysCys: 0.086 ± 0.01	0.532CysAsp: 0.532 ± 0.022	0.47CysGlu: 0.47 ± 0.023	0.302CysPhe: 0.302 ± 0.017	0.903CysGly: 0.903 ± 0.035	0.259CysHis: 0.259 ± 0.02	0.372CysIle: 0.372 ± 0.019	0.191CysLys: 0.191 ± 0.013	0.835CysLeu: 0.835 ± 0.027	0.154CysMet: 0.154 ± 0.013	0.177CysAsn: 0.177 ± 0.014	0.552CysPro: 0.552 ± 0.025	0.191CysGln: 0.191 ± 0.014	0.545CysArg: 0.545 ± 0.026	0.39CysSer: 0.39 ± 0.021	0.424CysThr: 0.424 ± 0.019	0.508CysVal: 0.508 ± 0.02	0.112CysTrp: 0.112 ± 0.011	0.198CysTyr: 0.198 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.505AspAla: 6.505 ± 0.081	0.453AspCys: 0.453 ± 0.02	2.503AspAsp: 2.503 ± 0.065	3.121AspGlu: 3.121 ± 0.057	2.181AspPhe: 2.181 ± 0.046	4.592AspGly: 4.592 ± 0.105	1.158AspHis: 1.158 ± 0.037	2.364AspIle: 2.364 ± 0.049	1.465AspLys: 1.465 ± 0.047	6.386AspLeu: 6.386 ± 0.081	1.27AspMet: 1.27 ± 0.039	0.929AspAsn: 0.929 ± 0.033	3.567AspPro: 3.567 ± 0.065	1.598AspGln: 1.598 ± 0.041	3.778AspArg: 3.778 ± 0.075	1.676AspSer: 1.676 ± 0.045	2.381AspThr: 2.381 ± 0.075	3.246AspVal: 3.246 ± 0.06	1.177AspTrp: 1.177 ± 0.034	1.499AspTyr: 1.499 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	10.511GluAla: 10.511 ± 0.134	0.335GluCys: 0.335 ± 0.017	3.044GluAsp: 3.044 ± 0.065	3.913GluGlu: 3.913 ± 0.078	1.893GluPhe: 1.893 ± 0.046	5.824GluGly: 5.824 ± 0.087	1.027GluHis: 1.027 ± 0.033	4.209GluIle: 4.209 ± 0.064	2.184GluLys: 2.184 ± 0.052	5.515GluLeu: 5.515 ± 0.075	1.875GluMet: 1.875 ± 0.041	1.46GluAsn: 1.46 ± 0.038	2.805GluPro: 2.805 ± 0.071	1.757GluGln: 1.757 ± 0.042	4.693GluArg: 4.693 ± 0.076	2.146GluSer: 2.146 ± 0.05	3.941GluThr: 3.941 ± 0.058	4.602GluVal: 4.602 ± 0.073	0.699GluTrp: 0.699 ± 0.028	0.919GluTyr: 0.919 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.927PheAla: 4.927 ± 0.065	0.4PheCys: 0.4 ± 0.02	2.516PheAsp: 2.516 ± 0.049	2.271PheGlu: 2.271 ± 0.052	1.347PhePhe: 1.347 ± 0.046	3.808PheGly: 3.808 ± 0.061	0.66PheHis: 0.66 ± 0.026	1.468PheIle: 1.468 ± 0.037	0.904PheLys: 0.904 ± 0.031	3.423PheLeu: 3.423 ± 0.063	0.729PheMet: 0.729 ± 0.025	0.952PheAsn: 0.952 ± 0.031	1.449PhePro: 1.449 ± 0.035	0.894PheGln: 0.894 ± 0.029	2.164PheArg: 2.164 ± 0.053	1.943PheSer: 1.943 ± 0.047	2.06PheThr: 2.06 ± 0.053	2.52PheVal: 2.52 ± 0.053	0.568PheTrp: 0.568 ± 0.025	0.862PheTyr: 0.862 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	13.218GlyAla: 13.218 ± 0.166	0.874GlyCys: 0.874 ± 0.029	4.205GlyAsp: 4.205 ± 0.107	5.108GlyGlu: 5.108 ± 0.069	3.783GlyPhe: 3.783 ± 0.065	7.803GlyGly: 7.803 ± 0.151	1.819GlyHis: 1.819 ± 0.047	3.917GlyIle: 3.917 ± 0.069	2.975GlyLys: 2.975 ± 0.06	10.29GlyLeu: 10.29 ± 0.114	2.478GlyMet: 2.478 ± 0.08	1.827GlyAsn: 1.827 ± 0.069	4.267GlyPro: 4.267 ± 0.058	2.982GlyGln: 2.982 ± 0.051	6.683GlyArg: 6.683 ± 0.078	3.629GlySer: 3.629 ± 0.062	4.271GlyThr: 4.271 ± 0.072	6.615GlyVal: 6.615 ± 0.101	1.637GlyTrp: 1.637 ± 0.038	2.243GlyTyr: 2.243 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.247HisAla: 2.247 ± 0.053	0.207HisCys: 0.207 ± 0.014	1.14HisAsp: 1.14 ± 0.029	1.047HisGlu: 1.047 ± 0.031	0.821HisPhe: 0.821 ± 0.027	1.801HisGly: 1.801 ± 0.05	0.49HisHis: 0.49 ± 0.023	0.876HisIle: 0.876 ± 0.027	0.451HisLys: 0.451 ± 0.027	2.026HisLeu: 2.026 ± 0.048	0.48HisMet: 0.48 ± 0.021	0.422HisAsn: 0.422 ± 0.02	1.379HisPro: 1.379 ± 0.04	0.52HisGln: 0.52 ± 0.025	1.333HisArg: 1.333 ± 0.037	0.78HisSer: 0.78 ± 0.026	0.661HisThr: 0.661 ± 0.028	1.331HisVal: 1.331 ± 0.033	0.332HisTrp: 0.332 ± 0.019	0.573HisTyr: 0.573 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.213IleAla: 7.213 ± 0.085	0.539IleCys: 0.539 ± 0.021	3.085IleAsp: 3.085 ± 0.056	3.693IleGlu: 3.693 ± 0.067	1.704IlePhe: 1.704 ± 0.039	4.647IleGly: 4.647 ± 0.071	0.841IleHis: 0.841 ± 0.028	1.735IleIle: 1.735 ± 0.044	1.285IleLys: 1.285 ± 0.04	4.504IleLeu: 4.504 ± 0.064	0.886IleMet: 0.886 ± 0.028	1.162IleAsn: 1.162 ± 0.038	2.107IlePro: 2.107 ± 0.049	0.957IleGln: 0.957 ± 0.027	3.256IleArg: 3.256 ± 0.062	2.68IleSer: 2.68 ± 0.047	2.721IleThr: 2.721 ± 0.051	3.482IleVal: 3.482 ± 0.057	0.695IleTrp: 0.695 ± 0.026	1.058IleTyr: 1.058 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.958LysAla: 3.958 ± 0.079	0.172LysCys: 0.172 ± 0.012	1.431LysAsp: 1.431 ± 0.042	1.497LysGlu: 1.497 ± 0.047	0.936LysPhe: 0.936 ± 0.032	2.699LysGly: 2.699 ± 0.062	0.53LysHis: 0.53 ± 0.026	1.813LysIle: 1.813 ± 0.039	1.123LysLys: 1.123 ± 0.04	2.945LysLeu: 2.945 ± 0.056	0.916LysMet: 0.916 ± 0.033	0.678LysAsn: 0.678 ± 0.029	1.788LysPro: 1.788 ± 0.047	0.782LysGln: 0.782 ± 0.027	2.178LysArg: 2.178 ± 0.047	1.537LysSer: 1.537 ± 0.039	1.833LysThr: 1.833 ± 0.04	2.279LysVal: 2.279 ± 0.053	0.364LysTrp: 0.364 ± 0.018	0.601LysTyr: 0.601 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	16.194LeuAla: 16.194 ± 0.189	0.887LeuCys: 0.887 ± 0.029	5.6LeuAsp: 5.6 ± 0.07	5.996LeuGlu: 5.996 ± 0.086	3.405LeuPhe: 3.405 ± 0.066	9.66LeuGly: 9.66 ± 0.118	1.812LeuHis: 1.812 ± 0.039	5.264LeuIle: 5.264 ± 0.079	3.318LeuLys: 3.318 ± 0.059	8.667LeuLeu: 8.667 ± 0.112	2.626LeuMet: 2.626 ± 0.058	2.221LeuAsn: 2.221 ± 0.048	5.779LeuPro: 5.779 ± 0.076	2.255LeuGln: 2.255 ± 0.052	7.713LeuArg: 7.713 ± 0.107	6.129LeuSer: 6.129 ± 0.079	5.814LeuThr: 5.814 ± 0.085	6.926LeuVal: 6.926 ± 0.092	1.526LeuTrp: 1.526 ± 0.045	1.948LeuTyr: 1.948 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.552MetAla: 3.552 ± 0.059	0.176MetCys: 0.176 ± 0.013	1.116MetAsp: 1.116 ± 0.034	1.302MetGlu: 1.302 ± 0.033	0.748MetPhe: 0.748 ± 0.028	2.238MetGly: 2.238 ± 0.054	0.416MetHis: 0.416 ± 0.022	1.442MetIle: 1.442 ± 0.035	1.035MetLys: 1.035 ± 0.035	2.462MetLeu: 2.462 ± 0.048	0.733MetMet: 0.733 ± 0.029	0.72MetAsn: 0.72 ± 0.026	1.433MetPro: 1.433 ± 0.037	0.808MetGln: 0.808 ± 0.03	1.917MetArg: 1.917 ± 0.043	1.579MetSer: 1.579 ± 0.054	1.887MetThr: 1.887 ± 0.043	1.795MetVal: 1.795 ± 0.05	0.204MetTrp: 0.204 ± 0.013	0.282MetTyr: 0.282 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.804AsnAla: 2.804 ± 0.059	0.222AsnCys: 0.222 ± 0.016	1.212AsnAsp: 1.212 ± 0.059	1.049AsnGlu: 1.049 ± 0.033	0.829AsnPhe: 0.829 ± 0.032	1.963AsnGly: 1.963 ± 0.041	0.432AsnHis: 0.432 ± 0.019	1.125AsnIle: 1.125 ± 0.033	0.568AsnLys: 0.568 ± 0.025	2.213AsnLeu: 2.213 ± 0.048	0.535AsnMet: 0.535 ± 0.022	0.474AsnAsn: 0.474 ± 0.024	1.676AsnPro: 1.676 ± 0.037	0.558AsnGln: 0.558 ± 0.024	1.568AsnArg: 1.568 ± 0.035	0.911AsnSer: 0.911 ± 0.025	1.108AsnThr: 1.108 ± 0.031	1.48AsnVal: 1.48 ± 0.042	0.387AsnTrp: 0.387 ± 0.019	0.551AsnTyr: 0.551 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.772ProAla: 7.772 ± 0.14	0.394ProCys: 0.394 ± 0.017	3.16ProAsp: 3.16 ± 0.062	5.154ProGlu: 5.154 ± 0.088	1.982ProPhe: 1.982 ± 0.047	5.418ProGly: 5.418 ± 0.08	0.971ProHis: 0.971 ± 0.033	2.079ProIle: 2.079 ± 0.039	1.648ProLys: 1.648 ± 0.041	4.877ProLeu: 4.877 ± 0.078	1.4ProMet: 1.4 ± 0.034	1.092ProAsn: 1.092 ± 0.031	2.58ProPro: 2.58 ± 0.063	1.637ProGln: 1.637 ± 0.045	3.251ProArg: 3.251 ± 0.072	2.319ProSer: 2.319 ± 0.055	2.264ProThr: 2.264 ± 0.051	4.4ProVal: 4.4 ± 0.068	0.73ProTrp: 0.73 ± 0.03	1.07ProTyr: 1.07 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.098GlnAla: 4.098 ± 0.067	0.168GlnCys: 0.168 ± 0.012	1.277GlnAsp: 1.277 ± 0.037	1.366GlnGlu: 1.366 ± 0.038	0.958GlnPhe: 0.958 ± 0.031	2.546GlnGly: 2.546 ± 0.054	0.473GlnHis: 0.473 ± 0.022	2.021GlnIle: 2.021 ± 0.043	0.94GlnLys: 0.94 ± 0.03	2.605GlnLeu: 2.605 ± 0.052	0.98GlnMet: 0.98 ± 0.029	0.777GlnAsn: 0.777 ± 0.03	1.474GlnPro: 1.474 ± 0.04	0.802GlnGln: 0.802 ± 0.033	1.946GlnArg: 1.946 ± 0.045	1.576GlnSer: 1.576 ± 0.037	1.512GlnThr: 1.512 ± 0.042	2.136GlnVal: 2.136 ± 0.045	0.369GlnTrp: 0.369 ± 0.018	0.525GlnTyr: 0.525 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	11.167ArgAla: 11.167 ± 0.123	0.465ArgCys: 0.465 ± 0.019	3.71ArgAsp: 3.71 ± 0.061	4.456ArgGlu: 4.456 ± 0.072	2.845ArgPhe: 2.845 ± 0.058	5.386ArgGly: 5.386 ± 0.081	1.599ArgHis: 1.599 ± 0.044	3.721ArgIle: 3.721 ± 0.062	2.171ArgLys: 2.171 ± 0.049	8.569ArgLeu: 8.569 ± 0.129	1.949ArgMet: 1.949 ± 0.046	1.499ArgAsn: 1.499 ± 0.038	3.984ArgPro: 3.984 ± 0.063	2.101ArgGln: 2.101 ± 0.048	5.553ArgArg: 5.553 ± 0.093	2.912ArgSer: 2.912 ± 0.064	2.741ArgThr: 2.741 ± 0.056	5.081ArgVal: 5.081 ± 0.068	1.031ArgTrp: 1.031 ± 0.031	1.554ArgTyr: 1.554 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.981SerAla: 5.981 ± 0.083	0.428SerCys: 0.428 ± 0.021	2.497SerAsp: 2.497 ± 0.055	2.681SerGlu: 2.681 ± 0.055	2.009SerPhe: 2.009 ± 0.044	4.995SerGly: 4.995 ± 0.092	0.959SerHis: 0.959 ± 0.028	1.904SerIle: 1.904 ± 0.044	1.262SerLys: 1.262 ± 0.035	4.722SerLeu: 4.722 ± 0.076	1.074SerMet: 1.074 ± 0.032	1.014SerAsn: 1.014 ± 0.034	2.396SerPro: 2.396 ± 0.048	1.341SerGln: 1.341 ± 0.037	3.03SerArg: 3.03 ± 0.059	2.119SerSer: 2.119 ± 0.045	2.086SerThr: 2.086 ± 0.054	3.392SerVal: 3.392 ± 0.054	0.745SerTrp: 0.745 ± 0.034	1.196SerTyr: 1.196 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.248ThrAla: 6.248 ± 0.083	0.418ThrCys: 0.418 ± 0.023	2.585ThrAsp: 2.585 ± 0.057	3.062ThrGlu: 3.062 ± 0.049	1.737ThrPhe: 1.737 ± 0.038	5.191ThrGly: 5.191 ± 0.08	0.961ThrHis: 0.961 ± 0.031	2.465ThrIle: 2.465 ± 0.056	1.34ThrLys: 1.34 ± 0.036	5.697ThrLeu: 5.697 ± 0.085	1.063ThrMet: 1.063 ± 0.03	1.115ThrAsn: 1.115 ± 0.034	3.389ThrPro: 3.389 ± 0.065	1.355ThrGln: 1.355 ± 0.045	3.677ThrArg: 3.677 ± 0.06	2.209ThrSer: 2.209 ± 0.054	2.67ThrThr: 2.67 ± 0.062	3.867ThrVal: 3.867 ± 0.059	0.578ThrTrp: 0.578 ± 0.028	1.052ThrTyr: 1.052 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.807ValAla: 9.807 ± 0.106	0.593ValCys: 0.593 ± 0.024	3.449ValAsp: 3.449 ± 0.059	4.535ValGlu: 4.535 ± 0.068	2.584ValPhe: 2.584 ± 0.052	5.105ValGly: 5.105 ± 0.081	1.21ValHis: 1.21 ± 0.035	4.036ValIle: 4.036 ± 0.067	2.2ValLys: 2.2 ± 0.055	7.459ValLeu: 7.459 ± 0.102	2.03ValMet: 2.03 ± 0.049	1.708ValAsn: 1.708 ± 0.045	3.463ValPro: 3.463 ± 0.056	1.877ValGln: 1.877 ± 0.049	4.22ValArg: 4.22 ± 0.063	3.879ValSer: 3.879 ± 0.057	4.448ValThr: 4.448 ± 0.077	5.506ValVal: 5.506 ± 0.086	0.951ValTrp: 0.951 ± 0.032	1.404ValTyr: 1.404 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.68TrpAla: 1.68 ± 0.051	0.13TrpCys: 0.13 ± 0.012	0.649TrpAsp: 0.649 ± 0.027	0.737TrpGlu: 0.737 ± 0.027	0.54TrpPhe: 0.54 ± 0.024	1.086TrpGly: 1.086 ± 0.034	0.353TrpHis: 0.353 ± 0.018	0.663TrpIle: 0.663 ± 0.027	0.474TrpLys: 0.474 ± 0.022	1.772TrpLeu: 1.772 ± 0.047	0.363TrpMet: 0.363 ± 0.019	0.355TrpAsn: 0.355 ± 0.019	0.755TrpPro: 0.755 ± 0.029	0.565TrpGln: 0.565 ± 0.024	1.278TrpArg: 1.278 ± 0.038	0.769TrpSer: 0.769 ± 0.029	0.652TrpThr: 0.652 ± 0.025	1.022TrpVal: 1.022 ± 0.038	0.225TrpTrp: 0.225 ± 0.015	0.268TrpTyr: 0.268 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.618TyrAla: 2.618 ± 0.048	0.221TyrCys: 0.221 ± 0.015	1.434TyrAsp: 1.434 ± 0.037	1.199TyrGlu: 1.199 ± 0.038	0.81TyrPhe: 0.81 ± 0.025	2.006TyrGly: 2.006 ± 0.043	0.47TyrHis: 0.47 ± 0.019	0.924TyrIle: 0.924 ± 0.029	0.559TyrLys: 0.559 ± 0.025	2.259TyrLeu: 2.259 ± 0.048	0.419TyrMet: 0.419 ± 0.018	0.54TyrAsn: 0.54 ± 0.022	1.001TyrPro: 1.001 ± 0.032	0.638TyrGln: 0.638 ± 0.024	1.586TyrArg: 1.586 ± 0.041	0.961TyrSer: 0.961 ± 0.033	0.985TyrThr: 0.985 ± 0.034	1.334TyrVal: 1.334 ± 0.036	0.341TyrTrp: 0.341 ± 0.017	0.544TyrTyr: 0.544 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3414 proteins (1065451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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