Amino acid dipepetide frequency for Leptospira phage vB_LalZ_80412-LE1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.599AlaAla: 2.599 ± 0.417
0.69AlaCys: 0.69 ± 0.144
2.517AlaAsp: 2.517 ± 0.401
2.396AlaGlu: 2.396 ± 0.333
2.477AlaPhe: 2.477 ± 0.339
3.817AlaGly: 3.817 ± 0.506
0.69AlaHis: 0.69 ± 0.189
3.248AlaIle: 3.248 ± 0.409
3.695AlaLys: 3.695 ± 0.503
4.75AlaLeu: 4.75 ± 0.541
0.853AlaMet: 0.853 ± 0.206
2.883AlaAsn: 2.883 ± 0.325
1.624AlaPro: 1.624 ± 0.251
1.38AlaGln: 1.38 ± 0.233
2.193AlaArg: 2.193 ± 0.265
4.669AlaSer: 4.669 ± 0.457
3.411AlaThr: 3.411 ± 0.377
3.005AlaVal: 3.005 ± 0.359
0.528AlaTrp: 0.528 ± 0.132
1.34AlaTyr: 1.34 ± 0.272
0.0AlaXaa: 0.0 ± 0.0
Cys
0.528CysAla: 0.528 ± 0.132
0.122CysCys: 0.122 ± 0.074
0.487CysAsp: 0.487 ± 0.129
0.406CysGlu: 0.406 ± 0.116
0.487CysPhe: 0.487 ± 0.167
0.65CysGly: 0.65 ± 0.178
0.0CysHis: 0.0 ± 0.0
0.69CysIle: 0.69 ± 0.187
0.528CysLys: 0.528 ± 0.162
0.934CysLeu: 0.934 ± 0.192
0.122CysMet: 0.122 ± 0.071
0.609CysAsn: 0.609 ± 0.148
0.325CysPro: 0.325 ± 0.148
0.162CysGln: 0.162 ± 0.094
0.487CysArg: 0.487 ± 0.142
0.447CysSer: 0.447 ± 0.16
0.244CysThr: 0.244 ± 0.102
0.65CysVal: 0.65 ± 0.156
0.162CysTrp: 0.162 ± 0.076
0.203CysTyr: 0.203 ± 0.092
0.0CysXaa: 0.0 ± 0.0
Asp
2.883AspAla: 2.883 ± 0.401
0.65AspCys: 0.65 ± 0.175
1.827AspAsp: 1.827 ± 0.311
2.152AspGlu: 2.152 ± 0.349
3.614AspPhe: 3.614 ± 0.412
3.208AspGly: 3.208 ± 0.597
0.853AspHis: 0.853 ± 0.17
3.045AspIle: 3.045 ± 0.336
3.208AspLys: 3.208 ± 0.315
5.806AspLeu: 5.806 ± 0.635
1.056AspMet: 1.056 ± 0.235
2.03AspAsn: 2.03 ± 0.28
2.883AspPro: 2.883 ± 0.339
0.893AspGln: 0.893 ± 0.205
2.233AspArg: 2.233 ± 0.295
4.385AspSer: 4.385 ± 0.41
1.949AspThr: 1.949 ± 0.348
2.436AspVal: 2.436 ± 0.306
0.609AspTrp: 0.609 ± 0.181
2.436AspTyr: 2.436 ± 0.376
0.0AspXaa: 0.0 ± 0.0
Glu
2.233GluAla: 2.233 ± 0.356
0.365GluCys: 0.365 ± 0.105
2.761GluAsp: 2.761 ± 0.386
6.415GluGlu: 6.415 ± 0.92
3.329GluPhe: 3.329 ± 0.413
3.411GluGly: 3.411 ± 0.527
0.934GluHis: 0.934 ± 0.222
6.293GluIle: 6.293 ± 0.449
6.821GluLys: 6.821 ± 0.91
6.902GluLeu: 6.902 ± 0.691
1.056GluMet: 1.056 ± 0.218
4.507GluAsn: 4.507 ± 0.39
1.787GluPro: 1.787 ± 0.273
1.096GluGln: 1.096 ± 0.253
2.639GluArg: 2.639 ± 0.364
5.522GluSer: 5.522 ± 0.525
3.817GluThr: 3.817 ± 0.342
3.817GluVal: 3.817 ± 0.436
1.056GluTrp: 1.056 ± 0.195
2.883GluTyr: 2.883 ± 0.366
0.0GluXaa: 0.0 ± 0.0
Phe
3.573PheAla: 3.573 ± 0.4
0.609PheCys: 0.609 ± 0.164
2.517PheAsp: 2.517 ± 0.334
2.72PheGlu: 2.72 ± 0.397
3.735PhePhe: 3.735 ± 0.475
3.857PheGly: 3.857 ± 0.448
1.259PheHis: 1.259 ± 0.216
2.111PheIle: 2.111 ± 0.301
3.329PheLys: 3.329 ± 0.39
6.902PheLeu: 6.902 ± 0.775
0.69PheMet: 0.69 ± 0.174
2.964PheAsn: 2.964 ± 0.48
1.827PhePro: 1.827 ± 0.273
2.558PheGln: 2.558 ± 0.322
2.964PheArg: 2.964 ± 0.371
4.182PheSer: 4.182 ± 0.519
3.086PheThr: 3.086 ± 0.289
3.695PheVal: 3.695 ± 0.406
0.934PheTrp: 0.934 ± 0.2
1.421PheTyr: 1.421 ± 0.205
0.0PheXaa: 0.0 ± 0.0
Gly
3.735GlyAla: 3.735 ± 0.517
0.447GlyCys: 0.447 ± 0.116
3.086GlyAsp: 3.086 ± 0.443
4.913GlyGlu: 4.913 ± 0.418
4.588GlyPhe: 4.588 ± 0.436
6.578GlyGly: 6.578 ± 0.976
0.893GlyHis: 0.893 ± 0.212
5.116GlyIle: 5.116 ± 0.425
5.035GlyLys: 5.035 ± 0.461
5.928GlyLeu: 5.928 ± 0.485
1.015GlyMet: 1.015 ± 0.215
4.385GlyAsn: 4.385 ± 0.768
2.274GlyPro: 2.274 ± 0.337
1.705GlyGln: 1.705 ± 0.339
3.208GlyArg: 3.208 ± 0.467
6.172GlySer: 6.172 ± 0.713
3.898GlyThr: 3.898 ± 0.414
4.385GlyVal: 4.385 ± 0.573
0.69GlyTrp: 0.69 ± 0.156
2.72GlyTyr: 2.72 ± 0.374
0.0GlyXaa: 0.0 ± 0.0
His
0.69HisAla: 0.69 ± 0.198
0.162HisCys: 0.162 ± 0.089
0.365HisAsp: 0.365 ± 0.132
0.853HisGlu: 0.853 ± 0.226
0.812HisPhe: 0.812 ± 0.216
1.177HisGly: 1.177 ± 0.181
0.284HisHis: 0.284 ± 0.104
0.812HisIle: 0.812 ± 0.172
1.137HisLys: 1.137 ± 0.26
1.624HisLeu: 1.624 ± 0.231
0.162HisMet: 0.162 ± 0.087
0.568HisAsn: 0.568 ± 0.17
1.502HisPro: 1.502 ± 0.208
0.244HisGln: 0.244 ± 0.098
0.568HisArg: 0.568 ± 0.179
1.015HisSer: 1.015 ± 0.197
0.934HisThr: 0.934 ± 0.197
0.812HisVal: 0.812 ± 0.178
0.162HisTrp: 0.162 ± 0.098
0.406HisTyr: 0.406 ± 0.113
0.0HisXaa: 0.0 ± 0.0
Ile
3.614IleAla: 3.614 ± 0.453
0.69IleCys: 0.69 ± 0.177
3.411IleAsp: 3.411 ± 0.475
5.684IleGlu: 5.684 ± 0.545
3.817IlePhe: 3.817 ± 0.487
4.669IleGly: 4.669 ± 0.497
1.096IleHis: 1.096 ± 0.22
2.477IleIle: 2.477 ± 0.377
4.913IleLys: 4.913 ± 0.678
7.836IleLeu: 7.836 ± 0.698
0.812IleMet: 0.812 ± 0.176
3.045IleAsn: 3.045 ± 0.341
4.344IlePro: 4.344 ± 0.425
3.492IleGln: 3.492 ± 0.367
3.776IleArg: 3.776 ± 0.319
6.74IleSer: 6.74 ± 0.527
3.979IleThr: 3.979 ± 0.528
3.654IleVal: 3.654 ± 0.377
0.406IleTrp: 0.406 ± 0.157
2.436IleTyr: 2.436 ± 0.3
0.0IleXaa: 0.0 ± 0.0
Lys
3.005LysAla: 3.005 ± 0.467
0.284LysCys: 0.284 ± 0.11
3.654LysAsp: 3.654 ± 0.357
6.902LysGlu: 6.902 ± 0.99
2.842LysPhe: 2.842 ± 0.352
4.466LysGly: 4.466 ± 0.466
0.487LysHis: 0.487 ± 0.149
7.674LysIle: 7.674 ± 0.779
9.054LysLys: 9.054 ± 1.4
6.537LysLeu: 6.537 ± 0.753
1.34LysMet: 1.34 ± 0.258
5.644LysAsn: 5.644 ± 0.646
2.842LysPro: 2.842 ± 0.425
2.03LysGln: 2.03 ± 0.36
3.208LysArg: 3.208 ± 0.436
6.05LysSer: 6.05 ± 0.593
5.684LysThr: 5.684 ± 0.483
3.289LysVal: 3.289 ± 0.392
0.528LysTrp: 0.528 ± 0.15
2.883LysTyr: 2.883 ± 0.37
0.0LysXaa: 0.0 ± 0.0
Leu
4.872LeuAla: 4.872 ± 0.438
0.812LeuCys: 0.812 ± 0.187
4.832LeuAsp: 4.832 ± 0.392
6.862LeuGlu: 6.862 ± 0.681
5.4LeuPhe: 5.4 ± 0.527
6.456LeuGly: 6.456 ± 0.641
1.462LeuHis: 1.462 ± 0.328
6.009LeuIle: 6.009 ± 0.636
9.298LeuLys: 9.298 ± 1.079
7.755LeuLeu: 7.755 ± 0.806
1.218LeuMet: 1.218 ± 0.191
6.415LeuAsn: 6.415 ± 0.58
4.426LeuPro: 4.426 ± 0.479
3.37LeuGln: 3.37 ± 0.366
4.141LeuArg: 4.141 ± 0.487
9.054LeuSer: 9.054 ± 0.656
5.806LeuThr: 5.806 ± 0.545
4.263LeuVal: 4.263 ± 0.437
1.34LeuTrp: 1.34 ± 0.254
3.248LeuTyr: 3.248 ± 0.345
0.0LeuXaa: 0.0 ± 0.0
Met
1.096MetAla: 1.096 ± 0.209
0.122MetCys: 0.122 ± 0.079
0.771MetAsp: 0.771 ± 0.149
0.853MetGlu: 0.853 ± 0.19
0.528MetPhe: 0.528 ± 0.149
1.056MetGly: 1.056 ± 0.199
0.244MetHis: 0.244 ± 0.083
1.056MetIle: 1.056 ± 0.178
1.38MetLys: 1.38 ± 0.234
1.015MetLeu: 1.015 ± 0.188
0.203MetMet: 0.203 ± 0.116
1.056MetAsn: 1.056 ± 0.168
0.609MetPro: 0.609 ± 0.17
0.65MetGln: 0.65 ± 0.169
0.487MetArg: 0.487 ± 0.161
1.218MetSer: 1.218 ± 0.225
0.934MetThr: 0.934 ± 0.169
0.609MetVal: 0.609 ± 0.164
0.041MetTrp: 0.041 ± 0.039
0.406MetTyr: 0.406 ± 0.122
0.0MetXaa: 0.0 ± 0.0
Asn
3.005AsnAla: 3.005 ± 0.322
0.447AsnCys: 0.447 ± 0.143
2.72AsnAsp: 2.72 ± 0.283
4.141AsnGlu: 4.141 ± 0.403
3.289AsnPhe: 3.289 ± 0.493
6.09AsnGly: 6.09 ± 1.153
0.812AsnHis: 0.812 ± 0.178
3.573AsnIle: 3.573 ± 0.382
4.101AsnLys: 4.101 ± 0.532
5.928AsnLeu: 5.928 ± 0.452
0.934AsnMet: 0.934 ± 0.216
2.152AsnAsn: 2.152 ± 0.328
2.923AsnPro: 2.923 ± 0.28
2.68AsnGln: 2.68 ± 0.423
3.451AsnArg: 3.451 ± 0.456
4.75AsnSer: 4.75 ± 0.422
3.938AsnThr: 3.938 ± 0.437
3.086AsnVal: 3.086 ± 0.398
0.568AsnTrp: 0.568 ± 0.15
2.152AsnTyr: 2.152 ± 0.308
0.0AsnXaa: 0.0 ± 0.0
Pro
1.583ProAla: 1.583 ± 0.292
0.203ProCys: 0.203 ± 0.096
2.599ProAsp: 2.599 ± 0.336
2.964ProGlu: 2.964 ± 0.357
1.787ProPhe: 1.787 ± 0.338
3.248ProGly: 3.248 ± 0.417
0.609ProHis: 0.609 ± 0.214
2.883ProIle: 2.883 ± 0.393
2.72ProLys: 2.72 ± 0.431
3.938ProLeu: 3.938 ± 0.386
0.325ProMet: 0.325 ± 0.112
3.126ProAsn: 3.126 ± 0.365
1.177ProPro: 1.177 ± 0.273
1.787ProGln: 1.787 ± 0.26
1.218ProArg: 1.218 ± 0.204
2.761ProSer: 2.761 ± 0.345
2.558ProThr: 2.558 ± 0.319
3.289ProVal: 3.289 ± 0.418
0.406ProTrp: 0.406 ± 0.136
1.38ProTyr: 1.38 ± 0.209
0.0ProXaa: 0.0 ± 0.0
Gln
1.787GlnAla: 1.787 ± 0.31
0.203GlnCys: 0.203 ± 0.095
1.462GlnAsp: 1.462 ± 0.269
1.949GlnGlu: 1.949 ± 0.272
1.462GlnPhe: 1.462 ± 0.262
2.355GlnGly: 2.355 ± 0.303
0.244GlnHis: 0.244 ± 0.109
3.208GlnIle: 3.208 ± 0.375
3.167GlnLys: 3.167 ± 0.498
2.477GlnLeu: 2.477 ± 0.354
0.447GlnMet: 0.447 ± 0.142
2.761GlnAsn: 2.761 ± 0.4
0.771GlnPro: 0.771 ± 0.168
0.69GlnGln: 0.69 ± 0.195
1.705GlnArg: 1.705 ± 0.239
2.233GlnSer: 2.233 ± 0.225
1.624GlnThr: 1.624 ± 0.268
1.624GlnVal: 1.624 ± 0.27
0.487GlnTrp: 0.487 ± 0.139
1.583GlnTyr: 1.583 ± 0.326
0.0GlnXaa: 0.0 ± 0.0
Arg
1.949ArgAla: 1.949 ± 0.302
0.203ArgCys: 0.203 ± 0.084
2.03ArgAsp: 2.03 ± 0.292
3.045ArgGlu: 3.045 ± 0.387
2.355ArgPhe: 2.355 ± 0.339
1.868ArgGly: 1.868 ± 0.312
0.69ArgHis: 0.69 ± 0.205
4.547ArgIle: 4.547 ± 0.473
3.167ArgLys: 3.167 ± 0.556
4.547ArgLeu: 4.547 ± 0.424
0.69ArgMet: 0.69 ± 0.188
3.532ArgAsn: 3.532 ± 0.386
1.177ArgPro: 1.177 ± 0.269
0.934ArgGln: 0.934 ± 0.182
2.396ArgArg: 2.396 ± 0.391
3.451ArgSer: 3.451 ± 0.422
3.532ArgThr: 3.532 ± 0.426
2.761ArgVal: 2.761 ± 0.394
0.325ArgTrp: 0.325 ± 0.116
1.787ArgTyr: 1.787 ± 0.283
0.0ArgXaa: 0.0 ± 0.0
Ser
3.979SerAla: 3.979 ± 0.461
0.65SerCys: 0.65 ± 0.164
3.857SerAsp: 3.857 ± 0.323
5.928SerGlu: 5.928 ± 0.613
4.913SerPhe: 4.913 ± 0.532
6.659SerGly: 6.659 ± 0.659
1.177SerHis: 1.177 ± 0.229
6.821SerIle: 6.821 ± 0.519
6.172SerLys: 6.172 ± 0.566
7.714SerLeu: 7.714 ± 0.62
1.218SerMet: 1.218 ± 0.23
5.766SerAsn: 5.766 ± 0.607
3.532SerPro: 3.532 ± 0.364
2.477SerGln: 2.477 ± 0.281
3.532SerArg: 3.532 ± 0.326
5.847SerSer: 5.847 ± 0.648
4.06SerThr: 4.06 ± 0.414
4.954SerVal: 4.954 ± 0.498
1.218SerTrp: 1.218 ± 0.194
3.208SerTyr: 3.208 ± 0.447
0.0SerXaa: 0.0 ± 0.0
Thr
2.72ThrAla: 2.72 ± 0.302
0.406ThrCys: 0.406 ± 0.127
3.573ThrAsp: 3.573 ± 0.389
3.532ThrGlu: 3.532 ± 0.423
3.126ThrPhe: 3.126 ± 0.381
4.791ThrGly: 4.791 ± 0.532
0.771ThrHis: 0.771 ± 0.216
3.817ThrIle: 3.817 ± 0.399
4.304ThrLys: 4.304 ± 0.491
6.537ThrLeu: 6.537 ± 0.507
0.771ThrMet: 0.771 ± 0.199
3.817ThrAsn: 3.817 ± 0.445
2.639ThrPro: 2.639 ± 0.307
2.355ThrGln: 2.355 ± 0.351
2.396ThrArg: 2.396 ± 0.402
4.71ThrSer: 4.71 ± 0.457
4.344ThrThr: 4.344 ± 0.512
2.396ThrVal: 2.396 ± 0.25
1.096ThrTrp: 1.096 ± 0.218
2.883ThrTyr: 2.883 ± 0.494
0.0ThrXaa: 0.0 ± 0.0
Val
2.639ValAla: 2.639 ± 0.322
0.69ValCys: 0.69 ± 0.187
2.396ValAsp: 2.396 ± 0.263
2.842ValGlu: 2.842 ± 0.377
3.411ValPhe: 3.411 ± 0.422
3.817ValGly: 3.817 ± 0.433
0.69ValHis: 0.69 ± 0.18
3.776ValIle: 3.776 ± 0.442
3.045ValLys: 3.045 ± 0.401
5.441ValLeu: 5.441 ± 0.503
0.528ValMet: 0.528 ± 0.149
2.436ValAsn: 2.436 ± 0.271
1.949ValPro: 1.949 ± 0.352
2.03ValGln: 2.03 ± 0.222
2.477ValArg: 2.477 ± 0.327
5.928ValSer: 5.928 ± 0.439
4.182ValThr: 4.182 ± 0.673
3.005ValVal: 3.005 ± 0.365
0.447ValTrp: 0.447 ± 0.157
2.436ValTyr: 2.436 ± 0.288
0.0ValXaa: 0.0 ± 0.0
Trp
0.609TrpAla: 0.609 ± 0.159
0.162TrpCys: 0.162 ± 0.083
0.528TrpAsp: 0.528 ± 0.146
0.69TrpGlu: 0.69 ± 0.141
0.528TrpPhe: 0.528 ± 0.166
0.812TrpGly: 0.812 ± 0.152
0.081TrpHis: 0.081 ± 0.051
1.096TrpIle: 1.096 ± 0.217
1.137TrpLys: 1.137 ± 0.225
0.974TrpLeu: 0.974 ± 0.175
0.162TrpMet: 0.162 ± 0.087
0.69TrpAsn: 0.69 ± 0.198
0.162TrpPro: 0.162 ± 0.08
0.447TrpGln: 0.447 ± 0.132
0.447TrpArg: 0.447 ± 0.124
1.015TrpSer: 1.015 ± 0.214
0.528TrpThr: 0.528 ± 0.167
0.528TrpVal: 0.528 ± 0.134
0.162TrpTrp: 0.162 ± 0.077
0.609TrpTyr: 0.609 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.665TyrAla: 1.665 ± 0.272
0.325TyrCys: 0.325 ± 0.145
2.761TyrAsp: 2.761 ± 0.521
2.396TyrGlu: 2.396 ± 0.323
2.436TyrPhe: 2.436 ± 0.315
1.787TyrGly: 1.787 ± 0.272
1.015TyrHis: 1.015 ± 0.213
2.639TyrIle: 2.639 ± 0.355
2.193TyrLys: 2.193 ± 0.293
3.492TyrLeu: 3.492 ± 0.421
0.69TyrMet: 0.69 ± 0.146
2.355TyrAsn: 2.355 ± 0.367
1.787TyrPro: 1.787 ± 0.281
1.299TyrGln: 1.299 ± 0.254
1.462TyrArg: 1.462 ± 0.214
3.532TyrSer: 3.532 ± 0.354
2.477TyrThr: 2.477 ± 0.355
1.908TyrVal: 1.908 ± 0.312
0.203TyrTrp: 0.203 ± 0.083
1.38TyrTyr: 1.38 ± 0.252
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 96 proteins (24630 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski