Amino acid dipepetide frequency for Vibrio sp. 10N.286.49.B3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.935AlaAla: 6.935 ± 0.098	0.936AlaCys: 0.936 ± 0.036	4.392AlaAsp: 4.392 ± 0.068	5.24AlaGlu: 5.24 ± 0.076	3.32AlaPhe: 3.32 ± 0.063	5.578AlaGly: 5.578 ± 0.092	1.595AlaHis: 1.595 ± 0.034	6.119AlaIle: 6.119 ± 0.087	4.829AlaLys: 4.829 ± 0.074	9.571AlaLeu: 9.571 ± 0.112	2.586AlaMet: 2.586 ± 0.048	3.536AlaAsn: 3.536 ± 0.061	2.714AlaPro: 2.714 ± 0.056	4.029AlaGln: 4.029 ± 0.068	3.347AlaArg: 3.347 ± 0.068	5.268AlaSer: 5.268 ± 0.074	4.513AlaThr: 4.513 ± 0.062	5.443AlaVal: 5.443 ± 0.074	0.916AlaTrp: 0.916 ± 0.029	2.341AlaTyr: 2.341 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.77CysAla: 0.77 ± 0.029	0.161CysCys: 0.161 ± 0.012	0.655CysAsp: 0.655 ± 0.025	0.588CysGlu: 0.588 ± 0.025	0.463CysPhe: 0.463 ± 0.022	0.875CysGly: 0.875 ± 0.031	0.354CysHis: 0.354 ± 0.019	0.628CysIle: 0.628 ± 0.025	0.46CysLys: 0.46 ± 0.023	0.923CysLeu: 0.923 ± 0.031	0.249CysMet: 0.249 ± 0.015	0.369CysAsn: 0.369 ± 0.017	0.425CysPro: 0.425 ± 0.019	0.5CysGln: 0.5 ± 0.022	0.473CysArg: 0.473 ± 0.023	0.697CysSer: 0.697 ± 0.031	0.502CysThr: 0.502 ± 0.021	0.592CysVal: 0.592 ± 0.025	0.119CysTrp: 0.119 ± 0.01	0.362CysTyr: 0.362 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.305AspAla: 4.305 ± 0.062	0.545AspCys: 0.545 ± 0.023	3.229AspAsp: 3.229 ± 0.066	3.961AspGlu: 3.961 ± 0.073	2.57AspPhe: 2.57 ± 0.056	3.798AspGly: 3.798 ± 0.074	1.18AspHis: 1.18 ± 0.033	4.382AspIle: 4.382 ± 0.076	3.419AspLys: 3.419 ± 0.055	5.581AspLeu: 5.581 ± 0.074	1.5AspMet: 1.5 ± 0.039	2.835AspAsn: 2.835 ± 0.055	2.044AspPro: 2.044 ± 0.049	2.192AspGln: 2.192 ± 0.049	2.266AspArg: 2.266 ± 0.047	3.587AspSer: 3.587 ± 0.06	2.73AspThr: 2.73 ± 0.053	3.906AspVal: 3.906 ± 0.075	0.823AspTrp: 0.823 ± 0.03	2.09AspTyr: 2.09 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.307GluAla: 5.307 ± 0.079	0.554GluCys: 0.554 ± 0.019	3.004GluAsp: 3.004 ± 0.059	3.823GluGlu: 3.823 ± 0.071	2.491GluPhe: 2.491 ± 0.05	3.624GluGly: 3.624 ± 0.068	1.594GluHis: 1.594 ± 0.04	3.75GluIle: 3.75 ± 0.066	3.825GluLys: 3.825 ± 0.061	7.083GluLeu: 7.083 ± 0.094	1.731GluMet: 1.731 ± 0.044	2.667GluAsn: 2.667 ± 0.057	1.947GluPro: 1.947 ± 0.051	3.929GluGln: 3.929 ± 0.068	3.145GluArg: 3.145 ± 0.063	3.907GluSer: 3.907 ± 0.065	3.099GluThr: 3.099 ± 0.055	4.502GluVal: 4.502 ± 0.074	0.802GluTrp: 0.802 ± 0.025	1.839GluTyr: 1.839 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.487PheAla: 3.487 ± 0.066	0.488PheCys: 0.488 ± 0.019	2.94PheAsp: 2.94 ± 0.058	2.535PheGlu: 2.535 ± 0.05	1.755PhePhe: 1.755 ± 0.05	3.114PheGly: 3.114 ± 0.054	0.851PheHis: 0.851 ± 0.028	3.166PheIle: 3.166 ± 0.06	2.0PheLys: 2.0 ± 0.046	3.395PheLeu: 3.395 ± 0.062	1.075PheMet: 1.075 ± 0.033	2.173PheAsn: 2.173 ± 0.051	1.383PhePro: 1.383 ± 0.035	1.307PheGln: 1.307 ± 0.033	1.408PheArg: 1.408 ± 0.037	3.466PheSer: 3.466 ± 0.068	2.457PheThr: 2.457 ± 0.047	2.579PheVal: 2.579 ± 0.058	0.493PheTrp: 0.493 ± 0.021	1.29PheTyr: 1.29 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.939GlyAla: 4.939 ± 0.094	0.903GlyCys: 0.903 ± 0.029	3.775GlyAsp: 3.775 ± 0.062	4.235GlyGlu: 4.235 ± 0.074	3.243GlyPhe: 3.243 ± 0.064	4.664GlyGly: 4.664 ± 0.084	1.573GlyHis: 1.573 ± 0.036	4.825GlyIle: 4.825 ± 0.075	3.834GlyLys: 3.834 ± 0.067	6.914GlyLeu: 6.914 ± 0.092	1.999GlyMet: 1.999 ± 0.04	2.593GlyAsn: 2.593 ± 0.051	1.548GlyPro: 1.548 ± 0.044	2.918GlyGln: 2.918 ± 0.061	2.99GlyArg: 2.99 ± 0.059	4.121GlySer: 4.121 ± 0.069	3.39GlyThr: 3.39 ± 0.072	5.001GlyVal: 5.001 ± 0.076	0.902GlyTrp: 0.902 ± 0.029	2.542GlyTyr: 2.542 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.636HisAla: 1.636 ± 0.041	0.353HisCys: 0.353 ± 0.019	1.219HisAsp: 1.219 ± 0.032	1.153HisGlu: 1.153 ± 0.035	1.116HisPhe: 1.116 ± 0.033	1.497HisGly: 1.497 ± 0.038	0.744HisHis: 0.744 ± 0.025	1.516HisIle: 1.516 ± 0.037	1.088HisLys: 1.088 ± 0.033	2.406HisLeu: 2.406 ± 0.048	0.511HisMet: 0.511 ± 0.019	0.998HisAsn: 0.998 ± 0.033	1.116HisPro: 1.116 ± 0.029	1.262HisGln: 1.262 ± 0.033	1.025HisArg: 1.025 ± 0.031	1.581HisSer: 1.581 ± 0.038	1.13HisThr: 1.13 ± 0.03	1.256HisVal: 1.256 ± 0.031	0.378HisTrp: 0.378 ± 0.02	0.914HisTyr: 0.914 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.473IleAla: 6.473 ± 0.086	0.715IleCys: 0.715 ± 0.024	4.682IleAsp: 4.682 ± 0.07	5.1IleGlu: 5.1 ± 0.075	2.505IlePhe: 2.505 ± 0.048	4.827IleGly: 4.827 ± 0.081	1.389IleHis: 1.389 ± 0.036	4.369IleIle: 4.369 ± 0.071	3.684IleLys: 3.684 ± 0.062	5.623IleLeu: 5.623 ± 0.094	1.465IleMet: 1.465 ± 0.034	3.371IleAsn: 3.371 ± 0.058	2.697IlePro: 2.697 ± 0.051	2.506IleGln: 2.506 ± 0.05	2.809IleArg: 2.809 ± 0.056	4.801IleSer: 4.801 ± 0.072	4.07IleThr: 4.07 ± 0.072	4.329IleVal: 4.329 ± 0.069	0.588IleTrp: 0.588 ± 0.023	1.866IleTyr: 1.866 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.832LysAla: 4.832 ± 0.067	0.351LysCys: 0.351 ± 0.019	2.69LysAsp: 2.69 ± 0.049	3.578LysGlu: 3.578 ± 0.06	1.568LysPhe: 1.568 ± 0.035	3.335LysGly: 3.335 ± 0.066	1.26LysHis: 1.26 ± 0.041	3.134LysIle: 3.134 ± 0.056	3.34LysLys: 3.34 ± 0.079	5.162LysLeu: 5.162 ± 0.069	1.532LysMet: 1.532 ± 0.043	2.389LysAsn: 2.389 ± 0.057	2.321LysPro: 2.321 ± 0.055	2.925LysGln: 2.925 ± 0.06	2.591LysArg: 2.591 ± 0.051	3.408LysSer: 3.408 ± 0.057	2.845LysThr: 2.845 ± 0.053	3.881LysVal: 3.881 ± 0.058	0.583LysTrp: 0.583 ± 0.023	1.497LysTyr: 1.497 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	9.599LeuAla: 9.599 ± 0.115	1.09LeuCys: 1.09 ± 0.036	5.949LeuAsp: 5.949 ± 0.07	6.263LeuGlu: 6.263 ± 0.084	4.246LeuPhe: 4.246 ± 0.085	6.807LeuGly: 6.807 ± 0.101	2.059LeuHis: 2.059 ± 0.048	6.752LeuIle: 6.752 ± 0.089	5.17LeuLys: 5.17 ± 0.075	10.31LeuLeu: 10.31 ± 0.141	2.789LeuMet: 2.789 ± 0.049	4.687LeuAsn: 4.687 ± 0.065	4.685LeuPro: 4.685 ± 0.065	3.679LeuGln: 3.679 ± 0.063	4.206LeuArg: 4.206 ± 0.071	8.036LeuSer: 8.036 ± 0.092	6.231LeuThr: 6.231 ± 0.085	6.773LeuVal: 6.773 ± 0.086	1.061LeuTrp: 1.061 ± 0.033	2.597LeuTyr: 2.597 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.464MetAla: 2.464 ± 0.05	0.196MetCys: 0.196 ± 0.013	1.386MetAsp: 1.386 ± 0.033	1.31MetGlu: 1.31 ± 0.035	0.965MetPhe: 0.965 ± 0.03	1.816MetGly: 1.816 ± 0.04	0.53MetHis: 0.53 ± 0.021	1.649MetIle: 1.649 ± 0.044	1.522MetLys: 1.522 ± 0.039	2.782MetLeu: 2.782 ± 0.052	0.889MetMet: 0.889 ± 0.031	1.231MetAsn: 1.231 ± 0.034	1.262MetPro: 1.262 ± 0.036	1.16MetGln: 1.16 ± 0.033	1.122MetArg: 1.122 ± 0.032	2.02MetSer: 2.02 ± 0.042	1.762MetThr: 1.762 ± 0.043	1.875MetVal: 1.875 ± 0.041	0.24MetTrp: 0.24 ± 0.014	0.563MetTyr: 0.563 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.319AsnAla: 3.319 ± 0.05	0.391AsnCys: 0.391 ± 0.02	2.636AsnAsp: 2.636 ± 0.072	2.599AsnGlu: 2.599 ± 0.052	1.62AsnPhe: 1.62 ± 0.042	2.975AsnGly: 2.975 ± 0.061	1.144AsnHis: 1.144 ± 0.038	3.164AsnIle: 3.164 ± 0.057	2.457AsnLys: 2.457 ± 0.053	4.187AsnLeu: 4.187 ± 0.065	1.079AsnMet: 1.079 ± 0.032	2.301AsnAsn: 2.301 ± 0.063	2.125AsnPro: 2.125 ± 0.046	2.305AsnGln: 2.305 ± 0.049	1.987AsnArg: 1.987 ± 0.041	2.789AsnSer: 2.789 ± 0.056	2.395AsnThr: 2.395 ± 0.05	2.772AsnVal: 2.772 ± 0.054	0.597AsnTrp: 0.597 ± 0.024	1.477AsnTyr: 1.477 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.835ProAla: 2.835 ± 0.054	0.326ProCys: 0.326 ± 0.019	2.172ProAsp: 2.172 ± 0.045	3.022ProGlu: 3.022 ± 0.052	1.717ProPhe: 1.717 ± 0.041	2.148ProGly: 2.148 ± 0.047	0.878ProHis: 0.878 ± 0.03	2.616ProIle: 2.616 ± 0.048	1.866ProLys: 1.866 ± 0.042	4.036ProLeu: 4.036 ± 0.069	1.023ProMet: 1.023 ± 0.031	1.645ProAsn: 1.645 ± 0.036	1.055ProPro: 1.055 ± 0.032	1.688ProGln: 1.688 ± 0.036	1.258ProArg: 1.258 ± 0.037	2.634ProSer: 2.634 ± 0.048	2.283ProThr: 2.283 ± 0.048	2.823ProVal: 2.823 ± 0.051	0.503ProTrp: 0.503 ± 0.022	1.241ProTyr: 1.241 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.472GlnAla: 4.472 ± 0.085	0.429GlnCys: 0.429 ± 0.022	2.272GlnAsp: 2.272 ± 0.052	2.599GlnGlu: 2.599 ± 0.054	1.819GlnPhe: 1.819 ± 0.039	3.066GlnGly: 3.066 ± 0.053	1.27GlnHis: 1.27 ± 0.035	2.594GlnIle: 2.594 ± 0.047	2.122GlnLys: 2.122 ± 0.05	5.326GlnLeu: 5.326 ± 0.084	1.12GlnMet: 1.12 ± 0.031	1.659GlnAsn: 1.659 ± 0.038	1.747GlnPro: 1.747 ± 0.041	3.057GlnGln: 3.057 ± 0.073	2.34GlnArg: 2.34 ± 0.048	2.901GlnSer: 2.901 ± 0.051	2.219GlnThr: 2.219 ± 0.055	3.358GlnVal: 3.358 ± 0.056	0.71GlnTrp: 0.71 ± 0.025	1.544GlnTyr: 1.544 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.063ArgAla: 3.063 ± 0.056	0.423ArgCys: 0.423 ± 0.021	2.433ArgAsp: 2.433 ± 0.052	2.735ArgGlu: 2.735 ± 0.057	2.101ArgPhe: 2.101 ± 0.049	2.473ArgGly: 2.473 ± 0.059	1.128ArgHis: 1.128 ± 0.036	3.029ArgIle: 3.029 ± 0.055	2.234ArgLys: 2.234 ± 0.052	4.753ArgLeu: 4.753 ± 0.072	1.179ArgMet: 1.179 ± 0.032	1.907ArgAsn: 1.907 ± 0.046	1.475ArgPro: 1.475 ± 0.041	2.07ArgGln: 2.07 ± 0.041	2.212ArgArg: 2.212 ± 0.057	2.705ArgSer: 2.705 ± 0.053	2.15ArgThr: 2.15 ± 0.05	2.929ArgVal: 2.929 ± 0.06	0.584ArgTrp: 0.584 ± 0.024	1.669ArgTyr: 1.669 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.369SerAla: 5.369 ± 0.07	0.574SerCys: 0.574 ± 0.024	3.995SerAsp: 3.995 ± 0.076	4.095SerGlu: 4.095 ± 0.074	2.953SerPhe: 2.953 ± 0.048	4.912SerGly: 4.912 ± 0.075	1.678SerHis: 1.678 ± 0.048	4.84SerIle: 4.84 ± 0.075	3.278SerLys: 3.278 ± 0.056	7.174SerLeu: 7.174 ± 0.104	1.763SerMet: 1.763 ± 0.037	2.9SerAsn: 2.9 ± 0.058	2.429SerPro: 2.429 ± 0.052	3.278SerGln: 3.278 ± 0.055	2.833SerArg: 2.833 ± 0.051	4.749SerSer: 4.749 ± 0.087	3.512SerThr: 3.512 ± 0.061	4.648SerVal: 4.648 ± 0.072	0.783SerTrp: 0.783 ± 0.028	2.089SerTyr: 2.089 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.336ThrAla: 4.336 ± 0.073	0.475ThrCys: 0.475 ± 0.024	2.961ThrAsp: 2.961 ± 0.057	3.101ThrGlu: 3.101 ± 0.059	2.292ThrPhe: 2.292 ± 0.052	3.956ThrGly: 3.956 ± 0.069	1.263ThrHis: 1.263 ± 0.035	3.747ThrIle: 3.747 ± 0.064	2.549ThrLys: 2.549 ± 0.051	6.411ThrLeu: 6.411 ± 0.088	1.265ThrMet: 1.265 ± 0.035	2.254ThrAsn: 2.254 ± 0.05	2.646ThrPro: 2.646 ± 0.039	2.553ThrGln: 2.553 ± 0.053	2.19ThrArg: 2.19 ± 0.051	3.52ThrSer: 3.52 ± 0.062	3.143ThrThr: 3.143 ± 0.06	3.712ThrVal: 3.712 ± 0.062	0.636ThrTrp: 0.636 ± 0.024	1.568ThrTyr: 1.568 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	6.009ValAla: 6.009 ± 0.087	0.71ValCys: 0.71 ± 0.03	4.205ValAsp: 4.205 ± 0.072	4.675ValGlu: 4.675 ± 0.062	2.588ValPhe: 2.588 ± 0.058	4.581ValGly: 4.581 ± 0.074	1.233ValHis: 1.233 ± 0.035	5.077ValIle: 5.077 ± 0.081	3.631ValLys: 3.631 ± 0.059	6.383ValLeu: 6.383 ± 0.076	2.028ValMet: 2.028 ± 0.046	3.031ValAsn: 3.031 ± 0.055	2.431ValPro: 2.431 ± 0.043	2.307ValGln: 2.307 ± 0.047	2.802ValArg: 2.802 ± 0.054	4.742ValSer: 4.742 ± 0.075	4.058ValThr: 4.058 ± 0.068	5.046ValVal: 5.046 ± 0.081	0.733ValTrp: 0.733 ± 0.027	1.717ValTyr: 1.717 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.809TrpAla: 0.809 ± 0.028	0.156TrpCys: 0.156 ± 0.012	0.623TrpAsp: 0.623 ± 0.025	0.523TrpGlu: 0.523 ± 0.023	0.607TrpPhe: 0.607 ± 0.028	0.777TrpGly: 0.777 ± 0.035	0.333TrpHis: 0.333 ± 0.018	0.698TrpIle: 0.698 ± 0.025	0.544TrpLys: 0.544 ± 0.025	1.667TrpLeu: 1.667 ± 0.046	0.319TrpMet: 0.319 ± 0.019	0.492TrpAsn: 0.492 ± 0.021	0.4TrpPro: 0.4 ± 0.021	0.908TrpGln: 0.908 ± 0.031	0.584TrpArg: 0.584 ± 0.024	0.798TrpSer: 0.798 ± 0.029	0.516TrpThr: 0.516 ± 0.028	0.803TrpVal: 0.803 ± 0.024	0.192TrpTrp: 0.192 ± 0.014	0.364TrpTyr: 0.364 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.246TyrAla: 2.246 ± 0.05	0.388TyrCys: 0.388 ± 0.02	1.727TyrAsp: 1.727 ± 0.045	1.486TyrGlu: 1.486 ± 0.04	1.422TyrPhe: 1.422 ± 0.045	2.084TyrGly: 2.084 ± 0.049	0.842TyrHis: 0.842 ± 0.029	1.816TyrIle: 1.816 ± 0.042	1.37TyrLys: 1.37 ± 0.036	3.303TyrLeu: 3.303 ± 0.057	0.642TyrMet: 0.642 ± 0.024	1.282TyrAsn: 1.282 ± 0.033	1.317TyrPro: 1.317 ± 0.035	2.05TyrGln: 2.05 ± 0.051	1.665TyrArg: 1.665 ± 0.044	2.126TyrSer: 2.126 ± 0.047	1.572TyrThr: 1.572 ± 0.041	1.759TyrVal: 1.759 ± 0.036	0.471TyrTrp: 0.471 ± 0.022	1.007TyrTyr: 1.007 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3192 proteins (1073679 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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