Amino acid dipepetide frequency for Leptospira phage vB_LnoZ_CZ214-LE1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.442AlaAla: 2.442 ± 0.738
0.4AlaCys: 0.4 ± 0.158
1.602AlaAsp: 1.602 ± 0.3
2.683AlaGlu: 2.683 ± 0.485
1.762AlaPhe: 1.762 ± 0.303
2.162AlaGly: 2.162 ± 0.471
0.521AlaHis: 0.521 ± 0.148
3.443AlaIle: 3.443 ± 0.389
3.323AlaLys: 3.323 ± 0.425
4.324AlaLeu: 4.324 ± 0.451
1.081AlaMet: 1.081 ± 0.237
2.202AlaAsn: 2.202 ± 0.589
1.241AlaPro: 1.241 ± 0.211
1.802AlaGln: 1.802 ± 0.565
1.441AlaArg: 1.441 ± 0.236
3.644AlaSer: 3.644 ± 0.708
2.482AlaThr: 2.482 ± 0.391
2.523AlaVal: 2.523 ± 0.324
0.24AlaTrp: 0.24 ± 0.108
1.241AlaTyr: 1.241 ± 0.332
0.0AlaXaa: 0.0 ± 0.0
Cys
0.48CysAla: 0.48 ± 0.13
0.12CysCys: 0.12 ± 0.067
0.32CysAsp: 0.32 ± 0.126
0.841CysGlu: 0.841 ± 0.191
0.521CysPhe: 0.521 ± 0.151
0.641CysGly: 0.641 ± 0.149
0.04CysHis: 0.04 ± 0.04
0.761CysIle: 0.761 ± 0.22
0.641CysLys: 0.641 ± 0.186
0.841CysLeu: 0.841 ± 0.183
0.08CysMet: 0.08 ± 0.05
0.601CysAsn: 0.601 ± 0.127
0.36CysPro: 0.36 ± 0.16
0.2CysGln: 0.2 ± 0.108
0.28CysArg: 0.28 ± 0.109
1.081CysSer: 1.081 ± 0.227
0.2CysThr: 0.2 ± 0.097
0.4CysVal: 0.4 ± 0.131
0.12CysTrp: 0.12 ± 0.069
0.36CysTyr: 0.36 ± 0.11
0.0CysXaa: 0.0 ± 0.0
Asp
2.042AspAla: 2.042 ± 0.256
0.561AspCys: 0.561 ± 0.162
1.602AspAsp: 1.602 ± 0.207
3.043AspGlu: 3.043 ± 0.368
2.763AspPhe: 2.763 ± 0.371
2.002AspGly: 2.002 ± 0.313
1.041AspHis: 1.041 ± 0.183
3.443AspIle: 3.443 ± 0.314
2.923AspLys: 2.923 ± 0.384
5.886AspLeu: 5.886 ± 0.698
0.681AspMet: 0.681 ± 0.149
2.322AspAsn: 2.322 ± 0.38
2.442AspPro: 2.442 ± 0.37
1.722AspGln: 1.722 ± 0.279
1.962AspArg: 1.962 ± 0.3
3.804AspSer: 3.804 ± 0.321
2.282AspThr: 2.282 ± 0.268
1.522AspVal: 1.522 ± 0.22
0.641AspTrp: 0.641 ± 0.155
2.042AspTyr: 2.042 ± 0.313
0.0AspXaa: 0.0 ± 0.0
Glu
2.883GluAla: 2.883 ± 0.326
0.641GluCys: 0.641 ± 0.144
2.683GluAsp: 2.683 ± 0.331
6.126GluGlu: 6.126 ± 0.837
3.524GluPhe: 3.524 ± 0.337
3.403GluGly: 3.403 ± 0.321
1.201GluHis: 1.201 ± 0.209
8.128GluIle: 8.128 ± 0.885
7.007GluLys: 7.007 ± 0.63
8.288GluLeu: 8.288 ± 0.623
1.201GluMet: 1.201 ± 0.258
5.405GluAsn: 5.405 ± 0.56
1.562GluPro: 1.562 ± 0.213
2.162GluGln: 2.162 ± 0.287
2.723GluArg: 2.723 ± 0.4
5.285GluSer: 5.285 ± 0.662
3.964GluThr: 3.964 ± 0.41
3.844GluVal: 3.844 ± 0.41
0.601GluTrp: 0.601 ± 0.13
3.163GluTyr: 3.163 ± 0.336
0.0GluXaa: 0.0 ± 0.0
Phe
1.642PheAla: 1.642 ± 0.279
0.841PheCys: 0.841 ± 0.161
2.523PheAsp: 2.523 ± 0.357
3.203PheGlu: 3.203 ± 0.349
3.403PhePhe: 3.403 ± 0.581
2.963PheGly: 2.963 ± 0.386
1.161PheHis: 1.161 ± 0.199
2.923PheIle: 2.923 ± 0.507
3.564PheLys: 3.564 ± 0.428
6.246PheLeu: 6.246 ± 0.74
0.761PheMet: 0.761 ± 0.174
3.564PheAsn: 3.564 ± 0.425
1.802PhePro: 1.802 ± 0.29
2.563PheGln: 2.563 ± 0.355
2.563PheArg: 2.563 ± 0.423
4.044PheSer: 4.044 ± 0.413
2.683PheThr: 2.683 ± 0.35
2.442PheVal: 2.442 ± 0.265
0.601PheTrp: 0.601 ± 0.179
1.762PheTyr: 1.762 ± 0.32
0.0PheXaa: 0.0 ± 0.0
Gly
3.163GlyAla: 3.163 ± 0.718
0.641GlyCys: 0.641 ± 0.145
2.322GlyAsp: 2.322 ± 0.383
3.524GlyGlu: 3.524 ± 0.385
3.884GlyPhe: 3.884 ± 0.403
4.565GlyGly: 4.565 ± 0.996
0.681GlyHis: 0.681 ± 0.158
4.484GlyIle: 4.484 ± 0.449
4.364GlyLys: 4.364 ± 0.518
5.285GlyLeu: 5.285 ± 0.594
1.121GlyMet: 1.121 ± 0.2
3.804GlyAsn: 3.804 ± 0.505
1.562GlyPro: 1.562 ± 0.316
2.282GlyGln: 2.282 ± 0.517
2.082GlyArg: 2.082 ± 0.315
4.444GlySer: 4.444 ± 0.58
3.003GlyThr: 3.003 ± 0.436
3.564GlyVal: 3.564 ± 0.435
0.601GlyTrp: 0.601 ± 0.145
3.163GlyTyr: 3.163 ± 0.395
0.0GlyXaa: 0.0 ± 0.0
His
0.681HisAla: 0.681 ± 0.154
0.24HisCys: 0.24 ± 0.096
0.681HisAsp: 0.681 ± 0.145
0.761HisGlu: 0.761 ± 0.178
0.761HisPhe: 0.761 ± 0.186
0.681HisGly: 0.681 ± 0.189
0.24HisHis: 0.24 ± 0.081
1.481HisIle: 1.481 ± 0.258
1.081HisLys: 1.081 ± 0.235
1.241HisLeu: 1.241 ± 0.189
0.16HisMet: 0.16 ± 0.076
0.841HisAsn: 0.841 ± 0.172
1.001HisPro: 1.001 ± 0.195
0.24HisGln: 0.24 ± 0.1
0.601HisArg: 0.601 ± 0.228
1.401HisSer: 1.401 ± 0.283
0.601HisThr: 0.601 ± 0.156
0.641HisVal: 0.641 ± 0.17
0.12HisTrp: 0.12 ± 0.065
0.561HisTyr: 0.561 ± 0.129
0.0HisXaa: 0.0 ± 0.0
Ile
3.203IleAla: 3.203 ± 0.366
0.721IleCys: 0.721 ± 0.182
3.804IleAsp: 3.804 ± 0.41
6.446IleGlu: 6.446 ± 0.407
3.804IlePhe: 3.804 ± 0.596
5.125IleGly: 5.125 ± 0.852
1.201IleHis: 1.201 ± 0.248
4.364IleIle: 4.364 ± 0.626
5.686IleLys: 5.686 ± 0.676
9.249IleLeu: 9.249 ± 0.989
0.881IleMet: 0.881 ± 0.203
3.483IleAsn: 3.483 ± 0.386
3.884IlePro: 3.884 ± 0.459
4.004IleGln: 4.004 ± 0.425
4.444IleArg: 4.444 ± 0.447
7.167IleSer: 7.167 ± 0.512
4.525IleThr: 4.525 ± 0.438
3.724IleVal: 3.724 ± 0.398
0.601IleTrp: 0.601 ± 0.176
2.523IleTyr: 2.523 ± 0.363
0.0IleXaa: 0.0 ± 0.0
Lys
2.843LysAla: 2.843 ± 0.348
0.44LysCys: 0.44 ± 0.132
4.084LysAsp: 4.084 ± 0.382
8.008LysGlu: 8.008 ± 0.769
3.524LysPhe: 3.524 ± 0.398
4.204LysGly: 4.204 ± 0.503
0.841LysHis: 0.841 ± 0.169
7.047LysIle: 7.047 ± 0.698
7.888LysLys: 7.888 ± 0.686
7.608LysLeu: 7.608 ± 0.757
1.682LysMet: 1.682 ± 0.259
7.808LysAsn: 7.808 ± 0.704
2.282LysPro: 2.282 ± 0.403
2.442LysGln: 2.442 ± 0.466
2.442LysArg: 2.442 ± 0.347
7.367LysSer: 7.367 ± 0.554
5.125LysThr: 5.125 ± 0.537
3.924LysVal: 3.924 ± 0.389
0.681LysTrp: 0.681 ± 0.14
3.443LysTyr: 3.443 ± 0.309
0.0LysXaa: 0.0 ± 0.0
Leu
4.164LeuAla: 4.164 ± 0.4
0.721LeuCys: 0.721 ± 0.197
5.165LeuAsp: 5.165 ± 0.647
7.728LeuGlu: 7.728 ± 0.636
4.685LeuPhe: 4.685 ± 0.606
5.485LeuGly: 5.485 ± 0.587
1.361LeuHis: 1.361 ± 0.227
6.807LeuIle: 6.807 ± 0.937
11.532LeuLys: 11.532 ± 1.026
7.447LeuLeu: 7.447 ± 0.517
1.201LeuMet: 1.201 ± 0.168
8.408LeuAsn: 8.408 ± 0.486
5.165LeuPro: 5.165 ± 0.697
5.766LeuGln: 5.766 ± 1.038
3.724LeuArg: 3.724 ± 0.437
9.65LeuSer: 9.65 ± 0.782
5.686LeuThr: 5.686 ± 0.573
4.525LeuVal: 4.525 ± 0.448
0.801LeuTrp: 0.801 ± 0.168
4.004LeuTyr: 4.004 ± 0.449
0.0LeuXaa: 0.0 ± 0.0
Met
0.801MetAla: 0.801 ± 0.175
0.08MetCys: 0.08 ± 0.056
0.961MetAsp: 0.961 ± 0.171
1.281MetGlu: 1.281 ± 0.282
0.44MetPhe: 0.44 ± 0.088
1.081MetGly: 1.081 ± 0.161
0.12MetHis: 0.12 ± 0.061
0.881MetIle: 0.881 ± 0.192
1.321MetLys: 1.321 ± 0.196
1.321MetLeu: 1.321 ± 0.267
0.2MetMet: 0.2 ± 0.088
1.201MetAsn: 1.201 ± 0.223
0.32MetPro: 0.32 ± 0.115
0.521MetGln: 0.521 ± 0.121
0.881MetArg: 0.881 ± 0.183
1.642MetSer: 1.642 ± 0.345
0.801MetThr: 0.801 ± 0.189
0.561MetVal: 0.561 ± 0.141
0.04MetTrp: 0.04 ± 0.036
0.44MetTyr: 0.44 ± 0.13
0.0MetXaa: 0.0 ± 0.0
Asn
2.803AsnAla: 2.803 ± 0.575
0.32AsnCys: 0.32 ± 0.099
2.482AsnAsp: 2.482 ± 0.313
6.446AsnGlu: 6.446 ± 0.843
2.843AsnPhe: 2.843 ± 0.349
4.525AsnGly: 4.525 ± 0.693
0.961AsnHis: 0.961 ± 0.186
5.085AsnIle: 5.085 ± 0.532
4.685AsnLys: 4.685 ± 0.473
8.168AsnLeu: 8.168 ± 0.886
0.721AsnMet: 0.721 ± 0.161
4.324AsnAsn: 4.324 ± 0.617
3.043AsnPro: 3.043 ± 0.383
5.726AsnGln: 5.726 ± 0.97
2.723AsnArg: 2.723 ± 0.374
6.166AsnSer: 6.166 ± 0.568
3.924AsnThr: 3.924 ± 0.449
3.604AsnVal: 3.604 ± 0.36
1.001AsnTrp: 1.001 ± 0.246
2.683AsnTyr: 2.683 ± 0.292
0.0AsnXaa: 0.0 ± 0.0
Pro
1.121ProAla: 1.121 ± 0.271
0.24ProCys: 0.24 ± 0.116
1.842ProAsp: 1.842 ± 0.36
2.643ProGlu: 2.643 ± 0.342
2.042ProPhe: 2.042 ± 0.283
2.803ProGly: 2.803 ± 0.343
0.36ProHis: 0.36 ± 0.123
2.523ProIle: 2.523 ± 0.36
2.803ProLys: 2.803 ± 0.419
3.083ProLeu: 3.083 ± 0.443
0.32ProMet: 0.32 ± 0.11
4.004ProAsn: 4.004 ± 0.63
0.641ProPro: 0.641 ± 0.134
1.241ProGln: 1.241 ± 0.209
1.161ProArg: 1.161 ± 0.202
2.122ProSer: 2.122 ± 0.329
2.322ProThr: 2.322 ± 0.293
2.042ProVal: 2.042 ± 0.264
0.4ProTrp: 0.4 ± 0.133
1.321ProTyr: 1.321 ± 0.218
0.0ProXaa: 0.0 ± 0.0
Gln
2.242GlnAla: 2.242 ± 0.701
0.24GlnCys: 0.24 ± 0.101
1.722GlnAsp: 1.722 ± 0.246
3.203GlnGlu: 3.203 ± 0.41
1.882GlnPhe: 1.882 ± 0.288
2.002GlnGly: 2.002 ± 0.476
0.24GlnHis: 0.24 ± 0.089
3.924GlnIle: 3.924 ± 0.381
4.244GlnLys: 4.244 ± 0.431
5.566GlnLeu: 5.566 ± 1.411
0.521GlnMet: 0.521 ± 0.162
3.924GlnAsn: 3.924 ± 0.503
0.961GlnPro: 0.961 ± 0.212
1.241GlnGln: 1.241 ± 0.361
1.522GlnArg: 1.522 ± 0.24
3.684GlnSer: 3.684 ± 0.519
2.843GlnThr: 2.843 ± 0.486
1.802GlnVal: 1.802 ± 0.29
0.641GlnTrp: 0.641 ± 0.187
1.161GlnTyr: 1.161 ± 0.215
0.0GlnXaa: 0.0 ± 0.0
Arg
1.001ArgAla: 1.001 ± 0.175
0.24ArgCys: 0.24 ± 0.097
2.202ArgAsp: 2.202 ± 0.305
2.723ArgGlu: 2.723 ± 0.445
2.042ArgPhe: 2.042 ± 0.279
1.481ArgGly: 1.481 ± 0.227
0.561ArgHis: 0.561 ± 0.119
4.204ArgIle: 4.204 ± 0.473
3.483ArgLys: 3.483 ± 0.511
3.924ArgLeu: 3.924 ± 0.56
0.721ArgMet: 0.721 ± 0.173
3.283ArgAsn: 3.283 ± 0.359
1.522ArgPro: 1.522 ± 0.276
1.121ArgGln: 1.121 ± 0.206
1.802ArgArg: 1.802 ± 0.293
2.563ArgSer: 2.563 ± 0.34
2.362ArgThr: 2.362 ± 0.3
2.402ArgVal: 2.402 ± 0.302
0.2ArgTrp: 0.2 ± 0.091
1.682ArgTyr: 1.682 ± 0.311
0.0ArgXaa: 0.0 ± 0.0
Ser
2.923SerAla: 2.923 ± 0.591
0.881SerCys: 0.881 ± 0.22
3.283SerAsp: 3.283 ± 0.333
5.165SerGlu: 5.165 ± 0.526
4.645SerPhe: 4.645 ± 0.505
5.686SerGly: 5.686 ± 0.579
1.081SerHis: 1.081 ± 0.275
7.047SerIle: 7.047 ± 0.694
6.967SerLys: 6.967 ± 0.598
8.008SerLeu: 8.008 ± 0.626
1.161SerMet: 1.161 ± 0.191
6.206SerAsn: 6.206 ± 0.485
2.523SerPro: 2.523 ± 0.265
3.644SerGln: 3.644 ± 0.643
2.723SerArg: 2.723 ± 0.357
5.405SerSer: 5.405 ± 0.525
3.483SerThr: 3.483 ± 0.441
5.045SerVal: 5.045 ± 0.465
1.161SerTrp: 1.161 ± 0.248
4.044SerTyr: 4.044 ± 0.417
0.0SerXaa: 0.0 ± 0.0
Thr
2.282ThrAla: 2.282 ± 0.363
0.4ThrCys: 0.4 ± 0.116
2.803ThrAsp: 2.803 ± 0.295
3.003ThrGlu: 3.003 ± 0.305
2.883ThrPhe: 2.883 ± 0.308
3.403ThrGly: 3.403 ± 0.496
0.921ThrHis: 0.921 ± 0.215
4.364ThrIle: 4.364 ± 0.399
4.805ThrLys: 4.805 ± 0.447
7.327ThrLeu: 7.327 ± 0.86
0.601ThrMet: 0.601 ± 0.137
4.084ThrAsn: 4.084 ± 0.482
1.602ThrPro: 1.602 ± 0.235
2.442ThrGln: 2.442 ± 0.277
1.922ThrArg: 1.922 ± 0.255
3.964ThrSer: 3.964 ± 0.416
3.443ThrThr: 3.443 ± 0.475
2.482ThrVal: 2.482 ± 0.326
0.681ThrTrp: 0.681 ± 0.161
2.042ThrTyr: 2.042 ± 0.225
0.0ThrXaa: 0.0 ± 0.0
Val
1.842ValAla: 1.842 ± 0.346
0.561ValCys: 0.561 ± 0.174
1.962ValAsp: 1.962 ± 0.275
3.964ValGlu: 3.964 ± 0.461
3.283ValPhe: 3.283 ± 0.338
3.243ValGly: 3.243 ± 0.377
0.601ValHis: 0.601 ± 0.18
3.884ValIle: 3.884 ± 0.408
3.724ValLys: 3.724 ± 0.485
4.965ValLeu: 4.965 ± 0.475
0.801ValMet: 0.801 ± 0.165
2.883ValAsn: 2.883 ± 0.314
1.762ValPro: 1.762 ± 0.282
2.042ValGln: 2.042 ± 0.305
2.162ValArg: 2.162 ± 0.258
4.124ValSer: 4.124 ± 0.426
2.723ValThr: 2.723 ± 0.489
2.803ValVal: 2.803 ± 0.331
0.681ValTrp: 0.681 ± 0.15
1.962ValTyr: 1.962 ± 0.302
0.0ValXaa: 0.0 ± 0.0
Trp
0.4TrpAla: 0.4 ± 0.127
0.12TrpCys: 0.12 ± 0.059
0.36TrpAsp: 0.36 ± 0.117
0.841TrpGlu: 0.841 ± 0.17
0.48TrpPhe: 0.48 ± 0.154
0.761TrpGly: 0.761 ± 0.146
0.08TrpHis: 0.08 ± 0.06
0.841TrpIle: 0.841 ± 0.173
0.761TrpLys: 0.761 ± 0.183
0.681TrpLeu: 0.681 ± 0.166
0.36TrpMet: 0.36 ± 0.115
1.201TrpAsn: 1.201 ± 0.229
0.16TrpPro: 0.16 ± 0.08
0.48TrpGln: 0.48 ± 0.141
0.2TrpArg: 0.2 ± 0.088
0.721TrpSer: 0.721 ± 0.141
0.601TrpThr: 0.601 ± 0.145
0.48TrpVal: 0.48 ± 0.131
0.08TrpTrp: 0.08 ± 0.052
0.601TrpTyr: 0.601 ± 0.163
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.602TyrAla: 1.602 ± 0.259
0.48TyrCys: 0.48 ± 0.163
2.322TyrAsp: 2.322 ± 0.256
2.202TyrGlu: 2.202 ± 0.296
2.082TyrPhe: 2.082 ± 0.362
2.322TyrGly: 2.322 ± 0.357
0.801TyrHis: 0.801 ± 0.169
3.203TyrIle: 3.203 ± 0.39
2.883TyrLys: 2.883 ± 0.336
4.565TyrLeu: 4.565 ± 0.513
0.601TyrMet: 0.601 ± 0.145
2.683TyrAsn: 2.683 ± 0.391
1.201TyrPro: 1.201 ± 0.278
1.922TyrGln: 1.922 ± 0.331
2.162TyrArg: 2.162 ± 0.285
2.803TyrSer: 2.803 ± 0.338
2.402TyrThr: 2.402 ± 0.374
1.642TyrVal: 1.642 ± 0.22
0.32TyrTrp: 0.32 ± 0.09
1.522TyrTyr: 1.522 ± 0.243
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 97 proteins (24976 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski