Amino acid dipepetide frequency for Desulfotomaculum profundi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.276AlaAla: 8.276 ± 0.165	1.07AlaCys: 1.07 ± 0.05	3.634AlaAsp: 3.634 ± 0.072	5.646AlaGlu: 5.646 ± 0.09	2.768AlaPhe: 2.768 ± 0.065	7.068AlaGly: 7.068 ± 0.124	1.28AlaHis: 1.28 ± 0.045	5.072AlaIle: 5.072 ± 0.102	4.724AlaLys: 4.724 ± 0.085	8.136AlaLeu: 8.136 ± 0.123	2.185AlaMet: 2.185 ± 0.072	2.759AlaAsn: 2.759 ± 0.068	2.554AlaPro: 2.554 ± 0.067	2.65AlaGln: 2.65 ± 0.064	4.999AlaArg: 4.999 ± 0.095	3.746AlaSer: 3.746 ± 0.084	3.579AlaThr: 3.579 ± 0.078	6.832AlaVal: 6.832 ± 0.105	0.793AlaTrp: 0.793 ± 0.033	2.101AlaTyr: 2.101 ± 0.056	0.014AlaXaa: 0.014 ± 0.005
Cys	0.857CysAla: 0.857 ± 0.039	0.331CysCys: 0.331 ± 0.027	0.581CysAsp: 0.581 ± 0.027	0.628CysGlu: 0.628 ± 0.029	0.484CysPhe: 0.484 ± 0.027	1.327CysGly: 1.327 ± 0.06	0.303CysHis: 0.303 ± 0.023	0.649CysIle: 0.649 ± 0.034	0.709CysLys: 0.709 ± 0.032	1.225CysLeu: 1.225 ± 0.044	0.337CysMet: 0.337 ± 0.025	0.479CysAsn: 0.479 ± 0.026	0.827CysPro: 0.827 ± 0.037	0.553CysGln: 0.553 ± 0.028	0.912CysArg: 0.912 ± 0.038	0.848CysSer: 0.848 ± 0.036	0.611CysThr: 0.611 ± 0.032	0.699CysVal: 0.699 ± 0.031	0.159CysTrp: 0.159 ± 0.016	0.406CysTyr: 0.406 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.197AspAla: 3.197 ± 0.069	0.619AspCys: 0.619 ± 0.03	2.026AspAsp: 2.026 ± 0.069	3.354AspGlu: 3.354 ± 0.077	2.151AspPhe: 2.151 ± 0.055	3.172AspGly: 3.172 ± 0.078	0.912AspHis: 0.912 ± 0.038	4.012AspIle: 4.012 ± 0.08	3.1AspLys: 3.1 ± 0.069	5.153AspLeu: 5.153 ± 0.089	1.301AspMet: 1.301 ± 0.048	1.752AspAsn: 1.752 ± 0.051	2.293AspPro: 2.293 ± 0.06	1.728AspGln: 1.728 ± 0.05	2.716AspArg: 2.716 ± 0.057	2.172AspSer: 2.172 ± 0.059	2.292AspThr: 2.292 ± 0.058	3.421AspVal: 3.421 ± 0.069	0.639AspTrp: 0.639 ± 0.031	1.895AspTyr: 1.895 ± 0.055	0.013AspXaa: 0.013 ± 0.005
Glu	5.421GluAla: 5.421 ± 0.092	0.611GluCys: 0.611 ± 0.031	3.286GluAsp: 3.286 ± 0.074	6.132GluGlu: 6.132 ± 0.121	2.407GluPhe: 2.407 ± 0.062	4.289GluGly: 4.289 ± 0.084	1.195GluHis: 1.195 ± 0.044	5.669GluIle: 5.669 ± 0.1	5.554GluLys: 5.554 ± 0.096	7.355GluLeu: 7.355 ± 0.123	2.127GluMet: 2.127 ± 0.058	2.914GluAsn: 2.914 ± 0.067	2.263GluPro: 2.263 ± 0.062	3.253GluGln: 3.253 ± 0.076	3.746GluArg: 3.746 ± 0.078	2.772GluSer: 2.772 ± 0.064	3.285GluThr: 3.285 ± 0.064	5.13GluVal: 5.13 ± 0.085	0.604GluTrp: 0.604 ± 0.03	2.067GluTyr: 2.067 ± 0.06	0.007GluXaa: 0.007 ± 0.004
Phe	2.789PheAla: 2.789 ± 0.064	0.578PheCys: 0.578 ± 0.028	1.942PheAsp: 1.942 ± 0.056	2.169PheGlu: 2.169 ± 0.061	1.766PhePhe: 1.766 ± 0.058	2.897PheGly: 2.897 ± 0.07	0.717PheHis: 0.717 ± 0.033	2.867PheIle: 2.867 ± 0.07	2.186PheLys: 2.186 ± 0.054	4.099PheLeu: 4.099 ± 0.089	1.067PheMet: 1.067 ± 0.041	1.605PheAsn: 1.605 ± 0.045	1.554PhePro: 1.554 ± 0.048	1.226PheGln: 1.226 ± 0.04	1.87PheArg: 1.87 ± 0.049	2.434PheSer: 2.434 ± 0.061	2.276PheThr: 2.276 ± 0.059	2.58PheVal: 2.58 ± 0.061	0.423PheTrp: 0.423 ± 0.026	1.418PheTyr: 1.418 ± 0.051	0.007PheXaa: 0.007 ± 0.003
Gly	5.423GlyAla: 5.423 ± 0.116	1.171GlyCys: 1.171 ± 0.043	3.377GlyAsp: 3.377 ± 0.072	4.755GlyGlu: 4.755 ± 0.078	3.063GlyPhe: 3.063 ± 0.063	5.386GlyGly: 5.386 ± 0.114	1.469GlyHis: 1.469 ± 0.046	5.68GlyIle: 5.68 ± 0.096	5.166GlyLys: 5.166 ± 0.094	7.562GlyLeu: 7.562 ± 0.119	2.148GlyMet: 2.148 ± 0.059	2.58GlyAsn: 2.58 ± 0.064	2.286GlyPro: 2.286 ± 0.049	3.002GlyGln: 3.002 ± 0.077	3.89GlyArg: 3.89 ± 0.085	4.026GlySer: 4.026 ± 0.08	3.942GlyThr: 3.942 ± 0.082	5.593GlyVal: 5.593 ± 0.104	0.787GlyTrp: 0.787 ± 0.032	2.611GlyTyr: 2.611 ± 0.062	0.007GlyXaa: 0.007 ± 0.003
His	1.223HisAla: 1.223 ± 0.043	0.345HisCys: 0.345 ± 0.021	0.817HisAsp: 0.817 ± 0.029	1.048HisGlu: 1.048 ± 0.045	0.851HisPhe: 0.851 ± 0.035	1.371HisGly: 1.371 ± 0.04	0.56HisHis: 0.56 ± 0.03	1.262HisIle: 1.262 ± 0.038	1.003HisLys: 1.003 ± 0.04	2.096HisLeu: 2.096 ± 0.059	0.492HisMet: 0.492 ± 0.025	0.698HisAsn: 0.698 ± 0.036	1.144HisPro: 1.144 ± 0.042	0.783HisGln: 0.783 ± 0.034	1.321HisArg: 1.321 ± 0.044	1.058HisSer: 1.058 ± 0.036	0.916HisThr: 0.916 ± 0.032	1.129HisVal: 1.129 ± 0.042	0.259HisTrp: 0.259 ± 0.018	0.783HisTyr: 0.783 ± 0.034	0.001HisXaa: 0.001 ± 0.002
Ile	5.298IleAla: 5.298 ± 0.102	0.902IleCys: 0.902 ± 0.034	3.447IleAsp: 3.447 ± 0.066	4.32IleGlu: 4.32 ± 0.078	2.627IlePhe: 2.627 ± 0.061	4.56IleGly: 4.56 ± 0.09	1.303IleHis: 1.303 ± 0.043	4.981IleIle: 4.981 ± 0.089	4.818IleLys: 4.818 ± 0.097	6.888IleLeu: 6.888 ± 0.107	1.659IleMet: 1.659 ± 0.052	3.155IleAsn: 3.155 ± 0.06	3.285IlePro: 3.285 ± 0.07	2.272IleGln: 2.272 ± 0.058	3.503IleArg: 3.503 ± 0.071	4.164IleSer: 4.164 ± 0.08	3.945IleThr: 3.945 ± 0.092	4.359IleVal: 4.359 ± 0.095	0.602IleTrp: 0.602 ± 0.027	2.209IleTyr: 2.209 ± 0.059	0.009IleXaa: 0.009 ± 0.003
Lys	4.776LysAla: 4.776 ± 0.094	0.666LysCys: 0.666 ± 0.032	3.231LysAsp: 3.231 ± 0.076	5.752LysGlu: 5.752 ± 0.105	1.986LysPhe: 1.986 ± 0.06	4.114LysGly: 4.114 ± 0.073	1.152LysHis: 1.152 ± 0.04	4.683LysIle: 4.683 ± 0.098	4.833LysLys: 4.833 ± 0.098	5.941LysLeu: 5.941 ± 0.095	1.897LysMet: 1.897 ± 0.052	2.88LysAsn: 2.88 ± 0.071	2.675LysPro: 2.675 ± 0.069	2.63LysGln: 2.63 ± 0.06	3.137LysArg: 3.137 ± 0.083	3.118LysSer: 3.118 ± 0.073	3.465LysThr: 3.465 ± 0.072	4.766LysVal: 4.766 ± 0.09	0.6LysTrp: 0.6 ± 0.033	2.141LysTyr: 2.141 ± 0.061	0.014LysXaa: 0.014 ± 0.006
Leu	9.598LeuAla: 9.598 ± 0.141	1.159LeuCys: 1.159 ± 0.046	5.105LeuAsp: 5.105 ± 0.095	7.14LeuGlu: 7.14 ± 0.114	3.904LeuPhe: 3.904 ± 0.079	7.369LeuGly: 7.369 ± 0.126	1.851LeuHis: 1.851 ± 0.053	6.083LeuIle: 6.083 ± 0.101	6.637LeuLys: 6.637 ± 0.12	10.618LeuLeu: 10.618 ± 0.138	2.5LeuMet: 2.5 ± 0.069	4.039LeuAsn: 4.039 ± 0.076	4.809LeuPro: 4.809 ± 0.087	3.726LeuGln: 3.726 ± 0.083	5.126LeuArg: 5.126 ± 0.077	6.211LeuSer: 6.211 ± 0.094	5.446LeuThr: 5.446 ± 0.092	7.477LeuVal: 7.477 ± 0.123	0.985LeuTrp: 0.985 ± 0.043	2.938LeuTyr: 2.938 ± 0.062	0.016LeuXaa: 0.016 ± 0.005
Met	2.577MetAla: 2.577 ± 0.067	0.254MetCys: 0.254 ± 0.017	1.365MetAsp: 1.365 ± 0.046	1.904MetGlu: 1.904 ± 0.055	0.845MetPhe: 0.845 ± 0.035	2.024MetGly: 2.024 ± 0.064	0.405MetHis: 0.405 ± 0.024	1.661MetIle: 1.661 ± 0.049	1.841MetLys: 1.841 ± 0.053	2.596MetLeu: 2.596 ± 0.066	0.771MetMet: 0.771 ± 0.042	1.185MetAsn: 1.185 ± 0.04	1.21MetPro: 1.21 ± 0.036	1.003MetGln: 1.003 ± 0.036	1.259MetArg: 1.259 ± 0.045	1.453MetSer: 1.453 ± 0.041	1.489MetThr: 1.489 ± 0.048	2.135MetVal: 2.135 ± 0.061	0.178MetTrp: 0.178 ± 0.015	0.598MetTyr: 0.598 ± 0.028	0.003MetXaa: 0.003 ± 0.002
Asn	2.415AsnAla: 2.415 ± 0.059	0.541AsnCys: 0.541 ± 0.031	1.708AsnAsp: 1.708 ± 0.057	2.11AsnGlu: 2.11 ± 0.064	1.57AsnPhe: 1.57 ± 0.052	2.583AsnGly: 2.583 ± 0.068	0.888AsnHis: 0.888 ± 0.037	2.931AsnIle: 2.931 ± 0.061	2.681AsnLys: 2.681 ± 0.063	4.315AsnLeu: 4.315 ± 0.087	0.996AsnMet: 0.996 ± 0.037	1.746AsnAsn: 1.746 ± 0.057	2.34AsnPro: 2.34 ± 0.061	1.648AsnGln: 1.648 ± 0.047	2.435AsnArg: 2.435 ± 0.065	2.023AsnSer: 2.023 ± 0.059	2.02AsnThr: 2.02 ± 0.054	2.404AsnVal: 2.404 ± 0.058	0.472AsnTrp: 0.472 ± 0.024	1.377AsnTyr: 1.377 ± 0.049	0.017AsnXaa: 0.017 ± 0.005
Pro	3.628ProAla: 3.628 ± 0.086	0.482ProCys: 0.482 ± 0.024	2.458ProAsp: 2.458 ± 0.059	3.779ProGlu: 3.779 ± 0.068	1.752ProPhe: 1.752 ± 0.055	4.08ProGly: 4.08 ± 0.086	0.821ProHis: 0.821 ± 0.033	2.051ProIle: 2.051 ± 0.057	2.233ProLys: 2.233 ± 0.063	3.896ProLeu: 3.896 ± 0.069	1.019ProMet: 1.019 ± 0.038	1.436ProAsn: 1.436 ± 0.044	1.765ProPro: 1.765 ± 0.062	1.509ProGln: 1.509 ± 0.048	2.002ProArg: 2.002 ± 0.06	2.043ProSer: 2.043 ± 0.054	1.932ProThr: 1.932 ± 0.058	4.17ProVal: 4.17 ± 0.076	0.514ProTrp: 0.514 ± 0.03	1.252ProTyr: 1.252 ± 0.043	0.01ProXaa: 0.01 ± 0.004
Gln	3.434GlnAla: 3.434 ± 0.082	0.376GlnCys: 0.376 ± 0.02	1.8GlnAsp: 1.8 ± 0.055	3.181GlnGlu: 3.181 ± 0.071	1.249GlnPhe: 1.249 ± 0.039	2.586GlnGly: 2.586 ± 0.07	0.693GlnHis: 0.693 ± 0.031	2.61GlnIle: 2.61 ± 0.064	2.495GlnLys: 2.495 ± 0.061	3.546GlnLeu: 3.546 ± 0.079	1.101GlnMet: 1.101 ± 0.04	1.574GlnAsn: 1.574 ± 0.053	1.506GlnPro: 1.506 ± 0.048	1.884GlnGln: 1.884 ± 0.066	2.147GlnArg: 2.147 ± 0.057	1.752GlnSer: 1.752 ± 0.06	1.755GlnThr: 1.755 ± 0.054	3.084GlnVal: 3.084 ± 0.071	0.452GlnTrp: 0.452 ± 0.024	1.185GlnTyr: 1.185 ± 0.039	0.007GlnXaa: 0.007 ± 0.003
Arg	3.707ArgAla: 3.707 ± 0.077	0.709ArgCys: 0.709 ± 0.036	2.564ArgAsp: 2.564 ± 0.062	4.408ArgGlu: 4.408 ± 0.081	2.046ArgPhe: 2.046 ± 0.049	3.508ArgGly: 3.508 ± 0.078	1.188ArgHis: 1.188 ± 0.038	3.613ArgIle: 3.613 ± 0.073	3.506ArgLys: 3.506 ± 0.085	5.566ArgLeu: 5.566 ± 0.095	1.534ArgMet: 1.534 ± 0.051	2.127ArgAsn: 2.127 ± 0.059	2.222ArgPro: 2.222 ± 0.058	2.689ArgGln: 2.689 ± 0.063	3.316ArgArg: 3.316 ± 0.074	2.642ArgSer: 2.642 ± 0.063	2.378ArgThr: 2.378 ± 0.055	3.928ArgVal: 3.928 ± 0.076	0.679ArgTrp: 0.679 ± 0.033	1.997ArgTyr: 1.997 ± 0.049	0.013ArgXaa: 0.013 ± 0.005
Ser	3.654SerAla: 3.654 ± 0.077	0.796SerCys: 0.796 ± 0.039	2.321SerAsp: 2.321 ± 0.059	3.164SerGlu: 3.164 ± 0.066	2.31SerPhe: 2.31 ± 0.056	4.379SerGly: 4.379 ± 0.097	1.121SerHis: 1.121 ± 0.041	3.393SerIle: 3.393 ± 0.07	3.012SerLys: 3.012 ± 0.078	5.913SerLeu: 5.913 ± 0.094	1.404SerMet: 1.404 ± 0.045	1.719SerAsn: 1.719 ± 0.052	2.523SerPro: 2.523 ± 0.07	1.961SerGln: 1.961 ± 0.057	3.043SerArg: 3.043 ± 0.071	2.969SerSer: 2.969 ± 0.069	2.682SerThr: 2.682 ± 0.061	3.627SerVal: 3.627 ± 0.078	0.699SerTrp: 0.699 ± 0.036	1.728SerTyr: 1.728 ± 0.046	0.007SerXaa: 0.007 ± 0.003
Thr	4.529ThrAla: 4.529 ± 0.084	0.683ThrCys: 0.683 ± 0.033	2.336ThrAsp: 2.336 ± 0.052	2.931ThrGlu: 2.931 ± 0.063	2.03ThrPhe: 2.03 ± 0.047	5.127ThrGly: 5.127 ± 0.082	0.914ThrHis: 0.914 ± 0.039	3.395ThrIle: 3.395 ± 0.07	2.689ThrLys: 2.689 ± 0.065	5.08ThrLeu: 5.08 ± 0.086	1.28ThrMet: 1.28 ± 0.036	1.843ThrAsn: 1.843 ± 0.05	2.515ThrPro: 2.515 ± 0.068	1.372ThrGln: 1.372 ± 0.047	2.584ThrArg: 2.584 ± 0.06	2.567ThrSer: 2.567 ± 0.061	2.661ThrThr: 2.661 ± 0.078	4.487ThrVal: 4.487 ± 0.088	0.523ThrTrp: 0.523 ± 0.031	1.478ThrTyr: 1.478 ± 0.044	0.007ThrXaa: 0.007 ± 0.003
Val	6.207ValAla: 6.207 ± 0.102	0.989ValCys: 0.989 ± 0.046	3.861ValAsp: 3.861 ± 0.075	5.137ValGlu: 5.137 ± 0.092	2.777ValPhe: 2.777 ± 0.069	4.914ValGly: 4.914 ± 0.097	1.296ValHis: 1.296 ± 0.038	5.113ValIle: 5.113 ± 0.08	4.873ValLys: 4.873 ± 0.079	7.721ValLeu: 7.721 ± 0.107	1.969ValMet: 1.969 ± 0.056	2.982ValAsn: 2.982 ± 0.073	3.145ValPro: 3.145 ± 0.072	2.549ValGln: 2.549 ± 0.061	3.572ValArg: 3.572 ± 0.069	4.167ValSer: 4.167 ± 0.095	4.228ValThr: 4.228 ± 0.078	6.035ValVal: 6.035 ± 0.112	0.661ValTrp: 0.661 ± 0.035	2.154ValTyr: 2.154 ± 0.05	0.009ValXaa: 0.009 ± 0.004
Trp	0.742TrpAla: 0.742 ± 0.033	0.134TrpCys: 0.134 ± 0.012	0.514TrpAsp: 0.514 ± 0.029	0.761TrpGlu: 0.761 ± 0.033	0.467TrpPhe: 0.467 ± 0.028	0.73TrpGly: 0.73 ± 0.036	0.251TrpHis: 0.251 ± 0.022	0.617TrpIle: 0.617 ± 0.029	0.565TrpLys: 0.565 ± 0.025	1.252TrpLeu: 1.252 ± 0.053	0.301TrpMet: 0.301 ± 0.019	0.402TrpAsn: 0.402 ± 0.022	0.48TrpPro: 0.48 ± 0.023	0.571TrpGln: 0.571 ± 0.028	0.588TrpArg: 0.588 ± 0.031	0.537TrpSer: 0.537 ± 0.029	0.459TrpThr: 0.459 ± 0.027	0.71TrpVal: 0.71 ± 0.031	0.172TrpTrp: 0.172 ± 0.016	0.337TrpTyr: 0.337 ± 0.022	0.004TrpXaa: 0.004 ± 0.003
Tyr	2.124TyrAla: 2.124 ± 0.054	0.503TyrCys: 0.503 ± 0.025	1.541TyrAsp: 1.541 ± 0.052	1.759TyrGlu: 1.759 ± 0.054	1.408TyrPhe: 1.408 ± 0.041	2.431TyrGly: 2.431 ± 0.065	0.834TyrHis: 0.834 ± 0.036	1.946TyrIle: 1.946 ± 0.054	1.827TyrLys: 1.827 ± 0.052	3.768TyrLeu: 3.768 ± 0.082	0.662TyrMet: 0.662 ± 0.031	1.34TyrAsn: 1.34 ± 0.043	1.431TyrPro: 1.431 ± 0.05	1.397TyrGln: 1.397 ± 0.045	2.162TyrArg: 2.162 ± 0.054	1.706TyrSer: 1.706 ± 0.051	1.661TyrThr: 1.661 ± 0.045	1.777TyrVal: 1.777 ± 0.047	0.392TyrTrp: 0.392 ± 0.024	1.279TyrTyr: 1.279 ± 0.046	0.01TyrXaa: 0.01 ± 0.004
Xaa	0.011XaaAla: 0.011 ± 0.003	0.004XaaCys: 0.004 ± 0.002	0.004XaaAsp: 0.004 ± 0.003	0.006XaaGlu: 0.006 ± 0.003	0.01XaaPhe: 0.01 ± 0.003	0.009XaaGly: 0.009 ± 0.004	0.007XaaHis: 0.007 ± 0.003	0.018XaaIle: 0.018 ± 0.006	0.006XaaLys: 0.006 ± 0.003	0.014XaaLeu: 0.014 ± 0.005	0.006XaaMet: 0.006 ± 0.003	0.006XaaAsn: 0.006 ± 0.003	0.004XaaPro: 0.004 ± 0.002	0.011XaaGln: 0.011 ± 0.004	0.013XaaArg: 0.013 ± 0.005	0.013XaaSer: 0.013 ± 0.005	0.01XaaThr: 0.01 ± 0.004	0.014XaaVal: 0.014 ± 0.004	0.004XaaTrp: 0.004 ± 0.003	0.004XaaTyr: 0.004 ± 0.002	0.021XaaXaa: 0.021 ± 0.008

Statistics based on 3299 proteins (703881 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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