Amino acid dipepetide frequency for Caproiciproducens sp. NJN-50

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.874AlaAla: 10.874 ± 0.15
1.408AlaCys: 1.408 ± 0.041
4.865AlaAsp: 4.865 ± 0.081
6.034AlaGlu: 6.034 ± 0.089
3.562AlaPhe: 3.562 ± 0.064
8.043AlaGly: 8.043 ± 0.105
1.235AlaHis: 1.235 ± 0.035
4.657AlaIle: 4.657 ± 0.084
4.611AlaLys: 4.611 ± 0.081
8.609AlaLeu: 8.609 ± 0.121
2.547AlaMet: 2.547 ± 0.052
2.506AlaAsn: 2.506 ± 0.06
2.84AlaPro: 2.84 ± 0.063
2.898AlaGln: 2.898 ± 0.058
4.278AlaArg: 4.278 ± 0.079
5.159AlaSer: 5.159 ± 0.096
3.412AlaThr: 3.412 ± 0.079
8.367AlaVal: 8.367 ± 0.11
0.678AlaTrp: 0.678 ± 0.025
2.54AlaTyr: 2.54 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.542CysAla: 1.542 ± 0.044
0.331CysCys: 0.331 ± 0.02
0.87CysAsp: 0.87 ± 0.028
0.939CysGlu: 0.939 ± 0.034
0.683CysPhe: 0.683 ± 0.028
1.912CysGly: 1.912 ± 0.05
0.332CysHis: 0.332 ± 0.019
0.902CysIle: 0.902 ± 0.035
0.675CysLys: 0.675 ± 0.026
1.278CysLeu: 1.278 ± 0.038
0.414CysMet: 0.414 ± 0.02
0.493CysAsn: 0.493 ± 0.027
0.763CysPro: 0.763 ± 0.031
0.345CysGln: 0.345 ± 0.017
1.053CysArg: 1.053 ± 0.031
1.084CysSer: 1.084 ± 0.033
0.775CysThr: 0.775 ± 0.028
1.169CysVal: 1.169 ± 0.035
0.134CysTrp: 0.134 ± 0.013
0.507CysTyr: 0.507 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.473AspAla: 4.473 ± 0.074
0.923AspCys: 0.923 ± 0.03
2.55AspAsp: 2.55 ± 0.073
3.641AspGlu: 3.641 ± 0.066
2.487AspPhe: 2.487 ± 0.052
4.747AspGly: 4.747 ± 0.082
0.964AspHis: 0.964 ± 0.032
3.421AspIle: 3.421 ± 0.06
2.37AspLys: 2.37 ± 0.053
5.122AspLeu: 5.122 ± 0.077
1.404AspMet: 1.404 ± 0.043
1.533AspAsn: 1.533 ± 0.049
2.441AspPro: 2.441 ± 0.055
1.509AspGln: 1.509 ± 0.047
3.328AspArg: 3.328 ± 0.059
3.359AspSer: 3.359 ± 0.064
2.691AspThr: 2.691 ± 0.088
3.58AspVal: 3.58 ± 0.071
0.582AspTrp: 0.582 ± 0.027
2.153AspTyr: 2.153 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
5.27GluAla: 5.27 ± 0.077
0.745GluCys: 0.745 ± 0.029
3.169GluAsp: 3.169 ± 0.063
5.113GluGlu: 5.113 ± 0.086
2.339GluPhe: 2.339 ± 0.054
3.742GluGly: 3.742 ± 0.066
1.09GluHis: 1.09 ± 0.034
4.851GluIle: 4.851 ± 0.08
5.298GluLys: 5.298 ± 0.086
6.142GluLeu: 6.142 ± 0.092
1.871GluMet: 1.871 ± 0.042
3.272GluAsn: 3.272 ± 0.062
2.144GluPro: 2.144 ± 0.054
2.552GluGln: 2.552 ± 0.06
3.681GluArg: 3.681 ± 0.073
3.566GluSer: 3.566 ± 0.063
3.399GluThr: 3.399 ± 0.062
3.434GluVal: 3.434 ± 0.059
0.505GluTrp: 0.505 ± 0.028
2.098GluTyr: 2.098 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.522PheAla: 3.522 ± 0.063
0.795PheCys: 0.795 ± 0.032
2.379PheAsp: 2.379 ± 0.051
2.329PheGlu: 2.329 ± 0.055
1.92PhePhe: 1.92 ± 0.056
3.582PheGly: 3.582 ± 0.066
0.913PheHis: 0.913 ± 0.031
2.341PheIle: 2.341 ± 0.056
1.524PheLys: 1.524 ± 0.04
4.436PheLeu: 4.436 ± 0.087
0.901PheMet: 0.901 ± 0.032
1.295PheAsn: 1.295 ± 0.036
1.706PhePro: 1.706 ± 0.039
1.429PheGln: 1.429 ± 0.041
2.252PheArg: 2.252 ± 0.057
3.421PheSer: 3.421 ± 0.067
2.365PheThr: 2.365 ± 0.066
2.708PheVal: 2.708 ± 0.062
0.41PheTrp: 0.41 ± 0.02
1.498PheTyr: 1.498 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
6.607GlyAla: 6.607 ± 0.105
1.525GlyCys: 1.525 ± 0.04
4.012GlyAsp: 4.012 ± 0.105
4.779GlyGlu: 4.779 ± 0.08
3.579GlyPhe: 3.579 ± 0.082
6.713GlyGly: 6.713 ± 0.113
1.327GlyHis: 1.327 ± 0.035
6.099GlyIle: 6.099 ± 0.082
5.348GlyLys: 5.348 ± 0.074
7.15GlyLeu: 7.15 ± 0.098
2.53GlyMet: 2.53 ± 0.056
2.954GlyAsn: 2.954 ± 0.054
2.31GlyPro: 2.31 ± 0.129
2.18GlyGln: 2.18 ± 0.054
4.293GlyArg: 4.293 ± 0.082
4.922GlySer: 4.922 ± 0.078
4.804GlyThr: 4.804 ± 0.083
5.667GlyVal: 5.667 ± 0.082
0.78GlyTrp: 0.78 ± 0.033
2.987GlyTyr: 2.987 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.304HisAla: 1.304 ± 0.042
0.344HisCys: 0.344 ± 0.018
0.814HisAsp: 0.814 ± 0.033
0.876HisGlu: 0.876 ± 0.03
0.794HisPhe: 0.794 ± 0.03
1.406HisGly: 1.406 ± 0.04
0.393HisHis: 0.393 ± 0.023
1.084HisIle: 1.084 ± 0.034
0.719HisLys: 0.719 ± 0.028
1.543HisLeu: 1.543 ± 0.043
0.448HisMet: 0.448 ± 0.022
0.569HisAsn: 0.569 ± 0.027
1.032HisPro: 1.032 ± 0.035
0.461HisGln: 0.461 ± 0.021
0.977HisArg: 0.977 ± 0.034
1.058HisSer: 1.058 ± 0.033
0.929HisThr: 0.929 ± 0.035
1.085HisVal: 1.085 ± 0.034
0.188HisTrp: 0.188 ± 0.014
0.608HisTyr: 0.608 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.985IleAla: 5.985 ± 0.087
1.132IleCys: 1.132 ± 0.038
3.527IleAsp: 3.527 ± 0.065
3.474IleGlu: 3.474 ± 0.067
2.543IlePhe: 2.543 ± 0.059
5.18IleGly: 5.18 ± 0.082
1.163IleHis: 1.163 ± 0.036
3.611IleIle: 3.611 ± 0.072
2.797IleLys: 2.797 ± 0.064
6.75IleLeu: 6.75 ± 0.091
1.445IleMet: 1.445 ± 0.046
2.15IleAsn: 2.15 ± 0.048
3.298IlePro: 3.298 ± 0.061
1.976IleGln: 1.976 ± 0.049
3.996IleArg: 3.996 ± 0.075
4.8IleSer: 4.8 ± 0.088
3.549IleThr: 3.549 ± 0.071
4.545IleVal: 4.545 ± 0.069
0.491IleTrp: 0.491 ± 0.026
2.001IleTyr: 2.001 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.753LysAla: 4.753 ± 0.07
0.63LysCys: 0.63 ± 0.026
3.021LysAsp: 3.021 ± 0.064
4.08LysGlu: 4.08 ± 0.073
1.63LysPhe: 1.63 ± 0.044
3.607LysGly: 3.607 ± 0.062
0.793LysHis: 0.793 ± 0.03
4.31LysIle: 4.31 ± 0.076
4.406LysLys: 4.406 ± 0.082
4.67LysLeu: 4.67 ± 0.065
1.872LysMet: 1.872 ± 0.042
2.902LysAsn: 2.902 ± 0.062
2.154LysPro: 2.154 ± 0.051
1.903LysGln: 1.903 ± 0.048
2.953LysArg: 2.953 ± 0.055
3.414LysSer: 3.414 ± 0.067
3.425LysThr: 3.425 ± 0.065
3.361LysVal: 3.361 ± 0.064
0.49LysTrp: 0.49 ± 0.023
2.018LysTyr: 2.018 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
8.174LeuAla: 8.174 ± 0.096
1.796LeuCys: 1.796 ± 0.043
5.011LeuAsp: 5.011 ± 0.083
5.53LeuGlu: 5.53 ± 0.087
4.395LeuPhe: 4.395 ± 0.08
6.694LeuGly: 6.694 ± 0.094
1.54LeuHis: 1.54 ± 0.04
6.17LeuIle: 6.17 ± 0.099
5.684LeuLys: 5.684 ± 0.079
9.759LeuLeu: 9.759 ± 0.14
2.594LeuMet: 2.594 ± 0.057
3.75LeuAsn: 3.75 ± 0.055
4.417LeuPro: 4.417 ± 0.076
2.743LeuGln: 2.743 ± 0.058
5.221LeuArg: 5.221 ± 0.099
7.521LeuSer: 7.521 ± 0.092
5.487LeuThr: 5.487 ± 0.075
5.756LeuVal: 5.756 ± 0.09
0.771LeuTrp: 0.771 ± 0.033
2.975LeuTyr: 2.975 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.383MetAla: 2.383 ± 0.051
0.297MetCys: 0.297 ± 0.016
1.569MetAsp: 1.569 ± 0.041
2.042MetGlu: 2.042 ± 0.043
0.903MetPhe: 0.903 ± 0.033
2.041MetGly: 2.041 ± 0.054
0.383MetHis: 0.383 ± 0.02
1.872MetIle: 1.872 ± 0.043
2.186MetLys: 2.186 ± 0.051
2.654MetLeu: 2.654 ± 0.059
0.792MetMet: 0.792 ± 0.028
1.348MetAsn: 1.348 ± 0.036
1.262MetPro: 1.262 ± 0.039
0.893MetGln: 0.893 ± 0.031
1.353MetArg: 1.353 ± 0.034
1.584MetSer: 1.584 ± 0.043
1.587MetThr: 1.587 ± 0.042
1.702MetVal: 1.702 ± 0.05
0.162MetTrp: 0.162 ± 0.013
0.564MetTyr: 0.564 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.274AsnAla: 3.274 ± 0.059
0.644AsnCys: 0.644 ± 0.027
1.711AsnAsp: 1.711 ± 0.042
2.018AsnGlu: 2.018 ± 0.051
1.484AsnPhe: 1.484 ± 0.044
3.44AsnGly: 3.44 ± 0.067
0.639AsnHis: 0.639 ± 0.025
2.588AsnIle: 2.588 ± 0.062
1.566AsnLys: 1.566 ± 0.042
3.675AsnLeu: 3.675 ± 0.067
0.933AsnMet: 0.933 ± 0.028
1.291AsnAsn: 1.291 ± 0.036
2.036AsnPro: 2.036 ± 0.048
1.23AsnGln: 1.23 ± 0.035
2.195AsnArg: 2.195 ± 0.05
2.288AsnSer: 2.288 ± 0.052
1.888AsnThr: 1.888 ± 0.051
2.554AsnVal: 2.554 ± 0.054
0.357AsnTrp: 0.357 ± 0.02
1.353AsnTyr: 1.353 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.759ProAla: 3.759 ± 0.063
0.62ProCys: 0.62 ± 0.028
2.932ProAsp: 2.932 ± 0.06
3.617ProGlu: 3.617 ± 0.07
1.772ProPhe: 1.772 ± 0.052
3.331ProGly: 3.331 ± 0.072
0.672ProHis: 0.672 ± 0.027
2.184ProIle: 2.184 ± 0.05
2.038ProLys: 2.038 ± 0.042
3.418ProLeu: 3.418 ± 0.065
1.0ProMet: 1.0 ± 0.034
1.343ProAsn: 1.343 ± 0.04
1.332ProPro: 1.332 ± 0.048
1.365ProGln: 1.365 ± 0.039
1.645ProArg: 1.645 ± 0.054
2.291ProSer: 2.291 ± 0.059
1.874ProThr: 1.874 ± 0.118
3.649ProVal: 3.649 ± 0.076
0.344ProTrp: 0.344 ± 0.019
1.385ProTyr: 1.385 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.806GlnAla: 2.806 ± 0.056
0.404GlnCys: 0.404 ± 0.021
1.416GlnAsp: 1.416 ± 0.044
2.047GlnGlu: 2.047 ± 0.054
1.156GlnPhe: 1.156 ± 0.036
1.992GlnGly: 1.992 ± 0.049
0.46GlnHis: 0.46 ± 0.022
2.368GlnIle: 2.368 ± 0.054
2.618GlnLys: 2.618 ± 0.054
2.629GlnLeu: 2.629 ± 0.05
1.0GlnMet: 1.0 ± 0.035
1.588GlnAsn: 1.588 ± 0.044
1.141GlnPro: 1.141 ± 0.033
1.112GlnGln: 1.112 ± 0.037
1.544GlnArg: 1.544 ± 0.041
2.01GlnSer: 2.01 ± 0.046
1.741GlnThr: 1.741 ± 0.043
2.0GlnVal: 2.0 ± 0.053
0.274GlnTrp: 0.274 ± 0.018
1.213GlnTyr: 1.213 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
4.107ArgAla: 4.107 ± 0.077
0.764ArgCys: 0.764 ± 0.027
2.812ArgAsp: 2.812 ± 0.063
4.375ArgGlu: 4.375 ± 0.083
2.454ArgPhe: 2.454 ± 0.058
3.613ArgGly: 3.613 ± 0.069
0.952ArgHis: 0.952 ± 0.032
3.884ArgIle: 3.884 ± 0.06
3.415ArgLys: 3.415 ± 0.068
5.473ArgLeu: 5.473 ± 0.1
1.689ArgMet: 1.689 ± 0.049
2.145ArgAsn: 2.145 ± 0.052
2.056ArgPro: 2.056 ± 0.058
2.0ArgGln: 2.0 ± 0.052
3.656ArgArg: 3.656 ± 0.086
3.142ArgSer: 3.142 ± 0.068
2.648ArgThr: 2.648 ± 0.061
3.362ArgVal: 3.362 ± 0.061
0.529ArgTrp: 0.529 ± 0.024
1.933ArgTyr: 1.933 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.144SerAla: 6.144 ± 0.101
1.067SerCys: 1.067 ± 0.032
3.477SerAsp: 3.477 ± 0.07
3.905SerGlu: 3.905 ± 0.068
2.845SerPhe: 2.845 ± 0.058
6.687SerGly: 6.687 ± 0.086
1.013SerHis: 1.013 ± 0.035
3.908SerIle: 3.908 ± 0.073
2.954SerLys: 2.954 ± 0.063
6.181SerLeu: 6.181 ± 0.083
1.886SerMet: 1.886 ± 0.041
2.034SerAsn: 2.034 ± 0.055
2.439SerPro: 2.439 ± 0.054
1.897SerGln: 1.897 ± 0.054
3.467SerArg: 3.467 ± 0.065
4.641SerSer: 4.641 ± 0.096
2.884SerThr: 2.884 ± 0.058
5.029SerVal: 5.029 ± 0.079
0.525SerTrp: 0.525 ± 0.025
2.178SerTyr: 2.178 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
5.381ThrAla: 5.381 ± 0.088
0.676ThrCys: 0.676 ± 0.03
3.055ThrAsp: 3.055 ± 0.074
3.037ThrGlu: 3.037 ± 0.061
2.006ThrPhe: 2.006 ± 0.052
5.593ThrGly: 5.593 ± 0.246
0.832ThrHis: 0.832 ± 0.032
3.143ThrIle: 3.143 ± 0.057
2.339ThrLys: 2.339 ± 0.048
5.029ThrLeu: 5.029 ± 0.083
1.351ThrMet: 1.351 ± 0.036
1.669ThrAsn: 1.669 ± 0.041
2.423ThrPro: 2.423 ± 0.052
1.459ThrGln: 1.459 ± 0.041
2.258ThrArg: 2.258 ± 0.047
2.849ThrSer: 2.849 ± 0.066
2.426ThrThr: 2.426 ± 0.059
4.772ThrVal: 4.772 ± 0.085
0.394ThrTrp: 0.394 ± 0.02
1.561ThrTyr: 1.561 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.471ValAla: 5.471 ± 0.086
1.349ValCys: 1.349 ± 0.037
3.566ValAsp: 3.566 ± 0.069
3.952ValGlu: 3.952 ± 0.07
3.157ValPhe: 3.157 ± 0.061
4.817ValGly: 4.817 ± 0.08
1.049ValHis: 1.049 ± 0.031
4.593ValIle: 4.593 ± 0.083
3.784ValLys: 3.784 ± 0.078
7.26ValLeu: 7.26 ± 0.094
1.921ValMet: 1.921 ± 0.05
2.576ValAsn: 2.576 ± 0.06
3.168ValPro: 3.168 ± 0.065
2.043ValGln: 2.043 ± 0.043
4.096ValArg: 4.096 ± 0.068
5.387ValSer: 5.387 ± 0.092
4.172ValThr: 4.172 ± 0.083
4.984ValVal: 4.984 ± 0.077
0.641ValTrp: 0.641 ± 0.027
2.214ValTyr: 2.214 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.636TrpAla: 0.636 ± 0.03
0.14TrpCys: 0.14 ± 0.013
0.489TrpAsp: 0.489 ± 0.024
0.526TrpGlu: 0.526 ± 0.024
0.432TrpPhe: 0.432 ± 0.026
0.623TrpGly: 0.623 ± 0.028
0.181TrpHis: 0.181 ± 0.019
0.598TrpIle: 0.598 ± 0.025
0.614TrpLys: 0.614 ± 0.024
0.875TrpLeu: 0.875 ± 0.033
0.273TrpMet: 0.273 ± 0.015
0.459TrpAsn: 0.459 ± 0.024
0.233TrpPro: 0.233 ± 0.014
0.321TrpGln: 0.321 ± 0.019
0.483TrpArg: 0.483 ± 0.023
0.443TrpSer: 0.443 ± 0.028
0.414TrpThr: 0.414 ± 0.021
0.55TrpVal: 0.55 ± 0.024
0.086TrpTrp: 0.086 ± 0.009
0.261TrpTyr: 0.261 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.659TyrAla: 2.659 ± 0.053
0.61TyrCys: 0.61 ± 0.03
2.035TyrAsp: 2.035 ± 0.048
1.967TyrGlu: 1.967 ± 0.044
1.586TyrPhe: 1.586 ± 0.047
2.803TyrGly: 2.803 ± 0.066
0.701TyrHis: 0.701 ± 0.025
1.831TyrIle: 1.831 ± 0.045
1.447TyrLys: 1.447 ± 0.037
3.332TyrLeu: 3.332 ± 0.07
0.708TyrMet: 0.708 ± 0.028
1.287TyrAsn: 1.287 ± 0.044
1.376TyrPro: 1.376 ± 0.037
1.201TyrGln: 1.201 ± 0.037
2.277TyrArg: 2.277 ± 0.047
2.223TyrSer: 2.223 ± 0.054
1.783TyrThr: 1.783 ± 0.041
1.928TyrVal: 1.928 ± 0.047
0.295TyrTrp: 0.295 ± 0.017
1.266TyrTyr: 1.266 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3089 proteins (945004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski