Amino acid dipepetide frequency for Krasilnikovia cinnamomea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
25.54AlaAla: 25.54 ± 0.223
1.098AlaCys: 1.098 ± 0.025
9.236AlaAsp: 9.236 ± 0.087
8.538AlaGlu: 8.538 ± 0.089
3.351AlaPhe: 3.351 ± 0.047
14.463AlaGly: 14.463 ± 0.11
2.85AlaHis: 2.85 ± 0.033
4.165AlaIle: 4.165 ± 0.058
2.539AlaLys: 2.539 ± 0.049
14.369AlaLeu: 14.369 ± 0.114
2.63AlaMet: 2.63 ± 0.034
2.283AlaAsn: 2.283 ± 0.041
7.721AlaPro: 7.721 ± 0.082
4.239AlaGln: 4.239 ± 0.045
11.108AlaArg: 11.108 ± 0.094
5.787AlaSer: 5.787 ± 0.055
8.424AlaThr: 8.424 ± 0.077
13.106AlaVal: 13.106 ± 0.106
2.025AlaTrp: 2.025 ± 0.034
2.826AlaTyr: 2.826 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.083CysAla: 1.083 ± 0.023
0.093CysCys: 0.093 ± 0.008
0.511CysAsp: 0.511 ± 0.018
0.317CysGlu: 0.317 ± 0.013
0.215CysPhe: 0.215 ± 0.011
0.924CysGly: 0.924 ± 0.024
0.176CysHis: 0.176 ± 0.01
0.165CysIle: 0.165 ± 0.009
0.112CysLys: 0.112 ± 0.007
0.698CysLeu: 0.698 ± 0.019
0.105CysMet: 0.105 ± 0.007
0.134CysAsn: 0.134 ± 0.008
0.545CysPro: 0.545 ± 0.022
0.186CysGln: 0.186 ± 0.01
0.686CysArg: 0.686 ± 0.021
0.378CysSer: 0.378 ± 0.013
0.497CysThr: 0.497 ± 0.016
0.621CysVal: 0.621 ± 0.02
0.12CysTrp: 0.12 ± 0.008
0.162CysTyr: 0.162 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
8.219AspAla: 8.219 ± 0.083
0.403AspCys: 0.403 ± 0.014
3.902AspAsp: 3.902 ± 0.054
3.612AspGlu: 3.612 ± 0.046
1.502AspPhe: 1.502 ± 0.033
6.303AspGly: 6.303 ± 0.07
1.276AspHis: 1.276 ± 0.025
1.775AspIle: 1.775 ± 0.038
0.962AspLys: 0.962 ± 0.024
6.618AspLeu: 6.618 ± 0.058
0.757AspMet: 0.757 ± 0.02
1.026AspAsn: 1.026 ± 0.027
4.837AspPro: 4.837 ± 0.048
1.68AspGln: 1.68 ± 0.03
5.146AspArg: 5.146 ± 0.056
2.319AspSer: 2.319 ± 0.036
3.298AspThr: 3.298 ± 0.041
4.914AspVal: 4.914 ± 0.053
0.981AspTrp: 0.981 ± 0.024
1.092AspTyr: 1.092 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
6.345GluAla: 6.345 ± 0.074
0.334GluCys: 0.334 ± 0.014
2.096GluAsp: 2.096 ± 0.036
2.193GluGlu: 2.193 ± 0.042
1.439GluPhe: 1.439 ± 0.027
2.994GluGly: 2.994 ± 0.044
1.426GluHis: 1.426 ± 0.025
2.121GluIle: 2.121 ± 0.039
0.94GluLys: 0.94 ± 0.026
6.266GluLeu: 6.266 ± 0.069
0.829GluMet: 0.829 ± 0.021
0.818GluAsn: 0.818 ± 0.02
3.256GluPro: 3.256 ± 0.054
2.345GluGln: 2.345 ± 0.045
4.758GluArg: 4.758 ± 0.055
2.128GluSer: 2.128 ± 0.034
2.464GluThr: 2.464 ± 0.038
4.377GluVal: 4.377 ± 0.041
0.631GluTrp: 0.631 ± 0.017
1.03GluTyr: 1.03 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.873PheAla: 3.873 ± 0.048
0.26PheCys: 0.26 ± 0.011
1.959PheAsp: 1.959 ± 0.035
1.22PheGlu: 1.22 ± 0.03
0.784PhePhe: 0.784 ± 0.019
2.962PheGly: 2.962 ± 0.041
0.598PheHis: 0.598 ± 0.021
0.704PheIle: 0.704 ± 0.021
0.443PheLys: 0.443 ± 0.015
2.378PheLeu: 2.378 ± 0.041
0.343PheMet: 0.343 ± 0.013
0.543PheAsn: 0.543 ± 0.015
1.282PhePro: 1.282 ± 0.025
0.633PheGln: 0.633 ± 0.016
1.802PheArg: 1.802 ± 0.029
1.285PheSer: 1.285 ± 0.026
1.929PheThr: 1.929 ± 0.029
2.278PheVal: 2.278 ± 0.036
0.408PheTrp: 0.408 ± 0.014
0.553PheTyr: 0.553 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
11.572GlyAla: 11.572 ± 0.089
0.835GlyCys: 0.835 ± 0.021
5.389GlyAsp: 5.389 ± 0.052
4.428GlyGlu: 4.428 ± 0.054
2.755GlyPhe: 2.755 ± 0.04
8.617GlyGly: 8.617 ± 0.096
2.218GlyHis: 2.218 ± 0.036
3.156GlyIle: 3.156 ± 0.037
2.024GlyLys: 2.024 ± 0.044
9.098GlyLeu: 9.098 ± 0.086
1.885GlyMet: 1.885 ± 0.033
1.83GlyAsn: 1.83 ± 0.038
5.293GlyPro: 5.293 ± 0.061
2.829GlyGln: 2.829 ± 0.041
7.858GlyArg: 7.858 ± 0.067
4.694GlySer: 4.694 ± 0.053
6.039GlyThr: 6.039 ± 0.065
7.751GlyVal: 7.751 ± 0.09
1.851GlyTrp: 1.851 ± 0.037
2.391GlyTyr: 2.391 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.831HisAla: 2.831 ± 0.039
0.186HisCys: 0.186 ± 0.009
1.375HisAsp: 1.375 ± 0.028
1.066HisGlu: 1.066 ± 0.024
0.542HisPhe: 0.542 ± 0.014
2.17HisGly: 2.17 ± 0.03
0.671HisHis: 0.671 ± 0.017
0.566HisIle: 0.566 ± 0.017
0.279HisLys: 0.279 ± 0.01
2.418HisLeu: 2.418 ± 0.032
0.301HisMet: 0.301 ± 0.011
0.371HisAsn: 0.371 ± 0.014
1.809HisPro: 1.809 ± 0.033
0.644HisGln: 0.644 ± 0.019
2.176HisArg: 2.176 ± 0.035
0.916HisSer: 0.916 ± 0.02
1.234HisThr: 1.234 ± 0.026
1.762HisVal: 1.762 ± 0.032
0.332HisTrp: 0.332 ± 0.012
0.399HisTyr: 0.399 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
5.095IleAla: 5.095 ± 0.058
0.306IleCys: 0.306 ± 0.012
2.367IleAsp: 2.367 ± 0.038
1.912IleGlu: 1.912 ± 0.032
0.776IlePhe: 0.776 ± 0.021
3.505IleGly: 3.505 ± 0.047
0.575IleHis: 0.575 ± 0.016
0.975IleIle: 0.975 ± 0.027
0.663IleLys: 0.663 ± 0.019
2.524IleLeu: 2.524 ± 0.043
0.455IleMet: 0.455 ± 0.015
0.783IleAsn: 0.783 ± 0.021
1.665IlePro: 1.665 ± 0.031
0.729IleGln: 0.729 ± 0.02
2.458IleArg: 2.458 ± 0.037
1.711IleSer: 1.711 ± 0.034
2.287IleThr: 2.287 ± 0.033
3.039IleVal: 3.039 ± 0.042
0.395IleTrp: 0.395 ± 0.015
0.57IleTyr: 0.57 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
2.348LysAla: 2.348 ± 0.048
0.114LysCys: 0.114 ± 0.008
0.885LysAsp: 0.885 ± 0.024
0.72LysGlu: 0.72 ± 0.021
0.423LysPhe: 0.423 ± 0.015
1.309LysGly: 1.309 ± 0.033
0.353LysHis: 0.353 ± 0.014
0.793LysIle: 0.793 ± 0.021
0.504LysLys: 0.504 ± 0.021
1.806LysLeu: 1.806 ± 0.034
0.328LysMet: 0.328 ± 0.013
0.392LysAsn: 0.392 ± 0.014
1.2LysPro: 1.2 ± 0.031
0.589LysGln: 0.589 ± 0.019
1.277LysArg: 1.277 ± 0.03
0.921LysSer: 0.921 ± 0.023
1.09LysThr: 1.09 ± 0.032
1.617LysVal: 1.617 ± 0.037
0.223LysTrp: 0.223 ± 0.01
0.369LysTyr: 0.369 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
16.37LeuAla: 16.37 ± 0.143
0.798LeuCys: 0.798 ± 0.023
6.536LeuAsp: 6.536 ± 0.064
3.895LeuGlu: 3.895 ± 0.046
2.557LeuPhe: 2.557 ± 0.042
9.023LeuGly: 9.023 ± 0.075
2.252LeuHis: 2.252 ± 0.04
3.505LeuIle: 3.505 ± 0.049
1.457LeuLys: 1.457 ± 0.028
11.007LeuLeu: 11.007 ± 0.12
1.429LeuMet: 1.429 ± 0.028
1.72LeuAsn: 1.72 ± 0.03
6.55LeuPro: 6.55 ± 0.071
2.226LeuGln: 2.226 ± 0.038
9.101LeuArg: 9.101 ± 0.077
5.151LeuSer: 5.151 ± 0.044
6.844LeuThr: 6.844 ± 0.063
8.978LeuVal: 8.978 ± 0.081
1.238LeuTrp: 1.238 ± 0.025
1.677LeuTyr: 1.677 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
2.201MetAla: 2.201 ± 0.034
0.112MetCys: 0.112 ± 0.007
0.743MetAsp: 0.743 ± 0.022
0.591MetGlu: 0.591 ± 0.017
0.476MetPhe: 0.476 ± 0.016
1.151MetGly: 1.151 ± 0.026
0.333MetHis: 0.333 ± 0.013
0.697MetIle: 0.697 ± 0.02
0.315MetLys: 0.315 ± 0.012
1.742MetLeu: 1.742 ± 0.028
0.264MetMet: 0.264 ± 0.012
0.372MetAsn: 0.372 ± 0.012
1.13MetPro: 1.13 ± 0.02
0.474MetGln: 0.474 ± 0.013
1.458MetArg: 1.458 ± 0.028
1.2MetSer: 1.2 ± 0.024
1.568MetThr: 1.568 ± 0.029
1.3MetVal: 1.3 ± 0.023
0.209MetTrp: 0.209 ± 0.01
0.317MetTyr: 0.317 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.312AsnAla: 2.312 ± 0.039
0.167AsnCys: 0.167 ± 0.01
1.006AsnAsp: 1.006 ± 0.027
0.736AsnGlu: 0.736 ± 0.021
0.445AsnPhe: 0.445 ± 0.014
1.884AsnGly: 1.884 ± 0.047
0.381AsnHis: 0.381 ± 0.014
0.586AsnIle: 0.586 ± 0.017
0.341AsnLys: 0.341 ± 0.015
1.885AsnLeu: 1.885 ± 0.032
0.275AsnMet: 0.275 ± 0.011
0.489AsnAsn: 0.489 ± 0.028
1.498AsnPro: 1.498 ± 0.031
0.525AsnGln: 0.525 ± 0.018
1.479AsnArg: 1.479 ± 0.032
0.894AsnSer: 0.894 ± 0.022
1.044AsnThr: 1.044 ± 0.033
1.411AsnVal: 1.411 ± 0.031
0.299AsnTrp: 0.299 ± 0.014
0.383AsnTyr: 0.383 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
10.241ProAla: 10.241 ± 0.109
0.315ProCys: 0.315 ± 0.013
4.763ProAsp: 4.763 ± 0.059
3.543ProGlu: 3.543 ± 0.041
1.446ProPhe: 1.446 ± 0.028
6.938ProGly: 6.938 ± 0.08
1.296ProHis: 1.296 ± 0.027
1.614ProIle: 1.614 ± 0.026
0.984ProLys: 0.984 ± 0.026
5.1ProLeu: 5.1 ± 0.061
1.017ProMet: 1.017 ± 0.023
0.992ProAsn: 0.992 ± 0.025
4.292ProPro: 4.292 ± 0.083
1.747ProGln: 1.747 ± 0.031
4.205ProArg: 4.205 ± 0.056
3.062ProSer: 3.062 ± 0.042
3.706ProThr: 3.706 ± 0.051
5.754ProVal: 5.754 ± 0.058
0.913ProTrp: 0.913 ± 0.021
1.249ProTyr: 1.249 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
4.227GlnAla: 4.227 ± 0.051
0.182GlnCys: 0.182 ± 0.01
1.221GlnAsp: 1.221 ± 0.024
1.188GlnGlu: 1.188 ± 0.025
0.728GlnPhe: 0.728 ± 0.018
1.939GlnGly: 1.939 ± 0.033
0.689GlnHis: 0.689 ± 0.018
1.174GlnIle: 1.174 ± 0.025
0.473GlnLys: 0.473 ± 0.017
3.221GlnLeu: 3.221 ± 0.043
0.497GlnMet: 0.497 ± 0.016
0.508GlnAsn: 0.508 ± 0.019
2.047GlnPro: 2.047 ± 0.039
1.332GlnGln: 1.332 ± 0.035
2.945GlnArg: 2.945 ± 0.041
1.25GlnSer: 1.25 ± 0.025
1.491GlnThr: 1.491 ± 0.031
2.711GlnVal: 2.711 ± 0.038
0.494GlnTrp: 0.494 ± 0.016
0.57GlnTyr: 0.57 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
10.681ArgAla: 10.681 ± 0.086
0.636ArgCys: 0.636 ± 0.018
4.826ArgAsp: 4.826 ± 0.052
4.004ArgGlu: 4.004 ± 0.047
2.385ArgPhe: 2.385 ± 0.033
5.805ArgGly: 5.805 ± 0.053
2.271ArgHis: 2.271 ± 0.033
3.227ArgIle: 3.227 ± 0.04
1.395ArgLys: 1.395 ± 0.031
9.41ArgLeu: 9.41 ± 0.078
1.812ArgMet: 1.812 ± 0.033
1.451ArgAsn: 1.451 ± 0.025
5.328ArgPro: 5.328 ± 0.057
2.638ArgGln: 2.638 ± 0.04
8.713ArgArg: 8.713 ± 0.1
3.945ArgSer: 3.945 ± 0.04
5.117ArgThr: 5.117 ± 0.047
6.263ArgVal: 6.263 ± 0.057
1.623ArgTrp: 1.623 ± 0.028
2.058ArgTyr: 2.058 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.812SerAla: 6.812 ± 0.059
0.37SerCys: 0.37 ± 0.015
2.541SerAsp: 2.541 ± 0.038
1.95SerGlu: 1.95 ± 0.029
1.301SerPhe: 1.301 ± 0.026
5.547SerGly: 5.547 ± 0.058
0.881SerHis: 0.881 ± 0.021
1.585SerIle: 1.585 ± 0.032
0.798SerLys: 0.798 ± 0.023
4.259SerLeu: 4.259 ± 0.054
0.983SerMet: 0.983 ± 0.019
0.813SerAsn: 0.813 ± 0.023
3.094SerPro: 3.094 ± 0.048
1.216SerGln: 1.216 ± 0.027
3.62SerArg: 3.62 ± 0.042
2.533SerSer: 2.533 ± 0.045
3.029SerThr: 3.029 ± 0.045
4.031SerVal: 4.031 ± 0.051
0.914SerTrp: 0.914 ± 0.025
1.08SerTyr: 1.08 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
9.132ThrAla: 9.132 ± 0.078
0.457ThrCys: 0.457 ± 0.017
3.726ThrAsp: 3.726 ± 0.042
2.873ThrGlu: 2.873 ± 0.04
1.698ThrPhe: 1.698 ± 0.029
6.92ThrGly: 6.92 ± 0.073
1.114ThrHis: 1.114 ± 0.024
2.108ThrIle: 2.108 ± 0.037
1.045ThrLys: 1.045 ± 0.029
5.756ThrLeu: 5.756 ± 0.053
1.039ThrMet: 1.039 ± 0.024
1.104ThrAsn: 1.104 ± 0.028
4.179ThrPro: 4.179 ± 0.053
1.387ThrGln: 1.387 ± 0.024
4.163ThrArg: 4.163 ± 0.047
2.97ThrSer: 2.97 ± 0.048
4.096ThrThr: 4.096 ± 0.074
6.374ThrVal: 6.374 ± 0.058
0.923ThrTrp: 0.923 ± 0.02
1.338ThrTyr: 1.338 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
12.71ValAla: 12.71 ± 0.099
0.724ValCys: 0.724 ± 0.019
5.473ValAsp: 5.473 ± 0.057
4.401ValGlu: 4.401 ± 0.048
2.294ValPhe: 2.294 ± 0.036
6.959ValGly: 6.959 ± 0.063
1.843ValHis: 1.843 ± 0.031
2.937ValIle: 2.937 ± 0.047
1.447ValLys: 1.447 ± 0.03
9.552ValLeu: 9.552 ± 0.094
1.238ValMet: 1.238 ± 0.023
1.669ValAsn: 1.669 ± 0.029
5.425ValPro: 5.425 ± 0.061
2.122ValGln: 2.122 ± 0.032
7.155ValArg: 7.155 ± 0.065
4.384ValSer: 4.384 ± 0.055
6.073ValThr: 6.073 ± 0.056
8.512ValVal: 8.512 ± 0.073
1.141ValTrp: 1.141 ± 0.024
1.498ValTyr: 1.498 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.789TrpAla: 1.789 ± 0.029
0.164TrpCys: 0.164 ± 0.009
0.734TrpAsp: 0.734 ± 0.023
0.594TrpGlu: 0.594 ± 0.016
0.519TrpPhe: 0.519 ± 0.017
0.991TrpGly: 0.991 ± 0.024
0.422TrpHis: 0.422 ± 0.013
0.541TrpIle: 0.541 ± 0.019
0.246TrpLys: 0.246 ± 0.011
1.885TrpLeu: 1.885 ± 0.034
0.269TrpMet: 0.269 ± 0.011
0.373TrpAsn: 0.373 ± 0.014
0.866TrpPro: 0.866 ± 0.02
0.689TrpGln: 0.689 ± 0.021
1.533TrpArg: 1.533 ± 0.03
0.989TrpSer: 0.989 ± 0.025
1.001TrpThr: 1.001 ± 0.023
1.097TrpVal: 1.097 ± 0.024
0.376TrpTrp: 0.376 ± 0.015
0.345TrpTyr: 0.345 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.916TyrAla: 2.916 ± 0.036
0.172TyrCys: 0.172 ± 0.01
1.333TyrAsp: 1.333 ± 0.038
1.01TyrGlu: 1.01 ± 0.021
0.599TyrPhe: 0.599 ± 0.018
2.109TyrGly: 2.109 ± 0.03
0.425TyrHis: 0.425 ± 0.014
0.397TyrIle: 0.397 ± 0.014
0.294TyrLys: 0.294 ± 0.013
2.32TyrLeu: 2.32 ± 0.035
0.2TyrMet: 0.2 ± 0.01
0.369TyrAsn: 0.369 ± 0.02
1.16TyrPro: 1.16 ± 0.026
0.659TyrGln: 0.659 ± 0.019
1.946TyrArg: 1.946 ± 0.032
0.838TyrSer: 0.838 ± 0.019
1.17TyrThr: 1.17 ± 0.029
1.661TyrVal: 1.661 ± 0.03
0.329TyrTrp: 0.329 ± 0.014
0.404TyrTyr: 0.404 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6517 proteins (2234958 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski