Amino acid dipepetide frequency for Cucumber necrosis virus (CNV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.543AlaAla: 7.543 ± 1.713
0.0AlaCys: 0.0 ± 0.0
0.539AlaAsp: 0.539 ± 0.343
1.078AlaGlu: 1.078 ± 0.37
3.233AlaPhe: 3.233 ± 0.547
3.772AlaGly: 3.772 ± 0.517
3.772AlaHis: 3.772 ± 0.814
5.927AlaIle: 5.927 ± 1.706
7.543AlaLys: 7.543 ± 1.642
9.159AlaLeu: 9.159 ± 1.296
3.233AlaMet: 3.233 ± 1.549
3.233AlaAsn: 3.233 ± 1.927
2.694AlaPro: 2.694 ± 0.679
3.233AlaGln: 3.233 ± 0.682
5.927AlaArg: 5.927 ± 1.012
5.388AlaSer: 5.388 ± 0.305
7.004AlaThr: 7.004 ± 1.471
3.772AlaVal: 3.772 ± 1.165
0.539AlaTrp: 0.539 ± 0.343
1.616AlaTyr: 1.616 ± 1.51
0.0AlaXaa: 0.0 ± 0.0
Cys
2.694CysAla: 2.694 ± 1.203
1.078CysCys: 1.078 ± 0.533
0.0CysAsp: 0.0 ± 0.0
1.078CysGlu: 1.078 ± 0.579
1.078CysPhe: 1.078 ± 0.533
1.078CysGly: 1.078 ± 0.579
0.0CysHis: 0.0 ± 0.0
0.539CysIle: 0.539 ± 0.343
0.0CysLys: 0.0 ± 0.0
2.155CysLeu: 2.155 ± 0.675
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.539CysPro: 0.539 ± 0.343
0.539CysGln: 0.539 ± 0.343
1.616CysArg: 1.616 ± 0.706
0.539CysSer: 0.539 ± 0.343
1.078CysThr: 1.078 ± 0.94
2.694CysVal: 2.694 ± 1.279
0.0CysTrp: 0.0 ± 0.0
0.539CysTyr: 0.539 ± 0.683
0.0CysXaa: 0.0 ± 0.0
Asp
2.694AspAla: 2.694 ± 1.231
3.772AspCys: 3.772 ± 1.722
1.078AspAsp: 1.078 ± 0.37
3.772AspGlu: 3.772 ± 1.235
1.078AspPhe: 1.078 ± 0.863
4.849AspGly: 4.849 ± 1.508
0.539AspHis: 0.539 ± 0.619
3.233AspIle: 3.233 ± 0.492
2.694AspLys: 2.694 ± 0.498
4.31AspLeu: 4.31 ± 1.011
0.0AspMet: 0.0 ± 0.0
1.078AspAsn: 1.078 ± 1.007
1.616AspPro: 1.616 ± 0.814
1.078AspGln: 1.078 ± 0.37
3.772AspArg: 3.772 ± 1.259
3.233AspSer: 3.233 ± 0.492
4.31AspThr: 4.31 ± 1.054
2.694AspVal: 2.694 ± 1.157
0.539AspTrp: 0.539 ± 0.343
1.616AspTyr: 1.616 ± 0.706
0.0AspXaa: 0.0 ± 0.0
Glu
5.388GluAla: 5.388 ± 0.305
0.0GluCys: 0.0 ± 0.0
5.388GluAsp: 5.388 ± 1.577
2.694GluGlu: 2.694 ± 0.86
1.078GluPhe: 1.078 ± 0.37
2.155GluGly: 2.155 ± 0.814
0.539GluHis: 0.539 ± 0.343
3.233GluIle: 3.233 ± 0.796
2.694GluLys: 2.694 ± 1.279
5.927GluLeu: 5.927 ± 1.69
1.616GluMet: 1.616 ± 1.079
3.233GluAsn: 3.233 ± 0.855
2.155GluPro: 2.155 ± 0.974
1.616GluGln: 1.616 ± 0.81
5.927GluArg: 5.927 ± 1.921
6.466GluSer: 6.466 ± 2.036
1.078GluThr: 1.078 ± 0.579
4.31GluVal: 4.31 ± 1.127
1.616GluTrp: 1.616 ± 0.637
3.233GluTyr: 3.233 ± 1.235
0.0GluXaa: 0.0 ± 0.0
Phe
1.616PheAla: 1.616 ± 0.496
1.078PheCys: 1.078 ± 0.686
1.616PheAsp: 1.616 ± 0.814
2.694PheGlu: 2.694 ± 1.175
0.0PhePhe: 0.0 ± 0.0
5.388PheGly: 5.388 ± 0.992
0.0PheHis: 0.0 ± 0.0
1.616PheIle: 1.616 ± 0.496
2.694PheLys: 2.694 ± 1.717
3.772PheLeu: 3.772 ± 0.833
1.616PheMet: 1.616 ± 0.706
2.694PheAsn: 2.694 ± 0.679
1.078PhePro: 1.078 ± 1.007
2.694PheGln: 2.694 ± 0.666
2.155PheArg: 2.155 ± 0.611
2.694PheSer: 2.694 ± 2.072
0.539PheThr: 0.539 ± 0.343
3.233PheVal: 3.233 ± 0.94
0.539PheTrp: 0.539 ± 0.343
1.078PheTyr: 1.078 ± 0.686
0.0PheXaa: 0.0 ± 0.0
Gly
2.694GlyAla: 2.694 ± 1.161
2.694GlyCys: 2.694 ± 0.86
4.849GlyAsp: 4.849 ± 1.344
2.694GlyGlu: 2.694 ± 0.666
2.155GlyPhe: 2.155 ± 0.814
5.388GlyGly: 5.388 ± 1.357
0.0GlyHis: 0.0 ± 0.0
1.078GlyIle: 1.078 ± 0.686
5.927GlyLys: 5.927 ± 1.25
6.466GlyLeu: 6.466 ± 0.823
0.539GlyMet: 0.539 ± 0.683
4.849GlyAsn: 4.849 ± 0.543
2.155GlyPro: 2.155 ± 1.302
1.616GlyGln: 1.616 ± 0.507
4.849GlyArg: 4.849 ± 1.006
5.927GlySer: 5.927 ± 2.174
5.927GlyThr: 5.927 ± 2.117
8.082GlyVal: 8.082 ± 1.908
1.078GlyTrp: 1.078 ± 0.37
4.31GlyTyr: 4.31 ± 1.716
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
2.155HisCys: 2.155 ± 0.992
0.0HisAsp: 0.0 ± 0.0
0.539HisGlu: 0.539 ± 0.343
0.0HisPhe: 0.0 ± 0.0
1.078HisGly: 1.078 ± 0.686
0.539HisHis: 0.539 ± 0.343
0.539HisIle: 0.539 ± 0.343
0.539HisLys: 0.539 ± 0.343
2.155HisLeu: 2.155 ± 0.621
1.616HisMet: 1.616 ± 0.706
1.616HisAsn: 1.616 ± 0.723
1.616HisPro: 1.616 ± 0.648
0.539HisGln: 0.539 ± 0.343
1.616HisArg: 1.616 ± 0.648
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.849IleAla: 4.849 ± 1.487
1.078IleCys: 1.078 ± 0.533
0.539IleAsp: 0.539 ± 0.343
2.694IleGlu: 2.694 ± 0.998
4.31IlePhe: 4.31 ± 0.953
2.155IleGly: 2.155 ± 0.675
0.0IleHis: 0.0 ± 0.0
1.078IleIle: 1.078 ± 0.863
2.694IleLys: 2.694 ± 1.157
1.616IleLeu: 1.616 ± 0.706
1.078IleMet: 1.078 ± 0.533
2.694IleAsn: 2.694 ± 1.161
3.772IlePro: 3.772 ± 1.199
1.616IleGln: 1.616 ± 0.723
3.772IleArg: 3.772 ± 1.041
3.233IleSer: 3.233 ± 1.902
4.31IleThr: 4.31 ± 1.79
2.694IleVal: 2.694 ± 0.454
1.078IleTrp: 1.078 ± 1.007
1.616IleTyr: 1.616 ± 0.706
0.0IleXaa: 0.0 ± 0.0
Lys
3.233LysAla: 3.233 ± 1.905
0.0LysCys: 0.0 ± 0.0
4.31LysAsp: 4.31 ± 0.89
4.31LysGlu: 4.31 ± 1.437
1.078LysPhe: 1.078 ± 0.37
7.004LysGly: 7.004 ± 1.448
0.539LysHis: 0.539 ± 0.343
3.772LysIle: 3.772 ± 1.275
4.849LysLys: 4.849 ± 1.194
8.621LysLeu: 8.621 ± 1.294
0.539LysMet: 0.539 ± 0.47
2.155LysAsn: 2.155 ± 0.476
2.155LysPro: 2.155 ± 1.3
0.539LysGln: 0.539 ± 0.343
4.31LysArg: 4.31 ± 1.082
1.078LysSer: 1.078 ± 0.533
2.694LysThr: 2.694 ± 0.969
4.849LysVal: 4.849 ± 1.188
3.233LysTrp: 3.233 ± 0.492
0.0LysTyr: 0.0 ± 0.0
0.539LysXaa: 0.539 ± 0.343
Leu
10.237LeuAla: 10.237 ± 2.698
0.0LeuCys: 0.0 ± 0.0
3.233LeuAsp: 3.233 ± 1.518
3.772LeuGlu: 3.772 ± 0.833
3.233LeuPhe: 3.233 ± 1.902
8.621LeuGly: 8.621 ± 1.178
2.694LeuHis: 2.694 ± 1.231
3.233LeuIle: 3.233 ± 0.74
5.927LeuLys: 5.927 ± 1.812
9.698LeuLeu: 9.698 ± 2.119
1.078LeuMet: 1.078 ± 0.686
1.078LeuAsn: 1.078 ± 0.37
6.466LeuPro: 6.466 ± 0.583
1.616LeuGln: 1.616 ± 1.149
8.082LeuArg: 8.082 ± 1.155
8.621LeuSer: 8.621 ± 0.813
7.543LeuThr: 7.543 ± 1.641
7.004LeuVal: 7.004 ± 1.16
2.155LeuTrp: 2.155 ± 1.065
2.155LeuTyr: 2.155 ± 1.3
0.0LeuXaa: 0.0 ± 0.0
Met
1.078MetAla: 1.078 ± 0.838
0.539MetCys: 0.539 ± 0.343
3.233MetAsp: 3.233 ± 1.035
2.694MetGlu: 2.694 ± 0.666
0.0MetPhe: 0.0 ± 0.0
0.539MetGly: 0.539 ± 0.503
0.0MetHis: 0.0 ± 0.0
1.616MetIle: 1.616 ± 0.706
3.233MetLys: 3.233 ± 1.413
1.616MetLeu: 1.616 ± 0.637
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.539MetGln: 0.539 ± 0.683
2.155MetArg: 2.155 ± 0.476
1.078MetSer: 1.078 ± 0.686
1.078MetThr: 1.078 ± 0.533
1.078MetVal: 1.078 ± 0.686
0.0MetTrp: 0.0 ± 0.0
2.155MetTyr: 2.155 ± 0.673
0.0MetXaa: 0.0 ± 0.0
Asn
2.694AsnAla: 2.694 ± 1.161
0.539AsnCys: 0.539 ± 0.343
1.078AsnAsp: 1.078 ± 0.838
2.155AsnGlu: 2.155 ± 0.673
2.155AsnPhe: 2.155 ± 0.637
3.772AsnGly: 3.772 ± 2.799
0.539AsnHis: 0.539 ± 0.343
3.233AsnIle: 3.233 ± 0.666
3.772AsnLys: 3.772 ± 1.209
2.694AsnLeu: 2.694 ± 0.818
0.539AsnMet: 0.539 ± 0.503
3.772AsnAsn: 3.772 ± 1.565
1.616AsnPro: 1.616 ± 0.814
0.0AsnGln: 0.0 ± 0.0
1.616AsnArg: 1.616 ± 0.706
3.233AsnSer: 3.233 ± 2.513
3.233AsnThr: 3.233 ± 0.94
3.233AsnVal: 3.233 ± 0.739
0.0AsnTrp: 0.0 ± 0.0
1.078AsnTyr: 1.078 ± 0.37
0.0AsnXaa: 0.0 ± 0.0
Pro
2.155ProAla: 2.155 ± 0.673
0.539ProCys: 0.539 ± 0.619
2.694ProAsp: 2.694 ± 0.498
2.155ProGlu: 2.155 ± 0.974
1.616ProPhe: 1.616 ± 0.648
2.694ProGly: 2.694 ± 1.161
0.0ProHis: 0.0 ± 0.0
2.155ProIle: 2.155 ± 0.637
3.772ProLys: 3.772 ± 0.909
5.927ProLeu: 5.927 ± 1.945
0.0ProMet: 0.0 ± 0.0
1.078ProAsn: 1.078 ± 0.37
1.616ProPro: 1.616 ± 0.759
2.155ProGln: 2.155 ± 0.611
5.388ProArg: 5.388 ± 1.78
4.849ProSer: 4.849 ± 0.907
2.155ProThr: 2.155 ± 1.302
3.772ProVal: 3.772 ± 1.927
1.616ProTrp: 1.616 ± 1.236
2.155ProTyr: 2.155 ± 0.637
0.0ProXaa: 0.0 ± 0.0
Gln
2.694GlnAla: 2.694 ± 0.855
0.539GlnCys: 0.539 ± 0.683
0.0GlnAsp: 0.0 ± 0.0
1.078GlnGlu: 1.078 ± 0.635
2.155GlnPhe: 2.155 ± 0.621
1.616GlnGly: 1.616 ± 0.723
1.616GlnHis: 1.616 ± 0.759
1.616GlnIle: 1.616 ± 0.723
0.0GlnLys: 0.0 ± 0.0
4.31GlnLeu: 4.31 ± 1.053
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
1.616GlnPro: 1.616 ± 0.507
0.0GlnGln: 0.0 ± 0.0
2.694GlnArg: 2.694 ± 1.085
0.0GlnSer: 0.0 ± 0.0
1.616GlnThr: 1.616 ± 0.814
2.155GlnVal: 2.155 ± 0.637
0.0GlnTrp: 0.0 ± 0.0
0.539GlnTyr: 0.539 ± 0.503
0.0GlnXaa: 0.0 ± 0.0
Arg
7.543ArgAla: 7.543 ± 1.669
0.539ArgCys: 0.539 ± 0.619
4.849ArgAsp: 4.849 ± 1.697
5.388ArgGlu: 5.388 ± 1.051
4.849ArgPhe: 4.849 ± 1.398
1.616ArgGly: 1.616 ± 0.723
1.078ArgHis: 1.078 ± 0.686
1.616ArgIle: 1.616 ± 0.669
2.694ArgLys: 2.694 ± 1.203
5.927ArgLeu: 5.927 ± 1.453
3.233ArgMet: 3.233 ± 0.94
4.31ArgAsn: 4.31 ± 1.142
3.772ArgPro: 3.772 ± 1.468
0.0ArgGln: 0.0 ± 0.0
7.004ArgArg: 7.004 ± 1.849
1.078ArgSer: 1.078 ± 0.94
7.004ArgThr: 7.004 ± 1.949
8.082ArgVal: 8.082 ± 1.345
1.616ArgTrp: 1.616 ± 0.81
4.31ArgTyr: 4.31 ± 1.349
0.0ArgXaa: 0.0 ± 0.0
Ser
4.31SerAla: 4.31 ± 1.48
0.539SerCys: 0.539 ± 0.619
3.233SerAsp: 3.233 ± 1.324
4.31SerGlu: 4.31 ± 3.173
2.694SerPhe: 2.694 ± 0.498
7.004SerGly: 7.004 ± 1.919
0.539SerHis: 0.539 ± 0.343
3.233SerIle: 3.233 ± 0.74
2.694SerLys: 2.694 ± 1.356
9.698SerLeu: 9.698 ± 1.35
0.0SerMet: 0.0 ± 0.0
1.078SerAsn: 1.078 ± 0.635
2.694SerPro: 2.694 ± 1.175
1.078SerGln: 1.078 ± 0.579
4.849SerArg: 4.849 ± 1.487
2.694SerSer: 2.694 ± 2.149
2.694SerThr: 2.694 ± 0.679
8.082SerVal: 8.082 ± 1.83
1.078SerTrp: 1.078 ± 1.238
2.155SerTyr: 2.155 ± 0.476
0.0SerXaa: 0.0 ± 0.0
Thr
3.772ThrAla: 3.772 ± 1.518
0.539ThrCys: 0.539 ± 0.343
4.849ThrAsp: 4.849 ± 1.158
3.233ThrGlu: 3.233 ± 1.324
1.616ThrPhe: 1.616 ± 0.706
6.466ThrGly: 6.466 ± 1.507
0.539ThrHis: 0.539 ± 0.503
4.31ThrIle: 4.31 ± 1.633
3.233ThrLys: 3.233 ± 0.512
4.849ThrLeu: 4.849 ± 1.487
2.694ThrMet: 2.694 ± 0.666
2.694ThrAsn: 2.694 ± 1.161
4.31ThrPro: 4.31 ± 1.021
0.539ThrGln: 0.539 ± 0.343
2.694ThrArg: 2.694 ± 0.818
3.772ThrSer: 3.772 ± 0.604
2.694ThrThr: 2.694 ± 0.838
4.31ThrVal: 4.31 ± 1.48
0.0ThrTrp: 0.0 ± 0.0
2.155ThrTyr: 2.155 ± 0.611
0.0ThrXaa: 0.0 ± 0.0
Val
7.004ValAla: 7.004 ± 1.448
1.616ValCys: 1.616 ± 0.706
4.31ValAsp: 4.31 ± 0.953
10.776ValGlu: 10.776 ± 3.171
3.772ValPhe: 3.772 ± 0.943
5.388ValGly: 5.388 ± 1.287
1.616ValHis: 1.616 ± 1.03
3.772ValIle: 3.772 ± 1.722
3.233ValLys: 3.233 ± 1.096
3.233ValLeu: 3.233 ± 0.947
2.694ValMet: 2.694 ± 1.137
3.772ValAsn: 3.772 ± 1.957
5.927ValPro: 5.927 ± 1.043
1.616ValGln: 1.616 ± 0.814
5.927ValArg: 5.927 ± 1.516
6.466ValSer: 6.466 ± 4.454
2.155ValThr: 2.155 ± 0.782
5.388ValVal: 5.388 ± 0.847
0.539ValTrp: 0.539 ± 0.503
1.078ValTyr: 1.078 ± 0.533
0.0ValXaa: 0.0 ± 0.0
Trp
1.078TrpAla: 1.078 ± 0.37
0.0TrpCys: 0.0 ± 0.0
1.078TrpAsp: 1.078 ± 0.579
2.155TrpGlu: 2.155 ± 0.675
1.078TrpPhe: 1.078 ± 0.533
1.616TrpGly: 1.616 ± 0.496
0.0TrpHis: 0.0 ± 0.0
0.539TrpIle: 0.539 ± 0.503
1.078TrpLys: 1.078 ± 0.635
0.539TrpLeu: 0.539 ± 0.503
0.0TrpMet: 0.0 ± 0.0
1.078TrpAsn: 1.078 ± 0.863
1.078TrpPro: 1.078 ± 0.533
1.616TrpGln: 1.616 ± 0.669
1.078TrpArg: 1.078 ± 0.579
1.078TrpSer: 1.078 ± 0.579
0.0TrpThr: 0.0 ± 0.0
0.539TrpVal: 0.539 ± 0.503
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.927TyrAla: 5.927 ± 1.823
0.0TyrCys: 0.0 ± 0.0
1.078TyrAsp: 1.078 ± 0.579
1.078TyrGlu: 1.078 ± 0.635
1.616TyrPhe: 1.616 ± 0.814
0.539TyrGly: 0.539 ± 0.343
0.0TyrHis: 0.0 ± 0.0
0.539TyrIle: 0.539 ± 0.683
1.078TyrLys: 1.078 ± 0.863
3.772TyrLeu: 3.772 ± 1.135
1.616TyrMet: 1.616 ± 0.706
0.539TyrAsn: 0.539 ± 0.343
1.616TyrPro: 1.616 ± 0.706
1.616TyrGln: 1.616 ± 0.647
1.078TyrArg: 1.078 ± 0.686
3.233TyrSer: 3.233 ± 0.739
2.155TyrThr: 2.155 ± 0.782
4.31TyrVal: 4.31 ± 1.402
0.0TyrTrp: 0.0 ± 0.0
0.539TyrTyr: 0.539 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.539XaaGly: 0.539 ± 0.343
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1857 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski