Amino acid dipepetide frequency for Phaeobacter gallaeciensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.567AlaAla: 16.567 ± 0.178	1.087AlaCys: 1.087 ± 0.033	7.003AlaAsp: 7.003 ± 0.083	8.742AlaGlu: 8.742 ± 0.108	3.986AlaPhe: 3.986 ± 0.059	10.51AlaGly: 10.51 ± 0.099	2.325AlaHis: 2.325 ± 0.048	5.541AlaIle: 5.541 ± 0.082	4.051AlaLys: 4.051 ± 0.076	13.412AlaLeu: 13.412 ± 0.141	3.827AlaMet: 3.827 ± 0.064	2.679AlaAsn: 2.679 ± 0.048	5.986AlaPro: 5.986 ± 0.088	4.465AlaGln: 4.465 ± 0.066	8.264AlaArg: 8.264 ± 0.111	5.589AlaSer: 5.589 ± 0.077	5.542AlaThr: 5.542 ± 0.072	8.127AlaVal: 8.127 ± 0.099	1.282AlaTrp: 1.282 ± 0.034	2.572AlaTyr: 2.572 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.152CysAla: 1.152 ± 0.035	0.127CysCys: 0.127 ± 0.012	0.624CysAsp: 0.624 ± 0.023	0.467CysGlu: 0.467 ± 0.02	0.371CysPhe: 0.371 ± 0.021	0.97CysGly: 0.97 ± 0.031	0.286CysHis: 0.286 ± 0.017	0.408CysIle: 0.408 ± 0.019	0.255CysLys: 0.255 ± 0.015	0.893CysLeu: 0.893 ± 0.027	0.177CysMet: 0.177 ± 0.011	0.236CysAsn: 0.236 ± 0.014	0.519CysPro: 0.519 ± 0.024	0.241CysGln: 0.241 ± 0.014	0.569CysArg: 0.569 ± 0.021	0.489CysSer: 0.489 ± 0.022	0.477CysThr: 0.477 ± 0.023	0.564CysVal: 0.564 ± 0.024	0.114CysTrp: 0.114 ± 0.01	0.214CysTyr: 0.214 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.831AspAla: 6.831 ± 0.094	0.545AspCys: 0.545 ± 0.023	3.109AspAsp: 3.109 ± 0.068	3.52AspGlu: 3.52 ± 0.056	2.339AspPhe: 2.339 ± 0.046	5.425AspGly: 5.425 ± 0.093	1.364AspHis: 1.364 ± 0.036	3.164AspIle: 3.164 ± 0.05	1.76AspLys: 1.76 ± 0.039	6.75AspLeu: 6.75 ± 0.093	1.808AspMet: 1.808 ± 0.042	1.366AspAsn: 1.366 ± 0.039	3.62AspPro: 3.62 ± 0.057	2.189AspGln: 2.189 ± 0.044	3.926AspArg: 3.926 ± 0.064	2.508AspSer: 2.508 ± 0.048	3.015AspThr: 3.015 ± 0.066	4.159AspVal: 4.159 ± 0.07	1.207AspTrp: 1.207 ± 0.035	1.551AspTyr: 1.551 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.487GluAla: 8.487 ± 0.096	0.377GluCys: 0.377 ± 0.019	3.647GluAsp: 3.647 ± 0.062	4.165GluGlu: 4.165 ± 0.072	1.884GluPhe: 1.884 ± 0.048	4.966GluGly: 4.966 ± 0.072	1.134GluHis: 1.134 ± 0.034	3.819GluIle: 3.819 ± 0.056	2.389GluLys: 2.389 ± 0.05	5.508GluLeu: 5.508 ± 0.07	1.955GluMet: 1.955 ± 0.039	1.839GluAsn: 1.839 ± 0.044	2.395GluPro: 2.395 ± 0.056	2.359GluGln: 2.359 ± 0.048	4.079GluArg: 4.079 ± 0.065	2.164GluSer: 2.164 ± 0.044	3.905GluThr: 3.905 ± 0.064	4.581GluVal: 4.581 ± 0.063	0.699GluTrp: 0.699 ± 0.021	1.117GluTyr: 1.117 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.42PheAla: 4.42 ± 0.073	0.459PheCys: 0.459 ± 0.024	2.85PheAsp: 2.85 ± 0.051	2.245PheGlu: 2.245 ± 0.038	1.394PhePhe: 1.394 ± 0.041	3.645PheGly: 3.645 ± 0.061	0.746PheHis: 0.746 ± 0.024	1.567PheIle: 1.567 ± 0.036	0.982PheLys: 0.982 ± 0.03	3.397PheLeu: 3.397 ± 0.058	0.887PheMet: 0.887 ± 0.029	1.1PheAsn: 1.1 ± 0.028	1.5PhePro: 1.5 ± 0.039	1.104PheGln: 1.104 ± 0.033	2.012PheArg: 2.012 ± 0.041	2.237PheSer: 2.237 ± 0.046	2.074PheThr: 2.074 ± 0.046	2.511PheVal: 2.511 ± 0.051	0.564PheTrp: 0.564 ± 0.023	0.897PheTyr: 0.897 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.89GlyAla: 9.89 ± 0.095	0.886GlyCys: 0.886 ± 0.029	4.966GlyAsp: 4.966 ± 0.099	4.814GlyGlu: 4.814 ± 0.069	3.64GlyPhe: 3.64 ± 0.061	7.652GlyGly: 7.652 ± 0.126	1.968GlyHis: 1.968 ± 0.045	4.444GlyIle: 4.444 ± 0.062	3.355GlyLys: 3.355 ± 0.062	9.074GlyLeu: 9.074 ± 0.098	2.694GlyMet: 2.694 ± 0.053	2.265GlyAsn: 2.265 ± 0.066	3.446GlyPro: 3.446 ± 0.056	3.453GlyGln: 3.453 ± 0.057	5.365GlyArg: 5.365 ± 0.071	4.611GlySer: 4.611 ± 0.068	4.651GlyThr: 4.651 ± 0.067	6.071GlyVal: 6.071 ± 0.07	1.434GlyTrp: 1.434 ± 0.036	2.373GlyTyr: 2.373 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.224HisAla: 2.224 ± 0.043	0.252HisCys: 0.252 ± 0.016	1.214HisAsp: 1.214 ± 0.034	1.063HisGlu: 1.063 ± 0.028	0.851HisPhe: 0.851 ± 0.029	1.952HisGly: 1.952 ± 0.043	0.539HisHis: 0.539 ± 0.021	1.02HisIle: 1.02 ± 0.027	0.559HisLys: 0.559 ± 0.022	2.191HisLeu: 2.191 ± 0.045	0.6HisMet: 0.6 ± 0.023	0.496HisAsn: 0.496 ± 0.021	1.322HisPro: 1.322 ± 0.036	0.685HisGln: 0.685 ± 0.023	1.314HisArg: 1.314 ± 0.033	1.019HisSer: 1.019 ± 0.035	0.883HisThr: 0.883 ± 0.029	1.489HisVal: 1.489 ± 0.039	0.39HisTrp: 0.39 ± 0.019	0.535HisTyr: 0.535 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.792IleAla: 6.792 ± 0.086	0.663IleCys: 0.663 ± 0.023	3.345IleAsp: 3.345 ± 0.062	3.478IleGlu: 3.478 ± 0.053	1.701IlePhe: 1.701 ± 0.041	4.768IleGly: 4.768 ± 0.066	0.913IleHis: 0.913 ± 0.03	2.121IleIle: 2.121 ± 0.048	1.566IleLys: 1.566 ± 0.041	4.912IleLeu: 4.912 ± 0.067	1.113IleMet: 1.113 ± 0.03	1.415IleAsn: 1.415 ± 0.039	2.304IlePro: 2.304 ± 0.051	1.241IleGln: 1.241 ± 0.032	3.121IleArg: 3.121 ± 0.053	3.103IleSer: 3.103 ± 0.062	3.044IleThr: 3.044 ± 0.05	3.457IleVal: 3.457 ± 0.061	0.748IleTrp: 0.748 ± 0.026	1.158IleTyr: 1.158 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.128LysAla: 4.128 ± 0.074	0.202LysCys: 0.202 ± 0.013	2.019LysAsp: 2.019 ± 0.047	1.873LysGlu: 1.873 ± 0.043	0.969LysPhe: 0.969 ± 0.033	2.96LysGly: 2.96 ± 0.057	0.638LysHis: 0.638 ± 0.024	1.791LysIle: 1.791 ± 0.036	1.378LysLys: 1.378 ± 0.041	3.028LysLeu: 3.028 ± 0.061	0.979LysMet: 0.979 ± 0.035	0.849LysAsn: 0.849 ± 0.031	1.856LysPro: 1.856 ± 0.044	1.075LysGln: 1.075 ± 0.03	2.241LysArg: 2.241 ± 0.055	1.923LysSer: 1.923 ± 0.035	2.061LysThr: 2.061 ± 0.044	2.426LysVal: 2.426 ± 0.052	0.403LysTrp: 0.403 ± 0.021	0.709LysTyr: 0.709 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.429LeuAla: 12.429 ± 0.127	0.993LeuCys: 0.993 ± 0.031	5.935LeuAsp: 5.935 ± 0.072	5.797LeuGlu: 5.797 ± 0.071	3.61LeuPhe: 3.61 ± 0.066	8.142LeuGly: 8.142 ± 0.094	1.95LeuHis: 1.95 ± 0.042	5.25LeuIle: 5.25 ± 0.07	3.598LeuLys: 3.598 ± 0.066	9.107LeuLeu: 9.107 ± 0.119	2.892LeuMet: 2.892 ± 0.054	2.926LeuAsn: 2.926 ± 0.054	5.704LeuPro: 5.704 ± 0.073	3.151LeuGln: 3.151 ± 0.05	6.888LeuArg: 6.888 ± 0.089	6.969LeuSer: 6.969 ± 0.092	6.019LeuThr: 6.019 ± 0.058	6.713LeuVal: 6.713 ± 0.093	1.261LeuTrp: 1.261 ± 0.032	1.892LeuTyr: 1.892 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.554MetAla: 3.554 ± 0.056	0.194MetCys: 0.194 ± 0.012	1.495MetAsp: 1.495 ± 0.029	1.53MetGlu: 1.53 ± 0.035	0.841MetPhe: 0.841 ± 0.026	2.345MetGly: 2.345 ± 0.047	0.519MetHis: 0.519 ± 0.021	1.568MetIle: 1.568 ± 0.037	1.164MetLys: 1.164 ± 0.035	2.72MetLeu: 2.72 ± 0.042	0.898MetMet: 0.898 ± 0.027	0.837MetAsn: 0.837 ± 0.026	1.523MetPro: 1.523 ± 0.036	1.223MetGln: 1.223 ± 0.031	1.941MetArg: 1.941 ± 0.045	1.909MetSer: 1.909 ± 0.039	2.102MetThr: 2.102 ± 0.039	1.95MetVal: 1.95 ± 0.042	0.251MetTrp: 0.251 ± 0.018	0.351MetTyr: 0.351 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.129AsnAla: 3.129 ± 0.049	0.255AsnCys: 0.255 ± 0.016	1.503AsnAsp: 1.503 ± 0.051	1.216AsnGlu: 1.216 ± 0.03	0.938AsnPhe: 0.938 ± 0.03	2.553AsnGly: 2.553 ± 0.05	0.492AsnHis: 0.492 ± 0.022	1.368AsnIle: 1.368 ± 0.032	0.749AsnLys: 0.749 ± 0.029	2.618AsnLeu: 2.618 ± 0.048	0.728AsnMet: 0.728 ± 0.025	0.701AsnAsn: 0.701 ± 0.034	1.829AsnPro: 1.829 ± 0.048	0.79AsnGln: 0.79 ± 0.029	1.753AsnArg: 1.753 ± 0.042	1.302AsnSer: 1.302 ± 0.035	1.436AsnThr: 1.436 ± 0.037	1.798AsnVal: 1.798 ± 0.041	0.446AsnTrp: 0.446 ± 0.02	0.636AsnTyr: 0.636 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.481ProAla: 5.481 ± 0.082	0.371ProCys: 0.371 ± 0.019	3.749ProAsp: 3.749 ± 0.07	4.413ProGlu: 4.413 ± 0.077	1.952ProPhe: 1.952 ± 0.041	4.513ProGly: 4.513 ± 0.072	1.083ProHis: 1.083 ± 0.032	2.054ProIle: 2.054 ± 0.045	1.73ProLys: 1.73 ± 0.043	4.654ProLeu: 4.654 ± 0.062	1.362ProMet: 1.362 ± 0.037	1.27ProAsn: 1.27 ± 0.034	2.123ProPro: 2.123 ± 0.045	1.937ProGln: 1.937 ± 0.042	2.582ProArg: 2.582 ± 0.049	2.423ProSer: 2.423 ± 0.045	2.333ProThr: 2.333 ± 0.047	4.333ProVal: 4.333 ± 0.064	0.622ProTrp: 0.622 ± 0.024	1.139ProTyr: 1.139 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.387GlnAla: 4.387 ± 0.065	0.229GlnCys: 0.229 ± 0.014	2.046GlnAsp: 2.046 ± 0.044	1.924GlnGlu: 1.924 ± 0.042	1.146GlnPhe: 1.146 ± 0.032	2.786GlnGly: 2.786 ± 0.052	0.67GlnHis: 0.67 ± 0.025	2.146GlnIle: 2.146 ± 0.044	1.237GlnLys: 1.237 ± 0.032	3.174GlnLeu: 3.174 ± 0.054	1.232GlnMet: 1.232 ± 0.034	1.01GlnAsn: 1.01 ± 0.027	1.776GlnPro: 1.776 ± 0.044	1.349GlnGln: 1.349 ± 0.041	2.344GlnArg: 2.344 ± 0.053	2.037GlnSer: 2.037 ± 0.043	1.874GlnThr: 1.874 ± 0.04	2.467GlnVal: 2.467 ± 0.048	0.386GlnTrp: 0.386 ± 0.019	0.632GlnTyr: 0.632 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.617ArgAla: 7.617 ± 0.106	0.503ArgCys: 0.503 ± 0.018	3.923ArgAsp: 3.923 ± 0.063	3.643ArgGlu: 3.643 ± 0.059	2.516ArgPhe: 2.516 ± 0.046	4.398ArgGly: 4.398 ± 0.066	1.492ArgHis: 1.492 ± 0.035	3.771ArgIle: 3.771 ± 0.062	2.34ArgLys: 2.34 ± 0.049	7.129ArgLeu: 7.129 ± 0.095	1.92ArgMet: 1.92 ± 0.044	1.693ArgAsn: 1.693 ± 0.037	3.169ArgPro: 3.169 ± 0.053	2.439ArgGln: 2.439 ± 0.047	4.578ArgArg: 4.578 ± 0.073	3.391ArgSer: 3.391 ± 0.054	2.816ArgThr: 2.816 ± 0.048	4.304ArgVal: 4.304 ± 0.068	0.847ArgTrp: 0.847 ± 0.029	1.451ArgTyr: 1.451 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.159SerAla: 6.159 ± 0.074	0.504SerCys: 0.504 ± 0.021	3.444SerAsp: 3.444 ± 0.054	3.114SerGlu: 3.114 ± 0.057	2.303SerPhe: 2.303 ± 0.045	5.567SerGly: 5.567 ± 0.076	1.21SerHis: 1.21 ± 0.034	2.552SerIle: 2.552 ± 0.055	1.625SerLys: 1.625 ± 0.037	5.327SerLeu: 5.327 ± 0.067	1.485SerMet: 1.485 ± 0.031	1.394SerAsn: 1.394 ± 0.036	2.502SerPro: 2.502 ± 0.042	1.809SerGln: 1.809 ± 0.04	3.212SerArg: 3.212 ± 0.05	2.767SerSer: 2.767 ± 0.051	2.49SerThr: 2.49 ± 0.043	3.869SerVal: 3.869 ± 0.065	0.699SerTrp: 0.699 ± 0.022	1.405SerTyr: 1.405 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.299ThrAla: 6.299 ± 0.077	0.5ThrCys: 0.5 ± 0.02	3.053ThrAsp: 3.053 ± 0.049	3.077ThrGlu: 3.077 ± 0.05	1.899ThrPhe: 1.899 ± 0.042	5.663ThrGly: 5.663 ± 0.079	1.102ThrHis: 1.102 ± 0.03	2.579ThrIle: 2.579 ± 0.054	1.434ThrLys: 1.434 ± 0.041	5.92ThrLeu: 5.92 ± 0.083	1.262ThrMet: 1.262 ± 0.035	1.2ThrAsn: 1.2 ± 0.032	3.381ThrPro: 3.381 ± 0.06	1.662ThrGln: 1.662 ± 0.038	3.348ThrArg: 3.348 ± 0.059	2.767ThrSer: 2.767 ± 0.056	2.71ThrThr: 2.71 ± 0.047	4.09ThrVal: 4.09 ± 0.057	0.63ThrTrp: 0.63 ± 0.025	1.285ThrTyr: 1.285 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.261ValAla: 8.261 ± 0.085	0.61ValCys: 0.61 ± 0.022	3.868ValAsp: 3.868 ± 0.06	4.431ValGlu: 4.431 ± 0.065	2.807ValPhe: 2.807 ± 0.052	5.071ValGly: 5.071 ± 0.069	1.297ValHis: 1.297 ± 0.035	4.16ValIle: 4.16 ± 0.062	2.263ValLys: 2.263 ± 0.054	7.611ValLeu: 7.611 ± 0.096	2.148ValMet: 2.148 ± 0.048	1.94ValAsn: 1.94 ± 0.043	3.485ValPro: 3.485 ± 0.055	2.294ValGln: 2.294 ± 0.042	3.905ValArg: 3.905 ± 0.055	4.228ValSer: 4.228 ± 0.069	4.591ValThr: 4.591 ± 0.074	5.363ValVal: 5.363 ± 0.08	0.908ValTrp: 0.908 ± 0.03	1.435ValTyr: 1.435 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.288TrpAla: 1.288 ± 0.032	0.142TrpCys: 0.142 ± 0.01	0.733TrpAsp: 0.733 ± 0.025	0.671TrpGlu: 0.671 ± 0.026	0.545TrpPhe: 0.545 ± 0.022	1.035TrpGly: 1.035 ± 0.032	0.338TrpHis: 0.338 ± 0.018	0.702TrpIle: 0.702 ± 0.029	0.464TrpLys: 0.464 ± 0.021	1.559TrpLeu: 1.559 ± 0.038	0.422TrpMet: 0.422 ± 0.019	0.422TrpAsn: 0.422 ± 0.019	0.648TrpPro: 0.648 ± 0.024	0.636TrpGln: 0.636 ± 0.024	1.052TrpArg: 1.052 ± 0.034	0.784TrpSer: 0.784 ± 0.028	0.675TrpThr: 0.675 ± 0.022	0.86TrpVal: 0.86 ± 0.027	0.205TrpTrp: 0.205 ± 0.015	0.278TrpTyr: 0.278 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.041	0.254TyrCys: 0.254 ± 0.015	1.631TyrAsp: 1.631 ± 0.039	1.287TyrGlu: 1.287 ± 0.035	0.9TyrPhe: 0.9 ± 0.03	2.13TyrGly: 2.13 ± 0.047	0.534TyrHis: 0.534 ± 0.023	0.938TyrIle: 0.938 ± 0.028	0.612TyrLys: 0.612 ± 0.022	2.242TyrLeu: 2.242 ± 0.042	0.524TyrMet: 0.524 ± 0.024	0.602TyrAsn: 0.602 ± 0.024	1.035TyrPro: 1.035 ± 0.034	0.75TyrGln: 0.75 ± 0.023	1.445TyrArg: 1.445 ± 0.038	1.217TyrSer: 1.217 ± 0.031	1.161TyrThr: 1.161 ± 0.033	1.543TyrVal: 1.543 ± 0.035	0.365TyrTrp: 0.365 ± 0.016	0.599TyrTyr: 0.599 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3897 proteins (1197673 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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