Amino acid dipepetide frequency for Klebsiella phage vB_KpnS_FZ41

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.915AlaAla: 8.915 ± 1.162
0.606AlaCys: 0.606 ± 0.182
3.981AlaAsp: 3.981 ± 0.417
5.583AlaGlu: 5.583 ± 0.578
2.683AlaPhe: 2.683 ± 0.391
5.713AlaGly: 5.713 ± 0.581
1.385AlaHis: 1.385 ± 0.282
5.366AlaIle: 5.366 ± 0.491
6.881AlaLys: 6.881 ± 0.676
7.314AlaLeu: 7.314 ± 0.903
2.337AlaMet: 2.337 ± 0.296
4.847AlaAsn: 4.847 ± 0.601
2.683AlaPro: 2.683 ± 0.36
2.986AlaGln: 2.986 ± 0.359
3.202AlaArg: 3.202 ± 0.428
5.583AlaSer: 5.583 ± 0.768
4.371AlaThr: 4.371 ± 0.627
4.804AlaVal: 4.804 ± 0.428
0.995AlaTrp: 0.995 ± 0.218
2.597AlaTyr: 2.597 ± 0.356
0.0AlaXaa: 0.0 ± 0.0
Cys
0.563CysAla: 0.563 ± 0.139
0.13CysCys: 0.13 ± 0.083
0.822CysAsp: 0.822 ± 0.255
0.519CysGlu: 0.519 ± 0.14
0.476CysPhe: 0.476 ± 0.126
0.736CysGly: 0.736 ± 0.206
0.13CysHis: 0.13 ± 0.075
0.563CysIle: 0.563 ± 0.15
0.563CysLys: 0.563 ± 0.144
0.779CysLeu: 0.779 ± 0.209
0.26CysMet: 0.26 ± 0.09
0.519CysAsn: 0.519 ± 0.161
0.389CysPro: 0.389 ± 0.168
0.476CysGln: 0.476 ± 0.189
0.389CysArg: 0.389 ± 0.128
0.779CysSer: 0.779 ± 0.165
0.476CysThr: 0.476 ± 0.114
0.736CysVal: 0.736 ± 0.19
0.087CysTrp: 0.087 ± 0.068
0.26CysTyr: 0.26 ± 0.096
0.0CysXaa: 0.0 ± 0.0
Asp
4.674AspAla: 4.674 ± 0.398
0.303AspCys: 0.303 ± 0.145
2.683AspAsp: 2.683 ± 0.416
4.198AspGlu: 4.198 ± 0.463
2.813AspPhe: 2.813 ± 0.447
4.674AspGly: 4.674 ± 0.55
1.298AspHis: 1.298 ± 0.297
4.155AspIle: 4.155 ± 0.497
3.808AspLys: 3.808 ± 0.409
5.063AspLeu: 5.063 ± 0.484
2.164AspMet: 2.164 ± 0.272
2.683AspAsn: 2.683 ± 0.324
2.856AspPro: 2.856 ± 0.345
1.861AspGln: 1.861 ± 0.306
2.9AspArg: 2.9 ± 0.338
4.111AspSer: 4.111 ± 0.365
3.246AspThr: 3.246 ± 0.4
4.414AspVal: 4.414 ± 0.41
1.212AspTrp: 1.212 ± 0.271
2.64AspTyr: 2.64 ± 0.413
0.0AspXaa: 0.0 ± 0.0
Glu
6.621GluAla: 6.621 ± 0.798
0.606GluCys: 0.606 ± 0.166
3.852GluAsp: 3.852 ± 0.518
4.587GluGlu: 4.587 ± 0.541
2.9GluPhe: 2.9 ± 0.297
4.284GluGly: 4.284 ± 0.454
1.515GluHis: 1.515 ± 0.243
4.674GluIle: 4.674 ± 0.453
3.852GluLys: 3.852 ± 0.398
6.405GluLeu: 6.405 ± 0.577
1.774GluMet: 1.774 ± 0.277
2.337GluAsn: 2.337 ± 0.35
1.428GluPro: 1.428 ± 0.299
2.467GluGln: 2.467 ± 0.36
3.159GluArg: 3.159 ± 0.364
3.722GluSer: 3.722 ± 0.418
3.462GluThr: 3.462 ± 0.327
4.458GluVal: 4.458 ± 0.551
0.909GluTrp: 0.909 ± 0.206
2.38GluTyr: 2.38 ± 0.287
0.0GluXaa: 0.0 ± 0.0
Phe
3.246PheAla: 3.246 ± 0.351
0.476PheCys: 0.476 ± 0.139
3.289PheAsp: 3.289 ± 0.516
2.943PheGlu: 2.943 ± 0.317
1.645PhePhe: 1.645 ± 0.275
2.121PheGly: 2.121 ± 0.348
1.298PheHis: 1.298 ± 0.251
2.467PheIle: 2.467 ± 0.379
2.467PheLys: 2.467 ± 0.313
2.856PheLeu: 2.856 ± 0.383
1.082PheMet: 1.082 ± 0.196
2.597PheAsn: 2.597 ± 0.313
2.077PhePro: 2.077 ± 0.323
1.428PheGln: 1.428 ± 0.256
1.515PheArg: 1.515 ± 0.271
2.597PheSer: 2.597 ± 0.313
2.64PheThr: 2.64 ± 0.331
2.077PheVal: 2.077 ± 0.364
0.692PheTrp: 0.692 ± 0.18
1.342PheTyr: 1.342 ± 0.215
0.0PheXaa: 0.0 ± 0.0
Gly
4.977GlyAla: 4.977 ± 0.528
0.995GlyCys: 0.995 ± 0.241
3.938GlyAsp: 3.938 ± 0.444
4.674GlyGlu: 4.674 ± 0.549
3.376GlyPhe: 3.376 ± 0.308
4.284GlyGly: 4.284 ± 0.597
1.168GlyHis: 1.168 ± 0.232
4.155GlyIle: 4.155 ± 0.407
5.107GlyLys: 5.107 ± 0.465
4.414GlyLeu: 4.414 ± 0.493
1.688GlyMet: 1.688 ± 0.235
3.938GlyAsn: 3.938 ± 0.63
1.731GlyPro: 1.731 ± 0.399
2.424GlyGln: 2.424 ± 0.347
3.289GlyArg: 3.289 ± 0.352
4.804GlySer: 4.804 ± 0.519
4.631GlyThr: 4.631 ± 0.518
5.713GlyVal: 5.713 ± 0.604
1.342GlyTrp: 1.342 ± 0.311
2.51GlyTyr: 2.51 ± 0.37
0.0GlyXaa: 0.0 ± 0.0
His
1.212HisAla: 1.212 ± 0.288
0.26HisCys: 0.26 ± 0.109
1.212HisAsp: 1.212 ± 0.291
1.125HisGlu: 1.125 ± 0.304
0.692HisPhe: 0.692 ± 0.209
1.298HisGly: 1.298 ± 0.217
0.519HisHis: 0.519 ± 0.148
0.995HisIle: 0.995 ± 0.249
1.168HisLys: 1.168 ± 0.297
1.428HisLeu: 1.428 ± 0.206
0.476HisMet: 0.476 ± 0.178
0.995HisAsn: 0.995 ± 0.255
0.909HisPro: 0.909 ± 0.227
0.346HisGln: 0.346 ± 0.107
0.995HisArg: 0.995 ± 0.216
1.082HisSer: 1.082 ± 0.194
0.822HisThr: 0.822 ± 0.227
1.342HisVal: 1.342 ± 0.249
0.13HisTrp: 0.13 ± 0.065
1.385HisTyr: 1.385 ± 0.271
0.0HisXaa: 0.0 ± 0.0
Ile
5.539IleAla: 5.539 ± 0.566
0.692IleCys: 0.692 ± 0.189
5.237IleAsp: 5.237 ± 0.568
3.981IleGlu: 3.981 ± 0.416
2.077IlePhe: 2.077 ± 0.374
3.462IleGly: 3.462 ± 0.385
1.168IleHis: 1.168 ± 0.22
3.116IleIle: 3.116 ± 0.308
3.592IleLys: 3.592 ± 0.365
4.89IleLeu: 4.89 ± 0.481
1.818IleMet: 1.818 ± 0.261
3.505IleAsn: 3.505 ± 0.366
3.029IlePro: 3.029 ± 0.378
2.337IleGln: 2.337 ± 0.343
3.549IleArg: 3.549 ± 0.367
4.587IleSer: 4.587 ± 0.501
3.635IleThr: 3.635 ± 0.422
3.722IleVal: 3.722 ± 0.458
0.346IleTrp: 0.346 ± 0.096
2.207IleTyr: 2.207 ± 0.256
0.0IleXaa: 0.0 ± 0.0
Lys
6.708LysAla: 6.708 ± 0.59
0.303LysCys: 0.303 ± 0.114
4.284LysAsp: 4.284 ± 0.46
4.111LysGlu: 4.111 ± 0.495
3.029LysPhe: 3.029 ± 0.308
3.289LysGly: 3.289 ± 0.353
1.082LysHis: 1.082 ± 0.241
4.284LysIle: 4.284 ± 0.428
3.765LysLys: 3.765 ± 0.459
6.275LysLeu: 6.275 ± 0.578
2.034LysMet: 2.034 ± 0.33
3.202LysAsn: 3.202 ± 0.344
2.553LysPro: 2.553 ± 0.314
2.424LysGln: 2.424 ± 0.284
3.289LysArg: 3.289 ± 0.311
4.284LysSer: 4.284 ± 0.475
3.938LysThr: 3.938 ± 0.408
3.722LysVal: 3.722 ± 0.319
0.649LysTrp: 0.649 ± 0.142
2.25LysTyr: 2.25 ± 0.291
0.0LysXaa: 0.0 ± 0.0
Leu
6.405LeuAla: 6.405 ± 0.671
0.822LeuCys: 0.822 ± 0.197
6.059LeuAsp: 6.059 ± 0.462
7.357LeuGlu: 7.357 ± 0.632
2.467LeuPhe: 2.467 ± 0.322
5.496LeuGly: 5.496 ± 0.641
1.255LeuHis: 1.255 ± 0.236
4.241LeuIle: 4.241 ± 0.505
4.544LeuLys: 4.544 ± 0.462
5.626LeuLeu: 5.626 ± 0.585
2.25LeuMet: 2.25 ± 0.303
5.28LeuAsn: 5.28 ± 0.684
3.635LeuPro: 3.635 ± 0.439
3.159LeuGln: 3.159 ± 0.392
4.501LeuArg: 4.501 ± 0.431
5.669LeuSer: 5.669 ± 0.563
4.458LeuThr: 4.458 ± 0.436
4.717LeuVal: 4.717 ± 0.513
0.692LeuTrp: 0.692 ± 0.173
2.51LeuTyr: 2.51 ± 0.343
0.0LeuXaa: 0.0 ± 0.0
Met
2.207MetAla: 2.207 ± 0.317
0.303MetCys: 0.303 ± 0.102
1.904MetAsp: 1.904 ± 0.32
1.947MetGlu: 1.947 ± 0.234
1.039MetPhe: 1.039 ± 0.257
1.645MetGly: 1.645 ± 0.247
0.476MetHis: 0.476 ± 0.152
1.645MetIle: 1.645 ± 0.248
2.034MetLys: 2.034 ± 0.268
2.164MetLeu: 2.164 ± 0.358
0.433MetMet: 0.433 ± 0.187
1.428MetAsn: 1.428 ± 0.211
0.952MetPro: 0.952 ± 0.214
1.212MetGln: 1.212 ± 0.206
1.558MetArg: 1.558 ± 0.224
1.774MetSer: 1.774 ± 0.281
1.645MetThr: 1.645 ± 0.348
1.298MetVal: 1.298 ± 0.246
0.173MetTrp: 0.173 ± 0.074
0.866MetTyr: 0.866 ± 0.193
0.0MetXaa: 0.0 ± 0.0
Asn
4.284AsnAla: 4.284 ± 0.587
0.433AsnCys: 0.433 ± 0.132
2.683AsnAsp: 2.683 ± 0.301
2.986AsnGlu: 2.986 ± 0.521
2.38AsnPhe: 2.38 ± 0.323
4.458AsnGly: 4.458 ± 0.519
0.866AsnHis: 0.866 ± 0.214
3.679AsnIle: 3.679 ± 0.335
3.332AsnLys: 3.332 ± 0.442
5.366AsnLeu: 5.366 ± 0.489
1.428AsnMet: 1.428 ± 0.26
3.462AsnAsn: 3.462 ± 0.512
2.294AsnPro: 2.294 ± 0.309
1.515AsnGln: 1.515 ± 0.409
2.25AsnArg: 2.25 ± 0.308
3.549AsnSer: 3.549 ± 0.363
3.332AsnThr: 3.332 ± 0.343
4.111AsnVal: 4.111 ± 0.412
0.606AsnTrp: 0.606 ± 0.142
1.645AsnTyr: 1.645 ± 0.259
0.0AsnXaa: 0.0 ± 0.0
Pro
2.683ProAla: 2.683 ± 0.323
0.433ProCys: 0.433 ± 0.127
2.207ProAsp: 2.207 ± 0.356
3.073ProGlu: 3.073 ± 0.373
1.645ProPhe: 1.645 ± 0.249
3.029ProGly: 3.029 ± 0.399
0.866ProHis: 0.866 ± 0.207
1.991ProIle: 1.991 ± 0.327
2.294ProLys: 2.294 ± 0.365
2.25ProLeu: 2.25 ± 0.263
0.822ProMet: 0.822 ± 0.173
2.337ProAsn: 2.337 ± 0.334
1.818ProPro: 1.818 ± 0.381
1.125ProGln: 1.125 ± 0.235
1.731ProArg: 1.731 ± 0.257
2.51ProSer: 2.51 ± 0.436
2.25ProThr: 2.25 ± 0.284
3.116ProVal: 3.116 ± 0.385
0.606ProTrp: 0.606 ± 0.167
1.255ProTyr: 1.255 ± 0.21
0.0ProXaa: 0.0 ± 0.0
Gln
2.726GlnAla: 2.726 ± 0.461
0.433GlnCys: 0.433 ± 0.123
1.731GlnAsp: 1.731 ± 0.229
2.51GlnGlu: 2.51 ± 0.4
1.645GlnPhe: 1.645 ± 0.291
2.38GlnGly: 2.38 ± 0.312
0.606GlnHis: 0.606 ± 0.142
2.467GlnIle: 2.467 ± 0.291
2.294GlnLys: 2.294 ± 0.4
3.159GlnLeu: 3.159 ± 0.477
0.909GlnMet: 0.909 ± 0.221
1.688GlnAsn: 1.688 ± 0.261
0.736GlnPro: 0.736 ± 0.212
1.558GlnGln: 1.558 ± 0.229
1.385GlnArg: 1.385 ± 0.262
2.164GlnSer: 2.164 ± 0.488
1.774GlnThr: 1.774 ± 0.29
2.38GlnVal: 2.38 ± 0.337
0.692GlnTrp: 0.692 ± 0.222
1.428GlnTyr: 1.428 ± 0.26
0.0GlnXaa: 0.0 ± 0.0
Arg
3.202ArgAla: 3.202 ± 0.343
0.606ArgCys: 0.606 ± 0.166
3.073ArgAsp: 3.073 ± 0.372
2.943ArgGlu: 2.943 ± 0.38
2.25ArgPhe: 2.25 ± 0.307
4.068ArgGly: 4.068 ± 0.386
0.606ArgHis: 0.606 ± 0.175
2.9ArgIle: 2.9 ± 0.249
3.505ArgLys: 3.505 ± 0.448
3.679ArgLeu: 3.679 ± 0.383
1.774ArgMet: 1.774 ± 0.232
2.813ArgAsn: 2.813 ± 0.37
1.688ArgPro: 1.688 ± 0.238
1.125ArgGln: 1.125 ± 0.219
2.337ArgArg: 2.337 ± 0.314
2.9ArgSer: 2.9 ± 0.337
2.553ArgThr: 2.553 ± 0.318
3.722ArgVal: 3.722 ± 0.416
0.519ArgTrp: 0.519 ± 0.138
1.558ArgTyr: 1.558 ± 0.281
0.0ArgXaa: 0.0 ± 0.0
Ser
5.28SerAla: 5.28 ± 0.568
0.779SerCys: 0.779 ± 0.226
3.376SerAsp: 3.376 ± 0.398
2.986SerGlu: 2.986 ± 0.386
2.726SerPhe: 2.726 ± 0.353
5.063SerGly: 5.063 ± 0.493
1.125SerHis: 1.125 ± 0.261
4.76SerIle: 4.76 ± 0.493
4.414SerLys: 4.414 ± 0.463
6.578SerLeu: 6.578 ± 0.563
1.515SerMet: 1.515 ± 0.253
3.549SerAsn: 3.549 ± 0.368
2.207SerPro: 2.207 ± 0.315
2.121SerGln: 2.121 ± 0.361
3.722SerArg: 3.722 ± 0.356
4.717SerSer: 4.717 ± 0.575
4.458SerThr: 4.458 ± 0.59
4.328SerVal: 4.328 ± 0.412
1.168SerTrp: 1.168 ± 0.225
2.121SerTyr: 2.121 ± 0.221
0.0SerXaa: 0.0 ± 0.0
Thr
5.107ThrAla: 5.107 ± 0.657
0.346ThrCys: 0.346 ± 0.103
3.029ThrAsp: 3.029 ± 0.298
2.856ThrGlu: 2.856 ± 0.335
2.683ThrPhe: 2.683 ± 0.405
5.583ThrGly: 5.583 ± 0.691
1.212ThrHis: 1.212 ± 0.258
3.722ThrIle: 3.722 ± 0.371
3.981ThrLys: 3.981 ± 0.482
4.025ThrLeu: 4.025 ± 0.382
1.428ThrMet: 1.428 ± 0.224
2.986ThrAsn: 2.986 ± 0.365
2.726ThrPro: 2.726 ± 0.372
2.25ThrGln: 2.25 ± 0.333
1.947ThrArg: 1.947 ± 0.254
4.241ThrSer: 4.241 ± 0.541
3.029ThrThr: 3.029 ± 0.331
4.284ThrVal: 4.284 ± 0.536
0.649ThrTrp: 0.649 ± 0.208
2.207ThrTyr: 2.207 ± 0.342
0.0ThrXaa: 0.0 ± 0.0
Val
4.934ValAla: 4.934 ± 0.462
0.563ValCys: 0.563 ± 0.172
4.804ValAsp: 4.804 ± 0.513
4.241ValGlu: 4.241 ± 0.394
2.64ValPhe: 2.64 ± 0.335
4.76ValGly: 4.76 ± 0.476
1.082ValHis: 1.082 ± 0.207
4.544ValIle: 4.544 ± 0.381
4.111ValLys: 4.111 ± 0.455
4.717ValLeu: 4.717 ± 0.417
0.952ValMet: 0.952 ± 0.219
3.462ValAsn: 3.462 ± 0.338
2.424ValPro: 2.424 ± 0.358
2.207ValGln: 2.207 ± 0.268
3.289ValArg: 3.289 ± 0.367
4.847ValSer: 4.847 ± 0.468
4.587ValThr: 4.587 ± 0.56
4.371ValVal: 4.371 ± 0.437
0.822ValTrp: 0.822 ± 0.178
3.202ValTyr: 3.202 ± 0.36
0.0ValXaa: 0.0 ± 0.0
Trp
0.649TrpAla: 0.649 ± 0.169
0.13TrpCys: 0.13 ± 0.072
1.082TrpAsp: 1.082 ± 0.199
0.952TrpGlu: 0.952 ± 0.21
0.303TrpPhe: 0.303 ± 0.117
0.736TrpGly: 0.736 ± 0.209
0.173TrpHis: 0.173 ± 0.085
0.563TrpIle: 0.563 ± 0.156
1.298TrpLys: 1.298 ± 0.228
1.428TrpLeu: 1.428 ± 0.28
0.476TrpMet: 0.476 ± 0.16
0.736TrpAsn: 0.736 ± 0.229
0.433TrpPro: 0.433 ± 0.127
0.26TrpGln: 0.26 ± 0.111
0.303TrpArg: 0.303 ± 0.103
0.995TrpSer: 0.995 ± 0.339
0.649TrpThr: 0.649 ± 0.226
1.039TrpVal: 1.039 ± 0.212
0.043TrpTrp: 0.043 ± 0.039
0.476TrpTyr: 0.476 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.9TyrAla: 2.9 ± 0.323
0.433TyrCys: 0.433 ± 0.155
2.51TyrAsp: 2.51 ± 0.393
1.818TyrGlu: 1.818 ± 0.353
1.385TyrPhe: 1.385 ± 0.323
2.077TyrGly: 2.077 ± 0.308
0.563TyrHis: 0.563 ± 0.169
2.207TyrIle: 2.207 ± 0.36
2.51TyrLys: 2.51 ± 0.277
2.726TyrLeu: 2.726 ± 0.372
1.039TyrMet: 1.039 ± 0.199
2.294TyrAsn: 2.294 ± 0.277
1.471TyrPro: 1.471 ± 0.237
1.385TyrGln: 1.385 ± 0.224
2.51TyrArg: 2.51 ± 0.309
2.077TyrSer: 2.077 ± 0.262
2.337TyrThr: 2.337 ± 0.253
2.207TyrVal: 2.207 ± 0.297
0.389TyrTrp: 0.389 ± 0.121
1.558TyrTyr: 1.558 ± 0.285
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (23108 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski