Amino acid dipepetide frequency for Aspergillus leporis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.067AlaAla: 8.067 ± 0.054	1.131AlaCys: 1.131 ± 0.016	3.951AlaAsp: 3.951 ± 0.028	4.775AlaGlu: 4.775 ± 0.036	3.224AlaPhe: 3.224 ± 0.026	5.494AlaGly: 5.494 ± 0.035	1.791AlaHis: 1.791 ± 0.018	4.367AlaIle: 4.367 ± 0.03	3.732AlaLys: 3.732 ± 0.03	7.78AlaLeu: 7.78 ± 0.039	1.92AlaMet: 1.92 ± 0.02	2.875AlaAsn: 2.875 ± 0.024	4.289AlaPro: 4.289 ± 0.033	3.185AlaGln: 3.185 ± 0.026	4.67AlaArg: 4.67 ± 0.035	6.934AlaSer: 6.934 ± 0.032	5.087AlaThr: 5.087 ± 0.029	5.338AlaVal: 5.338 ± 0.034	1.158AlaTrp: 1.158 ± 0.016	2.221AlaTyr: 2.221 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.992CysAla: 0.992 ± 0.015	0.26CysCys: 0.26 ± 0.008	0.713CysAsp: 0.713 ± 0.013	0.624CysGlu: 0.624 ± 0.011	0.596CysPhe: 0.596 ± 0.01	0.987CysGly: 0.987 ± 0.016	0.371CysHis: 0.371 ± 0.009	0.778CysIle: 0.778 ± 0.012	0.531CysLys: 0.531 ± 0.01	1.439CysLeu: 1.439 ± 0.016	0.309CysMet: 0.309 ± 0.008	0.474CysAsn: 0.474 ± 0.008	0.705CysPro: 0.705 ± 0.016	0.508CysGln: 0.508 ± 0.009	0.849CysArg: 0.849 ± 0.014	1.041CysSer: 1.041 ± 0.014	0.739CysThr: 0.739 ± 0.012	0.873CysVal: 0.873 ± 0.013	0.216CysTrp: 0.216 ± 0.005	0.404CysTyr: 0.404 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.318AspAla: 4.318 ± 0.029	0.637AspCys: 0.637 ± 0.01	3.681AspAsp: 3.681 ± 0.038	4.025AspGlu: 4.025 ± 0.037	2.144AspPhe: 2.144 ± 0.02	3.886AspGly: 3.886 ± 0.031	1.265AspHis: 1.265 ± 0.016	3.199AspIle: 3.199 ± 0.024	2.241AspLys: 2.241 ± 0.024	5.038AspLeu: 5.038 ± 0.029	1.227AspMet: 1.227 ± 0.014	1.922AspAsn: 1.922 ± 0.019	3.259AspPro: 3.259 ± 0.025	1.896AspGln: 1.896 ± 0.02	3.027AspArg: 3.027 ± 0.029	4.058AspSer: 4.058 ± 0.028	2.969AspThr: 2.969 ± 0.02	3.564AspVal: 3.564 ± 0.025	0.861AspTrp: 0.861 ± 0.013	1.667AspTyr: 1.667 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.976GluAla: 4.976 ± 0.034	0.643GluCys: 0.643 ± 0.011	3.858GluAsp: 3.858 ± 0.032	5.107GluGlu: 5.107 ± 0.052	1.933GluPhe: 1.933 ± 0.018	3.701GluGly: 3.701 ± 0.03	1.403GluHis: 1.403 ± 0.017	3.1GluIle: 3.1 ± 0.025	3.542GluLys: 3.542 ± 0.035	5.155GluLeu: 5.155 ± 0.035	1.391GluMet: 1.391 ± 0.015	2.34GluAsn: 2.34 ± 0.022	2.706GluPro: 2.706 ± 0.034	2.456GluGln: 2.456 ± 0.021	3.777GluArg: 3.777 ± 0.028	4.313GluSer: 4.313 ± 0.035	3.445GluThr: 3.445 ± 0.024	3.496GluVal: 3.496 ± 0.025	0.892GluTrp: 0.892 ± 0.012	1.727GluTyr: 1.727 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.076PheAla: 3.076 ± 0.026	0.613PheCys: 0.613 ± 0.011	2.237PheAsp: 2.237 ± 0.018	2.09PheGlu: 2.09 ± 0.018	1.791PhePhe: 1.791 ± 0.019	2.909PheGly: 2.909 ± 0.029	1.008PheHis: 1.008 ± 0.014	1.981PheIle: 1.981 ± 0.022	1.471PheLys: 1.471 ± 0.016	3.836PheLeu: 3.836 ± 0.034	0.827PheMet: 0.827 ± 0.014	1.484PheAsn: 1.484 ± 0.015	2.094PhePro: 2.094 ± 0.021	1.488PheGln: 1.488 ± 0.016	2.049PheArg: 2.049 ± 0.019	3.18PheSer: 3.18 ± 0.023	2.24PheThr: 2.24 ± 0.021	2.468PheVal: 2.468 ± 0.024	0.695PheTrp: 0.695 ± 0.013	1.235PheTyr: 1.235 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.122GlyAla: 5.122 ± 0.033	0.957GlyCys: 0.957 ± 0.013	3.547GlyAsp: 3.547 ± 0.027	3.526GlyGlu: 3.526 ± 0.027	2.887GlyPhe: 2.887 ± 0.026	5.33GlyGly: 5.33 ± 0.046	1.709GlyHis: 1.709 ± 0.018	3.733GlyIle: 3.733 ± 0.029	3.341GlyLys: 3.341 ± 0.028	6.321GlyLeu: 6.321 ± 0.033	1.569GlyMet: 1.569 ± 0.018	2.554GlyAsn: 2.554 ± 0.024	3.301GlyPro: 3.301 ± 0.028	2.575GlyGln: 2.575 ± 0.021	4.014GlyArg: 4.014 ± 0.026	5.723GlySer: 5.723 ± 0.035	3.983GlyThr: 3.983 ± 0.029	4.456GlyVal: 4.456 ± 0.031	1.176GlyTrp: 1.176 ± 0.017	2.26GlyTyr: 2.26 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.823HisAla: 1.823 ± 0.018	0.379HisCys: 0.379 ± 0.009	1.323HisAsp: 1.323 ± 0.018	1.336HisGlu: 1.336 ± 0.016	0.964HisPhe: 0.964 ± 0.014	1.757HisGly: 1.757 ± 0.016	0.849HisHis: 0.849 ± 0.016	1.328HisIle: 1.328 ± 0.017	0.876HisLys: 0.876 ± 0.013	2.36HisLeu: 2.36 ± 0.022	0.522HisMet: 0.522 ± 0.01	0.889HisAsn: 0.889 ± 0.012	1.713HisPro: 1.713 ± 0.017	1.002HisGln: 1.002 ± 0.014	1.613HisArg: 1.613 ± 0.015	1.951HisSer: 1.951 ± 0.017	1.321HisThr: 1.321 ± 0.014	1.457HisVal: 1.457 ± 0.015	0.378HisTrp: 0.378 ± 0.009	0.749HisTyr: 0.749 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.272IleAla: 4.272 ± 0.033	0.864IleCys: 0.864 ± 0.013	2.835IleAsp: 2.835 ± 0.027	2.879IleGlu: 2.879 ± 0.022	2.199IlePhe: 2.199 ± 0.023	3.412IleGly: 3.412 ± 0.032	1.333IleHis: 1.333 ± 0.016	2.746IleIle: 2.746 ± 0.031	2.102IleLys: 2.102 ± 0.021	4.973IleLeu: 4.973 ± 0.037	1.054IleMet: 1.054 ± 0.014	1.885IleAsn: 1.885 ± 0.02	3.248IlePro: 3.248 ± 0.028	2.038IleGln: 2.038 ± 0.022	2.866IleArg: 2.866 ± 0.022	4.136IleSer: 4.136 ± 0.027	2.962IleThr: 2.962 ± 0.022	3.36IleVal: 3.36 ± 0.028	0.767IleTrp: 0.767 ± 0.013	1.597IleTyr: 1.597 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.925LysAla: 3.925 ± 0.033	0.546LysCys: 0.546 ± 0.011	2.689LysAsp: 2.689 ± 0.024	3.237LysGlu: 3.237 ± 0.031	1.424LysPhe: 1.424 ± 0.016	2.934LysGly: 2.934 ± 0.024	1.1LysHis: 1.1 ± 0.014	2.223LysIle: 2.223 ± 0.019	2.954LysLys: 2.954 ± 0.038	4.026LysLeu: 4.026 ± 0.03	0.932LysMet: 0.932 ± 0.014	1.74LysAsn: 1.74 ± 0.021	2.57LysPro: 2.57 ± 0.024	1.825LysGln: 1.825 ± 0.018	3.213LysArg: 3.213 ± 0.027	3.427LysSer: 3.427 ± 0.029	2.647LysThr: 2.647 ± 0.025	2.825LysVal: 2.825 ± 0.023	0.68LysTrp: 0.68 ± 0.01	1.409LysTyr: 1.409 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.788LeuAla: 7.788 ± 0.041	1.341LeuCys: 1.341 ± 0.016	5.172LeuAsp: 5.172 ± 0.031	5.535LeuGlu: 5.535 ± 0.04	3.642LeuPhe: 3.642 ± 0.029	6.227LeuGly: 6.227 ± 0.038	2.357LeuHis: 2.357 ± 0.023	4.265LeuIle: 4.265 ± 0.035	4.152LeuLys: 4.152 ± 0.029	8.904LeuLeu: 8.904 ± 0.054	1.9LeuMet: 1.9 ± 0.018	3.347LeuAsn: 3.347 ± 0.027	5.566LeuPro: 5.566 ± 0.037	3.94LeuGln: 3.94 ± 0.028	5.902LeuArg: 5.902 ± 0.038	7.844LeuSer: 7.844 ± 0.041	5.012LeuThr: 5.012 ± 0.03	5.694LeuVal: 5.694 ± 0.037	1.263LeuTrp: 1.263 ± 0.016	2.609LeuTyr: 2.609 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.168MetAla: 2.168 ± 0.019	0.27MetCys: 0.27 ± 0.006	1.199MetAsp: 1.199 ± 0.014	1.275MetGlu: 1.275 ± 0.016	0.767MetPhe: 0.767 ± 0.012	1.499MetGly: 1.499 ± 0.017	0.487MetHis: 0.487 ± 0.01	1.079MetIle: 1.079 ± 0.014	1.018MetLys: 1.018 ± 0.013	1.888MetLeu: 1.888 ± 0.021	0.571MetMet: 0.571 ± 0.01	0.836MetAsn: 0.836 ± 0.015	1.194MetPro: 1.194 ± 0.013	0.837MetGln: 0.837 ± 0.012	1.248MetArg: 1.248 ± 0.016	1.876MetSer: 1.876 ± 0.02	1.307MetThr: 1.307 ± 0.016	1.392MetVal: 1.392 ± 0.016	0.278MetTrp: 0.278 ± 0.007	0.549MetTyr: 0.549 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.082AsnAla: 3.082 ± 0.027	0.509AsnCys: 0.509 ± 0.01	1.931AsnAsp: 1.931 ± 0.018	2.064AsnGlu: 2.064 ± 0.02	1.398AsnPhe: 1.398 ± 0.016	2.946AsnGly: 2.946 ± 0.025	0.909AsnHis: 0.909 ± 0.013	2.177AsnIle: 2.177 ± 0.019	1.554AsnLys: 1.554 ± 0.019	3.363AsnLeu: 3.363 ± 0.021	0.866AsnMet: 0.866 ± 0.013	1.498AsnAsn: 1.498 ± 0.018	2.492AsnPro: 2.492 ± 0.021	1.376AsnGln: 1.376 ± 0.017	1.998AsnArg: 1.998 ± 0.019	2.801AsnSer: 2.801 ± 0.022	2.216AsnThr: 2.216 ± 0.019	2.411AsnVal: 2.411 ± 0.017	0.594AsnTrp: 0.594 ± 0.01	1.123AsnTyr: 1.123 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.658ProAla: 4.658 ± 0.041	0.61ProCys: 0.61 ± 0.013	3.134ProAsp: 3.134 ± 0.026	3.807ProGlu: 3.807 ± 0.036	2.185ProPhe: 2.185 ± 0.021	3.854ProGly: 3.854 ± 0.033	1.32ProHis: 1.32 ± 0.018	2.634ProIle: 2.634 ± 0.023	2.536ProLys: 2.536 ± 0.026	4.83ProLeu: 4.83 ± 0.033	1.092ProMet: 1.092 ± 0.016	2.228ProAsn: 2.228 ± 0.019	4.445ProPro: 4.445 ± 0.061	2.366ProGln: 2.366 ± 0.027	3.323ProArg: 3.323 ± 0.029	5.921ProSer: 5.921 ± 0.04	3.887ProThr: 3.887 ± 0.032	3.589ProVal: 3.589 ± 0.03	0.779ProTrp: 0.779 ± 0.012	1.572ProTyr: 1.572 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.262GlnAla: 3.262 ± 0.027	0.498GlnCys: 0.498 ± 0.012	1.989GlnAsp: 1.989 ± 0.019	2.392GlnGlu: 2.392 ± 0.022	1.327GlnPhe: 1.327 ± 0.015	2.444GlnGly: 2.444 ± 0.025	1.053GlnHis: 1.053 ± 0.012	1.969GlnIle: 1.969 ± 0.019	1.961GlnLys: 1.961 ± 0.021	3.592GlnLeu: 3.592 ± 0.028	0.878GlnMet: 0.878 ± 0.013	1.573GlnAsn: 1.573 ± 0.017	2.443GlnPro: 2.443 ± 0.027	2.233GlnGln: 2.233 ± 0.038	2.623GlnArg: 2.623 ± 0.023	3.226GlnSer: 3.226 ± 0.028	2.332GlnThr: 2.332 ± 0.021	2.245GlnVal: 2.245 ± 0.02	0.604GlnTrp: 0.604 ± 0.009	1.23GlnTyr: 1.23 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.484ArgAla: 4.484 ± 0.033	0.784ArgCys: 0.784 ± 0.013	3.237ArgAsp: 3.237 ± 0.03	3.688ArgGlu: 3.688 ± 0.031	2.263ArgPhe: 2.263 ± 0.019	3.631ArgGly: 3.631 ± 0.028	1.594ArgHis: 1.594 ± 0.021	2.946ArgIle: 2.946 ± 0.022	3.381ArgLys: 3.381 ± 0.029	5.66ArgLeu: 5.66 ± 0.031	1.294ArgMet: 1.294 ± 0.014	2.24ArgAsn: 2.24 ± 0.017	3.395ArgPro: 3.395 ± 0.034	2.568ArgGln: 2.568 ± 0.023	4.912ArgArg: 4.912 ± 0.042	4.837ArgSer: 4.837 ± 0.036	3.255ArgThr: 3.255 ± 0.024	3.467ArgVal: 3.467 ± 0.026	0.988ArgTrp: 0.988 ± 0.014	1.778ArgTyr: 1.778 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.433SerAla: 6.433 ± 0.039	0.998SerCys: 0.998 ± 0.014	4.231SerAsp: 4.231 ± 0.026	4.202SerGlu: 4.202 ± 0.033	3.277SerPhe: 3.277 ± 0.025	5.571SerGly: 5.571 ± 0.032	2.049SerHis: 2.049 ± 0.02	4.217SerIle: 4.217 ± 0.028	3.653SerLys: 3.653 ± 0.031	7.665SerLeu: 7.665 ± 0.043	1.784SerMet: 1.784 ± 0.018	3.111SerAsn: 3.111 ± 0.024	5.347SerPro: 5.347 ± 0.042	3.337SerGln: 3.337 ± 0.03	5.033SerArg: 5.033 ± 0.042	8.773SerSer: 8.773 ± 0.065	5.583SerThr: 5.583 ± 0.036	4.847SerVal: 4.847 ± 0.03	1.204SerTrp: 1.204 ± 0.015	2.226SerTyr: 2.226 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.057ThrAla: 5.057 ± 0.03	0.802ThrCys: 0.802 ± 0.013	2.868ThrAsp: 2.868 ± 0.023	3.158ThrGlu: 3.158 ± 0.024	2.307ThrPhe: 2.307 ± 0.019	4.224ThrGly: 4.224 ± 0.031	1.334ThrHis: 1.334 ± 0.016	3.189ThrIle: 3.189 ± 0.023	2.527ThrLys: 2.527 ± 0.025	5.458ThrLeu: 5.458 ± 0.033	1.201ThrMet: 1.201 ± 0.014	2.096ThrAsn: 2.096 ± 0.019	4.119ThrPro: 4.119 ± 0.037	2.084ThrGln: 2.084 ± 0.019	3.084ThrArg: 3.084 ± 0.022	5.288ThrSer: 5.288 ± 0.036	4.105ThrThr: 4.105 ± 0.034	3.946ThrVal: 3.946 ± 0.03	0.884ThrTrp: 0.884 ± 0.014	1.699ThrTyr: 1.699 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.122ValAla: 5.122 ± 0.035	0.907ValCys: 0.907 ± 0.013	3.71ValAsp: 3.71 ± 0.027	3.792ValGlu: 3.792 ± 0.031	2.598ValPhe: 2.598 ± 0.024	4.092ValGly: 4.092 ± 0.03	1.466ValHis: 1.466 ± 0.016	3.191ValIle: 3.191 ± 0.027	2.792ValLys: 2.792 ± 0.022	5.801ValLeu: 5.801 ± 0.036	1.341ValMet: 1.341 ± 0.017	2.36ValAsn: 2.36 ± 0.02	3.631ValPro: 3.631 ± 0.029	2.436ValGln: 2.436 ± 0.023	3.462ValArg: 3.462 ± 0.029	4.947ValSer: 4.947 ± 0.032	3.655ValThr: 3.655 ± 0.025	4.331ValVal: 4.331 ± 0.037	0.902ValTrp: 0.902 ± 0.017	1.879ValTyr: 1.879 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.162TrpAla: 1.162 ± 0.017	0.204TrpCys: 0.204 ± 0.007	0.911TrpAsp: 0.911 ± 0.016	0.876TrpGlu: 0.876 ± 0.012	0.572TrpPhe: 0.572 ± 0.011	0.971TrpGly: 0.971 ± 0.014	0.374TrpHis: 0.374 ± 0.009	0.816TrpIle: 0.816 ± 0.012	0.821TrpLys: 0.821 ± 0.013	1.443TrpLeu: 1.443 ± 0.017	0.392TrpMet: 0.392 ± 0.009	0.664TrpAsn: 0.664 ± 0.01	0.64TrpPro: 0.64 ± 0.011	0.569TrpGln: 0.569 ± 0.009	0.975TrpArg: 0.975 ± 0.015	1.092TrpSer: 1.092 ± 0.014	0.947TrpThr: 0.947 ± 0.015	0.92TrpVal: 0.92 ± 0.013	0.293TrpTrp: 0.293 ± 0.007	0.459TrpTyr: 0.459 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.204TyrAla: 2.204 ± 0.021	0.457TyrCys: 0.457 ± 0.008	1.667TyrAsp: 1.667 ± 0.02	1.572TyrGlu: 1.572 ± 0.019	1.275TyrPhe: 1.275 ± 0.016	2.211TyrGly: 2.211 ± 0.023	0.821TyrHis: 0.821 ± 0.013	1.592TyrIle: 1.592 ± 0.019	1.142TyrLys: 1.142 ± 0.014	2.925TyrLeu: 2.925 ± 0.024	0.67TyrMet: 0.67 ± 0.01	1.192TyrAsn: 1.192 ± 0.014	1.613TyrPro: 1.613 ± 0.018	1.156TyrGln: 1.156 ± 0.013	1.764TyrArg: 1.764 ± 0.02	2.173TyrSer: 2.173 ± 0.02	1.74TyrThr: 1.74 ± 0.018	1.736TyrVal: 1.736 ± 0.018	0.486TyrTrp: 0.486 ± 0.01	1.029TyrTyr: 1.029 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 12743 proteins (5742925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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