Amino acid dipepetide frequency for Halococcus hamelinensis 100A6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.135AlaAla: 13.135 ± 0.179	0.75AlaCys: 0.75 ± 0.027	9.214AlaAsp: 9.214 ± 0.118	7.962AlaGlu: 7.962 ± 0.108	4.133AlaPhe: 4.133 ± 0.072	10.044AlaGly: 10.044 ± 0.134	1.887AlaHis: 1.887 ± 0.045	4.717AlaIle: 4.717 ± 0.074	1.726AlaLys: 1.726 ± 0.045	10.926AlaLeu: 10.926 ± 0.159	2.089AlaMet: 2.089 ± 0.046	2.763AlaAsn: 2.763 ± 0.052	3.736AlaPro: 3.736 ± 0.07	1.915AlaGln: 1.915 ± 0.048	6.543AlaArg: 6.543 ± 0.088	5.46AlaSer: 5.46 ± 0.089	7.347AlaThr: 7.347 ± 0.109	10.852AlaVal: 10.852 ± 0.128	1.149AlaTrp: 1.149 ± 0.042	2.695AlaTyr: 2.695 ± 0.054	0.007AlaXaa: 0.007 ± 0.003
Cys	0.635CysAla: 0.635 ± 0.028	0.112CysCys: 0.112 ± 0.011	0.515CysAsp: 0.515 ± 0.025	0.65CysGlu: 0.65 ± 0.032	0.249CysPhe: 0.249 ± 0.016	0.895CysGly: 0.895 ± 0.034	0.173CysHis: 0.173 ± 0.013	0.264CysIle: 0.264 ± 0.017	0.073CysLys: 0.073 ± 0.009	0.616CysLeu: 0.616 ± 0.026	0.107CysMet: 0.107 ± 0.012	0.183CysAsn: 0.183 ± 0.014	0.496CysPro: 0.496 ± 0.025	0.149CysGln: 0.149 ± 0.013	0.472CysArg: 0.472 ± 0.024	0.443CysSer: 0.443 ± 0.024	0.405CysThr: 0.405 ± 0.017	0.547CysVal: 0.547 ± 0.026	0.1CysTrp: 0.1 ± 0.011	0.22CysTyr: 0.22 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	8.751AspAla: 8.751 ± 0.126	0.61AspCys: 0.61 ± 0.026	7.184AspAsp: 7.184 ± 0.108	7.749AspGlu: 7.749 ± 0.111	1.982AspPhe: 1.982 ± 0.044	7.632AspGly: 7.632 ± 0.13	2.011AspHis: 2.011 ± 0.048	2.906AspIle: 2.906 ± 0.059	0.773AspLys: 0.773 ± 0.031	7.425AspLeu: 7.425 ± 0.101	1.205AspMet: 1.205 ± 0.037	1.134AspAsn: 1.134 ± 0.037	4.707AspPro: 4.707 ± 0.076	1.603AspGln: 1.603 ± 0.044	6.294AspArg: 6.294 ± 0.092	3.751AspSer: 3.751 ± 0.085	4.047AspThr: 4.047 ± 0.081	6.892AspVal: 6.892 ± 0.099	1.032AspTrp: 1.032 ± 0.029	1.803AspTyr: 1.803 ± 0.047	0.007AspXaa: 0.007 ± 0.003
Glu	8.713GluAla: 8.713 ± 0.117	0.55GluCys: 0.55 ± 0.025	4.925GluAsp: 4.925 ± 0.087	6.092GluGlu: 6.092 ± 0.114	2.95GluPhe: 2.95 ± 0.058	5.711GluGly: 5.711 ± 0.088	2.045GluHis: 2.045 ± 0.049	3.226GluIle: 3.226 ± 0.066	1.697GluLys: 1.697 ± 0.051	6.551GluLeu: 6.551 ± 0.086	1.805GluMet: 1.805 ± 0.05	2.526GluAsn: 2.526 ± 0.055	3.83GluPro: 3.83 ± 0.065	1.995GluGln: 1.995 ± 0.05	8.04GluArg: 8.04 ± 0.114	5.008GluSer: 5.008 ± 0.08	6.55GluThr: 6.55 ± 0.102	5.819GluVal: 5.819 ± 0.092	1.103GluTrp: 1.103 ± 0.035	2.572GluTyr: 2.572 ± 0.058	0.003GluXaa: 0.003 ± 0.002
Phe	4.033PheAla: 4.033 ± 0.071	0.311PheCys: 0.311 ± 0.018	3.194PheAsp: 3.194 ± 0.06	3.354PheGlu: 3.354 ± 0.071	1.253PhePhe: 1.253 ± 0.042	3.561PheGly: 3.561 ± 0.067	0.581PheHis: 0.581 ± 0.025	1.097PheIle: 1.097 ± 0.036	0.409PheLys: 0.409 ± 0.023	2.955PheLeu: 2.955 ± 0.065	0.543PheMet: 0.543 ± 0.027	0.669PheAsn: 0.669 ± 0.028	1.395PhePro: 1.395 ± 0.036	0.721PheGln: 0.721 ± 0.028	1.833PheArg: 1.833 ± 0.05	1.987PheSer: 1.987 ± 0.052	1.945PheThr: 1.945 ± 0.045	3.829PheVal: 3.829 ± 0.069	0.447PheTrp: 0.447 ± 0.023	0.915PheTyr: 0.915 ± 0.034	0.002PheXaa: 0.002 ± 0.001
Gly	8.299GlyAla: 8.299 ± 0.121	0.723GlyCys: 0.723 ± 0.031	5.869GlyAsp: 5.869 ± 0.096	7.148GlyGlu: 7.148 ± 0.093	3.703GlyPhe: 3.703 ± 0.071	8.0GlyGly: 8.0 ± 0.14	1.651GlyHis: 1.651 ± 0.044	4.445GlyIle: 4.445 ± 0.08	1.859GlyLys: 1.859 ± 0.041	8.308GlyLeu: 8.308 ± 0.119	2.019GlyMet: 2.019 ± 0.048	2.19GlyAsn: 2.19 ± 0.06	3.522GlyPro: 3.522 ± 0.064	1.941GlyGln: 1.941 ± 0.051	5.283GlyArg: 5.283 ± 0.084	5.73GlySer: 5.73 ± 0.08	6.223GlyThr: 6.223 ± 0.091	8.149GlyVal: 8.149 ± 0.11	1.22GlyTrp: 1.22 ± 0.035	2.776GlyTyr: 2.776 ± 0.055	0.005GlyXaa: 0.005 ± 0.002
His	2.044HisAla: 2.044 ± 0.049	0.21HisCys: 0.21 ± 0.015	1.989HisAsp: 1.989 ± 0.052	1.733HisGlu: 1.733 ± 0.047	0.508HisPhe: 0.508 ± 0.025	1.94HisGly: 1.94 ± 0.045	0.591HisHis: 0.591 ± 0.024	0.733HisIle: 0.733 ± 0.028	0.263HisLys: 0.263 ± 0.017	1.782HisLeu: 1.782 ± 0.044	0.272HisMet: 0.272 ± 0.017	0.435HisAsn: 0.435 ± 0.022	1.341HisPro: 1.341 ± 0.041	0.443HisGln: 0.443 ± 0.02	1.407HisArg: 1.407 ± 0.042	0.833HisSer: 0.833 ± 0.03	1.201HisThr: 1.201 ± 0.04	1.737HisVal: 1.737 ± 0.045	0.258HisTrp: 0.258 ± 0.015	0.529HisTyr: 0.529 ± 0.024	0.002HisXaa: 0.002 ± 0.001
Ile	4.677IleAla: 4.677 ± 0.073	0.224IleCys: 0.224 ± 0.016	3.734IleAsp: 3.734 ± 0.07	4.526IleGlu: 4.526 ± 0.076	0.898IlePhe: 0.898 ± 0.036	3.933IleGly: 3.933 ± 0.077	0.865IleHis: 0.865 ± 0.031	1.166IleIle: 1.166 ± 0.042	0.564IleLys: 0.564 ± 0.029	2.862IleLeu: 2.862 ± 0.07	0.422IleMet: 0.422 ± 0.022	0.898IleAsn: 0.898 ± 0.033	2.206IlePro: 2.206 ± 0.049	1.023IleGln: 1.023 ± 0.032	2.348IleArg: 2.348 ± 0.051	1.908IleSer: 1.908 ± 0.048	2.345IleThr: 2.345 ± 0.055	3.443IleVal: 3.443 ± 0.061	0.327IleTrp: 0.327 ± 0.019	0.886IleTyr: 0.886 ± 0.034	0.001IleXaa: 0.001 ± 0.001
Lys	1.539LysAla: 1.539 ± 0.042	0.118LysCys: 0.118 ± 0.012	0.859LysAsp: 0.859 ± 0.035	1.164LysGlu: 1.164 ± 0.039	0.529LysPhe: 0.529 ± 0.028	1.241LysGly: 1.241 ± 0.042	0.421LysHis: 0.421 ± 0.021	0.606LysIle: 0.606 ± 0.023	0.468LysLys: 0.468 ± 0.027	1.561LysLeu: 1.561 ± 0.047	0.326LysMet: 0.326 ± 0.019	0.562LysAsn: 0.562 ± 0.026	0.927LysPro: 0.927 ± 0.032	0.626LysGln: 0.626 ± 0.026	1.601LysArg: 1.601 ± 0.049	0.996LysSer: 0.996 ± 0.036	1.24LysThr: 1.24 ± 0.035	1.132LysVal: 1.132 ± 0.042	0.222LysTrp: 0.222 ± 0.015	0.545LysTyr: 0.545 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	11.571LeuAla: 11.571 ± 0.163	0.683LeuCys: 0.683 ± 0.032	8.53LeuAsp: 8.53 ± 0.11	5.712LeuGlu: 5.712 ± 0.093	3.308LeuPhe: 3.308 ± 0.074	8.259LeuGly: 8.259 ± 0.121	1.516LeuHis: 1.516 ± 0.044	2.82LeuIle: 2.82 ± 0.063	1.366LeuLys: 1.366 ± 0.043	8.455LeuLeu: 8.455 ± 0.161	1.322LeuMet: 1.322 ± 0.039	1.812LeuAsn: 1.812 ± 0.049	4.421LeuPro: 4.421 ± 0.07	1.89LeuGln: 1.89 ± 0.046	5.576LeuArg: 5.576 ± 0.075	5.755LeuSer: 5.755 ± 0.083	5.427LeuThr: 5.427 ± 0.085	9.329LeuVal: 9.329 ± 0.131	0.913LeuTrp: 0.913 ± 0.032	2.164LeuTyr: 2.164 ± 0.05	0.005LeuXaa: 0.005 ± 0.003
Met	2.009MetAla: 2.009 ± 0.044	0.119MetCys: 0.119 ± 0.01	1.287MetAsp: 1.287 ± 0.037	1.131MetGlu: 1.131 ± 0.035	0.533MetPhe: 0.533 ± 0.023	1.633MetGly: 1.633 ± 0.044	0.33MetHis: 0.33 ± 0.02	0.678MetIle: 0.678 ± 0.026	0.44MetLys: 0.44 ± 0.025	1.491MetLeu: 1.491 ± 0.041	0.323MetMet: 0.323 ± 0.019	0.718MetAsn: 0.718 ± 0.026	0.745MetPro: 0.745 ± 0.028	0.432MetGln: 0.432 ± 0.024	1.032MetArg: 1.032 ± 0.033	1.531MetSer: 1.531 ± 0.038	1.504MetThr: 1.504 ± 0.037	1.537MetVal: 1.537 ± 0.043	0.16MetTrp: 0.16 ± 0.014	0.389MetTyr: 0.389 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.889AsnAla: 2.889 ± 0.053	0.206AsnCys: 0.206 ± 0.017	1.819AsnAsp: 1.819 ± 0.049	1.852AsnGlu: 1.852 ± 0.054	0.706AsnPhe: 0.706 ± 0.028	2.244AsnGly: 2.244 ± 0.063	0.55AsnHis: 0.55 ± 0.023	0.869AsnIle: 0.869 ± 0.03	0.398AsnLys: 0.398 ± 0.023	1.959AsnLeu: 1.959 ± 0.048	0.412AsnMet: 0.412 ± 0.022	0.574AsnAsn: 0.574 ± 0.027	1.563AsnPro: 1.563 ± 0.041	0.742AsnGln: 0.742 ± 0.025	1.734AsnArg: 1.734 ± 0.044	1.002AsnSer: 1.002 ± 0.037	1.486AsnThr: 1.486 ± 0.04	2.269AsnVal: 2.269 ± 0.052	0.351AsnTrp: 0.351 ± 0.022	0.736AsnTyr: 0.736 ± 0.032	0.001AsnXaa: 0.001 ± 0.001
Pro	4.869ProAla: 4.869 ± 0.073	0.231ProCys: 0.231 ± 0.016	4.7ProAsp: 4.7 ± 0.074	4.526ProGlu: 4.526 ± 0.071	1.714ProPhe: 1.714 ± 0.046	3.896ProGly: 3.896 ± 0.069	0.932ProHis: 0.932 ± 0.032	1.863ProIle: 1.863 ± 0.049	0.843ProLys: 0.843 ± 0.026	3.913ProLeu: 3.913 ± 0.07	0.862ProMet: 0.862 ± 0.028	1.253ProAsn: 1.253 ± 0.034	2.104ProPro: 2.104 ± 0.047	0.922ProGln: 0.922 ± 0.031	2.393ProArg: 2.393 ± 0.054	2.614ProSer: 2.614 ± 0.051	3.374ProThr: 3.374 ± 0.059	4.25ProVal: 4.25 ± 0.072	0.55ProTrp: 0.55 ± 0.025	1.174ProTyr: 1.174 ± 0.038	0.003ProXaa: 0.003 ± 0.002
Gln	2.148GlnAla: 2.148 ± 0.05	0.172GlnCys: 0.172 ± 0.014	1.151GlnAsp: 1.151 ± 0.036	1.416GlnGlu: 1.416 ± 0.044	0.932GlnPhe: 0.932 ± 0.035	1.634GlnGly: 1.634 ± 0.04	0.508GlnHis: 0.508 ± 0.024	0.912GlnIle: 0.912 ± 0.032	0.465GlnLys: 0.465 ± 0.022	2.033GlnLeu: 2.033 ± 0.045	0.415GlnMet: 0.415 ± 0.022	0.718GlnAsn: 0.718 ± 0.031	1.17GlnPro: 1.17 ± 0.036	0.88GlnGln: 0.88 ± 0.033	1.879GlnArg: 1.879 ± 0.052	1.399GlnSer: 1.399 ± 0.046	1.367GlnThr: 1.367 ± 0.038	1.911GlnVal: 1.911 ± 0.053	0.347GlnTrp: 0.347 ± 0.02	0.814GlnTyr: 0.814 ± 0.032	0.001GlnXaa: 0.001 ± 0.001
Arg	6.705ArgAla: 6.705 ± 0.108	0.464ArgCys: 0.464 ± 0.024	4.898ArgAsp: 4.898 ± 0.078	6.642ArgGlu: 6.642 ± 0.104	2.561ArgPhe: 2.561 ± 0.061	4.628ArgGly: 4.628 ± 0.082	1.278ArgHis: 1.278 ± 0.039	2.977ArgIle: 2.977 ± 0.055	1.263ArgLys: 1.263 ± 0.035	6.342ArgLeu: 6.342 ± 0.099	1.422ArgMet: 1.422 ± 0.031	1.71ArgAsn: 1.71 ± 0.045	2.731ArgPro: 2.731 ± 0.056	1.496ArgGln: 1.496 ± 0.046	4.917ArgArg: 4.917 ± 0.107	3.749ArgSer: 3.749 ± 0.067	4.362ArgThr: 4.362 ± 0.072	5.641ArgVal: 5.641 ± 0.085	0.821ArgTrp: 0.821 ± 0.027	1.965ArgTyr: 1.965 ± 0.05	0.003ArgXaa: 0.003 ± 0.002
Ser	5.475SerAla: 5.475 ± 0.093	0.334SerCys: 0.334 ± 0.017	3.883SerAsp: 3.883 ± 0.077	4.076SerGlu: 4.076 ± 0.074	2.056SerPhe: 2.056 ± 0.052	5.75SerGly: 5.75 ± 0.086	1.07SerHis: 1.07 ± 0.041	2.502SerIle: 2.502 ± 0.052	1.058SerLys: 1.058 ± 0.038	5.191SerLeu: 5.191 ± 0.079	1.183SerMet: 1.183 ± 0.038	1.47SerAsn: 1.47 ± 0.04	2.584SerPro: 2.584 ± 0.05	1.37SerGln: 1.37 ± 0.042	3.245SerArg: 3.245 ± 0.059	3.258SerSer: 3.258 ± 0.079	3.896SerThr: 3.896 ± 0.066	5.182SerVal: 5.182 ± 0.078	0.572SerTrp: 0.572 ± 0.025	1.618SerTyr: 1.618 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	7.217ThrAla: 7.217 ± 0.119	0.391ThrCys: 0.391 ± 0.025	5.747ThrAsp: 5.747 ± 0.091	4.853ThrGlu: 4.853 ± 0.093	2.126ThrPhe: 2.126 ± 0.046	6.122ThrGly: 6.122 ± 0.091	1.308ThrHis: 1.308 ± 0.038	2.956ThrIle: 2.956 ± 0.063	1.007ThrLys: 1.007 ± 0.031	5.695ThrLeu: 5.695 ± 0.092	1.183ThrMet: 1.183 ± 0.036	1.698ThrAsn: 1.698 ± 0.046	3.451ThrPro: 3.451 ± 0.064	1.411ThrGln: 1.411 ± 0.042	3.424ThrArg: 3.424 ± 0.063	3.08ThrSer: 3.08 ± 0.068	4.951ThrThr: 4.951 ± 0.117	6.8ThrVal: 6.8 ± 0.099	0.616ThrTrp: 0.616 ± 0.025	1.699ThrTyr: 1.699 ± 0.038	0.003ThrXaa: 0.003 ± 0.002
Val	10.648ValAla: 10.648 ± 0.137	0.782ValCys: 0.782 ± 0.029	6.74ValAsp: 6.74 ± 0.092	8.098ValGlu: 8.098 ± 0.099	3.456ValPhe: 3.456 ± 0.062	8.618ValGly: 8.618 ± 0.104	1.702ValHis: 1.702 ± 0.048	3.224ValIle: 3.224 ± 0.064	1.287ValLys: 1.287 ± 0.036	8.9ValLeu: 8.9 ± 0.133	1.487ValMet: 1.487 ± 0.044	2.01ValAsn: 2.01 ± 0.044	4.214ValPro: 4.214 ± 0.063	1.629ValGln: 1.629 ± 0.047	5.568ValArg: 5.568 ± 0.088	5.364ValSer: 5.364 ± 0.079	5.661ValThr: 5.661 ± 0.09	10.532ValVal: 10.532 ± 0.14	0.89ValTrp: 0.89 ± 0.034	2.173ValTyr: 2.173 ± 0.051	0.002ValXaa: 0.002 ± 0.001
Trp	0.958TrpAla: 0.958 ± 0.033	0.102TrpCys: 0.102 ± 0.01	0.73TrpAsp: 0.73 ± 0.025	0.834TrpGlu: 0.834 ± 0.03	0.509TrpPhe: 0.509 ± 0.022	0.905TrpGly: 0.905 ± 0.032	0.225TrpHis: 0.225 ± 0.016	0.453TrpIle: 0.453 ± 0.023	0.294TrpLys: 0.294 ± 0.018	1.253TrpLeu: 1.253 ± 0.04	0.258TrpMet: 0.258 ± 0.015	0.387TrpAsn: 0.387 ± 0.021	0.469TrpPro: 0.469 ± 0.024	0.362TrpGln: 0.362 ± 0.018	0.905TrpArg: 0.905 ± 0.031	0.648TrpSer: 0.648 ± 0.027	0.788TrpThr: 0.788 ± 0.032	0.988TrpVal: 0.988 ± 0.035	0.203TrpTrp: 0.203 ± 0.015	0.376TrpTyr: 0.376 ± 0.023	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.732TyrAla: 2.732 ± 0.053	0.215TyrCys: 0.215 ± 0.018	2.526TyrAsp: 2.526 ± 0.051	2.191TyrGlu: 2.191 ± 0.051	0.928TyrPhe: 0.928 ± 0.032	2.408TyrGly: 2.408 ± 0.053	0.607TyrHis: 0.607 ± 0.026	0.834TyrIle: 0.834 ± 0.027	0.427TyrLys: 0.427 ± 0.024	2.612TyrLeu: 2.612 ± 0.056	0.365TyrMet: 0.365 ± 0.021	0.653TyrAsn: 0.653 ± 0.03	1.373TyrPro: 1.373 ± 0.039	0.72TyrGln: 0.72 ± 0.03	2.081TyrArg: 2.081 ± 0.049	1.253TyrSer: 1.253 ± 0.044	1.618TyrThr: 1.618 ± 0.039	2.143TyrVal: 2.143 ± 0.048	0.365TyrTrp: 0.365 ± 0.02	0.853TyrTyr: 0.853 ± 0.032	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.002	0.002XaaGlu: 0.002 ± 0.001	0.002XaaPhe: 0.002 ± 0.002	0.007XaaGly: 0.007 ± 0.003	0.0XaaHis: 0.0 ± 0.0	0.003XaaIle: 0.003 ± 0.002	0.001XaaLys: 0.001 ± 0.001	0.005XaaLeu: 0.005 ± 0.002	0.002XaaMet: 0.002 ± 0.001	0.002XaaAsn: 0.002 ± 0.002	0.0XaaPro: 0.0 ± 0.0	0.004XaaGln: 0.004 ± 0.002	0.001XaaArg: 0.001 ± 0.001	0.005XaaSer: 0.005 ± 0.003	0.001XaaThr: 0.001 ± 0.001	0.004XaaVal: 0.004 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 3400 proteins (957097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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