Amino acid dipepetide frequency for Streptomyces sp. SLBN-118

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.724AlaAla: 20.724 ± 0.154	1.113AlaCys: 1.113 ± 0.023	8.015AlaAsp: 8.015 ± 0.071	8.651AlaGlu: 8.651 ± 0.088	3.488AlaPhe: 3.488 ± 0.044	12.477AlaGly: 12.477 ± 0.091	2.776AlaHis: 2.776 ± 0.04	3.755AlaIle: 3.755 ± 0.045	3.214AlaLys: 3.214 ± 0.068	13.901AlaLeu: 13.901 ± 0.105	2.618AlaMet: 2.618 ± 0.032	2.079AlaAsn: 2.079 ± 0.035	6.824AlaPro: 6.824 ± 0.086	4.018AlaGln: 4.018 ± 0.048	9.795AlaArg: 9.795 ± 0.086	6.195AlaSer: 6.195 ± 0.056	6.866AlaThr: 6.866 ± 0.063	11.945AlaVal: 11.945 ± 0.077	1.848AlaTrp: 1.848 ± 0.028	2.748AlaTyr: 2.748 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.023	0.106CysCys: 0.106 ± 0.008	0.506CysAsp: 0.506 ± 0.015	0.459CysGlu: 0.459 ± 0.015	0.231CysPhe: 0.231 ± 0.011	1.021CysGly: 1.021 ± 0.022	0.201CysHis: 0.201 ± 0.01	0.216CysIle: 0.216 ± 0.01	0.128CysLys: 0.128 ± 0.007	0.758CysLeu: 0.758 ± 0.018	0.134CysMet: 0.134 ± 0.009	0.144CysAsn: 0.144 ± 0.008	0.535CysPro: 0.535 ± 0.016	0.196CysGln: 0.196 ± 0.009	0.63CysArg: 0.63 ± 0.018	0.5CysSer: 0.5 ± 0.016	0.566CysThr: 0.566 ± 0.017	0.674CysVal: 0.674 ± 0.017	0.131CysTrp: 0.131 ± 0.008	0.16CysTyr: 0.16 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.515AspAla: 7.515 ± 0.065	0.473AspCys: 0.473 ± 0.015	3.375AspAsp: 3.375 ± 0.043	3.969AspGlu: 3.969 ± 0.048	1.62AspPhe: 1.62 ± 0.03	5.968AspGly: 5.968 ± 0.059	1.322AspHis: 1.322 ± 0.026	2.051AspIle: 2.051 ± 0.027	1.373AspLys: 1.373 ± 0.03	6.029AspLeu: 6.029 ± 0.057	0.891AspMet: 0.891 ± 0.022	1.039AspAsn: 1.039 ± 0.027	4.264AspPro: 4.264 ± 0.06	1.618AspGln: 1.618 ± 0.029	4.657AspArg: 4.657 ± 0.043	2.707AspSer: 2.707 ± 0.037	3.134AspThr: 3.134 ± 0.043	4.533AspVal: 4.533 ± 0.046	1.037AspTrp: 1.037 ± 0.023	1.122AspTyr: 1.122 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.347GluAla: 7.347 ± 0.099	0.394GluCys: 0.394 ± 0.014	2.869GluAsp: 2.869 ± 0.043	3.573GluGlu: 3.573 ± 0.046	1.499GluPhe: 1.499 ± 0.027	4.408GluGly: 4.408 ± 0.052	1.531GluHis: 1.531 ± 0.031	2.382GluIle: 2.382 ± 0.033	1.551GluLys: 1.551 ± 0.032	7.004GluLeu: 7.004 ± 0.065	0.931GluMet: 0.931 ± 0.02	1.083GluAsn: 1.083 ± 0.024	3.45GluPro: 3.45 ± 0.058	2.417GluGln: 2.417 ± 0.046	5.374GluArg: 5.374 ± 0.063	2.769GluSer: 2.769 ± 0.037	2.892GluThr: 2.892 ± 0.043	4.433GluVal: 4.433 ± 0.051	0.77GluTrp: 0.77 ± 0.018	1.175GluTyr: 1.175 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.609PheAla: 3.609 ± 0.041	0.299PheCys: 0.299 ± 0.012	1.925PheAsp: 1.925 ± 0.034	1.471PheGlu: 1.471 ± 0.027	0.864PhePhe: 0.864 ± 0.021	2.97PheGly: 2.97 ± 0.041	0.613PheHis: 0.613 ± 0.016	0.797PheIle: 0.797 ± 0.019	0.587PheLys: 0.587 ± 0.017	2.513PheLeu: 2.513 ± 0.035	0.424PheMet: 0.424 ± 0.015	0.604PheAsn: 0.604 ± 0.017	1.409PhePro: 1.409 ± 0.027	0.653PheGln: 0.653 ± 0.018	1.805PheArg: 1.805 ± 0.032	1.531PheSer: 1.531 ± 0.031	2.021PheThr: 2.021 ± 0.038	2.17PheVal: 2.17 ± 0.036	0.406PheTrp: 0.406 ± 0.014	0.564PheTyr: 0.564 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.605GlyAla: 10.605 ± 0.082	0.886GlyCys: 0.886 ± 0.02	5.018GlyAsp: 5.018 ± 0.053	5.207GlyGlu: 5.207 ± 0.051	2.838GlyPhe: 2.838 ± 0.038	8.61GlyGly: 8.61 ± 0.093	2.352GlyHis: 2.352 ± 0.04	3.661GlyIle: 3.661 ± 0.038	2.695GlyLys: 2.695 ± 0.044	9.258GlyLeu: 9.258 ± 0.069	2.081GlyMet: 2.081 ± 0.032	1.792GlyAsn: 1.792 ± 0.036	5.034GlyPro: 5.034 ± 0.057	2.853GlyGln: 2.853 ± 0.039	7.545GlyArg: 7.545 ± 0.063	5.633GlySer: 5.633 ± 0.066	6.004GlyThr: 6.004 ± 0.059	7.169GlyVal: 7.169 ± 0.063	1.668GlyTrp: 1.668 ± 0.031	2.219GlyTyr: 2.219 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.626HisAla: 2.626 ± 0.039	0.229HisCys: 0.229 ± 0.01	1.317HisAsp: 1.317 ± 0.023	1.239HisGlu: 1.239 ± 0.026	0.635HisPhe: 0.635 ± 0.017	2.362HisGly: 2.362 ± 0.032	0.679HisHis: 0.679 ± 0.02	0.712HisIle: 0.712 ± 0.017	0.443HisLys: 0.443 ± 0.012	2.36HisLeu: 2.36 ± 0.037	0.356HisMet: 0.356 ± 0.013	0.388HisAsn: 0.388 ± 0.014	1.78HisPro: 1.78 ± 0.032	0.656HisGln: 0.656 ± 0.018	2.044HisArg: 2.044 ± 0.034	1.086HisSer: 1.086 ± 0.02	1.385HisThr: 1.385 ± 0.025	1.686HisVal: 1.686 ± 0.028	0.361HisTrp: 0.361 ± 0.012	0.462HisTyr: 0.462 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.106IleAla: 5.106 ± 0.05	0.331IleCys: 0.331 ± 0.013	2.409IleAsp: 2.409 ± 0.036	2.199IleGlu: 2.199 ± 0.037	0.802IlePhe: 0.802 ± 0.02	3.815IleGly: 3.815 ± 0.044	0.679IleHis: 0.679 ± 0.018	0.983IleIle: 0.983 ± 0.025	0.835IleLys: 0.835 ± 0.021	2.544IleLeu: 2.544 ± 0.04	0.462IleMet: 0.462 ± 0.016	0.779IleAsn: 0.779 ± 0.019	1.906IlePro: 1.906 ± 0.033	0.846IleGln: 0.846 ± 0.019	2.406IleArg: 2.406 ± 0.033	1.879IleSer: 1.879 ± 0.031	2.431IleThr: 2.431 ± 0.035	2.827IleVal: 2.827 ± 0.04	0.412IleTrp: 0.412 ± 0.016	0.618IleTyr: 0.618 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.238LysAla: 3.238 ± 0.06	0.134LysCys: 0.134 ± 0.009	1.508LysAsp: 1.508 ± 0.034	1.351LysGlu: 1.351 ± 0.027	0.521LysPhe: 0.521 ± 0.016	2.037LysGly: 2.037 ± 0.036	0.485LysHis: 0.485 ± 0.016	1.014LysIle: 1.014 ± 0.025	0.981LysLys: 0.981 ± 0.034	2.235LysLeu: 2.235 ± 0.038	0.417LysMet: 0.417 ± 0.013	0.642LysAsn: 0.642 ± 0.02	1.568LysPro: 1.568 ± 0.034	0.831LysGln: 0.831 ± 0.024	1.597LysArg: 1.597 ± 0.031	1.327LysSer: 1.327 ± 0.031	1.47LysThr: 1.47 ± 0.034	2.046LysVal: 2.046 ± 0.038	0.306LysTrp: 0.306 ± 0.012	0.496LysTyr: 0.496 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.57LeuAla: 14.57 ± 0.11	0.849LeuCys: 0.849 ± 0.022	6.438LeuAsp: 6.438 ± 0.062	4.788LeuGlu: 4.788 ± 0.06	2.557LeuPhe: 2.557 ± 0.033	9.043LeuGly: 9.043 ± 0.065	2.291LeuHis: 2.291 ± 0.037	3.562LeuIle: 3.562 ± 0.04	2.212LeuLys: 2.212 ± 0.036	11.031LeuLeu: 11.031 ± 0.105	1.726LeuMet: 1.726 ± 0.031	1.79LeuAsn: 1.79 ± 0.031	6.397LeuPro: 6.397 ± 0.053	2.377LeuGln: 2.377 ± 0.036	8.416LeuArg: 8.416 ± 0.074	5.525LeuSer: 5.525 ± 0.053	6.54LeuThr: 6.54 ± 0.052	8.599LeuVal: 8.599 ± 0.072	1.269LeuTrp: 1.269 ± 0.024	1.877LeuTyr: 1.877 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.349MetAla: 2.349 ± 0.036	0.156MetCys: 0.156 ± 0.009	0.927MetAsp: 0.927 ± 0.018	0.837MetGlu: 0.837 ± 0.022	0.489MetPhe: 0.489 ± 0.014	1.405MetGly: 1.405 ± 0.031	0.387MetHis: 0.387 ± 0.013	0.706MetIle: 0.706 ± 0.017	0.459MetLys: 0.459 ± 0.014	1.748MetLeu: 1.748 ± 0.031	0.324MetMet: 0.324 ± 0.014	0.461MetAsn: 0.461 ± 0.016	1.174MetPro: 1.174 ± 0.025	0.506MetGln: 0.506 ± 0.016	1.487MetArg: 1.487 ± 0.027	1.38MetSer: 1.38 ± 0.026	1.607MetThr: 1.607 ± 0.03	1.311MetVal: 1.311 ± 0.027	0.233MetTrp: 0.233 ± 0.01	0.34MetTyr: 0.34 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.359AsnAla: 2.359 ± 0.04	0.185AsnCys: 0.185 ± 0.009	1.039AsnAsp: 1.039 ± 0.024	0.904AsnGlu: 0.904 ± 0.02	0.495AsnPhe: 0.495 ± 0.016	1.972AsnGly: 1.972 ± 0.036	0.415AsnHis: 0.415 ± 0.014	0.662AsnIle: 0.662 ± 0.02	0.521AsnLys: 0.521 ± 0.019	1.732AsnLeu: 1.732 ± 0.032	0.309AsnMet: 0.309 ± 0.011	0.471AsnAsn: 0.471 ± 0.018	1.383AsnPro: 1.383 ± 0.027	0.588AsnGln: 0.588 ± 0.018	1.356AsnArg: 1.356 ± 0.028	1.058AsnSer: 1.058 ± 0.029	1.186AsnThr: 1.186 ± 0.031	1.386AsnVal: 1.386 ± 0.028	0.319AsnTrp: 0.319 ± 0.013	0.407AsnTyr: 0.407 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.257ProAla: 8.257 ± 0.087	0.37ProCys: 0.37 ± 0.015	4.289ProAsp: 4.289 ± 0.043	4.231ProGlu: 4.231 ± 0.054	1.493ProPhe: 1.493 ± 0.025	6.36ProGly: 6.36 ± 0.067	1.346ProHis: 1.346 ± 0.028	1.436ProIle: 1.436 ± 0.027	1.385ProLys: 1.385 ± 0.034	5.288ProLeu: 5.288 ± 0.05	1.046ProMet: 1.046 ± 0.023	0.951ProAsn: 0.951 ± 0.02	3.562ProPro: 3.562 ± 0.057	2.009ProGln: 2.009 ± 0.041	3.758ProArg: 3.758 ± 0.055	3.304ProSer: 3.304 ± 0.042	3.215ProThr: 3.215 ± 0.044	5.491ProVal: 5.491 ± 0.058	0.89ProTrp: 0.89 ± 0.022	1.46ProTyr: 1.46 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.985GlnAla: 3.985 ± 0.042	0.205GlnCys: 0.205 ± 0.009	1.491GlnAsp: 1.491 ± 0.023	1.546GlnGlu: 1.546 ± 0.033	0.754GlnPhe: 0.754 ± 0.018	2.394GlnGly: 2.394 ± 0.036	0.705GlnHis: 0.705 ± 0.019	1.233GlnIle: 1.233 ± 0.023	0.693GlnLys: 0.693 ± 0.022	3.381GlnLeu: 3.381 ± 0.043	0.574GlnMet: 0.574 ± 0.017	0.562GlnAsn: 0.562 ± 0.019	1.886GlnPro: 1.886 ± 0.039	1.43GlnGln: 1.43 ± 0.035	2.462GlnArg: 2.462 ± 0.034	1.486GlnSer: 1.486 ± 0.027	1.446GlnThr: 1.446 ± 0.028	2.389GlnVal: 2.389 ± 0.037	0.487GlnTrp: 0.487 ± 0.014	0.67GlnTyr: 0.67 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.367ArgAla: 9.367 ± 0.086	0.64ArgCys: 0.64 ± 0.018	4.058ArgAsp: 4.058 ± 0.046	4.661ArgGlu: 4.661 ± 0.056	2.226ArgPhe: 2.226 ± 0.029	5.807ArgGly: 5.807 ± 0.049	2.018ArgHis: 2.018 ± 0.031	3.418ArgIle: 3.418 ± 0.044	1.791ArgLys: 1.791 ± 0.032	8.494ArgLeu: 8.494 ± 0.074	1.794ArgMet: 1.794 ± 0.028	1.426ArgAsn: 1.426 ± 0.029	4.762ArgPro: 4.762 ± 0.056	2.379ArgGln: 2.379 ± 0.032	7.531ArgArg: 7.531 ± 0.087	4.133ArgSer: 4.133 ± 0.052	5.289ArgThr: 5.289 ± 0.049	5.492ArgVal: 5.492 ± 0.048	1.363ArgTrp: 1.363 ± 0.027	1.754ArgTyr: 1.754 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.029SerAla: 7.029 ± 0.058	0.458SerCys: 0.458 ± 0.016	2.801SerAsp: 2.801 ± 0.035	2.688SerGlu: 2.688 ± 0.036	1.618SerPhe: 1.618 ± 0.029	6.121SerGly: 6.121 ± 0.07	1.069SerHis: 1.069 ± 0.025	1.642SerIle: 1.642 ± 0.031	1.222SerLys: 1.222 ± 0.029	4.995SerLeu: 4.995 ± 0.053	1.146SerMet: 1.146 ± 0.024	0.955SerAsn: 0.955 ± 0.025	3.336SerPro: 3.336 ± 0.043	1.426SerGln: 1.426 ± 0.027	3.825SerArg: 3.825 ± 0.043	3.05SerSer: 3.05 ± 0.055	3.154SerThr: 3.154 ± 0.05	4.457SerVal: 4.457 ± 0.044	0.943SerTrp: 0.943 ± 0.021	1.311SerTyr: 1.311 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.561ThrAla: 8.561 ± 0.076	0.448ThrCys: 0.448 ± 0.015	3.552ThrAsp: 3.552 ± 0.048	3.271ThrGlu: 3.271 ± 0.039	1.628ThrPhe: 1.628 ± 0.029	6.548ThrGly: 6.548 ± 0.059	1.213ThrHis: 1.213 ± 0.027	1.854ThrIle: 1.854 ± 0.028	1.325ThrLys: 1.325 ± 0.031	5.628ThrLeu: 5.628 ± 0.061	0.99ThrMet: 0.99 ± 0.021	1.046ThrAsn: 1.046 ± 0.021	3.923ThrPro: 3.923 ± 0.048	1.477ThrGln: 1.477 ± 0.026	3.758ThrArg: 3.758 ± 0.044	3.317ThrSer: 3.317 ± 0.046	3.823ThrThr: 3.823 ± 0.06	5.923ThrVal: 5.923 ± 0.057	0.93ThrTrp: 0.93 ± 0.023	1.409ThrTyr: 1.409 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	10.267ValAla: 10.267 ± 0.079	0.761ValCys: 0.761 ± 0.019	4.79ValAsp: 4.79 ± 0.05	4.732ValGlu: 4.732 ± 0.053	2.316ValPhe: 2.316 ± 0.037	6.427ValGly: 6.427 ± 0.055	1.986ValHis: 1.986 ± 0.027	3.049ValIle: 3.049 ± 0.042	1.924ValLys: 1.924 ± 0.034	9.135ValLeu: 9.135 ± 0.079	1.503ValMet: 1.503 ± 0.026	1.7ValAsn: 1.7 ± 0.03	5.064ValPro: 5.064 ± 0.053	2.202ValGln: 2.202 ± 0.035	6.898ValArg: 6.898 ± 0.058	4.392ValSer: 4.392 ± 0.046	5.357ValThr: 5.357 ± 0.049	7.772ValVal: 7.772 ± 0.078	1.108ValTrp: 1.108 ± 0.026	1.55ValTyr: 1.55 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.675TrpAla: 1.675 ± 0.027	0.17TrpCys: 0.17 ± 0.008	0.846TrpAsp: 0.846 ± 0.02	0.709TrpGlu: 0.709 ± 0.018	0.5TrpPhe: 0.5 ± 0.017	1.058TrpGly: 1.058 ± 0.025	0.357TrpHis: 0.357 ± 0.014	0.59TrpIle: 0.59 ± 0.016	0.417TrpLys: 0.417 ± 0.016	1.732TrpLeu: 1.732 ± 0.035	0.286TrpMet: 0.286 ± 0.012	0.395TrpAsn: 0.395 ± 0.014	0.798TrpPro: 0.798 ± 0.021	0.655TrpGln: 0.655 ± 0.018	1.276TrpArg: 1.276 ± 0.024	0.95TrpSer: 0.95 ± 0.022	1.031TrpThr: 1.031 ± 0.023	0.99TrpVal: 0.99 ± 0.022	0.351TrpTrp: 0.351 ± 0.017	0.373TrpTyr: 0.373 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.769TyrAla: 2.769 ± 0.034	0.184TyrCys: 0.184 ± 0.009	1.524TyrAsp: 1.524 ± 0.038	1.367TyrGlu: 1.367 ± 0.028	0.662TyrPhe: 0.662 ± 0.018	2.327TyrGly: 2.327 ± 0.037	0.379TyrHis: 0.379 ± 0.014	0.544TyrIle: 0.544 ± 0.015	0.445TyrLys: 0.445 ± 0.013	2.092TyrLeu: 2.092 ± 0.03	0.274TyrMet: 0.274 ± 0.012	0.445TyrAsn: 0.445 ± 0.018	1.085TyrPro: 1.085 ± 0.023	0.642TyrGln: 0.642 ± 0.017	1.784TyrArg: 1.784 ± 0.032	1.022TyrSer: 1.022 ± 0.02	1.208TyrThr: 1.208 ± 0.029	1.636TyrVal: 1.636 ± 0.029	0.327TyrTrp: 0.327 ± 0.012	0.481TyrTyr: 0.481 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6747 proteins (2213585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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