Amino acid dipepetide frequency for Vibrio azureus NBRC 104587

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.551AlaAla: 6.551 ± 0.104
0.902AlaCys: 0.902 ± 0.032
4.083AlaAsp: 4.083 ± 0.057
5.276AlaGlu: 5.276 ± 0.074
3.353AlaPhe: 3.353 ± 0.057
5.172AlaGly: 5.172 ± 0.075
1.612AlaHis: 1.612 ± 0.031
5.539AlaIle: 5.539 ± 0.072
4.773AlaLys: 4.773 ± 0.063
9.093AlaLeu: 9.093 ± 0.104
2.461AlaMet: 2.461 ± 0.05
3.459AlaAsn: 3.459 ± 0.051
2.61AlaPro: 2.61 ± 0.047
3.881AlaGln: 3.881 ± 0.066
3.387AlaArg: 3.387 ± 0.056
5.272AlaSer: 5.272 ± 0.067
4.131AlaThr: 4.131 ± 0.063
5.137AlaVal: 5.137 ± 0.06
0.911AlaTrp: 0.911 ± 0.029
2.362AlaTyr: 2.362 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.752CysAla: 0.752 ± 0.026
0.171CysCys: 0.171 ± 0.012
0.676CysAsp: 0.676 ± 0.025
0.616CysGlu: 0.616 ± 0.021
0.51CysPhe: 0.51 ± 0.021
0.883CysGly: 0.883 ± 0.028
0.394CysHis: 0.394 ± 0.019
0.639CysIle: 0.639 ± 0.024
0.486CysLys: 0.486 ± 0.018
1.075CysLeu: 1.075 ± 0.031
0.223CysMet: 0.223 ± 0.014
0.387CysAsn: 0.387 ± 0.018
0.442CysPro: 0.442 ± 0.018
0.546CysGln: 0.546 ± 0.02
0.478CysArg: 0.478 ± 0.021
0.814CysSer: 0.814 ± 0.027
0.496CysThr: 0.496 ± 0.022
0.656CysVal: 0.656 ± 0.025
0.144CysTrp: 0.144 ± 0.012
0.353CysTyr: 0.353 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.082AspAla: 4.082 ± 0.069
0.577AspCys: 0.577 ± 0.022
3.045AspAsp: 3.045 ± 0.06
3.769AspGlu: 3.769 ± 0.072
2.637AspPhe: 2.637 ± 0.044
3.726AspGly: 3.726 ± 0.07
1.13AspHis: 1.13 ± 0.031
4.287AspIle: 4.287 ± 0.056
3.433AspLys: 3.433 ± 0.052
5.234AspLeu: 5.234 ± 0.067
1.47AspMet: 1.47 ± 0.038
2.583AspAsn: 2.583 ± 0.049
2.0AspPro: 2.0 ± 0.04
2.045AspGln: 2.045 ± 0.045
2.211AspArg: 2.211 ± 0.04
3.4AspSer: 3.4 ± 0.063
2.671AspThr: 2.671 ± 0.05
3.857AspVal: 3.857 ± 0.061
0.868AspTrp: 0.868 ± 0.029
2.079AspTyr: 2.079 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.237GluAla: 5.237 ± 0.07
0.614GluCys: 0.614 ± 0.025
2.88GluAsp: 2.88 ± 0.051
4.103GluGlu: 4.103 ± 0.065
2.621GluPhe: 2.621 ± 0.048
3.653GluGly: 3.653 ± 0.063
1.718GluHis: 1.718 ± 0.036
3.874GluIle: 3.874 ± 0.062
4.149GluLys: 4.149 ± 0.061
6.983GluLeu: 6.983 ± 0.085
1.757GluMet: 1.757 ± 0.043
2.747GluAsn: 2.747 ± 0.051
2.107GluPro: 2.107 ± 0.04
4.206GluGln: 4.206 ± 0.066
3.385GluArg: 3.385 ± 0.064
4.101GluSer: 4.101 ± 0.056
3.195GluThr: 3.195 ± 0.047
4.415GluVal: 4.415 ± 0.068
0.822GluTrp: 0.822 ± 0.027
1.96GluTyr: 1.96 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.4PheAla: 3.4 ± 0.055
0.52PheCys: 0.52 ± 0.019
2.854PheAsp: 2.854 ± 0.047
2.774PheGlu: 2.774 ± 0.044
1.841PhePhe: 1.841 ± 0.047
3.077PheGly: 3.077 ± 0.056
0.872PheHis: 0.872 ± 0.026
2.934PheIle: 2.934 ± 0.056
2.167PheLys: 2.167 ± 0.046
3.481PheLeu: 3.481 ± 0.07
1.019PheMet: 1.019 ± 0.027
2.27PheAsn: 2.27 ± 0.049
1.392PhePro: 1.392 ± 0.036
1.407PheGln: 1.407 ± 0.032
1.518PheArg: 1.518 ± 0.03
3.538PheSer: 3.538 ± 0.053
2.429PheThr: 2.429 ± 0.04
2.777PheVal: 2.777 ± 0.048
0.538PheTrp: 0.538 ± 0.019
1.453PheTyr: 1.453 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
4.748GlyAla: 4.748 ± 0.067
0.85GlyCys: 0.85 ± 0.026
3.485GlyAsp: 3.485 ± 0.056
4.275GlyGlu: 4.275 ± 0.071
3.145GlyPhe: 3.145 ± 0.051
4.486GlyGly: 4.486 ± 0.076
1.596GlyHis: 1.596 ± 0.039
4.348GlyIle: 4.348 ± 0.072
3.89GlyLys: 3.89 ± 0.059
6.661GlyLeu: 6.661 ± 0.066
1.858GlyMet: 1.858 ± 0.041
2.659GlyAsn: 2.659 ± 0.047
1.576GlyPro: 1.576 ± 0.035
3.001GlyGln: 3.001 ± 0.047
3.05GlyArg: 3.05 ± 0.055
4.098GlySer: 4.098 ± 0.058
3.271GlyThr: 3.271 ± 0.058
4.685GlyVal: 4.685 ± 0.068
0.921GlyTrp: 0.921 ± 0.029
2.564GlyTyr: 2.564 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.63HisAla: 1.63 ± 0.036
0.336HisCys: 0.336 ± 0.016
1.192HisAsp: 1.192 ± 0.035
1.194HisGlu: 1.194 ± 0.036
1.159HisPhe: 1.159 ± 0.029
1.506HisGly: 1.506 ± 0.037
0.75HisHis: 0.75 ± 0.027
1.494HisIle: 1.494 ± 0.033
1.111HisLys: 1.111 ± 0.034
2.371HisLeu: 2.371 ± 0.047
0.496HisMet: 0.496 ± 0.02
0.987HisAsn: 0.987 ± 0.027
1.11HisPro: 1.11 ± 0.029
1.248HisGln: 1.248 ± 0.035
1.105HisArg: 1.105 ± 0.035
1.602HisSer: 1.602 ± 0.036
1.184HisThr: 1.184 ± 0.032
1.311HisVal: 1.311 ± 0.034
0.353HisTrp: 0.353 ± 0.016
0.965HisTyr: 0.965 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.86IleAla: 5.86 ± 0.077
0.684IleCys: 0.684 ± 0.02
4.319IleAsp: 4.319 ± 0.057
4.996IleGlu: 4.996 ± 0.075
2.327IlePhe: 2.327 ± 0.053
4.463IleGly: 4.463 ± 0.074
1.386IleHis: 1.386 ± 0.029
3.774IleIle: 3.774 ± 0.062
3.757IleLys: 3.757 ± 0.058
5.29IleLeu: 5.29 ± 0.075
1.335IleMet: 1.335 ± 0.033
3.308IleAsn: 3.308 ± 0.049
2.686IlePro: 2.686 ± 0.051
2.51IleGln: 2.51 ± 0.046
2.773IleArg: 2.773 ± 0.045
4.735IleSer: 4.735 ± 0.065
3.839IleThr: 3.839 ± 0.057
3.942IleVal: 3.942 ± 0.048
0.623IleTrp: 0.623 ± 0.025
1.83IleTyr: 1.83 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.796LysAla: 4.796 ± 0.067
0.372LysCys: 0.372 ± 0.019
2.888LysAsp: 2.888 ± 0.056
3.702LysGlu: 3.702 ± 0.057
1.742LysPhe: 1.742 ± 0.032
3.502LysGly: 3.502 ± 0.057
1.378LysHis: 1.378 ± 0.033
3.102LysIle: 3.102 ± 0.052
3.461LysLys: 3.461 ± 0.064
5.673LysLeu: 5.673 ± 0.072
1.583LysMet: 1.583 ± 0.039
2.689LysAsn: 2.689 ± 0.052
2.516LysPro: 2.516 ± 0.05
3.177LysGln: 3.177 ± 0.05
2.831LysArg: 2.831 ± 0.056
3.541LysSer: 3.541 ± 0.058
3.022LysThr: 3.022 ± 0.054
4.051LysVal: 4.051 ± 0.066
0.619LysTrp: 0.619 ± 0.02
1.674LysTyr: 1.674 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
8.925LeuAla: 8.925 ± 0.101
1.17LeuCys: 1.17 ± 0.031
5.731LeuAsp: 5.731 ± 0.07
6.479LeuGlu: 6.479 ± 0.079
4.158LeuPhe: 4.158 ± 0.069
6.586LeuGly: 6.586 ± 0.075
2.029LeuHis: 2.029 ± 0.041
6.252LeuIle: 6.252 ± 0.093
5.673LeuLys: 5.673 ± 0.076
10.066LeuLeu: 10.066 ± 0.107
2.697LeuMet: 2.697 ± 0.051
5.019LeuAsn: 5.019 ± 0.065
4.654LeuPro: 4.654 ± 0.071
3.688LeuGln: 3.688 ± 0.06
4.236LeuArg: 4.236 ± 0.06
8.345LeuSer: 8.345 ± 0.089
5.98LeuThr: 5.98 ± 0.076
6.449LeuVal: 6.449 ± 0.079
0.999LeuTrp: 0.999 ± 0.031
2.716LeuTyr: 2.716 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.373MetAla: 2.373 ± 0.048
0.226MetCys: 0.226 ± 0.011
1.297MetAsp: 1.297 ± 0.035
1.369MetGlu: 1.369 ± 0.032
1.039MetPhe: 1.039 ± 0.039
1.651MetGly: 1.651 ± 0.037
0.481MetHis: 0.481 ± 0.019
1.603MetIle: 1.603 ± 0.035
1.562MetLys: 1.562 ± 0.034
2.743MetLeu: 2.743 ± 0.05
0.797MetMet: 0.797 ± 0.026
1.223MetAsn: 1.223 ± 0.032
1.199MetPro: 1.199 ± 0.027
1.111MetGln: 1.111 ± 0.028
1.185MetArg: 1.185 ± 0.032
1.982MetSer: 1.982 ± 0.037
1.629MetThr: 1.629 ± 0.036
1.782MetVal: 1.782 ± 0.04
0.232MetTrp: 0.232 ± 0.014
0.607MetTyr: 0.607 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.381AsnAla: 3.381 ± 0.058
0.441AsnCys: 0.441 ± 0.019
2.475AsnAsp: 2.475 ± 0.046
2.838AsnGlu: 2.838 ± 0.049
1.727AsnPhe: 1.727 ± 0.036
3.135AsnGly: 3.135 ± 0.054
1.132AsnHis: 1.132 ± 0.027
3.129AsnIle: 3.129 ± 0.047
2.725AsnLys: 2.725 ± 0.055
4.201AsnLeu: 4.201 ± 0.048
1.078AsnMet: 1.078 ± 0.031
2.275AsnAsn: 2.275 ± 0.046
2.16AsnPro: 2.16 ± 0.04
2.526AsnGln: 2.526 ± 0.051
1.954AsnArg: 1.954 ± 0.034
2.812AsnSer: 2.812 ± 0.053
2.425AsnThr: 2.425 ± 0.047
2.907AsnVal: 2.907 ± 0.046
0.638AsnTrp: 0.638 ± 0.023
1.468AsnTyr: 1.468 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
2.771ProAla: 2.771 ± 0.05
0.351ProCys: 0.351 ± 0.017
2.244ProAsp: 2.244 ± 0.043
3.107ProGlu: 3.107 ± 0.058
1.752ProPhe: 1.752 ± 0.038
2.01ProGly: 2.01 ± 0.044
0.877ProHis: 0.877 ± 0.025
2.608ProIle: 2.608 ± 0.044
2.127ProLys: 2.127 ± 0.045
3.999ProLeu: 3.999 ± 0.059
1.022ProMet: 1.022 ± 0.025
1.907ProAsn: 1.907 ± 0.041
1.215ProPro: 1.215 ± 0.042
1.63ProGln: 1.63 ± 0.036
1.338ProArg: 1.338 ± 0.036
2.801ProSer: 2.801 ± 0.052
2.3ProThr: 2.3 ± 0.044
2.818ProVal: 2.818 ± 0.048
0.499ProTrp: 0.499 ± 0.026
1.288ProTyr: 1.288 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.416GlnAla: 4.416 ± 0.067
0.472GlnCys: 0.472 ± 0.022
2.325GlnAsp: 2.325 ± 0.04
2.745GlnGlu: 2.745 ± 0.051
1.827GlnPhe: 1.827 ± 0.037
2.977GlnGly: 2.977 ± 0.051
1.21GlnHis: 1.21 ± 0.03
2.654GlnIle: 2.654 ± 0.045
2.392GlnLys: 2.392 ± 0.046
5.1GlnLeu: 5.1 ± 0.077
1.172GlnMet: 1.172 ± 0.029
1.79GlnAsn: 1.79 ± 0.037
1.846GlnPro: 1.846 ± 0.042
3.151GlnGln: 3.151 ± 0.077
2.448GlnArg: 2.448 ± 0.045
3.049GlnSer: 3.049 ± 0.056
2.449GlnThr: 2.449 ± 0.044
3.226GlnVal: 3.226 ± 0.052
0.672GlnTrp: 0.672 ± 0.024
1.59GlnTyr: 1.59 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.205ArgAla: 3.205 ± 0.051
0.499ArgCys: 0.499 ± 0.021
2.428ArgAsp: 2.428 ± 0.042
2.944ArgGlu: 2.944 ± 0.053
2.273ArgPhe: 2.273 ± 0.045
2.465ArgGly: 2.465 ± 0.044
1.088ArgHis: 1.088 ± 0.032
2.987ArgIle: 2.987 ± 0.046
2.447ArgLys: 2.447 ± 0.046
4.859ArgLeu: 4.859 ± 0.069
1.135ArgMet: 1.135 ± 0.028
1.961ArgAsn: 1.961 ± 0.04
1.554ArgPro: 1.554 ± 0.039
2.173ArgGln: 2.173 ± 0.047
2.26ArgArg: 2.26 ± 0.047
2.696ArgSer: 2.696 ± 0.047
2.107ArgThr: 2.107 ± 0.04
3.085ArgVal: 3.085 ± 0.053
0.596ArgTrp: 0.596 ± 0.021
1.761ArgTyr: 1.761 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.325SerAla: 5.325 ± 0.064
0.707SerCys: 0.707 ± 0.027
3.821SerAsp: 3.821 ± 0.06
4.249SerGlu: 4.249 ± 0.065
3.042SerPhe: 3.042 ± 0.053
4.991SerGly: 4.991 ± 0.074
1.711SerHis: 1.711 ± 0.042
4.595SerIle: 4.595 ± 0.065
3.528SerLys: 3.528 ± 0.054
7.36SerLeu: 7.36 ± 0.092
1.851SerMet: 1.851 ± 0.036
3.053SerAsn: 3.053 ± 0.059
2.637SerPro: 2.637 ± 0.047
3.241SerGln: 3.241 ± 0.06
2.883SerArg: 2.883 ± 0.047
5.089SerSer: 5.089 ± 0.086
3.507SerThr: 3.507 ± 0.05
4.64SerVal: 4.64 ± 0.069
0.892SerTrp: 0.892 ± 0.025
2.201SerTyr: 2.201 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
4.069ThrAla: 4.069 ± 0.066
0.499ThrCys: 0.499 ± 0.021
2.895ThrAsp: 2.895 ± 0.056
3.209ThrGlu: 3.209 ± 0.059
2.255ThrPhe: 2.255 ± 0.046
3.845ThrGly: 3.845 ± 0.057
1.256ThrHis: 1.256 ± 0.038
3.547ThrIle: 3.547 ± 0.063
2.632ThrLys: 2.632 ± 0.045
6.201ThrLeu: 6.201 ± 0.078
1.24ThrMet: 1.24 ± 0.03
2.228ThrAsn: 2.228 ± 0.043
2.63ThrPro: 2.63 ± 0.049
2.728ThrGln: 2.728 ± 0.05
2.24ThrArg: 2.24 ± 0.042
3.584ThrSer: 3.584 ± 0.062
3.029ThrThr: 3.029 ± 0.07
3.631ThrVal: 3.631 ± 0.054
0.581ThrTrp: 0.581 ± 0.022
1.562ThrTyr: 1.562 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.506ValAla: 5.506 ± 0.074
0.784ValCys: 0.784 ± 0.02
3.942ValAsp: 3.942 ± 0.066
4.654ValGlu: 4.654 ± 0.07
2.709ValPhe: 2.709 ± 0.046
4.297ValGly: 4.297 ± 0.056
1.234ValHis: 1.234 ± 0.029
4.624ValIle: 4.624 ± 0.06
3.846ValLys: 3.846 ± 0.059
6.368ValLeu: 6.368 ± 0.075
1.884ValMet: 1.884 ± 0.039
3.059ValAsn: 3.059 ± 0.05
2.489ValPro: 2.489 ± 0.048
2.285ValGln: 2.285 ± 0.047
2.818ValArg: 2.818 ± 0.051
4.854ValSer: 4.854 ± 0.062
4.107ValThr: 4.107 ± 0.078
4.906ValVal: 4.906 ± 0.069
0.757ValTrp: 0.757 ± 0.03
1.828ValTyr: 1.828 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.828TrpAla: 0.828 ± 0.024
0.168TrpCys: 0.168 ± 0.012
0.673TrpAsp: 0.673 ± 0.031
0.587TrpGlu: 0.587 ± 0.024
0.642TrpPhe: 0.642 ± 0.023
0.716TrpGly: 0.716 ± 0.026
0.38TrpHis: 0.38 ± 0.018
0.65TrpIle: 0.65 ± 0.02
0.601TrpLys: 0.601 ± 0.024
1.645TrpLeu: 1.645 ± 0.043
0.321TrpMet: 0.321 ± 0.016
0.501TrpAsn: 0.501 ± 0.018
0.447TrpPro: 0.447 ± 0.016
0.943TrpGln: 0.943 ± 0.031
0.655TrpArg: 0.655 ± 0.024
0.758TrpSer: 0.758 ± 0.03
0.458TrpThr: 0.458 ± 0.019
0.816TrpVal: 0.816 ± 0.026
0.186TrpTrp: 0.186 ± 0.013
0.407TrpTyr: 0.407 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.112TyrAla: 2.112 ± 0.045
0.397TyrCys: 0.397 ± 0.017
1.852TyrAsp: 1.852 ± 0.045
1.637TyrGlu: 1.637 ± 0.038
1.502TyrPhe: 1.502 ± 0.037
2.025TyrGly: 2.025 ± 0.038
0.871TyrHis: 0.871 ± 0.025
1.795TyrIle: 1.795 ± 0.04
1.561TyrLys: 1.561 ± 0.037
3.448TyrLeu: 3.448 ± 0.063
0.695TyrMet: 0.695 ± 0.023
1.321TyrAsn: 1.321 ± 0.033
1.393TyrPro: 1.393 ± 0.028
2.013TyrGln: 2.013 ± 0.041
1.77TyrArg: 1.77 ± 0.038
2.252TyrSer: 2.252 ± 0.041
1.634TyrThr: 1.634 ± 0.041
1.861TyrVal: 1.861 ± 0.035
0.529TyrTrp: 0.529 ± 0.02
1.123TyrTyr: 1.123 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4147 proteins (1329685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski