Amino acid dipepetide frequency for Rhizopogon vesiculosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.462AlaAla: 7.462 ± 0.051	1.147AlaCys: 1.147 ± 0.016	3.899AlaAsp: 3.899 ± 0.026	4.431AlaGlu: 4.431 ± 0.036	3.197AlaPhe: 3.197 ± 0.028	4.83AlaGly: 4.83 ± 0.035	2.031AlaHis: 2.031 ± 0.023	4.207AlaIle: 4.207 ± 0.034	3.541AlaLys: 3.541 ± 0.032	8.183AlaLeu: 8.183 ± 0.048	1.872AlaMet: 1.872 ± 0.019	2.646AlaAsn: 2.646 ± 0.022	4.806AlaPro: 4.806 ± 0.045	3.224AlaGln: 3.224 ± 0.028	4.894AlaArg: 4.894 ± 0.033	7.372AlaSer: 7.372 ± 0.045	4.92AlaThr: 4.92 ± 0.034	5.271AlaVal: 5.271 ± 0.035	1.099AlaTrp: 1.099 ± 0.016	2.081AlaTyr: 2.081 ± 0.022	0.029AlaXaa: 0.029 ± 0.002
Cys	1.007CysAla: 1.007 ± 0.016	0.259CysCys: 0.259 ± 0.008	0.694CysAsp: 0.694 ± 0.012	0.598CysGlu: 0.598 ± 0.012	0.577CysPhe: 0.577 ± 0.011	0.888CysGly: 0.888 ± 0.015	0.373CysHis: 0.373 ± 0.008	0.839CysIle: 0.839 ± 0.014	0.523CysLys: 0.523 ± 0.011	1.329CysLeu: 1.329 ± 0.019	0.33CysMet: 0.33 ± 0.009	0.475CysAsn: 0.475 ± 0.009	0.814CysPro: 0.814 ± 0.017	0.453CysGln: 0.453 ± 0.009	0.793CysArg: 0.793 ± 0.014	1.085CysSer: 1.085 ± 0.015	0.781CysThr: 0.781 ± 0.013	0.828CysVal: 0.828 ± 0.012	0.209CysTrp: 0.209 ± 0.007	0.35CysTyr: 0.35 ± 0.009	0.004CysXaa: 0.004 ± 0.001
Asp	4.68AspAla: 4.68 ± 0.035	0.629AspCys: 0.629 ± 0.011	4.229AspAsp: 4.229 ± 0.047	4.253AspGlu: 4.253 ± 0.038	2.058AspPhe: 2.058 ± 0.021	3.711AspGly: 3.711 ± 0.028	1.35AspHis: 1.35 ± 0.017	3.348AspIle: 3.348 ± 0.028	2.145AspLys: 2.145 ± 0.022	5.011AspLeu: 5.011 ± 0.034	1.307AspMet: 1.307 ± 0.017	1.782AspAsn: 1.782 ± 0.019	3.241AspPro: 3.241 ± 0.024	1.632AspGln: 1.632 ± 0.02	2.839AspArg: 2.839 ± 0.028	4.091AspSer: 4.091 ± 0.03	3.053AspThr: 3.053 ± 0.025	4.081AspVal: 4.081 ± 0.029	0.837AspTrp: 0.837 ± 0.015	1.436AspTyr: 1.436 ± 0.02	0.011AspXaa: 0.011 ± 0.002
Glu	4.584GluAla: 4.584 ± 0.041	0.682GluCys: 0.682 ± 0.013	3.981GluAsp: 3.981 ± 0.036	4.863GluGlu: 4.863 ± 0.053	1.865GluPhe: 1.865 ± 0.021	3.413GluGly: 3.413 ± 0.031	1.478GluHis: 1.478 ± 0.018	2.804GluIle: 2.804 ± 0.028	2.937GluLys: 2.937 ± 0.025	5.184GluLeu: 5.184 ± 0.036	1.351GluMet: 1.351 ± 0.017	1.876GluAsn: 1.876 ± 0.019	2.49GluPro: 2.49 ± 0.021	2.187GluGln: 2.187 ± 0.025	3.787GluArg: 3.787 ± 0.036	4.012GluSer: 4.012 ± 0.034	2.957GluThr: 2.957 ± 0.027	3.643GluVal: 3.643 ± 0.027	0.858GluTrp: 0.858 ± 0.013	1.504GluTyr: 1.504 ± 0.017	0.009GluXaa: 0.009 ± 0.001
Phe	3.023PheAla: 3.023 ± 0.027	0.574PheCys: 0.574 ± 0.01	2.201PheAsp: 2.201 ± 0.018	1.97PheGlu: 1.97 ± 0.019	1.599PhePhe: 1.599 ± 0.02	2.642PheGly: 2.642 ± 0.029	0.993PheHis: 0.993 ± 0.013	1.996PheIle: 1.996 ± 0.019	1.495PheLys: 1.495 ± 0.015	3.563PheLeu: 3.563 ± 0.029	0.861PheMet: 0.861 ± 0.014	1.393PheAsn: 1.393 ± 0.016	2.102PhePro: 2.102 ± 0.02	1.298PheGln: 1.298 ± 0.017	1.955PheArg: 1.955 ± 0.019	3.349PheSer: 3.349 ± 0.025	2.294PheThr: 2.294 ± 0.023	2.504PheVal: 2.504 ± 0.024	0.574PheTrp: 0.574 ± 0.01	1.078PheTyr: 1.078 ± 0.017	0.006PheXaa: 0.006 ± 0.001
Gly	4.569GlyAla: 4.569 ± 0.033	0.858GlyCys: 0.858 ± 0.015	3.278GlyAsp: 3.278 ± 0.029	3.291GlyGlu: 3.291 ± 0.026	2.381GlyPhe: 2.381 ± 0.027	4.718GlyGly: 4.718 ± 0.042	1.724GlyHis: 1.724 ± 0.019	3.287GlyIle: 3.287 ± 0.028	3.181GlyLys: 3.181 ± 0.029	5.378GlyLeu: 5.378 ± 0.032	1.515GlyMet: 1.515 ± 0.018	2.087GlyAsn: 2.087 ± 0.02	2.971GlyPro: 2.971 ± 0.029	2.156GlyGln: 2.156 ± 0.021	3.695GlyArg: 3.695 ± 0.031	5.269GlySer: 5.269 ± 0.034	3.714GlyThr: 3.714 ± 0.029	4.107GlyVal: 4.107 ± 0.031	0.99GlyTrp: 0.99 ± 0.013	1.791GlyTyr: 1.791 ± 0.022	0.023GlyXaa: 0.023 ± 0.002
His	2.159HisAla: 2.159 ± 0.021	0.391HisCys: 0.391 ± 0.009	1.471HisAsp: 1.471 ± 0.018	1.339HisGlu: 1.339 ± 0.017	1.038HisPhe: 1.038 ± 0.015	1.632HisGly: 1.632 ± 0.02	0.969HisHis: 0.969 ± 0.015	1.481HisIle: 1.481 ± 0.018	0.941HisLys: 0.941 ± 0.014	2.629HisLeu: 2.629 ± 0.021	0.532HisMet: 0.532 ± 0.01	0.872HisAsn: 0.872 ± 0.015	2.038HisPro: 2.038 ± 0.02	0.98HisGln: 0.98 ± 0.015	1.658HisArg: 1.658 ± 0.022	2.416HisSer: 2.416 ± 0.028	1.613HisThr: 1.613 ± 0.021	1.747HisVal: 1.747 ± 0.017	0.376HisTrp: 0.376 ± 0.009	0.732HisTyr: 0.732 ± 0.011	0.005HisXaa: 0.005 ± 0.001
Ile	4.306IleAla: 4.306 ± 0.031	0.809IleCys: 0.809 ± 0.014	2.932IleAsp: 2.932 ± 0.026	2.667IleGlu: 2.667 ± 0.024	2.097IlePhe: 2.097 ± 0.026	2.975IleGly: 2.975 ± 0.026	1.36IleHis: 1.36 ± 0.018	2.793IleIle: 2.793 ± 0.03	1.998IleLys: 1.998 ± 0.019	4.819IleLeu: 4.819 ± 0.038	1.108IleMet: 1.108 ± 0.015	1.749IleAsn: 1.749 ± 0.019	3.495IlePro: 3.495 ± 0.025	1.913IleGln: 1.913 ± 0.018	2.91IleArg: 2.91 ± 0.028	4.419IleSer: 4.419 ± 0.033	3.073IleThr: 3.073 ± 0.026	3.4IleVal: 3.4 ± 0.03	0.74IleTrp: 0.74 ± 0.013	1.403IleTyr: 1.403 ± 0.02	0.01IleXaa: 0.01 ± 0.001
Lys	3.738LysAla: 3.738 ± 0.035	0.531LysCys: 0.531 ± 0.013	2.467LysAsp: 2.467 ± 0.027	2.89LysGlu: 2.89 ± 0.031	1.406LysPhe: 1.406 ± 0.015	2.609LysGly: 2.609 ± 0.029	1.149LysHis: 1.149 ± 0.015	2.018LysIle: 2.018 ± 0.021	2.82LysLys: 2.82 ± 0.038	3.88LysLeu: 3.88 ± 0.028	0.956LysMet: 0.956 ± 0.015	1.437LysAsn: 1.437 ± 0.018	2.387LysPro: 2.387 ± 0.022	1.638LysGln: 1.638 ± 0.02	3.234LysArg: 3.234 ± 0.031	3.315LysSer: 3.315 ± 0.028	2.394LysThr: 2.394 ± 0.023	2.688LysVal: 2.688 ± 0.025	0.632LysTrp: 0.632 ± 0.01	1.219LysTyr: 1.219 ± 0.016	0.008LysXaa: 0.008 ± 0.001
Leu	7.863LeuAla: 7.863 ± 0.048	1.337LeuCys: 1.337 ± 0.017	5.24LeuAsp: 5.24 ± 0.038	5.276LeuGlu: 5.276 ± 0.035	3.469LeuPhe: 3.469 ± 0.032	5.304LeuGly: 5.304 ± 0.033	2.673LeuHis: 2.673 ± 0.024	4.213LeuIle: 4.213 ± 0.032	3.977LeuLys: 3.977 ± 0.031	8.884LeuLeu: 8.884 ± 0.054	1.875LeuMet: 1.875 ± 0.02	3.171LeuAsn: 3.171 ± 0.027	6.269LeuPro: 6.269 ± 0.045	3.899LeuGln: 3.899 ± 0.034	5.942LeuArg: 5.942 ± 0.042	8.426LeuSer: 8.426 ± 0.044	5.419LeuThr: 5.419 ± 0.034	5.712LeuVal: 5.712 ± 0.043	1.212LeuTrp: 1.212 ± 0.017	2.377LeuTyr: 2.377 ± 0.024	0.023LeuXaa: 0.023 ± 0.002
Met	1.811MetAla: 1.811 ± 0.021	0.276MetCys: 0.276 ± 0.009	1.302MetAsp: 1.302 ± 0.017	1.22MetGlu: 1.22 ± 0.014	0.819MetPhe: 0.819 ± 0.014	1.289MetGly: 1.289 ± 0.019	0.621MetHis: 0.621 ± 0.01	1.063MetIle: 1.063 ± 0.018	1.01MetLys: 1.01 ± 0.015	1.984MetLeu: 1.984 ± 0.019	0.58MetMet: 0.58 ± 0.012	0.827MetAsn: 0.827 ± 0.011	1.303MetPro: 1.303 ± 0.016	0.921MetGln: 0.921 ± 0.013	1.338MetArg: 1.338 ± 0.015	2.209MetSer: 2.209 ± 0.024	1.407MetThr: 1.407 ± 0.017	1.311MetVal: 1.311 ± 0.015	0.275MetTrp: 0.275 ± 0.007	0.559MetTyr: 0.559 ± 0.01	0.004MetXaa: 0.004 ± 0.001
Asn	2.991AsnAla: 2.991 ± 0.025	0.404AsnCys: 0.404 ± 0.01	1.845AsnAsp: 1.845 ± 0.019	1.733AsnGlu: 1.733 ± 0.018	1.326AsnPhe: 1.326 ± 0.017	2.415AsnGly: 2.415 ± 0.026	0.884AsnHis: 0.884 ± 0.012	2.046AsnIle: 2.046 ± 0.02	1.296AsnLys: 1.296 ± 0.016	3.171AsnLeu: 3.171 ± 0.026	0.796AsnMet: 0.796 ± 0.014	1.276AsnAsn: 1.276 ± 0.017	2.238AsnPro: 2.238 ± 0.021	1.155AsnGln: 1.155 ± 0.013	1.685AsnArg: 1.685 ± 0.015	2.696AsnSer: 2.696 ± 0.022	2.101AsnThr: 2.101 ± 0.021	2.402AsnVal: 2.402 ± 0.02	0.461AsnTrp: 0.461 ± 0.01	0.934AsnTyr: 0.934 ± 0.013	0.006AsnXaa: 0.006 ± 0.001
Pro	4.936ProAla: 4.936 ± 0.045	0.59ProCys: 0.59 ± 0.012	3.217ProAsp: 3.217 ± 0.027	3.416ProGlu: 3.416 ± 0.026	2.181ProPhe: 2.181 ± 0.021	3.566ProGly: 3.566 ± 0.029	1.732ProHis: 1.732 ± 0.021	2.782ProIle: 2.782 ± 0.026	2.319ProLys: 2.319 ± 0.024	5.448ProLeu: 5.448 ± 0.035	1.133ProMet: 1.133 ± 0.015	2.128ProAsn: 2.128 ± 0.023	6.218ProPro: 6.218 ± 0.081	2.508ProGln: 2.508 ± 0.028	3.499ProArg: 3.499 ± 0.035	7.55ProSer: 7.55 ± 0.062	4.303ProThr: 4.303 ± 0.035	3.939ProVal: 3.939 ± 0.035	0.73ProTrp: 0.73 ± 0.013	1.594ProTyr: 1.594 ± 0.02	0.017ProXaa: 0.017 ± 0.002
Gln	3.12GlnAla: 3.12 ± 0.03	0.506GlnCys: 0.506 ± 0.011	1.938GlnAsp: 1.938 ± 0.022	2.169GlnGlu: 2.169 ± 0.023	1.242GlnPhe: 1.242 ± 0.018	2.148GlnGly: 2.148 ± 0.022	1.136GlnHis: 1.136 ± 0.019	1.805GlnIle: 1.805 ± 0.021	1.627GlnLys: 1.627 ± 0.019	3.508GlnLeu: 3.508 ± 0.029	0.844GlnMet: 0.844 ± 0.013	1.335GlnAsn: 1.335 ± 0.016	2.506GlnPro: 2.506 ± 0.029	1.927GlnGln: 1.927 ± 0.032	2.512GlnArg: 2.512 ± 0.024	3.272GlnSer: 3.272 ± 0.028	2.193GlnThr: 2.193 ± 0.021	2.248GlnVal: 2.248 ± 0.022	0.561GlnTrp: 0.561 ± 0.012	1.07GlnTyr: 1.07 ± 0.014	0.007GlnXaa: 0.007 ± 0.001
Arg	4.87ArgAla: 4.87 ± 0.036	0.798ArgCys: 0.798 ± 0.014	3.227ArgAsp: 3.227 ± 0.033	3.577ArgGlu: 3.577 ± 0.039	2.171ArgPhe: 2.171 ± 0.024	3.407ArgGly: 3.407 ± 0.031	1.643ArgHis: 1.643 ± 0.018	3.043ArgIle: 3.043 ± 0.026	3.176ArgLys: 3.176 ± 0.029	5.468ArgLeu: 5.468 ± 0.04	1.42ArgMet: 1.42 ± 0.017	1.986ArgAsn: 1.986 ± 0.02	3.578ArgPro: 3.578 ± 0.034	2.294ArgGln: 2.294 ± 0.023	4.901ArgArg: 4.901 ± 0.046	5.143ArgSer: 5.143 ± 0.044	3.52ArgThr: 3.52 ± 0.026	3.635ArgVal: 3.635 ± 0.027	0.938ArgTrp: 0.938 ± 0.016	1.592ArgTyr: 1.592 ± 0.02	0.016ArgXaa: 0.016 ± 0.002
Ser	6.945SerAla: 6.945 ± 0.044	1.081SerCys: 1.081 ± 0.017	4.658SerAsp: 4.658 ± 0.032	4.11SerGlu: 4.11 ± 0.034	3.397SerPhe: 3.397 ± 0.028	5.404SerGly: 5.404 ± 0.035	2.411SerHis: 2.411 ± 0.026	4.378SerIle: 4.378 ± 0.031	3.447SerLys: 3.447 ± 0.03	8.32SerLeu: 8.32 ± 0.046	1.96SerMet: 1.96 ± 0.019	2.986SerAsn: 2.986 ± 0.028	6.605SerPro: 6.605 ± 0.066	3.386SerGln: 3.386 ± 0.034	5.356SerArg: 5.356 ± 0.044	10.757SerSer: 10.757 ± 0.089	6.314SerThr: 6.314 ± 0.046	5.222SerVal: 5.222 ± 0.033	1.082SerTrp: 1.082 ± 0.016	2.231SerTyr: 2.231 ± 0.021	0.023SerXaa: 0.023 ± 0.002
Thr	4.799ThrAla: 4.799 ± 0.032	0.817ThrCys: 0.817 ± 0.014	2.772ThrAsp: 2.772 ± 0.028	2.791ThrGlu: 2.791 ± 0.024	2.442ThrPhe: 2.442 ± 0.021	3.676ThrGly: 3.676 ± 0.031	1.598ThrHis: 1.598 ± 0.017	3.272ThrIle: 3.272 ± 0.025	2.359ThrLys: 2.359 ± 0.02	5.847ThrLeu: 5.847 ± 0.037	1.27ThrMet: 1.27 ± 0.014	1.982ThrAsn: 1.982 ± 0.02	4.618ThrPro: 4.618 ± 0.046	2.133ThrGln: 2.133 ± 0.02	3.378ThrArg: 3.378 ± 0.031	6.241ThrSer: 6.241 ± 0.048	4.22ThrThr: 4.22 ± 0.039	3.767ThrVal: 3.767 ± 0.029	0.811ThrTrp: 0.811 ± 0.014	1.611ThrTyr: 1.611 ± 0.018	0.02ThrXaa: 0.02 ± 0.002
Val	5.138ValAla: 5.138 ± 0.037	0.871ValCys: 0.871 ± 0.013	3.815ValAsp: 3.815 ± 0.028	3.712ValGlu: 3.712 ± 0.03	2.489ValPhe: 2.489 ± 0.024	3.729ValGly: 3.729 ± 0.031	1.751ValHis: 1.751 ± 0.021	3.41ValIle: 3.41 ± 0.032	2.84ValLys: 2.84 ± 0.027	6.133ValLeu: 6.133 ± 0.04	1.44ValMet: 1.44 ± 0.018	2.222ValAsn: 2.222 ± 0.025	3.964ValPro: 3.964 ± 0.032	2.461ValGln: 2.461 ± 0.023	3.58ValArg: 3.58 ± 0.029	5.146ValSer: 5.146 ± 0.034	3.665ValThr: 3.665 ± 0.027	4.535ValVal: 4.535 ± 0.038	0.911ValTrp: 0.911 ± 0.015	1.703ValTyr: 1.703 ± 0.018	0.017ValXaa: 0.017 ± 0.002
Trp	1.013TrpAla: 1.013 ± 0.014	0.229TrpCys: 0.229 ± 0.007	0.903TrpAsp: 0.903 ± 0.016	0.777TrpGlu: 0.777 ± 0.011	0.547TrpPhe: 0.547 ± 0.01	0.831TrpGly: 0.831 ± 0.015	0.363TrpHis: 0.363 ± 0.009	0.739TrpIle: 0.739 ± 0.013	0.765TrpLys: 0.765 ± 0.013	1.265TrpLeu: 1.265 ± 0.019	0.379TrpMet: 0.379 ± 0.009	0.608TrpAsn: 0.608 ± 0.012	0.564TrpPro: 0.564 ± 0.012	0.513TrpGln: 0.513 ± 0.01	0.924TrpArg: 0.924 ± 0.013	1.137TrpSer: 1.137 ± 0.017	0.885TrpThr: 0.885 ± 0.013	0.841TrpVal: 0.841 ± 0.013	0.295TrpTrp: 0.295 ± 0.008	0.391TrpTyr: 0.391 ± 0.01	0.003TrpXaa: 0.003 ± 0.001
Tyr	2.109TyrAla: 2.109 ± 0.02	0.415TyrCys: 0.415 ± 0.008	1.644TyrAsp: 1.644 ± 0.02	1.371TyrGlu: 1.371 ± 0.018	1.16TyrPhe: 1.16 ± 0.016	1.781TyrGly: 1.781 ± 0.021	0.77TyrHis: 0.77 ± 0.012	1.441TyrIle: 1.441 ± 0.017	1.01TyrLys: 1.01 ± 0.015	2.534TyrLeu: 2.534 ± 0.023	0.589TyrMet: 0.589 ± 0.01	1.017TyrAsn: 1.017 ± 0.014	1.583TyrPro: 1.583 ± 0.025	0.985TyrGln: 0.985 ± 0.014	1.507TyrArg: 1.507 ± 0.018	2.146TyrSer: 2.146 ± 0.021	1.582TyrThr: 1.582 ± 0.019	1.637TyrVal: 1.637 ± 0.021	0.377TyrTrp: 0.377 ± 0.008	0.869TyrTyr: 0.869 ± 0.017	0.006TyrXaa: 0.006 ± 0.001
Xaa	0.02XaaAla: 0.02 ± 0.002	0.006XaaCys: 0.006 ± 0.001	0.01XaaAsp: 0.01 ± 0.001	0.012XaaGlu: 0.012 ± 0.002	0.009XaaPhe: 0.009 ± 0.001	0.015XaaGly: 0.015 ± 0.002	0.008XaaHis: 0.008 ± 0.001	0.011XaaIle: 0.011 ± 0.002	0.009XaaLys: 0.009 ± 0.001	0.024XaaLeu: 0.024 ± 0.002	0.008XaaMet: 0.008 ± 0.001	0.007XaaAsn: 0.007 ± 0.001	0.016XaaPro: 0.016 ± 0.002	0.009XaaGln: 0.009 ± 0.001	0.018XaaArg: 0.018 ± 0.002	0.022XaaSer: 0.022 ± 0.002	0.015XaaThr: 0.015 ± 0.002	0.014XaaVal: 0.014 ± 0.002	0.004XaaTrp: 0.004 ± 0.001	0.007XaaTyr: 0.007 ± 0.001	8.383XaaXaa: 8.383 ± 0.347

Statistics based on 14146 proteins (5198710 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---