Amino acid dipepetide frequency for Oceanicola sp. 22II-s10i

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.304AlaAla: 17.304 ± 0.162
1.107AlaCys: 1.107 ± 0.03
7.083AlaAsp: 7.083 ± 0.081
8.7AlaGlu: 8.7 ± 0.104
4.357AlaPhe: 4.357 ± 0.063
11.187AlaGly: 11.187 ± 0.1
2.224AlaHis: 2.224 ± 0.046
6.034AlaIle: 6.034 ± 0.067
3.619AlaLys: 3.619 ± 0.058
13.762AlaLeu: 13.762 ± 0.134
4.046AlaMet: 4.046 ± 0.066
2.547AlaAsn: 2.547 ± 0.045
5.901AlaPro: 5.901 ± 0.074
4.03AlaGln: 4.03 ± 0.059
9.198AlaArg: 9.198 ± 0.108
5.377AlaSer: 5.377 ± 0.073
6.171AlaThr: 6.171 ± 0.076
8.721AlaVal: 8.721 ± 0.095
1.483AlaTrp: 1.483 ± 0.035
2.587AlaTyr: 2.587 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.027CysAla: 1.027 ± 0.029
0.109CysCys: 0.109 ± 0.01
0.604CysAsp: 0.604 ± 0.023
0.449CysGlu: 0.449 ± 0.018
0.319CysPhe: 0.319 ± 0.014
0.94CysGly: 0.94 ± 0.03
0.279CysHis: 0.279 ± 0.017
0.398CysIle: 0.398 ± 0.016
0.194CysLys: 0.194 ± 0.012
0.829CysLeu: 0.829 ± 0.027
0.17CysMet: 0.17 ± 0.011
0.203CysAsn: 0.203 ± 0.011
0.49CysPro: 0.49 ± 0.02
0.23CysGln: 0.23 ± 0.014
0.589CysArg: 0.589 ± 0.023
0.419CysSer: 0.419 ± 0.017
0.453CysThr: 0.453 ± 0.019
0.631CysVal: 0.631 ± 0.022
0.113CysTrp: 0.113 ± 0.009
0.203CysTyr: 0.203 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.278AspAla: 7.278 ± 0.092
0.525AspCys: 0.525 ± 0.022
3.442AspAsp: 3.442 ± 0.056
3.646AspGlu: 3.646 ± 0.066
2.298AspPhe: 2.298 ± 0.041
5.831AspGly: 5.831 ± 0.081
1.335AspHis: 1.335 ± 0.034
3.07AspIle: 3.07 ± 0.049
1.628AspLys: 1.628 ± 0.038
6.419AspLeu: 6.419 ± 0.068
1.805AspMet: 1.805 ± 0.033
1.23AspAsn: 1.23 ± 0.029
3.859AspPro: 3.859 ± 0.054
1.613AspGln: 1.613 ± 0.039
5.101AspArg: 5.101 ± 0.073
2.152AspSer: 2.152 ± 0.046
3.162AspThr: 3.162 ± 0.053
4.2AspVal: 4.2 ± 0.054
1.184AspTrp: 1.184 ± 0.032
1.562AspTyr: 1.562 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
8.446GluAla: 8.446 ± 0.106
0.383GluCys: 0.383 ± 0.015
3.541GluAsp: 3.541 ± 0.06
3.607GluGlu: 3.607 ± 0.072
1.838GluPhe: 1.838 ± 0.035
5.258GluGly: 5.258 ± 0.062
1.074GluHis: 1.074 ± 0.031
3.603GluIle: 3.603 ± 0.054
2.201GluLys: 2.201 ± 0.047
5.002GluLeu: 5.002 ± 0.068
1.956GluMet: 1.956 ± 0.04
1.59GluAsn: 1.59 ± 0.034
2.605GluPro: 2.605 ± 0.053
1.812GluGln: 1.812 ± 0.042
4.367GluArg: 4.367 ± 0.064
2.132GluSer: 2.132 ± 0.041
3.806GluThr: 3.806 ± 0.05
4.655GluVal: 4.655 ± 0.056
0.745GluTrp: 0.745 ± 0.027
1.017GluTyr: 1.017 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.437PheAla: 4.437 ± 0.059
0.42PheCys: 0.42 ± 0.016
2.848PheAsp: 2.848 ± 0.049
2.115PheGlu: 2.115 ± 0.038
1.376PhePhe: 1.376 ± 0.037
3.843PheGly: 3.843 ± 0.059
0.706PheHis: 0.706 ± 0.022
1.58PheIle: 1.58 ± 0.04
0.799PheLys: 0.799 ± 0.024
3.255PheLeu: 3.255 ± 0.055
0.822PheMet: 0.822 ± 0.026
0.986PheAsn: 0.986 ± 0.028
1.586PhePro: 1.586 ± 0.038
0.92PheGln: 0.92 ± 0.026
2.429PheArg: 2.429 ± 0.046
2.071PheSer: 2.071 ± 0.043
2.042PheThr: 2.042 ± 0.052
2.701PheVal: 2.701 ± 0.052
0.539PheTrp: 0.539 ± 0.018
0.916PheTyr: 0.916 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.485GlyAla: 10.485 ± 0.103
0.82GlyCys: 0.82 ± 0.025
5.058GlyAsp: 5.058 ± 0.074
4.905GlyGlu: 4.905 ± 0.056
3.684GlyPhe: 3.684 ± 0.058
8.139GlyGly: 8.139 ± 0.103
2.049GlyHis: 2.049 ± 0.043
4.789GlyIle: 4.789 ± 0.059
3.037GlyLys: 3.037 ± 0.055
9.415GlyLeu: 9.415 ± 0.098
2.928GlyMet: 2.928 ± 0.053
2.107GlyAsn: 2.107 ± 0.053
4.098GlyPro: 4.098 ± 0.055
3.062GlyGln: 3.062 ± 0.048
6.264GlyArg: 6.264 ± 0.076
4.367GlySer: 4.367 ± 0.074
5.046GlyThr: 5.046 ± 0.066
6.536GlyVal: 6.536 ± 0.072
1.61GlyTrp: 1.61 ± 0.032
2.391GlyTyr: 2.391 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.306HisAla: 2.306 ± 0.046
0.22HisCys: 0.22 ± 0.013
1.266HisAsp: 1.266 ± 0.033
1.042HisGlu: 1.042 ± 0.029
0.8HisPhe: 0.8 ± 0.025
1.952HisGly: 1.952 ± 0.038
0.548HisHis: 0.548 ± 0.021
0.932HisIle: 0.932 ± 0.027
0.481HisLys: 0.481 ± 0.019
1.975HisLeu: 1.975 ± 0.035
0.555HisMet: 0.555 ± 0.019
0.447HisAsn: 0.447 ± 0.017
1.407HisPro: 1.407 ± 0.031
0.477HisGln: 0.477 ± 0.017
1.327HisArg: 1.327 ± 0.033
0.859HisSer: 0.859 ± 0.023
0.841HisThr: 0.841 ± 0.024
1.541HisVal: 1.541 ± 0.036
0.377HisTrp: 0.377 ± 0.019
0.584HisTyr: 0.584 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.338IleAla: 7.338 ± 0.075
0.6IleCys: 0.6 ± 0.021
3.355IleAsp: 3.355 ± 0.05
3.521IleGlu: 3.521 ± 0.054
1.726IlePhe: 1.726 ± 0.04
5.192IleGly: 5.192 ± 0.06
0.937IleHis: 0.937 ± 0.025
2.053IleIle: 2.053 ± 0.04
1.184IleLys: 1.184 ± 0.032
4.726IleLeu: 4.726 ± 0.069
1.091IleMet: 1.091 ± 0.027
1.186IleAsn: 1.186 ± 0.032
2.381IlePro: 2.381 ± 0.04
1.087IleGln: 1.087 ± 0.026
3.442IleArg: 3.442 ± 0.047
2.69IleSer: 2.69 ± 0.048
2.809IleThr: 2.809 ± 0.049
3.987IleVal: 3.987 ± 0.062
0.67IleTrp: 0.67 ± 0.021
1.149IleTyr: 1.149 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.843LysAla: 3.843 ± 0.067
0.166LysCys: 0.166 ± 0.013
1.746LysAsp: 1.746 ± 0.038
1.54LysGlu: 1.54 ± 0.037
0.88LysPhe: 0.88 ± 0.026
2.671LysGly: 2.671 ± 0.051
0.54LysHis: 0.54 ± 0.02
1.481LysIle: 1.481 ± 0.039
1.074LysLys: 1.074 ± 0.031
2.793LysLeu: 2.793 ± 0.048
0.826LysMet: 0.826 ± 0.028
0.664LysAsn: 0.664 ± 0.022
1.683LysPro: 1.683 ± 0.04
0.792LysGln: 0.792 ± 0.025
2.183LysArg: 2.183 ± 0.046
1.595LysSer: 1.595 ± 0.033
1.752LysThr: 1.752 ± 0.041
2.367LysVal: 2.367 ± 0.046
0.383LysTrp: 0.383 ± 0.017
0.626LysTyr: 0.626 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
12.751LeuAla: 12.751 ± 0.113
0.895LeuCys: 0.895 ± 0.024
6.235LeuAsp: 6.235 ± 0.067
5.044LeuGlu: 5.044 ± 0.061
3.369LeuPhe: 3.369 ± 0.061
8.448LeuGly: 8.448 ± 0.093
1.812LeuHis: 1.812 ± 0.031
5.228LeuIle: 5.228 ± 0.08
3.279LeuLys: 3.279 ± 0.048
8.411LeuLeu: 8.411 ± 0.118
2.743LeuMet: 2.743 ± 0.052
2.577LeuAsn: 2.577 ± 0.046
5.535LeuPro: 5.535 ± 0.066
2.369LeuGln: 2.369 ± 0.046
6.867LeuArg: 6.867 ± 0.083
6.382LeuSer: 6.382 ± 0.071
6.19LeuThr: 6.19 ± 0.077
6.814LeuVal: 6.814 ± 0.081
1.256LeuTrp: 1.256 ± 0.031
1.934LeuTyr: 1.934 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.696MetAla: 3.696 ± 0.048
0.198MetCys: 0.198 ± 0.012
1.456MetAsp: 1.456 ± 0.037
1.46MetGlu: 1.46 ± 0.035
0.876MetPhe: 0.876 ± 0.028
2.241MetGly: 2.241 ± 0.049
0.48MetHis: 0.48 ± 0.02
1.652MetIle: 1.652 ± 0.038
1.081MetLys: 1.081 ± 0.034
2.777MetLeu: 2.777 ± 0.052
0.791MetMet: 0.791 ± 0.025
0.87MetAsn: 0.87 ± 0.026
1.65MetPro: 1.65 ± 0.032
1.009MetGln: 1.009 ± 0.029
2.051MetArg: 2.051 ± 0.038
1.842MetSer: 1.842 ± 0.039
2.301MetThr: 2.301 ± 0.047
1.9MetVal: 1.9 ± 0.04
0.255MetTrp: 0.255 ± 0.014
0.363MetTyr: 0.363 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.059AsnAla: 3.059 ± 0.051
0.248AsnCys: 0.248 ± 0.013
1.331AsnAsp: 1.331 ± 0.04
1.181AsnGlu: 1.181 ± 0.028
0.941AsnPhe: 0.941 ± 0.03
2.366AsnGly: 2.366 ± 0.049
0.47AsnHis: 0.47 ± 0.019
1.224AsnIle: 1.224 ± 0.032
0.578AsnLys: 0.578 ± 0.022
2.32AsnLeu: 2.32 ± 0.043
0.681AsnMet: 0.681 ± 0.022
0.634AsnAsn: 0.634 ± 0.028
1.713AsnPro: 1.713 ± 0.035
0.629AsnGln: 0.629 ± 0.024
1.79AsnArg: 1.79 ± 0.039
1.024AsnSer: 1.024 ± 0.03
1.246AsnThr: 1.246 ± 0.034
1.832AsnVal: 1.832 ± 0.037
0.377AsnTrp: 0.377 ± 0.015
0.615AsnTyr: 0.615 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.067ProAla: 6.067 ± 0.082
0.34ProCys: 0.34 ± 0.015
4.34ProAsp: 4.34 ± 0.066
4.405ProGlu: 4.405 ± 0.063
1.877ProPhe: 1.877 ± 0.038
5.007ProGly: 5.007 ± 0.065
1.049ProHis: 1.049 ± 0.024
2.107ProIle: 2.107 ± 0.043
1.523ProLys: 1.523 ± 0.039
4.619ProLeu: 4.619 ± 0.06
1.343ProMet: 1.343 ± 0.028
1.269ProAsn: 1.269 ± 0.03
2.378ProPro: 2.378 ± 0.042
1.552ProGln: 1.552 ± 0.031
2.99ProArg: 2.99 ± 0.049
2.349ProSer: 2.349 ± 0.04
2.287ProThr: 2.287 ± 0.04
4.669ProVal: 4.669 ± 0.062
0.667ProTrp: 0.667 ± 0.022
1.148ProTyr: 1.148 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.763GlnAla: 3.763 ± 0.058
0.189GlnCys: 0.189 ± 0.011
1.553GlnAsp: 1.553 ± 0.036
1.437GlnGlu: 1.437 ± 0.033
1.007GlnPhe: 1.007 ± 0.03
2.496GlnGly: 2.496 ± 0.047
0.519GlnHis: 0.519 ± 0.018
1.805GlnIle: 1.805 ± 0.038
0.987GlnLys: 0.987 ± 0.03
2.415GlnLeu: 2.415 ± 0.048
1.03GlnMet: 1.03 ± 0.028
0.792GlnAsn: 0.792 ± 0.025
1.546GlnPro: 1.546 ± 0.034
0.92GlnGln: 0.92 ± 0.028
2.002GlnArg: 2.002 ± 0.041
1.565GlnSer: 1.565 ± 0.034
1.635GlnThr: 1.635 ± 0.036
2.297GlnVal: 2.297 ± 0.042
0.374GlnTrp: 0.374 ± 0.017
0.521GlnTyr: 0.521 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
8.428ArgAla: 8.428 ± 0.092
0.507ArgCys: 0.507 ± 0.018
4.639ArgAsp: 4.639 ± 0.059
3.971ArgGlu: 3.971 ± 0.056
2.752ArgPhe: 2.752 ± 0.048
5.068ArgGly: 5.068 ± 0.065
1.643ArgHis: 1.643 ± 0.038
4.17ArgIle: 4.17 ± 0.052
2.173ArgLys: 2.173 ± 0.045
7.543ArgLeu: 7.543 ± 0.093
2.256ArgMet: 2.256 ± 0.047
1.773ArgAsn: 1.773 ± 0.036
3.576ArgPro: 3.576 ± 0.058
2.276ArgGln: 2.276 ± 0.036
5.406ArgArg: 5.406 ± 0.088
3.277ArgSer: 3.277 ± 0.051
3.344ArgThr: 3.344 ± 0.046
4.898ArgVal: 4.898 ± 0.057
0.941ArgTrp: 0.941 ± 0.026
1.608ArgTyr: 1.608 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
5.676SerAla: 5.676 ± 0.071
0.415SerCys: 0.415 ± 0.018
3.19SerAsp: 3.19 ± 0.054
2.781SerGlu: 2.781 ± 0.048
2.098SerPhe: 2.098 ± 0.044
5.525SerGly: 5.525 ± 0.063
0.997SerHis: 0.997 ± 0.027
2.354SerIle: 2.354 ± 0.039
1.32SerLys: 1.32 ± 0.036
4.706SerLeu: 4.706 ± 0.054
1.388SerMet: 1.388 ± 0.032
1.234SerAsn: 1.234 ± 0.033
2.441SerPro: 2.441 ± 0.04
1.387SerGln: 1.387 ± 0.037
3.207SerArg: 3.207 ± 0.054
2.314SerSer: 2.314 ± 0.049
2.376SerThr: 2.376 ± 0.051
3.836SerVal: 3.836 ± 0.061
0.655SerTrp: 0.655 ± 0.024
1.241SerTyr: 1.241 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
6.554ThrAla: 6.554 ± 0.077
0.468ThrCys: 0.468 ± 0.018
3.209ThrAsp: 3.209 ± 0.061
3.203ThrGlu: 3.203 ± 0.047
2.029ThrPhe: 2.029 ± 0.041
5.946ThrGly: 5.946 ± 0.077
1.044ThrHis: 1.044 ± 0.029
2.716ThrIle: 2.716 ± 0.046
1.337ThrLys: 1.337 ± 0.034
5.841ThrLeu: 5.841 ± 0.087
1.306ThrMet: 1.306 ± 0.033
1.239ThrAsn: 1.239 ± 0.029
3.482ThrPro: 3.482 ± 0.061
1.478ThrGln: 1.478 ± 0.034
3.708ThrArg: 3.708 ± 0.045
2.572ThrSer: 2.572 ± 0.039
2.816ThrThr: 2.816 ± 0.052
4.382ThrVal: 4.382 ± 0.082
0.707ThrTrp: 0.707 ± 0.024
1.306ThrTyr: 1.306 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
9.032ValAla: 9.032 ± 0.097
0.635ValCys: 0.635 ± 0.021
4.011ValAsp: 4.011 ± 0.06
4.675ValGlu: 4.675 ± 0.065
2.778ValPhe: 2.778 ± 0.053
5.449ValGly: 5.449 ± 0.07
1.363ValHis: 1.363 ± 0.03
4.314ValIle: 4.314 ± 0.065
2.164ValLys: 2.164 ± 0.043
7.382ValLeu: 7.382 ± 0.091
2.262ValMet: 2.262 ± 0.047
1.976ValAsn: 1.976 ± 0.038
3.875ValPro: 3.875 ± 0.053
2.08ValGln: 2.08 ± 0.037
4.592ValArg: 4.592 ± 0.059
4.227ValSer: 4.227 ± 0.055
5.055ValThr: 5.055 ± 0.071
5.715ValVal: 5.715 ± 0.083
0.983ValTrp: 0.983 ± 0.03
1.55ValTyr: 1.55 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.328TrpAla: 1.328 ± 0.031
0.151TrpCys: 0.151 ± 0.01
0.761TrpAsp: 0.761 ± 0.024
0.674TrpGlu: 0.674 ± 0.023
0.543TrpPhe: 0.543 ± 0.022
1.051TrpGly: 1.051 ± 0.025
0.352TrpHis: 0.352 ± 0.017
0.722TrpIle: 0.722 ± 0.022
0.423TrpLys: 0.423 ± 0.02
1.678TrpLeu: 1.678 ± 0.037
0.43TrpMet: 0.43 ± 0.018
0.4TrpAsn: 0.4 ± 0.017
0.68TrpPro: 0.68 ± 0.023
0.531TrpGln: 0.531 ± 0.02
1.114TrpArg: 1.114 ± 0.03
0.822TrpSer: 0.822 ± 0.025
0.874TrpThr: 0.874 ± 0.027
0.894TrpVal: 0.894 ± 0.026
0.207TrpTrp: 0.207 ± 0.014
0.248TrpTyr: 0.248 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.62TyrAla: 2.62 ± 0.05
0.252TyrCys: 0.252 ± 0.012
1.672TyrAsp: 1.672 ± 0.037
1.281TyrGlu: 1.281 ± 0.036
0.842TyrPhe: 0.842 ± 0.026
2.177TyrGly: 2.177 ± 0.042
0.518TyrHis: 0.518 ± 0.022
0.893TyrIle: 0.893 ± 0.025
0.525TyrLys: 0.525 ± 0.02
2.27TyrLeu: 2.27 ± 0.042
0.519TyrMet: 0.519 ± 0.02
0.532TyrAsn: 0.532 ± 0.02
1.103TyrPro: 1.103 ± 0.026
0.597TyrGln: 0.597 ± 0.023
1.623TyrArg: 1.623 ± 0.035
1.103TyrSer: 1.103 ± 0.031
1.141TyrThr: 1.141 ± 0.034
1.541TyrVal: 1.541 ± 0.041
0.36TyrTrp: 0.36 ± 0.018
0.597TyrTyr: 0.597 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4471 proteins (1400842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski