Amino acid dipepetide frequency for Verrucomicrobiaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.66AlaAla: 16.66 ± 0.173	1.113AlaCys: 1.113 ± 0.026	6.055AlaAsp: 6.055 ± 0.07	6.778AlaGlu: 6.778 ± 0.07	3.81AlaPhe: 3.81 ± 0.052	11.718AlaGly: 11.718 ± 0.107	1.838AlaHis: 1.838 ± 0.031	3.934AlaIle: 3.934 ± 0.058	3.728AlaLys: 3.728 ± 0.053	11.574AlaLeu: 11.574 ± 0.105	2.553AlaMet: 2.553 ± 0.041	2.549AlaAsn: 2.549 ± 0.052	6.065AlaPro: 6.065 ± 0.073	3.308AlaGln: 3.308 ± 0.047	7.118AlaArg: 7.118 ± 0.07	6.304AlaSer: 6.304 ± 0.071	5.265AlaThr: 5.265 ± 0.065	8.751AlaVal: 8.751 ± 0.086	2.061AlaTrp: 2.061 ± 0.039	1.909AlaTyr: 1.909 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.05CysAla: 1.05 ± 0.026	0.151CysCys: 0.151 ± 0.011	0.442CysAsp: 0.442 ± 0.015	0.428CysGlu: 0.428 ± 0.015	0.401CysPhe: 0.401 ± 0.016	1.06CysGly: 1.06 ± 0.027	0.355CysHis: 0.355 ± 0.016	0.343CysIle: 0.343 ± 0.015	0.172CysLys: 0.172 ± 0.01	1.112CysLeu: 1.112 ± 0.026	0.175CysMet: 0.175 ± 0.011	0.18CysAsn: 0.18 ± 0.01	0.571CysPro: 0.571 ± 0.018	0.344CysGln: 0.344 ± 0.014	0.823CysArg: 0.823 ± 0.024	0.518CysSer: 0.518 ± 0.018	0.456CysThr: 0.456 ± 0.017	0.603CysVal: 0.603 ± 0.018	0.182CysTrp: 0.182 ± 0.01	0.238CysTyr: 0.238 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.522AspAla: 5.522 ± 0.059	0.48AspCys: 0.48 ± 0.019	2.603AspAsp: 2.603 ± 0.043	2.728AspGlu: 2.728 ± 0.042	2.533AspPhe: 2.533 ± 0.037	5.751AspGly: 5.751 ± 0.083	1.231AspHis: 1.231 ± 0.027	2.2AspIle: 2.2 ± 0.037	1.661AspLys: 1.661 ± 0.038	5.263AspLeu: 5.263 ± 0.061	0.939AspMet: 0.939 ± 0.024	1.466AspAsn: 1.466 ± 0.035	3.93AspPro: 3.93 ± 0.047	1.694AspGln: 1.694 ± 0.032	3.511AspArg: 3.511 ± 0.054	3.18AspSer: 3.18 ± 0.049	2.873AspThr: 2.873 ± 0.044	2.832AspVal: 2.832 ± 0.04	1.073AspTrp: 1.073 ± 0.023	1.467AspTyr: 1.467 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.834GluAla: 6.834 ± 0.071	0.49GluCys: 0.49 ± 0.017	2.735GluAsp: 2.735 ± 0.043	3.809GluGlu: 3.809 ± 0.056	2.165GluPhe: 2.165 ± 0.034	4.302GluGly: 4.302 ± 0.052	1.129GluHis: 1.129 ± 0.03	3.129GluIle: 3.129 ± 0.052	2.909GluLys: 2.909 ± 0.048	5.468GluLeu: 5.468 ± 0.068	1.412GluMet: 1.412 ± 0.028	1.977GluAsn: 1.977 ± 0.039	2.834GluPro: 2.834 ± 0.049	1.825GluGln: 1.825 ± 0.033	3.929GluArg: 3.929 ± 0.054	3.363GluSer: 3.363 ± 0.044	3.491GluThr: 3.491 ± 0.046	3.895GluVal: 3.895 ± 0.052	0.977GluTrp: 0.977 ± 0.025	1.216GluTyr: 1.216 ± 0.031	0.001GluXaa: 0.001 ± 0.001
Phe	3.569PheAla: 3.569 ± 0.046	0.437PheCys: 0.437 ± 0.017	2.151PheAsp: 2.151 ± 0.038	2.048PheGlu: 2.048 ± 0.037	1.525PhePhe: 1.525 ± 0.029	3.112PheGly: 3.112 ± 0.049	0.906PheHis: 0.906 ± 0.025	1.546PheIle: 1.546 ± 0.031	1.159PheLys: 1.159 ± 0.026	3.851PheLeu: 3.851 ± 0.052	0.733PheMet: 0.733 ± 0.022	1.207PheAsn: 1.207 ± 0.028	2.224PhePro: 2.224 ± 0.038	1.354PheGln: 1.354 ± 0.027	2.541PheArg: 2.541 ± 0.042	2.786PheSer: 2.786 ± 0.042	2.675PheThr: 2.675 ± 0.042	2.118PheVal: 2.118 ± 0.035	0.546PheTrp: 0.546 ± 0.02	1.085PheTyr: 1.085 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.474GlyAla: 8.474 ± 0.098	0.989GlyCys: 0.989 ± 0.025	4.602GlyAsp: 4.602 ± 0.06	4.504GlyGlu: 4.504 ± 0.055	3.499GlyPhe: 3.499 ± 0.05	8.792GlyGly: 8.792 ± 0.092	1.856GlyHis: 1.856 ± 0.037	4.248GlyIle: 4.248 ± 0.051	3.824GlyLys: 3.824 ± 0.053	8.53GlyLeu: 8.53 ± 0.085	2.221GlyMet: 2.221 ± 0.037	2.919GlyAsn: 2.919 ± 0.046	3.968GlyPro: 3.968 ± 0.054	3.098GlyGln: 3.098 ± 0.047	5.679GlyArg: 5.679 ± 0.056	5.509GlySer: 5.509 ± 0.062	5.855GlyThr: 5.855 ± 0.084	5.698GlyVal: 5.698 ± 0.064	1.7GlyTrp: 1.7 ± 0.033	2.151GlyTyr: 2.151 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.096HisAla: 2.096 ± 0.042	0.272HisCys: 0.272 ± 0.013	1.064HisAsp: 1.064 ± 0.027	1.089HisGlu: 1.089 ± 0.027	0.926HisPhe: 0.926 ± 0.023	2.009HisGly: 2.009 ± 0.042	0.65HisHis: 0.65 ± 0.024	0.824HisIle: 0.824 ± 0.023	0.471HisLys: 0.471 ± 0.016	2.271HisLeu: 2.271 ± 0.046	0.382HisMet: 0.382 ± 0.015	0.539HisAsn: 0.539 ± 0.02	1.7HisPro: 1.7 ± 0.035	0.756HisGln: 0.756 ± 0.021	1.65HisArg: 1.65 ± 0.034	1.312HisSer: 1.312 ± 0.029	1.093HisThr: 1.093 ± 0.031	1.172HisVal: 1.172 ± 0.027	0.445HisTrp: 0.445 ± 0.015	0.644HisTyr: 0.644 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.448IleAla: 4.448 ± 0.054	0.47IleCys: 0.47 ± 0.018	2.287IleAsp: 2.287 ± 0.039	2.189IleGlu: 2.189 ± 0.043	1.573IlePhe: 1.573 ± 0.033	3.511IleGly: 3.511 ± 0.057	1.087IleHis: 1.087 ± 0.026	1.947IleIle: 1.947 ± 0.037	1.253IleLys: 1.253 ± 0.029	4.395IleLeu: 4.395 ± 0.06	0.812IleMet: 0.812 ± 0.024	1.255IleAsn: 1.255 ± 0.031	2.785IlePro: 2.785 ± 0.047	1.441IleGln: 1.441 ± 0.032	3.096IleArg: 3.096 ± 0.042	2.997IleSer: 2.997 ± 0.041	3.027IleThr: 3.027 ± 0.049	2.597IleVal: 2.597 ± 0.047	0.512IleTrp: 0.512 ± 0.019	1.064IleTyr: 1.064 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.14LysAla: 4.14 ± 0.06	0.254LysCys: 0.254 ± 0.012	1.955LysAsp: 1.955 ± 0.042	2.1LysGlu: 2.1 ± 0.037	1.21LysPhe: 1.21 ± 0.029	2.733LysGly: 2.733 ± 0.05	0.603LysHis: 0.603 ± 0.02	1.727LysIle: 1.727 ± 0.033	1.737LysLys: 1.737 ± 0.037	3.349LysLeu: 3.349 ± 0.044	0.781LysMet: 0.781 ± 0.023	1.227LysAsn: 1.227 ± 0.028	2.558LysPro: 2.558 ± 0.038	1.056LysGln: 1.056 ± 0.027	2.058LysArg: 2.058 ± 0.04	2.157LysSer: 2.157 ± 0.033	2.261LysThr: 2.261 ± 0.042	2.438LysVal: 2.438 ± 0.049	0.55LysTrp: 0.55 ± 0.019	0.804LysTyr: 0.804 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	11.616LeuAla: 11.616 ± 0.112	1.084LeuCys: 1.084 ± 0.028	5.233LeuAsp: 5.233 ± 0.062	6.119LeuGlu: 6.119 ± 0.07	3.454LeuPhe: 3.454 ± 0.047	7.354LeuGly: 7.354 ± 0.077	2.33LeuHis: 2.33 ± 0.048	4.328LeuIle: 4.328 ± 0.056	4.367LeuLys: 4.367 ± 0.052	10.772LeuLeu: 10.772 ± 0.108	2.355LeuMet: 2.355 ± 0.047	3.225LeuAsn: 3.225 ± 0.049	6.666LeuPro: 6.666 ± 0.075	3.054LeuGln: 3.054 ± 0.045	7.661LeuArg: 7.661 ± 0.081	6.532LeuSer: 6.532 ± 0.065	7.061LeuThr: 7.061 ± 0.076	6.072LeuVal: 6.072 ± 0.065	1.482LeuTrp: 1.482 ± 0.033	2.035LeuTyr: 2.035 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.603MetAla: 2.603 ± 0.032	0.147MetCys: 0.147 ± 0.01	1.245MetAsp: 1.245 ± 0.028	1.507MetGlu: 1.507 ± 0.028	0.517MetPhe: 0.517 ± 0.016	1.636MetGly: 1.636 ± 0.031	0.405MetHis: 0.405 ± 0.014	0.942MetIle: 0.942 ± 0.025	1.172MetLys: 1.172 ± 0.025	2.11MetLeu: 2.11 ± 0.041	0.559MetMet: 0.559 ± 0.024	0.827MetAsn: 0.827 ± 0.02	1.517MetPro: 1.517 ± 0.028	0.663MetGln: 0.663 ± 0.021	1.567MetArg: 1.567 ± 0.035	1.258MetSer: 1.258 ± 0.032	1.375MetThr: 1.375 ± 0.031	1.368MetVal: 1.368 ± 0.031	0.219MetTrp: 0.219 ± 0.011	0.237MetTyr: 0.237 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.102AsnAla: 3.102 ± 0.045	0.284AsnCys: 0.284 ± 0.015	1.47AsnAsp: 1.47 ± 0.033	1.341AsnGlu: 1.341 ± 0.034	1.199AsnPhe: 1.199 ± 0.03	3.061AsnGly: 3.061 ± 0.055	0.643AsnHis: 0.643 ± 0.018	1.211AsnIle: 1.211 ± 0.028	0.716AsnLys: 0.716 ± 0.021	2.877AsnLeu: 2.877 ± 0.042	0.481AsnMet: 0.481 ± 0.015	0.903AsnAsn: 0.903 ± 0.025	2.525AsnPro: 2.525 ± 0.041	0.973AsnGln: 0.973 ± 0.018	1.915AsnArg: 1.915 ± 0.036	1.801AsnSer: 1.801 ± 0.04	1.621AsnThr: 1.621 ± 0.037	1.7AsnVal: 1.7 ± 0.036	0.51AsnTrp: 0.51 ± 0.019	0.776AsnTyr: 0.776 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.656ProAla: 8.656 ± 0.1	0.449ProCys: 0.449 ± 0.016	4.414ProAsp: 4.414 ± 0.05	4.853ProGlu: 4.853 ± 0.068	1.996ProPhe: 1.996 ± 0.036	5.942ProGly: 5.942 ± 0.071	1.147ProHis: 1.147 ± 0.031	1.665ProIle: 1.665 ± 0.031	1.673ProLys: 1.673 ± 0.037	5.566ProLeu: 5.566 ± 0.062	1.233ProMet: 1.233 ± 0.027	1.442ProAsn: 1.442 ± 0.032	4.265ProPro: 4.265 ± 0.064	1.86ProGln: 1.86 ± 0.036	3.065ProArg: 3.065 ± 0.045	3.617ProSer: 3.617 ± 0.049	2.358ProThr: 2.358 ± 0.035	5.425ProVal: 5.425 ± 0.068	1.047ProTrp: 1.047 ± 0.03	1.017ProTyr: 1.017 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.95GlnAla: 3.95 ± 0.042	0.261GlnCys: 0.261 ± 0.012	1.509GlnAsp: 1.509 ± 0.032	1.996GlnGlu: 1.996 ± 0.036	1.153GlnPhe: 1.153 ± 0.029	2.517GlnGly: 2.517 ± 0.041	0.628GlnHis: 0.628 ± 0.018	1.424GlnIle: 1.424 ± 0.031	1.225GlnLys: 1.225 ± 0.032	3.062GlnLeu: 3.062 ± 0.04	0.659GlnMet: 0.659 ± 0.017	0.961GlnAsn: 0.961 ± 0.024	2.209GlnPro: 2.209 ± 0.04	1.191GlnGln: 1.191 ± 0.028	2.394GlnArg: 2.394 ± 0.04	2.029GlnSer: 2.029 ± 0.04	1.691GlnThr: 1.691 ± 0.03	2.206GlnVal: 2.206 ± 0.034	0.677GlnTrp: 0.677 ± 0.019	0.654GlnTyr: 0.654 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.217ArgAla: 6.217 ± 0.067	0.601ArgCys: 0.601 ± 0.02	3.579ArgAsp: 3.579 ± 0.055	4.466ArgGlu: 4.466 ± 0.058	2.718ArgPhe: 2.718 ± 0.036	4.614ArgGly: 4.614 ± 0.055	1.787ArgHis: 1.787 ± 0.033	3.51ArgIle: 3.51 ± 0.048	2.359ArgLys: 2.359 ± 0.045	8.066ArgLeu: 8.066 ± 0.085	1.739ArgMet: 1.739 ± 0.031	2.01ArgAsn: 2.01 ± 0.038	3.452ArgPro: 3.452 ± 0.044	2.824ArgGln: 2.824 ± 0.038	5.907ArgArg: 5.907 ± 0.081	3.668ArgSer: 3.668 ± 0.05	3.765ArgThr: 3.765 ± 0.047	4.283ArgVal: 4.283 ± 0.053	1.247ArgTrp: 1.247 ± 0.03	1.439ArgTyr: 1.439 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.746SerAla: 6.746 ± 0.074	0.555SerCys: 0.555 ± 0.017	2.972SerAsp: 2.972 ± 0.044	2.779SerGlu: 2.779 ± 0.04	2.334SerPhe: 2.334 ± 0.038	6.747SerGly: 6.747 ± 0.086	1.313SerHis: 1.313 ± 0.03	2.458SerIle: 2.458 ± 0.043	1.85SerLys: 1.85 ± 0.04	6.698SerLeu: 6.698 ± 0.073	1.327SerMet: 1.327 ± 0.027	1.661SerAsn: 1.661 ± 0.032	4.117SerPro: 4.117 ± 0.046	1.914SerGln: 1.914 ± 0.035	4.044SerArg: 4.044 ± 0.053	3.822SerSer: 3.822 ± 0.059	3.288SerThr: 3.288 ± 0.048	4.058SerVal: 4.058 ± 0.05	1.053SerTrp: 1.053 ± 0.03	1.243SerTyr: 1.243 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.649ThrAla: 7.649 ± 0.088	0.402ThrCys: 0.402 ± 0.015	3.19ThrAsp: 3.19 ± 0.048	2.933ThrGlu: 2.933 ± 0.039	2.082ThrPhe: 2.082 ± 0.044	6.427ThrGly: 6.427 ± 0.077	1.122ThrHis: 1.122 ± 0.029	2.234ThrIle: 2.234 ± 0.045	1.492ThrLys: 1.492 ± 0.034	6.305ThrLeu: 6.305 ± 0.069	1.004ThrMet: 1.004 ± 0.023	1.376ThrAsn: 1.376 ± 0.04	4.031ThrPro: 4.031 ± 0.054	1.488ThrGln: 1.488 ± 0.03	3.197ThrArg: 3.197 ± 0.045	3.051ThrSer: 3.051 ± 0.049	3.022ThrThr: 3.022 ± 0.054	5.045ThrVal: 5.045 ± 0.082	0.932ThrTrp: 0.932 ± 0.027	1.126ThrTyr: 1.126 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	6.29ValAla: 6.29 ± 0.068	0.727ValCys: 0.727 ± 0.02	3.314ValAsp: 3.314 ± 0.046	4.048ValGlu: 4.048 ± 0.049	2.787ValPhe: 2.787 ± 0.048	3.95ValGly: 3.95 ± 0.059	1.333ValHis: 1.333 ± 0.031	3.522ValIle: 3.522 ± 0.053	2.604ValLys: 2.604 ± 0.049	7.181ValLeu: 7.181 ± 0.071	1.722ValMet: 1.722 ± 0.034	2.069ValAsn: 2.069 ± 0.041	4.265ValPro: 4.265 ± 0.052	1.925ValGln: 1.925 ± 0.034	5.03ValArg: 5.03 ± 0.054	4.602ValSer: 4.602 ± 0.058	4.553ValThr: 4.553 ± 0.062	4.576ValVal: 4.576 ± 0.06	1.106ValTrp: 1.106 ± 0.027	1.511ValTyr: 1.511 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.437TrpAla: 1.437 ± 0.035	0.21TrpCys: 0.21 ± 0.012	0.821TrpAsp: 0.821 ± 0.021	0.93TrpGlu: 0.93 ± 0.023	0.651TrpPhe: 0.651 ± 0.02	1.005TrpGly: 1.005 ± 0.029	0.439TrpHis: 0.439 ± 0.016	0.805TrpIle: 0.805 ± 0.021	0.713TrpLys: 0.713 ± 0.023	2.119TrpLeu: 2.119 ± 0.043	0.46TrpMet: 0.46 ± 0.016	0.617TrpAsn: 0.617 ± 0.023	0.838TrpPro: 0.838 ± 0.024	0.705TrpGln: 0.705 ± 0.019	1.497TrpArg: 1.497 ± 0.032	1.075TrpSer: 1.075 ± 0.026	1.083TrpThr: 1.083 ± 0.028	0.974TrpVal: 0.974 ± 0.025	0.314TrpTrp: 0.314 ± 0.015	0.308TrpTyr: 0.308 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.031TyrAla: 2.031 ± 0.035	0.226TyrCys: 0.226 ± 0.012	1.293TyrAsp: 1.293 ± 0.036	1.244TyrGlu: 1.244 ± 0.028	1.041TyrPhe: 1.041 ± 0.025	1.877TyrGly: 1.877 ± 0.034	0.565TyrHis: 0.565 ± 0.019	0.75TyrIle: 0.75 ± 0.02	0.613TyrLys: 0.613 ± 0.019	2.231TyrLeu: 2.231 ± 0.043	0.329TyrMet: 0.329 ± 0.013	0.699TyrAsn: 0.699 ± 0.026	1.171TyrPro: 1.171 ± 0.027	0.926TyrGln: 0.926 ± 0.02	1.567TyrArg: 1.567 ± 0.035	1.397TyrSer: 1.397 ± 0.03	1.296TyrThr: 1.296 ± 0.036	1.302TyrVal: 1.302 ± 0.029	0.366TyrTrp: 0.366 ± 0.016	0.719TyrTyr: 0.719 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 5527 proteins (1744395 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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