Amino acid dipepetide frequency for Keratinibaculum paraultunense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.243AlaAla: 3.243 ± 0.097	0.528AlaCys: 0.528 ± 0.031	2.328AlaAsp: 2.328 ± 0.069	3.402AlaGlu: 3.402 ± 0.087	2.167AlaPhe: 2.167 ± 0.066	3.476AlaGly: 3.476 ± 0.087	0.859AlaHis: 0.859 ± 0.035	5.787AlaIle: 5.787 ± 0.112	4.512AlaLys: 4.512 ± 0.093	5.527AlaLeu: 5.527 ± 0.1	1.567AlaMet: 1.567 ± 0.05	2.524AlaAsn: 2.524 ± 0.06	1.314AlaPro: 1.314 ± 0.05	1.328AlaGln: 1.328 ± 0.047	1.868AlaArg: 1.868 ± 0.052	2.691AlaSer: 2.691 ± 0.071	2.559AlaThr: 2.559 ± 0.068	3.297AlaVal: 3.297 ± 0.09	0.286AlaTrp: 0.286 ± 0.023	2.074AlaTyr: 2.074 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.416CysAla: 0.416 ± 0.03	0.115CysCys: 0.115 ± 0.014	0.519CysAsp: 0.519 ± 0.027	0.572CysGlu: 0.572 ± 0.033	0.328CysPhe: 0.328 ± 0.025	0.868CysGly: 0.868 ± 0.042	0.182CysHis: 0.182 ± 0.016	0.957CysIle: 0.957 ± 0.043	0.721CysLys: 0.721 ± 0.038	0.579CysLeu: 0.579 ± 0.029	0.192CysMet: 0.192 ± 0.018	0.555CysAsn: 0.555 ± 0.033	0.481CysPro: 0.481 ± 0.032	0.189CysGln: 0.189 ± 0.018	0.342CysArg: 0.342 ± 0.024	0.584CysSer: 0.584 ± 0.031	0.387CysThr: 0.387 ± 0.021	0.448CysVal: 0.448 ± 0.032	0.068CysTrp: 0.068 ± 0.011	0.36CysTyr: 0.36 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.437AspAla: 2.437 ± 0.071	0.495AspCys: 0.495 ± 0.03	2.915AspAsp: 2.915 ± 0.074	5.711AspGlu: 5.711 ± 0.114	2.732AspPhe: 2.732 ± 0.065	3.455AspGly: 3.455 ± 0.079	0.6AspHis: 0.6 ± 0.029	7.327AspIle: 7.327 ± 0.112	5.81AspLys: 5.81 ± 0.104	5.208AspLeu: 5.208 ± 0.093	1.755AspMet: 1.755 ± 0.048	3.244AspAsn: 3.244 ± 0.079	1.644AspPro: 1.644 ± 0.055	0.824AspGln: 0.824 ± 0.04	2.174AspArg: 2.174 ± 0.065	2.648AspSer: 2.648 ± 0.073	2.57AspThr: 2.57 ± 0.061	3.629AspVal: 3.629 ± 0.079	0.407AspTrp: 0.407 ± 0.028	3.046AspTyr: 3.046 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	4.134GluAla: 4.134 ± 0.092	0.472GluCys: 0.472 ± 0.034	5.539GluAsp: 5.539 ± 0.092	8.907GluGlu: 8.907 ± 0.141	2.942GluPhe: 2.942 ± 0.069	5.059GluGly: 5.059 ± 0.084	1.016GluHis: 1.016 ± 0.038	8.584GluIle: 8.584 ± 0.146	8.807GluLys: 8.807 ± 0.125	7.207GluLeu: 7.207 ± 0.108	2.084GluMet: 2.084 ± 0.063	5.268GluAsn: 5.268 ± 0.1	1.86GluPro: 1.86 ± 0.057	1.877GluGln: 1.877 ± 0.055	2.907GluArg: 2.907 ± 0.069	3.064GluSer: 3.064 ± 0.073	3.086GluThr: 3.086 ± 0.075	4.842GluVal: 4.842 ± 0.096	0.454GluTrp: 0.454 ± 0.024	3.435GluTyr: 3.435 ± 0.081	0.0GluXaa: 0.0 ± 0.0
Phe	1.968PheAla: 1.968 ± 0.059	0.399PheCys: 0.399 ± 0.026	2.497PheAsp: 2.497 ± 0.066	2.706PheGlu: 2.706 ± 0.063	1.759PhePhe: 1.759 ± 0.058	2.73PheGly: 2.73 ± 0.067	0.549PheHis: 0.549 ± 0.028	4.743PheIle: 4.743 ± 0.104	3.766PheLys: 3.766 ± 0.076	3.86PheLeu: 3.86 ± 0.1	1.074PheMet: 1.074 ± 0.044	2.692PheAsn: 2.692 ± 0.062	1.251PhePro: 1.251 ± 0.043	0.935PheGln: 0.935 ± 0.033	1.313PheArg: 1.313 ± 0.046	2.744PheSer: 2.744 ± 0.066	2.174PheThr: 2.174 ± 0.056	2.435PheVal: 2.435 ± 0.062	0.287PheTrp: 0.287 ± 0.021	1.82PheTyr: 1.82 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	3.65GlyAla: 3.65 ± 0.093	0.708GlyCys: 0.708 ± 0.037	3.47GlyAsp: 3.47 ± 0.083	4.636GlyGlu: 4.636 ± 0.094	3.054GlyPhe: 3.054 ± 0.079	4.344GlyGly: 4.344 ± 0.102	1.088GlyHis: 1.088 ± 0.037	7.584GlyIle: 7.584 ± 0.131	6.053GlyLys: 6.053 ± 0.103	5.714GlyLeu: 5.714 ± 0.111	1.753GlyMet: 1.753 ± 0.045	3.361GlyAsn: 3.361 ± 0.069	1.49GlyPro: 1.49 ± 0.05	1.452GlyGln: 1.452 ± 0.048	2.505GlyArg: 2.505 ± 0.067	3.211GlySer: 3.211 ± 0.08	3.439GlyThr: 3.439 ± 0.073	4.249GlyVal: 4.249 ± 0.085	0.434GlyTrp: 0.434 ± 0.025	3.152GlyTyr: 3.152 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.666HisAla: 0.666 ± 0.027	0.156HisCys: 0.156 ± 0.015	0.643HisAsp: 0.643 ± 0.028	0.988HisGlu: 0.988 ± 0.045	0.623HisPhe: 0.623 ± 0.03	1.062HisGly: 1.062 ± 0.041	0.284HisHis: 0.284 ± 0.021	1.588HisIle: 1.588 ± 0.049	1.113HisLys: 1.113 ± 0.037	1.19HisLeu: 1.19 ± 0.039	0.374HisMet: 0.374 ± 0.024	0.735HisAsn: 0.735 ± 0.03	0.685HisPro: 0.685 ± 0.035	0.286HisGln: 0.286 ± 0.019	0.607HisArg: 0.607 ± 0.029	0.821HisSer: 0.821 ± 0.042	0.664HisThr: 0.664 ± 0.031	0.826HisVal: 0.826 ± 0.038	0.123HisTrp: 0.123 ± 0.013	0.56HisTyr: 0.56 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.938IleAla: 5.938 ± 0.105	0.989IleCys: 0.989 ± 0.044	7.543IleAsp: 7.543 ± 0.118	8.906IleGlu: 8.906 ± 0.136	4.494IlePhe: 4.494 ± 0.11	6.874IleGly: 6.874 ± 0.115	1.435IleHis: 1.435 ± 0.046	11.175IleIle: 11.175 ± 0.174	9.347IleLys: 9.347 ± 0.127	10.208IleLeu: 10.208 ± 0.142	2.596IleMet: 2.596 ± 0.062	6.217IleAsn: 6.217 ± 0.114	3.801IlePro: 3.801 ± 0.081	2.403IleGln: 2.403 ± 0.059	3.721IleArg: 3.721 ± 0.074	6.62IleSer: 6.62 ± 0.126	4.745IleThr: 4.745 ± 0.087	6.676IleVal: 6.676 ± 0.111	0.605IleTrp: 0.605 ± 0.031	4.158IleTyr: 4.158 ± 0.089	0.0IleXaa: 0.0 ± 0.0
Lys	4.589LysAla: 4.589 ± 0.088	0.623LysCys: 0.623 ± 0.033	6.427LysAsp: 6.427 ± 0.096	9.618LysGlu: 9.618 ± 0.127	3.111LysPhe: 3.111 ± 0.062	5.835LysGly: 5.835 ± 0.106	1.205LysHis: 1.205 ± 0.044	8.889LysIle: 8.889 ± 0.134	8.441LysLys: 8.441 ± 0.117	7.923LysLeu: 7.923 ± 0.116	2.239LysMet: 2.239 ± 0.056	5.967LysAsn: 5.967 ± 0.1	2.39LysPro: 2.39 ± 0.07	2.108LysGln: 2.108 ± 0.057	3.399LysArg: 3.399 ± 0.077	4.209LysSer: 4.209 ± 0.08	4.045LysThr: 4.045 ± 0.076	5.708LysVal: 5.708 ± 0.103	0.59LysTrp: 0.59 ± 0.031	4.521LysTyr: 4.521 ± 0.096	0.0LysXaa: 0.0 ± 0.0
Leu	5.0LeuAla: 5.0 ± 0.104	0.75LeuCys: 0.75 ± 0.04	5.795LeuAsp: 5.795 ± 0.094	7.277LeuGlu: 7.277 ± 0.117	3.721LeuPhe: 3.721 ± 0.107	6.086LeuGly: 6.086 ± 0.108	1.021LeuHis: 1.021 ± 0.037	8.977LeuIle: 8.977 ± 0.121	8.906LeuLys: 8.906 ± 0.119	8.317LeuLeu: 8.317 ± 0.144	2.311LeuMet: 2.311 ± 0.053	6.029LeuAsn: 6.029 ± 0.099	3.011LeuPro: 3.011 ± 0.07	1.824LeuGln: 1.824 ± 0.05	3.104LeuArg: 3.104 ± 0.069	5.875LeuSer: 5.875 ± 0.093	4.258LeuThr: 4.258 ± 0.086	5.409LeuVal: 5.409 ± 0.101	0.573LeuTrp: 0.573 ± 0.031	3.368LeuTyr: 3.368 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	1.759MetAla: 1.759 ± 0.058	0.188MetCys: 0.188 ± 0.017	1.93MetAsp: 1.93 ± 0.057	2.423MetGlu: 2.423 ± 0.053	0.992MetPhe: 0.992 ± 0.047	1.833MetGly: 1.833 ± 0.057	0.266MetHis: 0.266 ± 0.02	2.287MetIle: 2.287 ± 0.061	2.538MetLys: 2.538 ± 0.063	2.186MetLeu: 2.186 ± 0.059	0.625MetMet: 0.625 ± 0.03	1.561MetAsn: 1.561 ± 0.046	0.83MetPro: 0.83 ± 0.039	0.489MetGln: 0.489 ± 0.028	0.929MetArg: 0.929 ± 0.039	1.323MetSer: 1.323 ± 0.043	1.264MetThr: 1.264 ± 0.046	1.694MetVal: 1.694 ± 0.05	0.145MetTrp: 0.145 ± 0.015	0.927MetTyr: 0.927 ± 0.039	0.0MetXaa: 0.0 ± 0.0
Asn	2.428AsnAla: 2.428 ± 0.064	0.602AsnCys: 0.602 ± 0.032	2.31AsnAsp: 2.31 ± 0.063	3.964AsnGlu: 3.964 ± 0.086	2.329AsnPhe: 2.329 ± 0.068	2.996AsnGly: 2.996 ± 0.067	0.774AsnHis: 0.774 ± 0.036	8.254AsnIle: 8.254 ± 0.138	5.958AsnLys: 5.958 ± 0.114	5.503AsnLeu: 5.503 ± 0.091	1.845AsnMet: 1.845 ± 0.061	3.612AsnAsn: 3.612 ± 0.089	2.35AsnPro: 2.35 ± 0.06	1.44AsnGln: 1.44 ± 0.049	2.5AsnArg: 2.5 ± 0.07	3.087AsnSer: 3.087 ± 0.075	2.753AsnThr: 2.753 ± 0.071	3.343AsnVal: 3.343 ± 0.073	0.452AsnTrp: 0.452 ± 0.027	2.648AsnTyr: 2.648 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.31ProAla: 1.31 ± 0.05	0.293ProCys: 0.293 ± 0.025	1.685ProAsp: 1.685 ± 0.052	2.503ProGlu: 2.503 ± 0.075	1.478ProPhe: 1.478 ± 0.047	1.968ProGly: 1.968 ± 0.063	0.549ProHis: 0.549 ± 0.033	3.406ProIle: 3.406 ± 0.069	2.512ProLys: 2.512 ± 0.066	2.651ProLeu: 2.651 ± 0.064	0.783ProMet: 0.783 ± 0.036	1.788ProAsn: 1.788 ± 0.053	0.814ProPro: 0.814 ± 0.037	0.832ProGln: 0.832 ± 0.036	1.018ProArg: 1.018 ± 0.036	1.683ProSer: 1.683 ± 0.05	1.629ProThr: 1.629 ± 0.05	2.131ProVal: 2.131 ± 0.068	0.216ProTrp: 0.216 ± 0.016	1.475ProTyr: 1.475 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.18GlnAla: 1.18 ± 0.042	0.203GlnCys: 0.203 ± 0.018	1.165GlnAsp: 1.165 ± 0.047	1.768GlnGlu: 1.768 ± 0.052	1.01GlnPhe: 1.01 ± 0.038	1.449GlnGly: 1.449 ± 0.044	0.278GlnHis: 0.278 ± 0.02	2.317GlnIle: 2.317 ± 0.061	2.013GlnLys: 2.013 ± 0.051	2.343GlnLeu: 2.343 ± 0.068	0.69GlnMet: 0.69 ± 0.032	1.331GlnAsn: 1.331 ± 0.048	0.578GlnPro: 0.578 ± 0.029	0.658GlnGln: 0.658 ± 0.035	0.988GlnArg: 0.988 ± 0.043	1.148GlnSer: 1.148 ± 0.041	0.923GlnThr: 0.923 ± 0.036	1.508GlnVal: 1.508 ± 0.041	0.183GlnTrp: 0.183 ± 0.017	0.977GlnTyr: 0.977 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.886ArgAla: 1.886 ± 0.053	0.357ArgCys: 0.357 ± 0.026	2.151ArgAsp: 2.151 ± 0.062	3.302ArgGlu: 3.302 ± 0.07	1.482ArgPhe: 1.482 ± 0.044	2.459ArgGly: 2.459 ± 0.064	0.495ArgHis: 0.495 ± 0.027	3.828ArgIle: 3.828 ± 0.087	3.334ArgLys: 3.334 ± 0.076	3.306ArgLeu: 3.306 ± 0.075	0.951ArgMet: 0.951 ± 0.041	2.164ArgAsn: 2.164 ± 0.057	1.047ArgPro: 1.047 ± 0.042	0.945ArgGln: 0.945 ± 0.037	1.694ArgArg: 1.694 ± 0.06	1.417ArgSer: 1.417 ± 0.053	1.618ArgThr: 1.618 ± 0.053	2.37ArgVal: 2.37 ± 0.063	0.239ArgTrp: 0.239 ± 0.022	1.68ArgTyr: 1.68 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	2.37SerAla: 2.37 ± 0.064	0.493SerCys: 0.493 ± 0.03	2.237SerAsp: 2.237 ± 0.063	3.049SerGlu: 3.049 ± 0.071	2.585SerPhe: 2.585 ± 0.059	3.66SerGly: 3.66 ± 0.083	0.915SerHis: 0.915 ± 0.044	6.442SerIle: 6.442 ± 0.096	4.899SerLys: 4.899 ± 0.096	5.196SerLeu: 5.196 ± 0.096	1.526SerMet: 1.526 ± 0.046	3.322SerAsn: 3.322 ± 0.068	1.632SerPro: 1.632 ± 0.045	1.578SerGln: 1.578 ± 0.042	2.057SerArg: 2.057 ± 0.055	3.388SerSer: 3.388 ± 0.08	2.798SerThr: 2.798 ± 0.064	2.841SerVal: 2.841 ± 0.064	0.392SerTrp: 0.392 ± 0.024	2.308SerTyr: 2.308 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	2.453ThrAla: 2.453 ± 0.059	0.405ThrCys: 0.405 ± 0.024	2.207ThrAsp: 2.207 ± 0.056	2.839ThrGlu: 2.839 ± 0.073	2.028ThrPhe: 2.028 ± 0.062	3.644ThrGly: 3.644 ± 0.084	0.794ThrHis: 0.794 ± 0.035	5.357ThrIle: 5.357 ± 0.097	3.71ThrLys: 3.71 ± 0.079	4.442ThrLeu: 4.442 ± 0.089	1.1ThrMet: 1.1 ± 0.037	2.449ThrAsn: 2.449 ± 0.069	1.765ThrPro: 1.765 ± 0.056	1.059ThrGln: 1.059 ± 0.039	1.632ThrArg: 1.632 ± 0.053	2.745ThrSer: 2.745 ± 0.07	2.582ThrThr: 2.582 ± 0.07	3.095ThrVal: 3.095 ± 0.069	0.262ThrTrp: 0.262 ± 0.022	1.844ThrTyr: 1.844 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	3.615ValAla: 3.615 ± 0.09	0.602ValCys: 0.602 ± 0.034	4.294ValAsp: 4.294 ± 0.082	5.141ValGlu: 5.141 ± 0.103	2.614ValPhe: 2.614 ± 0.066	4.305ValGly: 4.305 ± 0.101	0.908ValHis: 0.908 ± 0.035	5.643ValIle: 5.643 ± 0.088	5.137ValLys: 5.137 ± 0.105	5.785ValLeu: 5.785 ± 0.106	1.414ValMet: 1.414 ± 0.046	3.149ValAsn: 3.149 ± 0.064	2.163ValPro: 2.163 ± 0.065	1.354ValGln: 1.354 ± 0.042	2.048ValArg: 2.048 ± 0.074	3.638ValSer: 3.638 ± 0.07	2.709ValThr: 2.709 ± 0.063	4.326ValVal: 4.326 ± 0.09	0.343ValTrp: 0.343 ± 0.024	2.352ValTyr: 2.352 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.377TrpAla: 0.377 ± 0.026	0.062TrpCys: 0.062 ± 0.009	0.401TrpAsp: 0.401 ± 0.025	0.572TrpGlu: 0.572 ± 0.031	0.271TrpPhe: 0.271 ± 0.019	0.481TrpGly: 0.481 ± 0.028	0.119TrpHis: 0.119 ± 0.013	0.638TrpIle: 0.638 ± 0.033	0.476TrpLys: 0.476 ± 0.03	0.591TrpLeu: 0.591 ± 0.039	0.227TrpMet: 0.227 ± 0.018	0.371TrpAsn: 0.371 ± 0.022	0.136TrpPro: 0.136 ± 0.015	0.174TrpGln: 0.174 ± 0.016	0.216TrpArg: 0.216 ± 0.019	0.324TrpSer: 0.324 ± 0.023	0.234TrpThr: 0.234 ± 0.018	0.381TrpVal: 0.381 ± 0.026	0.074TrpTrp: 0.074 ± 0.011	0.293TrpTyr: 0.293 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.919TyrAla: 1.919 ± 0.054	0.424TyrCys: 0.424 ± 0.025	2.576TyrAsp: 2.576 ± 0.063	3.263TyrGlu: 3.263 ± 0.075	1.981TyrPhe: 1.981 ± 0.059	2.76TyrGly: 2.76 ± 0.07	0.653TyrHis: 0.653 ± 0.031	4.668TyrIle: 4.668 ± 0.093	3.783TyrLys: 3.783 ± 0.077	3.875TyrLeu: 3.875 ± 0.072	1.083TyrMet: 1.083 ± 0.043	2.81TyrAsn: 2.81 ± 0.069	1.482TyrPro: 1.482 ± 0.047	0.954TyrGln: 0.954 ± 0.038	1.708TyrArg: 1.708 ± 0.053	2.465TyrSer: 2.465 ± 0.06	1.975TyrThr: 1.975 ± 0.061	2.332TyrVal: 2.332 ± 0.061	0.286TyrTrp: 0.286 ± 0.022	2.127TyrTyr: 2.127 ± 0.07	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2180 proteins (661144 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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