Amino acid dipepetide frequency for Pararhodospirillum oryzae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.819AlaAla: 16.819 ± 0.178	1.479AlaCys: 1.479 ± 0.038	6.907AlaAsp: 6.907 ± 0.081	7.117AlaGlu: 7.117 ± 0.104	4.22AlaPhe: 4.22 ± 0.064	11.589AlaGly: 11.589 ± 0.132	2.784AlaHis: 2.784 ± 0.054	4.525AlaIle: 4.525 ± 0.066	2.265AlaLys: 2.265 ± 0.052	18.339AlaLeu: 18.339 ± 0.169	2.906AlaMet: 2.906 ± 0.055	2.263AlaAsn: 2.263 ± 0.055	7.65AlaPro: 7.65 ± 0.117	4.371AlaGln: 4.371 ± 0.075	12.371AlaArg: 12.371 ± 0.132	6.198AlaSer: 6.198 ± 0.089	6.507AlaThr: 6.507 ± 0.1	10.006AlaVal: 10.006 ± 0.118	2.045AlaTrp: 2.045 ± 0.048	2.212AlaTyr: 2.212 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.035	0.097CysCys: 0.097 ± 0.01	0.562CysAsp: 0.562 ± 0.021	0.414CysGlu: 0.414 ± 0.021	0.294CysPhe: 0.294 ± 0.018	0.911CysGly: 0.911 ± 0.037	0.271CysHis: 0.271 ± 0.016	0.284CysIle: 0.284 ± 0.016	0.169CysLys: 0.169 ± 0.012	1.131CysLeu: 1.131 ± 0.033	0.141CysMet: 0.141 ± 0.012	0.18CysAsn: 0.18 ± 0.013	0.656CysPro: 0.656 ± 0.032	0.296CysGln: 0.296 ± 0.016	0.711CysArg: 0.711 ± 0.025	0.428CysSer: 0.428 ± 0.02	0.421CysThr: 0.421 ± 0.021	0.707CysVal: 0.707 ± 0.025	0.097CysTrp: 0.097 ± 0.009	0.184CysTyr: 0.184 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.903AspAla: 6.903 ± 0.09	0.395AspCys: 0.395 ± 0.018	3.35AspAsp: 3.35 ± 0.061	3.403AspGlu: 3.403 ± 0.059	1.72AspPhe: 1.72 ± 0.042	4.956AspGly: 4.956 ± 0.069	1.279AspHis: 1.279 ± 0.033	2.454AspIle: 2.454 ± 0.056	1.216AspLys: 1.216 ± 0.036	7.199AspLeu: 7.199 ± 0.093	1.201AspMet: 1.201 ± 0.034	1.042AspAsn: 1.042 ± 0.033	4.671AspPro: 4.671 ± 0.067	1.875AspGln: 1.875 ± 0.048	4.348AspArg: 4.348 ± 0.068	2.284AspSer: 2.284 ± 0.047	2.981AspThr: 2.981 ± 0.046	4.069AspVal: 4.069 ± 0.065	0.88AspTrp: 0.88 ± 0.032	1.061AspTyr: 1.061 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	9.134GluAla: 9.134 ± 0.116	0.388GluCys: 0.388 ± 0.022	2.971GluAsp: 2.971 ± 0.063	3.37GluGlu: 3.37 ± 0.075	1.276GluPhe: 1.276 ± 0.027	5.032GluGly: 5.032 ± 0.08	1.111GluHis: 1.111 ± 0.033	2.932GluIle: 2.932 ± 0.055	1.604GluLys: 1.604 ± 0.05	3.772GluLeu: 3.772 ± 0.057	1.262GluMet: 1.262 ± 0.042	1.422GluAsn: 1.422 ± 0.042	2.769GluPro: 2.769 ± 0.063	1.84GluGln: 1.84 ± 0.049	5.332GluArg: 5.332 ± 0.08	2.63GluSer: 2.63 ± 0.049	4.163GluThr: 4.163 ± 0.068	3.947GluVal: 3.947 ± 0.069	0.583GluTrp: 0.583 ± 0.025	0.801GluTyr: 0.801 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.675PheAla: 3.675 ± 0.057	0.387PheCys: 0.387 ± 0.02	2.191PheAsp: 2.191 ± 0.046	1.768PheGlu: 1.768 ± 0.044	1.185PhePhe: 1.185 ± 0.037	2.767PheGly: 2.767 ± 0.05	0.758PheHis: 0.758 ± 0.027	1.22PheIle: 1.22 ± 0.038	0.815PheLys: 0.815 ± 0.034	3.637PheLeu: 3.637 ± 0.053	0.704PheMet: 0.704 ± 0.028	0.851PheAsn: 0.851 ± 0.028	1.625PhePro: 1.625 ± 0.041	1.049PheGln: 1.049 ± 0.031	2.112PheArg: 2.112 ± 0.049	1.928PheSer: 1.928 ± 0.04	1.753PheThr: 1.753 ± 0.04	2.444PheVal: 2.444 ± 0.047	0.459PheTrp: 0.459 ± 0.02	0.691PheTyr: 0.691 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.607GlyAla: 10.607 ± 0.136	0.979GlyCys: 0.979 ± 0.034	4.328GlyAsp: 4.328 ± 0.063	4.731GlyGlu: 4.731 ± 0.061	3.134GlyPhe: 3.134 ± 0.059	7.55GlyGly: 7.55 ± 0.118	1.981GlyHis: 1.981 ± 0.044	3.546GlyIle: 3.546 ± 0.059	2.37GlyLys: 2.37 ± 0.05	10.715GlyLeu: 10.715 ± 0.119	2.151GlyMet: 2.151 ± 0.048	1.636GlyAsn: 1.636 ± 0.044	4.835GlyPro: 4.835 ± 0.077	2.951GlyGln: 2.951 ± 0.052	7.392GlyArg: 7.392 ± 0.082	4.2GlySer: 4.2 ± 0.07	5.063GlyThr: 5.063 ± 0.076	7.061GlyVal: 7.061 ± 0.082	1.375GlyTrp: 1.375 ± 0.038	1.877GlyTyr: 1.877 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.862HisAla: 2.862 ± 0.063	0.233HisCys: 0.233 ± 0.016	1.4HisAsp: 1.4 ± 0.039	1.103HisGlu: 1.103 ± 0.035	0.696HisPhe: 0.696 ± 0.023	2.129HisGly: 2.129 ± 0.046	0.643HisHis: 0.643 ± 0.027	0.691HisIle: 0.691 ± 0.026	0.466HisLys: 0.466 ± 0.021	2.386HisLeu: 2.386 ± 0.047	0.42HisMet: 0.42 ± 0.02	0.433HisAsn: 0.433 ± 0.021	1.695HisPro: 1.695 ± 0.043	0.653HisGln: 0.653 ± 0.025	1.576HisArg: 1.576 ± 0.04	0.742HisSer: 0.742 ± 0.025	0.909HisThr: 0.909 ± 0.033	1.545HisVal: 1.545 ± 0.037	0.288HisTrp: 0.288 ± 0.017	0.472HisTyr: 0.472 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.406IleAla: 5.406 ± 0.084	0.338IleCys: 0.338 ± 0.019	2.977IleAsp: 2.977 ± 0.048	2.954IleGlu: 2.954 ± 0.053	1.066IlePhe: 1.066 ± 0.035	3.738IleGly: 3.738 ± 0.069	0.869IleHis: 0.869 ± 0.029	1.416IleIle: 1.416 ± 0.038	1.109IleLys: 1.109 ± 0.039	4.079IleLeu: 4.079 ± 0.07	0.763IleMet: 0.763 ± 0.031	1.169IleAsn: 1.169 ± 0.039	2.071IlePro: 2.071 ± 0.049	1.157IleGln: 1.157 ± 0.032	2.761IleArg: 2.761 ± 0.05	1.957IleSer: 1.957 ± 0.044	2.431IleThr: 2.431 ± 0.054	2.992IleVal: 2.992 ± 0.059	0.354IleTrp: 0.354 ± 0.017	0.689IleTyr: 0.689 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.498LysAla: 3.498 ± 0.068	0.12LysCys: 0.12 ± 0.011	1.311LysAsp: 1.311 ± 0.036	1.284LysGlu: 1.284 ± 0.04	0.507LysPhe: 0.507 ± 0.023	2.328LysGly: 2.328 ± 0.055	0.369LysHis: 0.369 ± 0.019	1.091LysIle: 1.091 ± 0.031	0.782LysLys: 0.782 ± 0.031	1.682LysLeu: 1.682 ± 0.047	0.503LysMet: 0.503 ± 0.026	0.594LysAsn: 0.594 ± 0.03	1.357LysPro: 1.357 ± 0.037	0.564LysGln: 0.564 ± 0.023	1.668LysArg: 1.668 ± 0.04	1.13LysSer: 1.13 ± 0.038	1.528LysThr: 1.528 ± 0.04	1.865LysVal: 1.865 ± 0.051	0.183LysTrp: 0.183 ± 0.014	0.399LysTyr: 0.399 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	17.21LeuAla: 17.21 ± 0.168	0.971LeuCys: 0.971 ± 0.034	7.221LeuAsp: 7.221 ± 0.113	6.336LeuGlu: 6.336 ± 0.096	3.621LeuPhe: 3.621 ± 0.07	10.365LeuGly: 10.365 ± 0.121	2.063LeuHis: 2.063 ± 0.048	4.897LeuIle: 4.897 ± 0.068	2.802LeuLys: 2.802 ± 0.055	10.348LeuLeu: 10.348 ± 0.138	2.527LeuMet: 2.527 ± 0.047	2.367LeuAsn: 2.367 ± 0.051	6.653LeuPro: 6.653 ± 0.091	2.33LeuGln: 2.33 ± 0.05	8.145LeuArg: 8.145 ± 0.087	6.614LeuSer: 6.614 ± 0.092	5.967LeuThr: 5.967 ± 0.073	8.762LeuVal: 8.762 ± 0.102	1.255LeuTrp: 1.255 ± 0.037	1.958LeuTyr: 1.958 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.216MetAla: 3.216 ± 0.058	0.113MetCys: 0.113 ± 0.012	1.208MetAsp: 1.208 ± 0.037	1.13MetGlu: 1.13 ± 0.034	0.504MetPhe: 0.504 ± 0.022	1.927MetGly: 1.927 ± 0.047	0.388MetHis: 0.388 ± 0.019	1.17MetIle: 1.17 ± 0.034	0.642MetLys: 0.642 ± 0.028	1.928MetLeu: 1.928 ± 0.047	0.556MetMet: 0.556 ± 0.024	0.639MetAsn: 0.639 ± 0.023	1.325MetPro: 1.325 ± 0.042	0.536MetGln: 0.536 ± 0.023	1.532MetArg: 1.532 ± 0.04	1.373MetSer: 1.373 ± 0.036	1.731MetThr: 1.731 ± 0.039	1.771MetVal: 1.771 ± 0.042	0.156MetTrp: 0.156 ± 0.013	0.243MetTyr: 0.243 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.831AsnAla: 2.831 ± 0.054	0.166AsnCys: 0.166 ± 0.014	1.198AsnAsp: 1.198 ± 0.034	1.043AsnGlu: 1.043 ± 0.03	0.602AsnPhe: 0.602 ± 0.029	1.935AsnGly: 1.935 ± 0.044	0.456AsnHis: 0.456 ± 0.021	0.909AsnIle: 0.909 ± 0.03	0.531AsnLys: 0.531 ± 0.026	2.098AsnLeu: 2.098 ± 0.052	0.442AsnMet: 0.442 ± 0.021	0.522AsnAsn: 0.522 ± 0.024	1.586AsnPro: 1.586 ± 0.039	0.728AsnGln: 0.728 ± 0.027	1.657AsnArg: 1.657 ± 0.036	0.76AsnSer: 0.76 ± 0.031	1.205AsnThr: 1.205 ± 0.038	1.481AsnVal: 1.481 ± 0.036	0.246AsnTrp: 0.246 ± 0.015	0.431AsnTyr: 0.431 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.343ProAla: 8.343 ± 0.133	0.521ProCys: 0.521 ± 0.025	4.408ProAsp: 4.408 ± 0.07	4.243ProGlu: 4.243 ± 0.067	2.121ProPhe: 2.121 ± 0.043	6.109ProGly: 6.109 ± 0.081	1.124ProHis: 1.124 ± 0.033	1.697ProIle: 1.697 ± 0.039	1.045ProLys: 1.045 ± 0.034	6.495ProLeu: 6.495 ± 0.088	1.284ProMet: 1.284 ± 0.032	0.983ProAsn: 0.983 ± 0.031	4.493ProPro: 4.493 ± 0.13	1.519ProGln: 1.519 ± 0.045	4.022ProArg: 4.022 ± 0.059	3.077ProSer: 3.077 ± 0.052	2.856ProThr: 2.856 ± 0.057	5.21ProVal: 5.21 ± 0.075	0.995ProTrp: 0.995 ± 0.033	1.032ProTyr: 1.032 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.111GlnAla: 5.111 ± 0.079	0.188GlnCys: 0.188 ± 0.013	1.636GlnAsp: 1.636 ± 0.038	1.665GlnGlu: 1.665 ± 0.044	0.698GlnPhe: 0.698 ± 0.026	3.168GlnGly: 3.168 ± 0.053	0.477GlnHis: 0.477 ± 0.023	1.363GlnIle: 1.363 ± 0.035	0.751GlnLys: 0.751 ± 0.029	1.931GlnLeu: 1.931 ± 0.05	0.702GlnMet: 0.702 ± 0.024	0.643GlnAsn: 0.643 ± 0.024	1.63GlnPro: 1.63 ± 0.039	0.85GlnGln: 0.85 ± 0.031	2.395GlnArg: 2.395 ± 0.05	1.277GlnSer: 1.277 ± 0.041	1.702GlnThr: 1.702 ± 0.05	2.537GlnVal: 2.537 ± 0.051	0.316GlnTrp: 0.316 ± 0.018	0.484GlnTyr: 0.484 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	10.834ArgAla: 10.834 ± 0.115	0.577ArgCys: 0.577 ± 0.024	4.444ArgAsp: 4.444 ± 0.065	4.578ArgGlu: 4.578 ± 0.081	2.865ArgPhe: 2.865 ± 0.061	5.247ArgGly: 5.247 ± 0.077	2.043ArgHis: 2.043 ± 0.046	3.107ArgIle: 3.107 ± 0.061	1.858ArgLys: 1.858 ± 0.056	10.733ArgLeu: 10.733 ± 0.131	1.688ArgMet: 1.688 ± 0.042	1.444ArgAsn: 1.444 ± 0.038	4.877ArgPro: 4.877 ± 0.077	2.695ArgGln: 2.695 ± 0.054	6.807ArgArg: 6.807 ± 0.093	3.157ArgSer: 3.157 ± 0.062	3.653ArgThr: 3.653 ± 0.057	6.501ArgVal: 6.501 ± 0.083	1.118ArgTrp: 1.118 ± 0.033	1.502ArgTyr: 1.502 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.689SerAla: 5.689 ± 0.073	0.431SerCys: 0.431 ± 0.019	2.496SerAsp: 2.496 ± 0.053	2.331SerGlu: 2.331 ± 0.052	1.741SerPhe: 1.741 ± 0.042	4.818SerGly: 4.818 ± 0.072	1.081SerHis: 1.081 ± 0.032	1.916SerIle: 1.916 ± 0.042	0.952SerLys: 0.952 ± 0.03	5.741SerLeu: 5.741 ± 0.07	1.184SerMet: 1.184 ± 0.036	0.965SerAsn: 0.965 ± 0.033	3.243SerPro: 3.243 ± 0.062	1.5SerGln: 1.5 ± 0.041	3.631SerArg: 3.631 ± 0.065	2.598SerSer: 2.598 ± 0.055	2.547SerThr: 2.547 ± 0.051	4.079SerVal: 4.079 ± 0.062	0.675SerTrp: 0.675 ± 0.025	0.914SerTyr: 0.914 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.97ThrAla: 5.97 ± 0.081	0.463ThrCys: 0.463 ± 0.023	2.777ThrAsp: 2.777 ± 0.05	2.632ThrGlu: 2.632 ± 0.052	1.837ThrPhe: 1.837 ± 0.041	5.075ThrGly: 5.075 ± 0.069	1.198ThrHis: 1.198 ± 0.036	2.146ThrIle: 2.146 ± 0.046	0.948ThrLys: 0.948 ± 0.028	7.496ThrLeu: 7.496 ± 0.098	1.033ThrMet: 1.033 ± 0.035	1.081ThrAsn: 1.081 ± 0.031	4.166ThrPro: 4.166 ± 0.061	1.506ThrGln: 1.506 ± 0.038	4.159ThrArg: 4.159 ± 0.072	2.34ThrSer: 2.34 ± 0.048	3.068ThrThr: 3.068 ± 0.061	4.793ThrVal: 4.793 ± 0.067	0.789ThrTrp: 0.789 ± 0.027	1.071ThrTyr: 1.071 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.035ValAla: 10.035 ± 0.111	0.867ValCys: 0.867 ± 0.032	4.106ValAsp: 4.106 ± 0.074	4.633ValGlu: 4.633 ± 0.068	2.841ValPhe: 2.841 ± 0.045	6.174ValGly: 6.174 ± 0.071	1.614ValHis: 1.614 ± 0.038	3.706ValIle: 3.706 ± 0.058	1.625ValLys: 1.625 ± 0.049	9.221ValLeu: 9.221 ± 0.099	1.887ValMet: 1.887 ± 0.042	1.769ValAsn: 1.769 ± 0.042	4.556ValPro: 4.556 ± 0.068	1.983ValGln: 1.983 ± 0.042	6.191ValArg: 6.191 ± 0.08	4.304ValSer: 4.304 ± 0.069	4.279ValThr: 4.279 ± 0.059	7.164ValVal: 7.164 ± 0.098	0.935ValTrp: 0.935 ± 0.028	1.349ValTyr: 1.349 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.319TrpAla: 1.319 ± 0.039	0.137TrpCys: 0.137 ± 0.011	0.647TrpAsp: 0.647 ± 0.026	0.658TrpGlu: 0.658 ± 0.024	0.442TrpPhe: 0.442 ± 0.024	1.021TrpGly: 1.021 ± 0.033	0.323TrpHis: 0.323 ± 0.019	0.628TrpIle: 0.628 ± 0.025	0.341TrpLys: 0.341 ± 0.017	1.555TrpLeu: 1.555 ± 0.039	0.369TrpMet: 0.369 ± 0.018	0.341TrpAsn: 0.341 ± 0.016	0.774TrpPro: 0.774 ± 0.03	0.451TrpGln: 0.451 ± 0.024	1.296TrpArg: 1.296 ± 0.039	0.733TrpSer: 0.733 ± 0.026	0.79TrpThr: 0.79 ± 0.031	0.983TrpVal: 0.983 ± 0.029	0.2TrpTrp: 0.2 ± 0.014	0.232TrpTyr: 0.232 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.016TyrAla: 2.016 ± 0.038	0.204TyrCys: 0.204 ± 0.016	1.151TyrAsp: 1.151 ± 0.036	0.945TyrGlu: 0.945 ± 0.03	0.648TyrPhe: 0.648 ± 0.028	1.642TyrGly: 1.642 ± 0.044	0.513TyrHis: 0.513 ± 0.022	0.6TyrIle: 0.6 ± 0.027	0.472TyrLys: 0.472 ± 0.022	1.927TyrLeu: 1.927 ± 0.049	0.36TyrMet: 0.36 ± 0.018	0.484TyrAsn: 0.484 ± 0.026	0.948TyrPro: 0.948 ± 0.027	0.67TyrGln: 0.67 ± 0.027	1.618TyrArg: 1.618 ± 0.042	0.803TyrSer: 0.803 ± 0.03	0.993TyrThr: 0.993 ± 0.029	1.319TyrVal: 1.319 ± 0.036	0.289TyrTrp: 0.289 ± 0.016	0.531TyrTyr: 0.531 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3199 proteins (1075380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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