Amino acid dipepetide frequency for Halococcus morrhuae DSM 1307

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.455AlaAla: 13.455 ± 0.167	0.702AlaCys: 0.702 ± 0.031	9.489AlaAsp: 9.489 ± 0.131	8.129AlaGlu: 8.129 ± 0.112	3.98AlaPhe: 3.98 ± 0.071	9.837AlaGly: 9.837 ± 0.126	1.971AlaHis: 1.971 ± 0.052	5.836AlaIle: 5.836 ± 0.091	1.888AlaLys: 1.888 ± 0.045	11.255AlaLeu: 11.255 ± 0.149	2.156AlaMet: 2.156 ± 0.05	2.795AlaAsn: 2.795 ± 0.063	3.775AlaPro: 3.775 ± 0.062	2.146AlaGln: 2.146 ± 0.051	6.627AlaArg: 6.627 ± 0.101	5.563AlaSer: 5.563 ± 0.09	7.379AlaThr: 7.379 ± 0.122	9.671AlaVal: 9.671 ± 0.152	1.088AlaTrp: 1.088 ± 0.039	2.56AlaTyr: 2.56 ± 0.056	0.009AlaXaa: 0.009 ± 0.003
Cys	0.662CysAla: 0.662 ± 0.028	0.108CysCys: 0.108 ± 0.01	0.553CysAsp: 0.553 ± 0.03	0.669CysGlu: 0.669 ± 0.023	0.211CysPhe: 0.211 ± 0.018	0.939CysGly: 0.939 ± 0.039	0.165CysHis: 0.165 ± 0.015	0.307CysIle: 0.307 ± 0.02	0.108CysLys: 0.108 ± 0.011	0.561CysLeu: 0.561 ± 0.024	0.122CysMet: 0.122 ± 0.014	0.199CysAsn: 0.199 ± 0.015	0.509CysPro: 0.509 ± 0.025	0.139CysGln: 0.139 ± 0.014	0.473CysArg: 0.473 ± 0.024	0.454CysSer: 0.454 ± 0.024	0.42CysThr: 0.42 ± 0.024	0.528CysVal: 0.528 ± 0.024	0.102CysTrp: 0.102 ± 0.012	0.202CysTyr: 0.202 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	9.173AspAla: 9.173 ± 0.118	0.793AspCys: 0.793 ± 0.029	7.456AspAsp: 7.456 ± 0.111	8.919AspGlu: 8.919 ± 0.154	1.928AspPhe: 1.928 ± 0.055	7.81AspGly: 7.81 ± 0.112	1.89AspHis: 1.89 ± 0.053	3.255AspIle: 3.255 ± 0.067	0.92AspLys: 0.92 ± 0.034	6.366AspLeu: 6.366 ± 0.094	1.283AspMet: 1.283 ± 0.039	1.322AspAsn: 1.322 ± 0.045	4.141AspPro: 4.141 ± 0.072	1.549AspGln: 1.549 ± 0.046	5.991AspArg: 5.991 ± 0.094	3.848AspSer: 3.848 ± 0.073	4.228AspThr: 4.228 ± 0.07	6.89AspVal: 6.89 ± 0.097	1.035AspTrp: 1.035 ± 0.044	1.86AspTyr: 1.86 ± 0.049	0.007AspXaa: 0.007 ± 0.003
Glu	7.733GluAla: 7.733 ± 0.13	0.566GluCys: 0.566 ± 0.029	4.61GluAsp: 4.61 ± 0.081	6.589GluGlu: 6.589 ± 0.135	3.245GluPhe: 3.245 ± 0.066	5.388GluGly: 5.388 ± 0.091	2.296GluHis: 2.296 ± 0.065	4.324GluIle: 4.324 ± 0.081	1.91GluLys: 1.91 ± 0.053	7.904GluLeu: 7.904 ± 0.112	1.83GluMet: 1.83 ± 0.051	2.573GluAsn: 2.573 ± 0.057	3.645GluPro: 3.645 ± 0.074	2.821GluGln: 2.821 ± 0.06	8.698GluArg: 8.698 ± 0.139	5.327GluSer: 5.327 ± 0.08	6.415GluThr: 6.415 ± 0.087	4.539GluVal: 4.539 ± 0.082	1.1GluTrp: 1.1 ± 0.038	2.462GluTyr: 2.462 ± 0.054	0.008GluXaa: 0.008 ± 0.003
Phe	4.039PheAla: 4.039 ± 0.077	0.313PheCys: 0.313 ± 0.019	3.341PheAsp: 3.341 ± 0.051	2.989PheGlu: 2.989 ± 0.062	1.141PhePhe: 1.141 ± 0.041	3.437PheGly: 3.437 ± 0.079	0.637PheHis: 0.637 ± 0.026	1.15PheIle: 1.15 ± 0.041	0.497PheLys: 0.497 ± 0.024	2.952PheLeu: 2.952 ± 0.062	0.545PheMet: 0.545 ± 0.027	0.612PheAsn: 0.612 ± 0.025	1.336PhePro: 1.336 ± 0.045	0.733PheGln: 0.733 ± 0.032	1.762PheArg: 1.762 ± 0.05	1.818PheSer: 1.818 ± 0.054	2.009PheThr: 2.009 ± 0.05	3.622PheVal: 3.622 ± 0.076	0.423PheTrp: 0.423 ± 0.022	0.88PheTyr: 0.88 ± 0.038	0.002PheXaa: 0.002 ± 0.002
Gly	8.244GlyAla: 8.244 ± 0.124	0.681GlyCys: 0.681 ± 0.032	6.023GlyAsp: 6.023 ± 0.087	7.412GlyGlu: 7.412 ± 0.101	3.473GlyPhe: 3.473 ± 0.065	7.672GlyGly: 7.672 ± 0.146	1.696GlyHis: 1.696 ± 0.048	4.802GlyIle: 4.802 ± 0.086	1.96GlyLys: 1.96 ± 0.057	7.674GlyLeu: 7.674 ± 0.123	1.863GlyMet: 1.863 ± 0.048	2.081GlyAsn: 2.081 ± 0.062	3.224GlyPro: 3.224 ± 0.066	2.06GlyGln: 2.06 ± 0.05	4.973GlyArg: 4.973 ± 0.091	5.306GlySer: 5.306 ± 0.087	5.95GlyThr: 5.95 ± 0.088	7.372GlyVal: 7.372 ± 0.112	1.153GlyTrp: 1.153 ± 0.043	2.656GlyTyr: 2.656 ± 0.061	0.005GlyXaa: 0.005 ± 0.003
His	2.204HisAla: 2.204 ± 0.062	0.194HisCys: 0.194 ± 0.016	1.943HisAsp: 1.943 ± 0.049	1.948HisGlu: 1.948 ± 0.046	0.517HisPhe: 0.517 ± 0.026	2.045HisGly: 2.045 ± 0.05	0.57HisHis: 0.57 ± 0.027	0.786HisIle: 0.786 ± 0.028	0.292HisLys: 0.292 ± 0.021	1.711HisLeu: 1.711 ± 0.055	0.302HisMet: 0.302 ± 0.016	0.445HisAsn: 0.445 ± 0.019	1.282HisPro: 1.282 ± 0.037	0.445HisGln: 0.445 ± 0.022	1.399HisArg: 1.399 ± 0.039	0.899HisSer: 0.899 ± 0.031	1.212HisThr: 1.212 ± 0.043	1.728HisVal: 1.728 ± 0.045	0.248HisTrp: 0.248 ± 0.017	0.539HisTyr: 0.539 ± 0.026	0.004HisXaa: 0.004 ± 0.002
Ile	5.783IleAla: 5.783 ± 0.093	0.285IleCys: 0.285 ± 0.02	4.616IleAsp: 4.616 ± 0.08	4.92IleGlu: 4.92 ± 0.082	0.97IlePhe: 0.97 ± 0.041	4.458IleGly: 4.458 ± 0.095	0.958IleHis: 0.958 ± 0.033	1.458IleIle: 1.458 ± 0.046	0.685IleLys: 0.685 ± 0.029	2.795IleLeu: 2.795 ± 0.062	0.531IleMet: 0.531 ± 0.026	0.962IleAsn: 0.962 ± 0.036	2.162IlePro: 2.162 ± 0.056	1.135IleGln: 1.135 ± 0.041	2.489IleArg: 2.489 ± 0.057	2.101IleSer: 2.101 ± 0.055	2.584IleThr: 2.584 ± 0.064	4.239IleVal: 4.239 ± 0.072	0.347IleTrp: 0.347 ± 0.021	1.019IleTyr: 1.019 ± 0.034	0.005IleXaa: 0.005 ± 0.002
Lys	1.585LysAla: 1.585 ± 0.043	0.12LysCys: 0.12 ± 0.012	0.996LysAsp: 0.996 ± 0.034	1.323LysGlu: 1.323 ± 0.041	0.573LysPhe: 0.573 ± 0.027	1.323LysGly: 1.323 ± 0.047	0.504LysHis: 0.504 ± 0.025	0.819LysIle: 0.819 ± 0.034	0.516LysLys: 0.516 ± 0.03	1.831LysLeu: 1.831 ± 0.049	0.341LysMet: 0.341 ± 0.019	0.604LysAsn: 0.604 ± 0.03	0.975LysPro: 0.975 ± 0.037	0.81LysGln: 0.81 ± 0.033	1.729LysArg: 1.729 ± 0.053	1.139LysSer: 1.139 ± 0.039	1.332LysThr: 1.332 ± 0.043	1.045LysVal: 1.045 ± 0.038	0.242LysTrp: 0.242 ± 0.016	0.569LysTyr: 0.569 ± 0.022	0.004LysXaa: 0.004 ± 0.002
Leu	12.108LeuAla: 12.108 ± 0.166	0.711LeuCys: 0.711 ± 0.032	8.762LeuAsp: 8.762 ± 0.127	5.463LeuGlu: 5.463 ± 0.089	3.558LeuPhe: 3.558 ± 0.08	7.841LeuGly: 7.841 ± 0.127	1.582LeuHis: 1.582 ± 0.043	3.118LeuIle: 3.118 ± 0.075	1.56LeuLys: 1.56 ± 0.053	8.829LeuLeu: 8.829 ± 0.146	1.335LeuMet: 1.335 ± 0.039	1.788LeuAsn: 1.788 ± 0.048	4.346LeuPro: 4.346 ± 0.073	2.001LeuGln: 2.001 ± 0.053	5.415LeuArg: 5.415 ± 0.082	5.721LeuSer: 5.721 ± 0.084	5.484LeuThr: 5.484 ± 0.082	8.658LeuVal: 8.658 ± 0.14	0.877LeuTrp: 0.877 ± 0.038	2.233LeuTyr: 2.233 ± 0.048	0.009LeuXaa: 0.009 ± 0.004
Met	2.073MetAla: 2.073 ± 0.049	0.129MetCys: 0.129 ± 0.011	1.396MetAsp: 1.396 ± 0.044	1.175MetGlu: 1.175 ± 0.039	0.507MetPhe: 0.507 ± 0.026	1.538MetGly: 1.538 ± 0.042	0.328MetHis: 0.328 ± 0.019	0.691MetIle: 0.691 ± 0.028	0.428MetLys: 0.428 ± 0.023	1.594MetLeu: 1.594 ± 0.046	0.337MetMet: 0.337 ± 0.024	0.7MetAsn: 0.7 ± 0.029	0.806MetPro: 0.806 ± 0.029	0.537MetGln: 0.537 ± 0.024	1.03MetArg: 1.03 ± 0.036	1.583MetSer: 1.583 ± 0.039	1.46MetThr: 1.46 ± 0.038	1.288MetVal: 1.288 ± 0.036	0.139MetTrp: 0.139 ± 0.012	0.364MetTyr: 0.364 ± 0.021	0.001MetXaa: 0.001 ± 0.001
Asn	2.869AsnAla: 2.869 ± 0.065	0.218AsnCys: 0.218 ± 0.015	1.821AsnAsp: 1.821 ± 0.056	1.917AsnGlu: 1.917 ± 0.051	0.714AsnPhe: 0.714 ± 0.029	2.304AsnGly: 2.304 ± 0.069	0.537AsnHis: 0.537 ± 0.027	0.863AsnIle: 0.863 ± 0.031	0.427AsnLys: 0.427 ± 0.024	1.926AsnLeu: 1.926 ± 0.046	0.401AsnMet: 0.401 ± 0.023	0.581AsnAsn: 0.581 ± 0.031	1.525AsnPro: 1.525 ± 0.042	0.65AsnGln: 0.65 ± 0.027	1.666AsnArg: 1.666 ± 0.049	1.061AsnSer: 1.061 ± 0.038	1.403AsnThr: 1.403 ± 0.043	2.273AsnVal: 2.273 ± 0.058	0.327AsnTrp: 0.327 ± 0.021	0.745AsnTyr: 0.745 ± 0.03	0.001AsnXaa: 0.001 ± 0.001
Pro	4.68ProAla: 4.68 ± 0.071	0.212ProCys: 0.212 ± 0.015	4.636ProAsp: 4.636 ± 0.071	4.31ProGlu: 4.31 ± 0.068	1.588ProPhe: 1.588 ± 0.047	3.574ProGly: 3.574 ± 0.072	0.931ProHis: 0.931 ± 0.035	2.119ProIle: 2.119 ± 0.05	0.87ProLys: 0.87 ± 0.034	3.769ProLeu: 3.769 ± 0.072	0.89ProMet: 0.89 ± 0.029	1.221ProAsn: 1.221 ± 0.042	2.098ProPro: 2.098 ± 0.063	1.027ProGln: 1.027 ± 0.036	2.222ProArg: 2.222 ± 0.056	2.572ProSer: 2.572 ± 0.057	3.329ProThr: 3.329 ± 0.084	3.769ProVal: 3.769 ± 0.071	0.523ProTrp: 0.523 ± 0.024	1.192ProTyr: 1.192 ± 0.038	0.009ProXaa: 0.009 ± 0.003
Gln	2.361GlnAla: 2.361 ± 0.058	0.177GlnCys: 0.177 ± 0.014	1.194GlnAsp: 1.194 ± 0.038	1.622GlnGlu: 1.622 ± 0.048	1.068GlnPhe: 1.068 ± 0.036	1.757GlnGly: 1.757 ± 0.046	0.539GlnHis: 0.539 ± 0.026	1.045GlnIle: 1.045 ± 0.038	0.579GlnLys: 0.579 ± 0.026	2.505GlnLeu: 2.505 ± 0.056	0.493GlnMet: 0.493 ± 0.023	0.726GlnAsn: 0.726 ± 0.029	1.316GlnPro: 1.316 ± 0.043	1.059GlnGln: 1.059 ± 0.04	2.073GlnArg: 2.073 ± 0.057	1.685GlnSer: 1.685 ± 0.052	1.456GlnThr: 1.456 ± 0.042	1.63GlnVal: 1.63 ± 0.041	0.306GlnTrp: 0.306 ± 0.017	0.864GlnTyr: 0.864 ± 0.033	0.001GlnXaa: 0.001 ± 0.001
Arg	6.879ArgAla: 6.879 ± 0.109	0.487ArgCys: 0.487 ± 0.028	4.519ArgAsp: 4.519 ± 0.071	7.125ArgGlu: 7.125 ± 0.115	2.471ArgPhe: 2.471 ± 0.062	4.303ArgGly: 4.303 ± 0.069	1.257ArgHis: 1.257 ± 0.037	3.079ArgIle: 3.079 ± 0.059	1.417ArgLys: 1.417 ± 0.047	6.284ArgLeu: 6.284 ± 0.089	1.348ArgMet: 1.348 ± 0.041	1.594ArgAsn: 1.594 ± 0.046	2.517ArgPro: 2.517 ± 0.059	1.713ArgGln: 1.713 ± 0.049	4.765ArgArg: 4.765 ± 0.089	3.832ArgSer: 3.832 ± 0.085	4.343ArgThr: 4.343 ± 0.078	5.072ArgVal: 5.072 ± 0.084	0.787ArgTrp: 0.787 ± 0.032	1.984ArgTyr: 1.984 ± 0.049	0.015ArgXaa: 0.015 ± 0.004
Ser	5.689SerAla: 5.689 ± 0.096	0.358SerCys: 0.358 ± 0.024	4.125SerAsp: 4.125 ± 0.077	4.267SerGlu: 4.267 ± 0.072	1.971SerPhe: 1.971 ± 0.051	5.418SerGly: 5.418 ± 0.093	1.115SerHis: 1.115 ± 0.037	2.682SerIle: 2.682 ± 0.059	1.176SerLys: 1.176 ± 0.038	5.144SerLeu: 5.144 ± 0.089	1.17SerMet: 1.17 ± 0.036	1.402SerAsn: 1.402 ± 0.045	2.568SerPro: 2.568 ± 0.061	1.493SerGln: 1.493 ± 0.048	3.204SerArg: 3.204 ± 0.068	3.301SerSer: 3.301 ± 0.083	3.689SerThr: 3.689 ± 0.081	4.937SerVal: 4.937 ± 0.08	0.622SerTrp: 0.622 ± 0.027	1.684SerTyr: 1.684 ± 0.055	0.006SerXaa: 0.006 ± 0.003
Thr	7.068ThrAla: 7.068 ± 0.116	0.372ThrCys: 0.372 ± 0.02	5.784ThrAsp: 5.784 ± 0.082	4.839ThrGlu: 4.839 ± 0.095	2.028ThrPhe: 2.028 ± 0.054	5.888ThrGly: 5.888 ± 0.089	1.302ThrHis: 1.302 ± 0.042	3.411ThrIle: 3.411 ± 0.058	1.061ThrLys: 1.061 ± 0.033	5.767ThrLeu: 5.767 ± 0.091	1.183ThrMet: 1.183 ± 0.043	1.691ThrAsn: 1.691 ± 0.042	3.468ThrPro: 3.468 ± 0.083	1.404ThrGln: 1.404 ± 0.043	3.292ThrArg: 3.292 ± 0.063	3.028ThrSer: 3.028 ± 0.062	4.772ThrThr: 4.772 ± 0.106	6.607ThrVal: 6.607 ± 0.086	0.586ThrTrp: 0.586 ± 0.027	1.578ThrTyr: 1.578 ± 0.041	0.004ThrXaa: 0.004 ± 0.002
Val	9.993ValAla: 9.993 ± 0.147	0.681ValCys: 0.681 ± 0.033	6.189ValAsp: 6.189 ± 0.089	7.316ValGlu: 7.316 ± 0.107	3.021ValPhe: 3.021 ± 0.06	7.59ValGly: 7.59 ± 0.106	1.632ValHis: 1.632 ± 0.048	3.39ValIle: 3.39 ± 0.063	1.302ValLys: 1.302 ± 0.044	8.572ValLeu: 8.572 ± 0.136	1.345ValMet: 1.345 ± 0.044	1.901ValAsn: 1.901 ± 0.053	4.105ValPro: 4.105 ± 0.073	1.681ValGln: 1.681 ± 0.044	5.104ValArg: 5.104 ± 0.088	4.871ValSer: 4.871 ± 0.071	5.394ValThr: 5.394 ± 0.082	8.3ValVal: 8.3 ± 0.123	0.796ValTrp: 0.796 ± 0.034	1.851ValTyr: 1.851 ± 0.044	0.009ValXaa: 0.009 ± 0.003
Trp	0.933TrpAla: 0.933 ± 0.038	0.09TrpCys: 0.09 ± 0.011	0.716TrpAsp: 0.716 ± 0.03	0.792TrpGlu: 0.792 ± 0.033	0.445TrpPhe: 0.445 ± 0.022	0.759TrpGly: 0.759 ± 0.033	0.226TrpHis: 0.226 ± 0.015	0.515TrpIle: 0.515 ± 0.027	0.35TrpLys: 0.35 ± 0.021	1.378TrpLeu: 1.378 ± 0.043	0.241TrpMet: 0.241 ± 0.016	0.389TrpAsn: 0.389 ± 0.024	0.465TrpPro: 0.465 ± 0.022	0.373TrpGln: 0.373 ± 0.022	0.834TrpArg: 0.834 ± 0.034	0.622TrpSer: 0.622 ± 0.028	0.76TrpThr: 0.76 ± 0.034	0.781TrpVal: 0.781 ± 0.031	0.179TrpTrp: 0.179 ± 0.015	0.371TrpTyr: 0.371 ± 0.024	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.77TyrAla: 2.77 ± 0.061	0.224TyrCys: 0.224 ± 0.017	2.49TyrAsp: 2.49 ± 0.058	2.253TyrGlu: 2.253 ± 0.06	0.824TyrPhe: 0.824 ± 0.03	2.392TyrGly: 2.392 ± 0.061	0.579TyrHis: 0.579 ± 0.024	0.848TyrIle: 0.848 ± 0.029	0.429TyrLys: 0.429 ± 0.025	2.577TyrLeu: 2.577 ± 0.055	0.381TyrMet: 0.381 ± 0.022	0.643TyrAsn: 0.643 ± 0.032	1.277TyrPro: 1.277 ± 0.042	0.678TyrGln: 0.678 ± 0.032	2.041TyrArg: 2.041 ± 0.048	1.277TyrSer: 1.277 ± 0.04	1.509TyrThr: 1.509 ± 0.049	2.087TyrVal: 2.087 ± 0.053	0.339TyrTrp: 0.339 ± 0.02	0.838TyrTyr: 0.838 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.009XaaAla: 0.009 ± 0.003	0.007XaaCys: 0.007 ± 0.003	0.004XaaAsp: 0.004 ± 0.002	0.007XaaGlu: 0.007 ± 0.003	0.006XaaPhe: 0.006 ± 0.002	0.005XaaGly: 0.005 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.004XaaLys: 0.004 ± 0.002	0.009XaaLeu: 0.009 ± 0.003	0.005XaaMet: 0.005 ± 0.002	0.004XaaAsn: 0.004 ± 0.002	0.004XaaPro: 0.004 ± 0.002	0.004XaaGln: 0.004 ± 0.002	0.007XaaArg: 0.007 ± 0.003	0.011XaaSer: 0.011 ± 0.003	0.007XaaThr: 0.007 ± 0.003	0.006XaaVal: 0.006 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.005XaaTyr: 0.005 ± 0.002	0.008XaaXaa: 0.008 ± 0.004

Statistics based on 3035 proteins (843377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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