Amino acid dipepetide frequency for Leptospira phage vb_LkmZ_Bejolso9-LE1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.596AlaAla: 1.596 ± 0.448
0.456AlaCys: 0.456 ± 0.157
2.204AlaAsp: 2.204 ± 0.505
3.192AlaGlu: 3.192 ± 0.609
3.724AlaPhe: 3.724 ± 0.443
2.66AlaGly: 2.66 ± 0.599
0.304AlaHis: 0.304 ± 0.137
3.876AlaIle: 3.876 ± 0.479
3.344AlaLys: 3.344 ± 0.46
5.472AlaLeu: 5.472 ± 0.712
0.684AlaMet: 0.684 ± 0.273
2.432AlaAsn: 2.432 ± 0.4
1.064AlaPro: 1.064 ± 0.284
1.444AlaGln: 1.444 ± 0.36
1.368AlaArg: 1.368 ± 0.396
3.04AlaSer: 3.04 ± 0.43
2.128AlaThr: 2.128 ± 0.44
1.976AlaVal: 1.976 ± 0.295
0.456AlaTrp: 0.456 ± 0.182
1.216AlaTyr: 1.216 ± 0.391
0.0AlaXaa: 0.0 ± 0.0
Cys
0.456CysAla: 0.456 ± 0.165
0.304CysCys: 0.304 ± 0.297
0.152CysAsp: 0.152 ± 0.096
0.76CysGlu: 0.76 ± 0.218
0.76CysPhe: 0.76 ± 0.25
0.532CysGly: 0.532 ± 0.208
0.456CysHis: 0.456 ± 0.41
1.064CysIle: 1.064 ± 0.348
0.684CysLys: 0.684 ± 0.202
0.836CysLeu: 0.836 ± 0.256
0.0CysMet: 0.0 ± 0.0
0.836CysAsn: 0.836 ± 0.193
0.304CysPro: 0.304 ± 0.203
0.152CysGln: 0.152 ± 0.115
0.532CysArg: 0.532 ± 0.182
0.684CysSer: 0.684 ± 0.184
0.228CysThr: 0.228 ± 0.123
0.456CysVal: 0.456 ± 0.194
0.076CysTrp: 0.076 ± 0.086
0.456CysTyr: 0.456 ± 0.195
0.0CysXaa: 0.0 ± 0.0
Asp
2.508AspAla: 2.508 ± 0.57
0.76AspCys: 0.76 ± 0.254
1.292AspAsp: 1.292 ± 0.336
2.28AspGlu: 2.28 ± 0.372
3.344AspPhe: 3.344 ± 0.411
4.408AspGly: 4.408 ± 1.074
0.836AspHis: 0.836 ± 0.291
4.484AspIle: 4.484 ± 0.456
3.04AspLys: 3.04 ± 0.457
6.992AspLeu: 6.992 ± 0.664
0.76AspMet: 0.76 ± 0.271
2.66AspAsn: 2.66 ± 0.397
2.204AspPro: 2.204 ± 0.454
1.976AspGln: 1.976 ± 0.359
2.812AspArg: 2.812 ± 0.604
4.788AspSer: 4.788 ± 0.813
2.432AspThr: 2.432 ± 0.596
2.204AspVal: 2.204 ± 0.397
0.456AspTrp: 0.456 ± 0.167
2.356AspTyr: 2.356 ± 0.36
0.0AspXaa: 0.0 ± 0.0
Glu
3.344GluAla: 3.344 ± 0.739
0.532GluCys: 0.532 ± 0.21
4.256GluAsp: 4.256 ± 0.497
4.18GluGlu: 4.18 ± 0.898
3.04GluPhe: 3.04 ± 0.692
3.04GluGly: 3.04 ± 0.515
0.608GluHis: 0.608 ± 0.208
6.46GluIle: 6.46 ± 1.392
6.384GluLys: 6.384 ± 0.998
5.548GluLeu: 5.548 ± 1.099
0.988GluMet: 0.988 ± 0.243
5.168GluAsn: 5.168 ± 0.935
1.292GluPro: 1.292 ± 0.261
1.14GluGln: 1.14 ± 0.384
2.964GluArg: 2.964 ± 0.492
4.56GluSer: 4.56 ± 0.584
3.648GluThr: 3.648 ± 0.396
3.116GluVal: 3.116 ± 0.356
0.836GluTrp: 0.836 ± 0.277
2.964GluTyr: 2.964 ± 0.413
0.0GluXaa: 0.0 ± 0.0
Phe
2.508PheAla: 2.508 ± 0.264
0.532PheCys: 0.532 ± 0.177
2.584PheAsp: 2.584 ± 0.374
3.268PheGlu: 3.268 ± 0.623
2.66PhePhe: 2.66 ± 0.501
2.736PheGly: 2.736 ± 0.535
1.444PheHis: 1.444 ± 0.326
4.56PheIle: 4.56 ± 0.674
4.408PheLys: 4.408 ± 0.593
6.232PheLeu: 6.232 ± 0.621
0.456PheMet: 0.456 ± 0.171
3.116PheAsn: 3.116 ± 0.494
2.508PhePro: 2.508 ± 0.482
2.736PheGln: 2.736 ± 0.525
2.66PheArg: 2.66 ± 0.58
5.472PheSer: 5.472 ± 0.716
2.28PheThr: 2.28 ± 0.316
2.812PheVal: 2.812 ± 0.455
0.38PheTrp: 0.38 ± 0.148
2.432PheTyr: 2.432 ± 0.445
0.0PheXaa: 0.0 ± 0.0
Gly
1.9GlyAla: 1.9 ± 0.547
0.532GlyCys: 0.532 ± 0.275
2.736GlyAsp: 2.736 ± 0.562
3.496GlyGlu: 3.496 ± 0.572
3.496GlyPhe: 3.496 ± 0.422
3.268GlyGly: 3.268 ± 0.91
0.988GlyHis: 0.988 ± 0.248
4.332GlyIle: 4.332 ± 0.602
4.788GlyLys: 4.788 ± 0.747
3.876GlyLeu: 3.876 ± 0.421
0.608GlyMet: 0.608 ± 0.151
4.104GlyAsn: 4.104 ± 0.882
1.216GlyPro: 1.216 ± 0.373
2.28GlyGln: 2.28 ± 0.575
2.356GlyArg: 2.356 ± 0.376
4.636GlySer: 4.636 ± 1.071
4.56GlyThr: 4.56 ± 1.232
2.356GlyVal: 2.356 ± 0.398
0.76GlyTrp: 0.76 ± 0.189
2.66GlyTyr: 2.66 ± 0.362
0.0GlyXaa: 0.0 ± 0.0
His
1.368HisAla: 1.368 ± 0.36
0.304HisCys: 0.304 ± 0.179
0.988HisAsp: 0.988 ± 0.207
1.216HisGlu: 1.216 ± 0.264
0.836HisPhe: 0.836 ± 0.247
0.532HisGly: 0.532 ± 0.194
0.38HisHis: 0.38 ± 0.156
0.76HisIle: 0.76 ± 0.241
1.596HisLys: 1.596 ± 0.462
1.368HisLeu: 1.368 ± 0.282
0.228HisMet: 0.228 ± 0.14
0.608HisAsn: 0.608 ± 0.186
0.912HisPro: 0.912 ± 0.278
0.988HisGln: 0.988 ± 0.303
0.988HisArg: 0.988 ± 0.308
1.52HisSer: 1.52 ± 0.335
0.532HisThr: 0.532 ± 0.214
0.988HisVal: 0.988 ± 0.226
0.228HisTrp: 0.228 ± 0.132
0.532HisTyr: 0.532 ± 0.229
0.0HisXaa: 0.0 ± 0.0
Ile
3.572IleAla: 3.572 ± 0.458
0.532IleCys: 0.532 ± 0.226
4.636IleAsp: 4.636 ± 0.508
6.384IleGlu: 6.384 ± 0.955
4.56IlePhe: 4.56 ± 0.447
3.876IleGly: 3.876 ± 0.693
1.976IleHis: 1.976 ± 0.316
4.94IleIle: 4.94 ± 1.107
6.384IleLys: 6.384 ± 0.883
7.829IleLeu: 7.829 ± 0.997
1.444IleMet: 1.444 ± 0.313
3.724IleAsn: 3.724 ± 0.555
3.496IlePro: 3.496 ± 0.43
3.344IleGln: 3.344 ± 0.637
3.876IleArg: 3.876 ± 0.736
7.068IleSer: 7.068 ± 0.662
4.864IleThr: 4.864 ± 0.632
4.332IleVal: 4.332 ± 0.767
0.836IleTrp: 0.836 ± 0.339
3.8IleTyr: 3.8 ± 0.453
0.0IleXaa: 0.0 ± 0.0
Lys
3.268LysAla: 3.268 ± 0.518
0.608LysCys: 0.608 ± 0.277
5.092LysAsp: 5.092 ± 0.688
6.612LysGlu: 6.612 ± 1.049
3.876LysPhe: 3.876 ± 0.611
4.408LysGly: 4.408 ± 0.44
0.988LysHis: 0.988 ± 0.33
6.688LysIle: 6.688 ± 0.899
6.004LysLys: 6.004 ± 0.864
7.144LysLeu: 7.144 ± 1.1
1.064LysMet: 1.064 ± 0.345
6.156LysAsn: 6.156 ± 0.707
2.28LysPro: 2.28 ± 0.418
2.888LysGln: 2.888 ± 0.52
3.268LysArg: 3.268 ± 0.74
6.612LysSer: 6.612 ± 0.639
4.56LysThr: 4.56 ± 0.63
4.18LysVal: 4.18 ± 0.546
0.684LysTrp: 0.684 ± 0.248
4.56LysTyr: 4.56 ± 0.737
0.0LysXaa: 0.0 ± 0.0
Leu
3.116LeuAla: 3.116 ± 0.519
1.444LeuCys: 1.444 ± 0.25
4.864LeuAsp: 4.864 ± 0.863
6.384LeuGlu: 6.384 ± 0.82
5.548LeuPhe: 5.548 ± 0.831
4.94LeuGly: 4.94 ± 0.516
2.128LeuHis: 2.128 ± 0.469
8.209LeuIle: 8.209 ± 0.737
9.805LeuLys: 9.805 ± 1.307
9.425LeuLeu: 9.425 ± 1.327
1.596LeuMet: 1.596 ± 0.263
7.373LeuAsn: 7.373 ± 0.947
3.192LeuPro: 3.192 ± 0.753
3.952LeuGln: 3.952 ± 0.858
4.712LeuArg: 4.712 ± 0.648
8.133LeuSer: 8.133 ± 0.708
5.548LeuThr: 5.548 ± 0.884
3.8LeuVal: 3.8 ± 0.716
1.216LeuTrp: 1.216 ± 0.324
4.028LeuTyr: 4.028 ± 0.572
0.0LeuXaa: 0.0 ± 0.0
Met
1.216MetAla: 1.216 ± 0.337
0.076MetCys: 0.076 ± 0.078
0.76MetAsp: 0.76 ± 0.222
1.368MetGlu: 1.368 ± 0.376
0.608MetPhe: 0.608 ± 0.167
0.456MetGly: 0.456 ± 0.176
0.076MetHis: 0.076 ± 0.08
1.292MetIle: 1.292 ± 0.396
1.748MetLys: 1.748 ± 0.413
0.912MetLeu: 0.912 ± 0.237
0.304MetMet: 0.304 ± 0.123
1.216MetAsn: 1.216 ± 0.287
0.608MetPro: 0.608 ± 0.328
0.38MetGln: 0.38 ± 0.144
0.532MetArg: 0.532 ± 0.205
0.912MetSer: 0.912 ± 0.196
0.912MetThr: 0.912 ± 0.234
0.456MetVal: 0.456 ± 0.234
0.152MetTrp: 0.152 ± 0.11
0.988MetTyr: 0.988 ± 0.253
0.0MetXaa: 0.0 ± 0.0
Asn
3.344AsnAla: 3.344 ± 0.516
0.608AsnCys: 0.608 ± 0.179
3.268AsnAsp: 3.268 ± 0.515
4.104AsnGlu: 4.104 ± 0.866
3.268AsnPhe: 3.268 ± 0.445
4.636AsnGly: 4.636 ± 1.095
0.988AsnHis: 0.988 ± 0.311
4.712AsnIle: 4.712 ± 0.571
5.168AsnLys: 5.168 ± 0.872
7.373AsnLeu: 7.373 ± 1.511
0.38AsnMet: 0.38 ± 0.19
4.104AsnAsn: 4.104 ± 0.542
3.496AsnPro: 3.496 ± 0.826
2.812AsnGln: 2.812 ± 0.369
3.648AsnArg: 3.648 ± 0.619
7.449AsnSer: 7.449 ± 0.875
3.42AsnThr: 3.42 ± 0.672
3.344AsnVal: 3.344 ± 0.403
1.216AsnTrp: 1.216 ± 0.34
2.204AsnTyr: 2.204 ± 0.323
0.0AsnXaa: 0.0 ± 0.0
Pro
1.14ProAla: 1.14 ± 0.362
0.152ProCys: 0.152 ± 0.109
1.976ProAsp: 1.976 ± 0.36
2.204ProGlu: 2.204 ± 0.409
1.52ProPhe: 1.52 ± 0.347
2.204ProGly: 2.204 ± 0.486
0.38ProHis: 0.38 ± 0.179
2.584ProIle: 2.584 ± 0.494
2.812ProLys: 2.812 ± 0.471
3.344ProLeu: 3.344 ± 0.635
0.76ProMet: 0.76 ± 0.258
3.344ProAsn: 3.344 ± 0.504
1.14ProPro: 1.14 ± 0.217
0.684ProGln: 0.684 ± 0.221
1.064ProArg: 1.064 ± 0.327
3.496ProSer: 3.496 ± 0.796
2.66ProThr: 2.66 ± 0.446
1.52ProVal: 1.52 ± 0.365
0.456ProTrp: 0.456 ± 0.16
1.368ProTyr: 1.368 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
1.14GlnAla: 1.14 ± 0.231
0.456GlnCys: 0.456 ± 0.183
1.444GlnAsp: 1.444 ± 0.348
1.976GlnGlu: 1.976 ± 0.393
1.9GlnPhe: 1.9 ± 0.376
1.9GlnGly: 1.9 ± 0.309
0.456GlnHis: 0.456 ± 0.201
3.8GlnIle: 3.8 ± 0.589
2.356GlnLys: 2.356 ± 0.545
3.42GlnLeu: 3.42 ± 0.696
0.912GlnMet: 0.912 ± 0.245
2.964GlnAsn: 2.964 ± 0.48
0.836GlnPro: 0.836 ± 0.226
1.368GlnGln: 1.368 ± 0.325
1.672GlnArg: 1.672 ± 0.357
2.66GlnSer: 2.66 ± 0.323
2.28GlnThr: 2.28 ± 0.51
1.9GlnVal: 1.9 ± 0.315
0.608GlnTrp: 0.608 ± 0.21
1.9GlnTyr: 1.9 ± 0.501
0.0GlnXaa: 0.0 ± 0.0
Arg
1.748ArgAla: 1.748 ± 0.36
0.076ArgCys: 0.076 ± 0.078
1.748ArgAsp: 1.748 ± 0.371
3.268ArgGlu: 3.268 ± 0.73
2.888ArgPhe: 2.888 ± 0.466
1.596ArgGly: 1.596 ± 0.285
0.684ArgHis: 0.684 ± 0.226
4.104ArgIle: 4.104 ± 0.633
3.8ArgLys: 3.8 ± 0.648
4.18ArgLeu: 4.18 ± 0.616
1.292ArgMet: 1.292 ± 0.303
3.116ArgAsn: 3.116 ± 0.503
1.368ArgPro: 1.368 ± 0.206
1.216ArgGln: 1.216 ± 0.381
2.204ArgArg: 2.204 ± 0.585
3.496ArgSer: 3.496 ± 0.556
1.976ArgThr: 1.976 ± 0.29
1.824ArgVal: 1.824 ± 0.463
0.38ArgTrp: 0.38 ± 0.229
2.128ArgTyr: 2.128 ± 0.429
0.0ArgXaa: 0.0 ± 0.0
Ser
3.268SerAla: 3.268 ± 0.564
0.988SerCys: 0.988 ± 0.423
5.244SerAsp: 5.244 ± 0.516
5.092SerGlu: 5.092 ± 0.681
4.636SerPhe: 4.636 ± 0.557
5.168SerGly: 5.168 ± 0.947
1.824SerHis: 1.824 ± 0.377
7.753SerIle: 7.753 ± 0.634
6.536SerLys: 6.536 ± 0.686
10.413SerLeu: 10.413 ± 0.871
1.292SerMet: 1.292 ± 0.247
7.449SerAsn: 7.449 ± 0.814
2.812SerPro: 2.812 ± 0.56
2.812SerGln: 2.812 ± 0.43
2.584SerArg: 2.584 ± 0.323
6.08SerSer: 6.08 ± 1.048
3.496SerThr: 3.496 ± 0.664
4.636SerVal: 4.636 ± 0.812
0.608SerTrp: 0.608 ± 0.247
3.8SerTyr: 3.8 ± 0.514
0.0SerXaa: 0.0 ± 0.0
Thr
2.66ThrAla: 2.66 ± 0.444
0.456ThrCys: 0.456 ± 0.241
3.04ThrAsp: 3.04 ± 0.54
2.888ThrGlu: 2.888 ± 0.447
3.648ThrPhe: 3.648 ± 0.461
3.648ThrGly: 3.648 ± 1.192
0.456ThrHis: 0.456 ± 0.208
4.332ThrIle: 4.332 ± 0.549
4.788ThrLys: 4.788 ± 0.674
4.712ThrLeu: 4.712 ± 0.577
0.912ThrMet: 0.912 ± 0.258
3.724ThrAsn: 3.724 ± 0.721
2.66ThrPro: 2.66 ± 0.461
2.128ThrGln: 2.128 ± 0.617
1.52ThrArg: 1.52 ± 0.364
5.7ThrSer: 5.7 ± 0.771
3.344ThrThr: 3.344 ± 0.741
1.9ThrVal: 1.9 ± 0.494
0.456ThrTrp: 0.456 ± 0.158
2.28ThrTyr: 2.28 ± 0.568
0.0ThrXaa: 0.0 ± 0.0
Val
2.28ValAla: 2.28 ± 0.385
0.456ValCys: 0.456 ± 0.152
2.66ValAsp: 2.66 ± 0.505
2.66ValGlu: 2.66 ± 0.458
2.66ValPhe: 2.66 ± 0.358
2.66ValGly: 2.66 ± 0.411
1.064ValHis: 1.064 ± 0.343
3.496ValIle: 3.496 ± 0.645
2.66ValLys: 2.66 ± 0.44
4.332ValLeu: 4.332 ± 0.555
0.38ValMet: 0.38 ± 0.16
3.42ValAsn: 3.42 ± 0.638
1.444ValPro: 1.444 ± 0.303
1.444ValGln: 1.444 ± 0.411
2.356ValArg: 2.356 ± 0.276
4.332ValSer: 4.332 ± 0.719
3.192ValThr: 3.192 ± 0.662
2.66ValVal: 2.66 ± 0.387
0.38ValTrp: 0.38 ± 0.197
1.976ValTyr: 1.976 ± 0.32
0.0ValXaa: 0.0 ± 0.0
Trp
0.456TrpAla: 0.456 ± 0.192
0.152TrpCys: 0.152 ± 0.1
0.684TrpAsp: 0.684 ± 0.165
0.684TrpGlu: 0.684 ± 0.252
0.152TrpPhe: 0.152 ± 0.111
0.38TrpGly: 0.38 ± 0.177
0.0TrpHis: 0.0 ± 0.0
1.216TrpIle: 1.216 ± 0.373
1.292TrpLys: 1.292 ± 0.416
0.912TrpLeu: 0.912 ± 0.313
0.304TrpMet: 0.304 ± 0.145
0.684TrpAsn: 0.684 ± 0.273
0.152TrpPro: 0.152 ± 0.116
0.532TrpGln: 0.532 ± 0.203
0.304TrpArg: 0.304 ± 0.171
0.912TrpSer: 0.912 ± 0.291
0.76TrpThr: 0.76 ± 0.457
0.76TrpVal: 0.76 ± 0.229
0.304TrpTrp: 0.304 ± 0.147
0.304TrpTyr: 0.304 ± 0.148
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.748TyrAla: 1.748 ± 0.336
0.304TyrCys: 0.304 ± 0.175
2.964TyrAsp: 2.964 ± 0.92
2.052TyrGlu: 2.052 ± 0.483
2.66TyrPhe: 2.66 ± 0.483
1.9TyrGly: 1.9 ± 0.521
0.912TyrHis: 0.912 ± 0.29
2.812TyrIle: 2.812 ± 0.437
3.344TyrLys: 3.344 ± 0.62
5.092TyrLeu: 5.092 ± 0.606
0.532TyrMet: 0.532 ± 0.154
3.344TyrAsn: 3.344 ± 0.484
1.824TyrPro: 1.824 ± 0.428
1.672TyrGln: 1.672 ± 0.369
1.672TyrArg: 1.672 ± 0.39
4.94TyrSer: 4.94 ± 0.578
2.432TyrThr: 2.432 ± 0.318
1.292TyrVal: 1.292 ± 0.316
0.456TyrTrp: 0.456 ± 0.202
1.976TyrTyr: 1.976 ± 0.394
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 34 proteins (13158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski