Amino acid dipepetide frequency for Thalassomonas actiniarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.866AlaAla: 7.866 ± 0.086
0.972AlaCys: 0.972 ± 0.028
5.069AlaAsp: 5.069 ± 0.054
5.316AlaGlu: 5.316 ± 0.065
3.625AlaPhe: 3.625 ± 0.047
6.512AlaGly: 6.512 ± 0.072
1.544AlaHis: 1.544 ± 0.033
5.704AlaIle: 5.704 ± 0.056
4.993AlaLys: 4.993 ± 0.06
10.215AlaLeu: 10.215 ± 0.09
2.32AlaMet: 2.32 ± 0.045
3.841AlaAsn: 3.841 ± 0.05
2.979AlaPro: 2.979 ± 0.046
4.002AlaGln: 4.002 ± 0.053
3.742AlaArg: 3.742 ± 0.054
5.683AlaSer: 5.683 ± 0.056
4.078AlaThr: 4.078 ± 0.061
5.6AlaVal: 5.6 ± 0.057
0.894AlaTrp: 0.894 ± 0.024
2.558AlaTyr: 2.558 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.738CysAla: 0.738 ± 0.018
0.152CysCys: 0.152 ± 0.01
0.559CysAsp: 0.559 ± 0.02
0.512CysGlu: 0.512 ± 0.018
0.489CysPhe: 0.489 ± 0.016
0.797CysGly: 0.797 ± 0.026
0.343CysHis: 0.343 ± 0.015
0.553CysIle: 0.553 ± 0.016
0.405CysLys: 0.405 ± 0.017
1.087CysLeu: 1.087 ± 0.027
0.199CysMet: 0.199 ± 0.011
0.351CysAsn: 0.351 ± 0.015
0.442CysPro: 0.442 ± 0.019
0.595CysGln: 0.595 ± 0.016
0.549CysArg: 0.549 ± 0.02
0.682CysSer: 0.682 ± 0.02
0.433CysThr: 0.433 ± 0.015
0.494CysVal: 0.494 ± 0.017
0.143CysTrp: 0.143 ± 0.01
0.384CysTyr: 0.384 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.172AspAla: 4.172 ± 0.057
0.522AspCys: 0.522 ± 0.017
3.403AspAsp: 3.403 ± 0.061
3.775AspGlu: 3.775 ± 0.053
2.832AspPhe: 2.832 ± 0.049
4.021AspGly: 4.021 ± 0.095
1.1AspHis: 1.1 ± 0.024
4.53AspIle: 4.53 ± 0.049
3.599AspLys: 3.599 ± 0.052
5.32AspLeu: 5.32 ± 0.063
1.331AspMet: 1.331 ± 0.03
3.19AspAsn: 3.19 ± 0.057
2.007AspPro: 2.007 ± 0.04
1.991AspGln: 1.991 ± 0.038
1.947AspArg: 1.947 ± 0.04
3.502AspSer: 3.502 ± 0.051
2.696AspThr: 2.696 ± 0.044
3.521AspVal: 3.521 ± 0.049
0.785AspTrp: 0.785 ± 0.024
2.309AspTyr: 2.309 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.628GluAla: 4.628 ± 0.063
0.434GluCys: 0.434 ± 0.018
2.747GluAsp: 2.747 ± 0.04
3.27GluGlu: 3.27 ± 0.054
2.446GluPhe: 2.446 ± 0.039
3.092GluGly: 3.092 ± 0.051
1.617GluHis: 1.617 ± 0.037
4.077GluIle: 4.077 ± 0.055
3.902GluLys: 3.902 ± 0.052
7.209GluLeu: 7.209 ± 0.076
1.491GluMet: 1.491 ± 0.029
3.15GluAsn: 3.15 ± 0.041
1.942GluPro: 1.942 ± 0.04
4.917GluGln: 4.917 ± 0.075
2.635GluArg: 2.635 ± 0.037
3.398GluSer: 3.398 ± 0.041
2.947GluThr: 2.947 ± 0.038
4.04GluVal: 4.04 ± 0.049
0.502GluTrp: 0.502 ± 0.016
1.803GluTyr: 1.803 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.747PheAla: 3.747 ± 0.048
0.495PheCys: 0.495 ± 0.019
2.944PheAsp: 2.944 ± 0.049
2.52PheGlu: 2.52 ± 0.049
1.879PhePhe: 1.879 ± 0.037
2.861PheGly: 2.861 ± 0.043
0.834PheHis: 0.834 ± 0.021
3.069PheIle: 3.069 ± 0.045
2.1PheLys: 2.1 ± 0.036
3.462PheLeu: 3.462 ± 0.055
0.96PheMet: 0.96 ± 0.026
2.329PheAsn: 2.329 ± 0.038
1.352PhePro: 1.352 ± 0.026
1.32PheGln: 1.32 ± 0.025
1.477PheArg: 1.477 ± 0.03
3.787PheSer: 3.787 ± 0.051
2.67PheThr: 2.67 ± 0.046
2.475PheVal: 2.475 ± 0.044
0.487PheTrp: 0.487 ± 0.017
1.553PheTyr: 1.553 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.16GlyAla: 5.16 ± 0.071
0.788GlyCys: 0.788 ± 0.022
3.994GlyAsp: 3.994 ± 0.077
4.63GlyGlu: 4.63 ± 0.068
3.368GlyPhe: 3.368 ± 0.049
4.853GlyGly: 4.853 ± 0.089
1.552GlyHis: 1.552 ± 0.032
4.614GlyIle: 4.614 ± 0.053
4.149GlyLys: 4.149 ± 0.051
6.793GlyLeu: 6.793 ± 0.07
1.728GlyMet: 1.728 ± 0.033
3.04GlyAsn: 3.04 ± 0.076
1.686GlyPro: 1.686 ± 0.032
3.48GlyGln: 3.48 ± 0.052
2.862GlyArg: 2.862 ± 0.044
4.454GlySer: 4.454 ± 0.11
3.332GlyThr: 3.332 ± 0.063
4.46GlyVal: 4.46 ± 0.062
0.882GlyTrp: 0.882 ± 0.025
2.668GlyTyr: 2.668 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.462HisAla: 1.462 ± 0.027
0.287HisCys: 0.287 ± 0.013
1.067HisAsp: 1.067 ± 0.028
1.123HisGlu: 1.123 ± 0.03
1.118HisPhe: 1.118 ± 0.028
1.466HisGly: 1.466 ± 0.027
0.708HisHis: 0.708 ± 0.024
1.351HisIle: 1.351 ± 0.03
1.142HisLys: 1.142 ± 0.028
2.359HisLeu: 2.359 ± 0.046
0.472HisMet: 0.472 ± 0.017
0.883HisAsn: 0.883 ± 0.025
1.008HisPro: 1.008 ± 0.026
1.396HisGln: 1.396 ± 0.032
0.986HisArg: 0.986 ± 0.025
1.443HisSer: 1.443 ± 0.034
0.971HisThr: 0.971 ± 0.022
1.08HisVal: 1.08 ± 0.027
0.401HisTrp: 0.401 ± 0.015
0.961HisTyr: 0.961 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.005IleAla: 6.005 ± 0.075
0.697IleCys: 0.697 ± 0.021
4.017IleAsp: 4.017 ± 0.049
4.177IleGlu: 4.177 ± 0.047
2.395IlePhe: 2.395 ± 0.039
4.158IleGly: 4.158 ± 0.054
1.247IleHis: 1.247 ± 0.024
3.558IleIle: 3.558 ± 0.053
3.737IleLys: 3.737 ± 0.06
5.136IleLeu: 5.136 ± 0.068
1.128IleMet: 1.128 ± 0.029
3.561IleAsn: 3.561 ± 0.051
2.436IlePro: 2.436 ± 0.035
2.032IleGln: 2.032 ± 0.035
2.819IleArg: 2.819 ± 0.043
5.06IleSer: 5.06 ± 0.062
4.033IleThr: 4.033 ± 0.056
3.431IleVal: 3.431 ± 0.05
0.596IleTrp: 0.596 ± 0.021
1.822IleTyr: 1.822 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
5.13LysAla: 5.13 ± 0.069
0.342LysCys: 0.342 ± 0.016
2.693LysAsp: 2.693 ± 0.048
3.158LysGlu: 3.158 ± 0.053
1.745LysPhe: 1.745 ± 0.033
3.251LysGly: 3.251 ± 0.044
1.297LysHis: 1.297 ± 0.029
3.297LysIle: 3.297 ± 0.047
3.332LysLys: 3.332 ± 0.054
5.647LysLeu: 5.647 ± 0.058
1.353LysMet: 1.353 ± 0.029
2.588LysAsn: 2.588 ± 0.042
2.196LysPro: 2.196 ± 0.042
3.213LysGln: 3.213 ± 0.054
2.475LysArg: 2.475 ± 0.04
3.435LysSer: 3.435 ± 0.048
3.136LysThr: 3.136 ± 0.044
3.974LysVal: 3.974 ± 0.051
0.531LysTrp: 0.531 ± 0.017
1.487LysTyr: 1.487 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
11.192LeuAla: 11.192 ± 0.105
1.095LeuCys: 1.095 ± 0.03
6.024LeuAsp: 6.024 ± 0.076
5.901LeuGlu: 5.901 ± 0.058
4.274LeuPhe: 4.274 ± 0.059
6.693LeuGly: 6.693 ± 0.067
1.922LeuHis: 1.922 ± 0.034
5.976LeuIle: 5.976 ± 0.073
5.73LeuLys: 5.73 ± 0.071
11.515LeuLeu: 11.515 ± 0.138
2.618LeuMet: 2.618 ± 0.048
4.823LeuAsn: 4.823 ± 0.06
4.791LeuPro: 4.791 ± 0.068
4.04LeuGln: 4.04 ± 0.058
3.887LeuArg: 3.887 ± 0.055
8.669LeuSer: 8.669 ± 0.084
6.895LeuThr: 6.895 ± 0.089
6.83LeuVal: 6.83 ± 0.071
1.131LeuTrp: 1.131 ± 0.032
2.925LeuTyr: 2.925 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.473MetAla: 2.473 ± 0.033
0.171MetCys: 0.171 ± 0.011
1.148MetAsp: 1.148 ± 0.027
1.158MetGlu: 1.158 ± 0.027
0.831MetPhe: 0.831 ± 0.022
1.367MetGly: 1.367 ± 0.031
0.432MetHis: 0.432 ± 0.016
1.29MetIle: 1.29 ± 0.029
1.445MetLys: 1.445 ± 0.026
2.632MetLeu: 2.632 ± 0.042
0.628MetMet: 0.628 ± 0.021
1.009MetAsn: 1.009 ± 0.023
1.165MetPro: 1.165 ± 0.03
1.088MetGln: 1.088 ± 0.025
0.938MetArg: 0.938 ± 0.025
1.738MetSer: 1.738 ± 0.033
1.415MetThr: 1.415 ± 0.029
1.534MetVal: 1.534 ± 0.033
0.178MetTrp: 0.178 ± 0.01
0.499MetTyr: 0.499 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.568AsnAla: 3.568 ± 0.053
0.452AsnCys: 0.452 ± 0.017
2.414AsnAsp: 2.414 ± 0.058
2.604AsnGlu: 2.604 ± 0.041
1.85AsnPhe: 1.85 ± 0.036
3.202AsnGly: 3.202 ± 0.061
1.001AsnHis: 1.001 ± 0.029
3.199AsnIle: 3.199 ± 0.044
2.651AsnLys: 2.651 ± 0.041
4.308AsnLeu: 4.308 ± 0.069
1.023AsnMet: 1.023 ± 0.025
2.523AsnAsn: 2.523 ± 0.074
2.0AsnPro: 2.0 ± 0.038
2.287AsnGln: 2.287 ± 0.043
2.121AsnArg: 2.121 ± 0.033
3.109AsnSer: 3.109 ± 0.074
2.573AsnThr: 2.573 ± 0.047
2.429AsnVal: 2.429 ± 0.041
0.693AsnTrp: 0.693 ± 0.018
1.629AsnTyr: 1.629 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.36ProAla: 3.36 ± 0.049
0.332ProCys: 0.332 ± 0.014
2.607ProAsp: 2.607 ± 0.044
3.16ProGlu: 3.16 ± 0.05
1.615ProPhe: 1.615 ± 0.032
3.237ProGly: 3.237 ± 0.049
0.738ProHis: 0.738 ± 0.017
1.765ProIle: 1.765 ± 0.037
1.835ProLys: 1.835 ± 0.034
4.201ProLeu: 4.201 ± 0.061
0.826ProMet: 0.826 ± 0.024
1.279ProAsn: 1.279 ± 0.029
1.238ProPro: 1.238 ± 0.03
1.837ProGln: 1.837 ± 0.037
1.313ProArg: 1.313 ± 0.026
2.119ProSer: 2.119 ± 0.035
1.621ProThr: 1.621 ± 0.033
3.293ProVal: 3.293 ± 0.048
0.516ProTrp: 0.516 ± 0.018
1.207ProTyr: 1.207 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
5.33GlnAla: 5.33 ± 0.069
0.385GlnCys: 0.385 ± 0.014
2.437GlnAsp: 2.437 ± 0.041
3.015GlnGlu: 3.015 ± 0.052
1.597GlnPhe: 1.597 ± 0.029
3.56GlnGly: 3.56 ± 0.05
1.264GlnHis: 1.264 ± 0.024
2.602GlnIle: 2.602 ± 0.037
2.305GlnLys: 2.305 ± 0.042
6.135GlnLeu: 6.135 ± 0.085
1.092GlnMet: 1.092 ± 0.024
1.668GlnAsn: 1.668 ± 0.036
1.661GlnPro: 1.661 ± 0.033
4.176GlnGln: 4.176 ± 0.082
2.114GlnArg: 2.114 ± 0.037
2.97GlnSer: 2.97 ± 0.046
2.391GlnThr: 2.391 ± 0.038
3.698GlnVal: 3.698 ± 0.05
0.639GlnTrp: 0.639 ± 0.023
1.477GlnTyr: 1.477 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.292ArgAla: 3.292 ± 0.046
0.377ArgCys: 0.377 ± 0.015
2.36ArgAsp: 2.36 ± 0.039
2.975ArgGlu: 2.975 ± 0.045
2.036ArgPhe: 2.036 ± 0.038
2.549ArgGly: 2.549 ± 0.039
1.155ArgHis: 1.155 ± 0.03
2.721ArgIle: 2.721 ± 0.041
2.181ArgLys: 2.181 ± 0.035
5.065ArgLeu: 5.065 ± 0.065
0.976ArgMet: 0.976 ± 0.025
1.687ArgAsn: 1.687 ± 0.035
1.445ArgPro: 1.445 ± 0.03
2.584ArgGln: 2.584 ± 0.045
2.078ArgArg: 2.078 ± 0.038
2.431ArgSer: 2.431 ± 0.037
1.769ArgThr: 1.769 ± 0.034
2.772ArgVal: 2.772 ± 0.042
0.547ArgTrp: 0.547 ± 0.016
1.765ArgTyr: 1.765 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
5.959SerAla: 5.959 ± 0.063
0.726SerCys: 0.726 ± 0.022
3.908SerAsp: 3.908 ± 0.058
4.05SerGlu: 4.05 ± 0.046
3.13SerPhe: 3.13 ± 0.042
5.818SerGly: 5.818 ± 0.117
1.571SerHis: 1.571 ± 0.03
3.755SerIle: 3.755 ± 0.043
3.207SerLys: 3.207 ± 0.047
7.375SerLeu: 7.375 ± 0.074
1.429SerMet: 1.429 ± 0.031
2.712SerAsn: 2.712 ± 0.057
2.643SerPro: 2.643 ± 0.04
3.385SerGln: 3.385 ± 0.045
3.17SerArg: 3.17 ± 0.05
4.821SerSer: 4.821 ± 0.09
3.192SerThr: 3.192 ± 0.046
4.322SerVal: 4.322 ± 0.066
0.967SerTrp: 0.967 ± 0.037
2.483SerTyr: 2.483 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
4.733ThrAla: 4.733 ± 0.064
0.522ThrCys: 0.522 ± 0.019
3.032ThrAsp: 3.032 ± 0.049
3.087ThrGlu: 3.087 ± 0.045
2.123ThrPhe: 2.123 ± 0.04
4.353ThrGly: 4.353 ± 0.06
0.918ThrHis: 0.918 ± 0.025
3.086ThrIle: 3.086 ± 0.051
2.135ThrLys: 2.135 ± 0.036
6.423ThrLeu: 6.423 ± 0.077
1.036ThrMet: 1.036 ± 0.024
1.963ThrAsn: 1.963 ± 0.049
2.687ThrPro: 2.687 ± 0.042
2.136ThrGln: 2.136 ± 0.039
2.469ThrArg: 2.469 ± 0.044
3.57ThrSer: 3.57 ± 0.053
2.876ThrThr: 2.876 ± 0.051
3.615ThrVal: 3.615 ± 0.061
0.585ThrTrp: 0.585 ± 0.024
1.459ThrTyr: 1.459 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
5.614ValAla: 5.614 ± 0.059
0.65ValCys: 0.65 ± 0.019
3.792ValAsp: 3.792 ± 0.059
4.031ValGlu: 4.031 ± 0.054
2.811ValPhe: 2.811 ± 0.047
3.738ValGly: 3.738 ± 0.049
1.151ValHis: 1.151 ± 0.025
4.606ValIle: 4.606 ± 0.055
3.691ValLys: 3.691 ± 0.058
6.552ValLeu: 6.552 ± 0.081
1.647ValMet: 1.647 ± 0.029
3.341ValAsn: 3.341 ± 0.049
2.441ValPro: 2.441 ± 0.046
2.147ValGln: 2.147 ± 0.038
2.549ValArg: 2.549 ± 0.04
4.781ValSer: 4.781 ± 0.062
3.865ValThr: 3.865 ± 0.058
4.298ValVal: 4.298 ± 0.061
0.628ValTrp: 0.628 ± 0.019
1.911ValTyr: 1.911 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
0.729TrpAla: 0.729 ± 0.022
0.127TrpCys: 0.127 ± 0.009
0.563TrpAsp: 0.563 ± 0.02
0.417TrpGlu: 0.417 ± 0.016
0.534TrpPhe: 0.534 ± 0.019
0.76TrpGly: 0.76 ± 0.022
0.395TrpHis: 0.395 ± 0.014
0.507TrpIle: 0.507 ± 0.015
0.4TrpLys: 0.4 ± 0.016
1.711TrpLeu: 1.711 ± 0.033
0.248TrpMet: 0.248 ± 0.011
0.406TrpAsn: 0.406 ± 0.017
0.489TrpPro: 0.489 ± 0.017
1.339TrpGln: 1.339 ± 0.03
0.629TrpArg: 0.629 ± 0.022
0.826TrpSer: 0.826 ± 0.024
0.478TrpThr: 0.478 ± 0.02
0.659TrpVal: 0.659 ± 0.025
0.168TrpTrp: 0.168 ± 0.012
0.377TrpTyr: 0.377 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.354TyrAla: 2.354 ± 0.036
0.377TyrCys: 0.377 ± 0.015
1.774TyrAsp: 1.774 ± 0.034
1.368TyrGlu: 1.368 ± 0.031
1.623TyrPhe: 1.623 ± 0.035
2.206TyrGly: 2.206 ± 0.037
0.896TyrHis: 0.896 ± 0.023
1.785TyrIle: 1.785 ± 0.033
1.343TyrLys: 1.343 ± 0.03
3.788TyrLeu: 3.788 ± 0.054
0.633TyrMet: 0.633 ± 0.02
1.289TyrAsn: 1.289 ± 0.029
1.491TyrPro: 1.491 ± 0.028
2.554TyrGln: 2.554 ± 0.039
2.006TyrArg: 2.006 ± 0.036
2.145TyrSer: 2.145 ± 0.037
1.437TyrThr: 1.437 ± 0.032
1.718TyrVal: 1.718 ± 0.034
0.49TyrTrp: 0.49 ± 0.016
1.156TyrTyr: 1.156 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5460 proteins (1788439 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski