Amino acid dipepetide frequency for Pediococcus cellicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.203AlaAla: 6.203 ± 0.116
0.411AlaCys: 0.411 ± 0.025
4.404AlaAsp: 4.404 ± 0.103
3.66AlaGlu: 3.66 ± 0.092
3.267AlaPhe: 3.267 ± 0.079
5.387AlaGly: 5.387 ± 0.111
1.676AlaHis: 1.676 ± 0.057
5.952AlaIle: 5.952 ± 0.116
5.568AlaLys: 5.568 ± 0.115
7.379AlaLeu: 7.379 ± 0.115
2.062AlaMet: 2.062 ± 0.065
3.753AlaAsn: 3.753 ± 0.102
2.195AlaPro: 2.195 ± 0.054
3.651AlaGln: 3.651 ± 0.087
2.567AlaArg: 2.567 ± 0.078
4.656AlaSer: 4.656 ± 0.105
4.863AlaThr: 4.863 ± 0.108
5.544AlaVal: 5.544 ± 0.106
0.659AlaTrp: 0.659 ± 0.037
2.762AlaTyr: 2.762 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.36CysAla: 0.36 ± 0.023
0.038CysCys: 0.038 ± 0.008
0.222CysAsp: 0.222 ± 0.019
0.222CysGlu: 0.222 ± 0.02
0.244CysPhe: 0.244 ± 0.024
0.425CysGly: 0.425 ± 0.028
0.155CysHis: 0.155 ± 0.017
0.288CysIle: 0.288 ± 0.02
0.184CysLys: 0.184 ± 0.021
0.527CysLeu: 0.527 ± 0.034
0.113CysMet: 0.113 ± 0.013
0.126CysAsn: 0.126 ± 0.017
0.167CysPro: 0.167 ± 0.022
0.225CysGln: 0.225 ± 0.02
0.186CysArg: 0.186 ± 0.019
0.246CysSer: 0.246 ± 0.021
0.222CysThr: 0.222 ± 0.02
0.34CysVal: 0.34 ± 0.025
0.053CysTrp: 0.053 ± 0.011
0.213CysTyr: 0.213 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.035AspAla: 4.035 ± 0.092
0.196AspCys: 0.196 ± 0.02
3.282AspAsp: 3.282 ± 0.098
3.782AspGlu: 3.782 ± 0.091
2.676AspPhe: 2.676 ± 0.077
3.491AspGly: 3.491 ± 0.102
1.439AspHis: 1.439 ± 0.055
3.316AspIle: 3.316 ± 0.082
3.446AspLys: 3.446 ± 0.081
5.341AspLeu: 5.341 ± 0.108
1.447AspMet: 1.447 ± 0.049
2.204AspAsn: 2.204 ± 0.069
2.265AspPro: 2.265 ± 0.069
3.026AspGln: 3.026 ± 0.086
2.255AspArg: 2.255 ± 0.071
2.816AspSer: 2.816 ± 0.085
2.978AspThr: 2.978 ± 0.083
3.856AspVal: 3.856 ± 0.101
0.707AspTrp: 0.707 ± 0.043
2.434AspTyr: 2.434 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
4.187GluAla: 4.187 ± 0.106
0.171GluCys: 0.171 ± 0.016
2.845GluAsp: 2.845 ± 0.087
2.999GluGlu: 2.999 ± 0.089
2.103GluPhe: 2.103 ± 0.055
2.75GluGly: 2.75 ± 0.083
1.074GluHis: 1.074 ± 0.041
4.286GluIle: 4.286 ± 0.085
4.6GluLys: 4.6 ± 0.085
5.267GluLeu: 5.267 ± 0.105
1.63GluMet: 1.63 ± 0.053
3.054GluAsn: 3.054 ± 0.074
1.678GluPro: 1.678 ± 0.059
2.458GluGln: 2.458 ± 0.068
2.301GluArg: 2.301 ± 0.068
2.751GluSer: 2.751 ± 0.075
3.253GluThr: 3.253 ± 0.08
3.671GluVal: 3.671 ± 0.082
0.451GluTrp: 0.451 ± 0.027
1.553GluTyr: 1.553 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.347PheAla: 3.347 ± 0.075
0.285PheCys: 0.285 ± 0.025
2.743PheAsp: 2.743 ± 0.067
2.42PheGlu: 2.42 ± 0.061
2.185PhePhe: 2.185 ± 0.086
3.264PheGly: 3.264 ± 0.075
0.874PheHis: 0.874 ± 0.041
3.269PheIle: 3.269 ± 0.093
2.731PheLys: 2.731 ± 0.082
4.31PheLeu: 4.31 ± 0.093
1.167PheMet: 1.167 ± 0.049
2.21PheAsn: 2.21 ± 0.073
1.512PhePro: 1.512 ± 0.049
1.579PheGln: 1.579 ± 0.058
1.4PheArg: 1.4 ± 0.053
3.178PheSer: 3.178 ± 0.079
2.564PheThr: 2.564 ± 0.075
3.458PheVal: 3.458 ± 0.096
0.582PheTrp: 0.582 ± 0.036
1.702PheTyr: 1.702 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.673GlyAla: 4.673 ± 0.111
0.37GlyCys: 0.37 ± 0.028
3.236GlyAsp: 3.236 ± 0.097
3.246GlyGlu: 3.246 ± 0.08
3.219GlyPhe: 3.219 ± 0.087
4.223GlyGly: 4.223 ± 0.094
1.471GlyHis: 1.471 ± 0.046
5.742GlyIle: 5.742 ± 0.106
4.875GlyLys: 4.875 ± 0.109
6.507GlyLeu: 6.507 ± 0.117
1.886GlyMet: 1.886 ± 0.059
2.943GlyAsn: 2.943 ± 0.09
1.543GlyPro: 1.543 ± 0.052
2.7GlyGln: 2.7 ± 0.07
2.463GlyArg: 2.463 ± 0.067
3.929GlySer: 3.929 ± 0.091
4.224GlyThr: 4.224 ± 0.103
4.904GlyVal: 4.904 ± 0.099
0.72GlyTrp: 0.72 ± 0.039
2.791GlyTyr: 2.791 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.512HisAla: 1.512 ± 0.057
0.104HisCys: 0.104 ± 0.014
1.306HisAsp: 1.306 ± 0.047
1.301HisGlu: 1.301 ± 0.043
1.244HisPhe: 1.244 ± 0.045
1.567HisGly: 1.567 ± 0.051
0.814HisHis: 0.814 ± 0.04
1.511HisIle: 1.511 ± 0.053
1.287HisLys: 1.287 ± 0.048
2.344HisLeu: 2.344 ± 0.067
0.527HisMet: 0.527 ± 0.028
1.029HisAsn: 1.029 ± 0.043
1.07HisPro: 1.07 ± 0.046
1.123HisGln: 1.123 ± 0.044
0.99HisArg: 0.99 ± 0.047
1.125HisSer: 1.125 ± 0.053
1.156HisThr: 1.156 ± 0.047
1.582HisVal: 1.582 ± 0.051
0.271HisTrp: 0.271 ± 0.023
1.014HisTyr: 1.014 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.807IleAla: 5.807 ± 0.099
0.468IleCys: 0.468 ± 0.027
4.079IleAsp: 4.079 ± 0.092
3.726IleGlu: 3.726 ± 0.089
3.315IlePhe: 3.315 ± 0.084
5.38IleGly: 5.38 ± 0.116
1.54IleHis: 1.54 ± 0.056
4.998IleIle: 4.998 ± 0.116
4.426IleLys: 4.426 ± 0.094
7.169IleLeu: 7.169 ± 0.152
1.78IleMet: 1.78 ± 0.056
3.381IleAsn: 3.381 ± 0.073
2.927IlePro: 2.927 ± 0.074
3.062IleGln: 3.062 ± 0.083
2.772IleArg: 2.772 ± 0.072
4.976IleSer: 4.976 ± 0.098
4.429IleThr: 4.429 ± 0.117
5.353IleVal: 5.353 ± 0.102
0.736IleTrp: 0.736 ± 0.035
2.4IleTyr: 2.4 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
5.284LysAla: 5.284 ± 0.134
0.15LysCys: 0.15 ± 0.016
3.584LysAsp: 3.584 ± 0.091
3.736LysGlu: 3.736 ± 0.095
2.267LysPhe: 2.267 ± 0.068
3.339LysGly: 3.339 ± 0.08
1.483LysHis: 1.483 ± 0.047
4.982LysIle: 4.982 ± 0.093
5.768LysLys: 5.768 ± 0.119
6.309LysLeu: 6.309 ± 0.111
2.393LysMet: 2.393 ± 0.061
3.95LysAsn: 3.95 ± 0.096
2.14LysPro: 2.14 ± 0.064
3.858LysGln: 3.858 ± 0.101
3.489LysArg: 3.489 ± 0.075
3.671LysSer: 3.671 ± 0.085
4.409LysThr: 4.409 ± 0.089
4.634LysVal: 4.634 ± 0.124
0.604LysTrp: 0.604 ± 0.03
2.564LysTyr: 2.564 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
8.207LeuAla: 8.207 ± 0.132
0.507LeuCys: 0.507 ± 0.032
5.247LeuAsp: 5.247 ± 0.115
4.463LeuGlu: 4.463 ± 0.098
4.501LeuPhe: 4.501 ± 0.115
6.457LeuGly: 6.457 ± 0.098
1.99LeuHis: 1.99 ± 0.064
7.42LeuIle: 7.42 ± 0.143
7.126LeuLys: 7.126 ± 0.126
9.328LeuLeu: 9.328 ± 0.18
2.675LeuMet: 2.675 ± 0.07
5.122LeuAsn: 5.122 ± 0.104
3.975LeuPro: 3.975 ± 0.089
3.948LeuGln: 3.948 ± 0.082
3.649LeuArg: 3.649 ± 0.086
6.537LeuSer: 6.537 ± 0.118
6.332LeuThr: 6.332 ± 0.118
6.998LeuVal: 6.998 ± 0.123
0.821LeuTrp: 0.821 ± 0.038
2.881LeuTyr: 2.881 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.306MetAla: 2.306 ± 0.067
0.116MetCys: 0.116 ± 0.016
1.376MetAsp: 1.376 ± 0.052
1.108MetGlu: 1.108 ± 0.045
0.981MetPhe: 0.981 ± 0.037
1.883MetGly: 1.883 ± 0.057
0.553MetHis: 0.553 ± 0.032
1.973MetIle: 1.973 ± 0.053
1.968MetLys: 1.968 ± 0.055
2.379MetLeu: 2.379 ± 0.071
0.799MetMet: 0.799 ± 0.042
1.48MetAsn: 1.48 ± 0.052
1.084MetPro: 1.084 ± 0.043
1.239MetGln: 1.239 ± 0.044
1.026MetArg: 1.026 ± 0.045
1.709MetSer: 1.709 ± 0.056
1.9MetThr: 1.9 ± 0.055
1.782MetVal: 1.782 ± 0.057
0.207MetTrp: 0.207 ± 0.02
0.64MetTyr: 0.64 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.661AsnAla: 3.661 ± 0.09
0.23AsnCys: 0.23 ± 0.021
2.678AsnAsp: 2.678 ± 0.086
2.943AsnGlu: 2.943 ± 0.077
2.277AsnPhe: 2.277 ± 0.07
3.641AsnGly: 3.641 ± 0.09
1.36AsnHis: 1.36 ± 0.061
3.028AsnIle: 3.028 ± 0.071
2.903AsnLys: 2.903 ± 0.096
4.68AsnLeu: 4.68 ± 0.105
1.224AsnMet: 1.224 ± 0.04
2.313AsnAsn: 2.313 ± 0.081
2.171AsnPro: 2.171 ± 0.073
2.652AsnGln: 2.652 ± 0.071
2.084AsnArg: 2.084 ± 0.065
2.77AsnSer: 2.77 ± 0.094
2.47AsnThr: 2.47 ± 0.064
3.388AsnVal: 3.388 ± 0.084
0.702AsnTrp: 0.702 ± 0.039
2.0AsnTyr: 2.0 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
2.466ProAla: 2.466 ± 0.069
0.097ProCys: 0.097 ± 0.012
2.326ProAsp: 2.326 ± 0.073
2.721ProGlu: 2.721 ± 0.073
1.801ProPhe: 1.801 ± 0.072
2.117ProGly: 2.117 ± 0.051
0.732ProHis: 0.732 ± 0.037
2.769ProIle: 2.769 ± 0.071
2.434ProLys: 2.434 ± 0.067
3.19ProLeu: 3.19 ± 0.074
0.797ProMet: 0.797 ± 0.04
1.843ProAsn: 1.843 ± 0.054
0.56ProPro: 0.56 ± 0.035
1.507ProGln: 1.507 ± 0.059
1.026ProArg: 1.026 ± 0.042
1.999ProSer: 1.999 ± 0.059
2.156ProThr: 2.156 ± 0.068
2.985ProVal: 2.985 ± 0.081
0.343ProTrp: 0.343 ± 0.026
1.275ProTyr: 1.275 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.934GlnAla: 3.934 ± 0.087
0.109GlnCys: 0.109 ± 0.014
2.222GlnAsp: 2.222 ± 0.06
2.243GlnGlu: 2.243 ± 0.065
1.809GlnPhe: 1.809 ± 0.061
2.366GlnGly: 2.366 ± 0.059
1.051GlnHis: 1.051 ± 0.045
3.504GlnIle: 3.504 ± 0.087
3.827GlnLys: 3.827 ± 0.103
5.305GlnLeu: 5.305 ± 0.12
1.203GlnMet: 1.203 ± 0.046
2.557GlnAsn: 2.557 ± 0.077
1.533GlnPro: 1.533 ± 0.054
2.589GlnGln: 2.589 ± 0.081
2.007GlnArg: 2.007 ± 0.058
2.49GlnSer: 2.49 ± 0.072
3.105GlnThr: 3.105 ± 0.07
3.438GlnVal: 3.438 ± 0.095
0.416GlnTrp: 0.416 ± 0.029
1.533GlnTyr: 1.533 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
2.596ArgAla: 2.596 ± 0.064
0.15ArgCys: 0.15 ± 0.017
2.096ArgAsp: 2.096 ± 0.056
2.231ArgGlu: 2.231 ± 0.073
1.881ArgPhe: 1.881 ± 0.053
2.156ArgGly: 2.156 ± 0.071
1.068ArgHis: 1.068 ± 0.047
2.91ArgIle: 2.91 ± 0.072
2.806ArgLys: 2.806 ± 0.077
4.085ArgLeu: 4.085 ± 0.081
1.101ArgMet: 1.101 ± 0.047
1.802ArgAsn: 1.802 ± 0.062
1.355ArgPro: 1.355 ± 0.051
2.156ArgGln: 2.156 ± 0.067
1.84ArgArg: 1.84 ± 0.06
2.036ArgSer: 2.036 ± 0.064
2.142ArgThr: 2.142 ± 0.062
2.787ArgVal: 2.787 ± 0.071
0.36ArgTrp: 0.36 ± 0.027
1.635ArgTyr: 1.635 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
4.388SerAla: 4.388 ± 0.098
0.215SerCys: 0.215 ± 0.019
3.334SerAsp: 3.334 ± 0.079
3.514SerGlu: 3.514 ± 0.093
2.936SerPhe: 2.936 ± 0.081
4.624SerGly: 4.624 ± 0.101
1.388SerHis: 1.388 ± 0.049
3.934SerIle: 3.934 ± 0.088
3.873SerLys: 3.873 ± 0.092
5.965SerLeu: 5.965 ± 0.106
1.463SerMet: 1.463 ± 0.05
2.734SerAsn: 2.734 ± 0.087
1.775SerPro: 1.775 ± 0.048
2.958SerGln: 2.958 ± 0.082
2.367SerArg: 2.367 ± 0.075
4.347SerSer: 4.347 ± 0.18
3.523SerThr: 3.523 ± 0.103
4.383SerVal: 4.383 ± 0.093
0.671SerTrp: 0.671 ± 0.039
2.21SerTyr: 2.21 ± 0.066
0.002SerXaa: 0.002 ± 0.001
Thr
4.475ThrAla: 4.475 ± 0.107
0.232ThrCys: 0.232 ± 0.022
3.439ThrAsp: 3.439 ± 0.09
2.97ThrGlu: 2.97 ± 0.079
2.69ThrPhe: 2.69 ± 0.071
4.378ThrGly: 4.378 ± 0.099
1.441ThrHis: 1.441 ± 0.048
4.778ThrIle: 4.778 ± 0.126
3.955ThrLys: 3.955 ± 0.088
5.836ThrLeu: 5.836 ± 0.115
1.313ThrMet: 1.313 ± 0.044
3.095ThrAsn: 3.095 ± 0.093
2.601ThrPro: 2.601 ± 0.072
2.702ThrGln: 2.702 ± 0.085
2.05ThrArg: 2.05 ± 0.059
3.728ThrSer: 3.728 ± 0.099
4.061ThrThr: 4.061 ± 0.114
4.656ThrVal: 4.656 ± 0.11
0.64ThrTrp: 0.64 ± 0.03
2.267ThrTyr: 2.267 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
6.105ValAla: 6.105 ± 0.115
0.449ValCys: 0.449 ± 0.027
4.069ValAsp: 4.069 ± 0.092
3.482ValGlu: 3.482 ± 0.097
2.965ValPhe: 2.965 ± 0.07
5.066ValGly: 5.066 ± 0.098
1.458ValHis: 1.458 ± 0.053
5.25ValIle: 5.25 ± 0.105
4.523ValLys: 4.523 ± 0.099
6.962ValLeu: 6.962 ± 0.129
1.855ValMet: 1.855 ± 0.064
3.502ValAsn: 3.502 ± 0.098
2.755ValPro: 2.755 ± 0.073
2.77ValGln: 2.77 ± 0.072
2.574ValArg: 2.574 ± 0.07
5.109ValSer: 5.109 ± 0.082
5.023ValThr: 5.023 ± 0.141
5.549ValVal: 5.549 ± 0.117
0.64ValTrp: 0.64 ± 0.032
2.309ValTyr: 2.309 ± 0.056
0.002ValXaa: 0.002 ± 0.002
Trp
0.597TrpAla: 0.597 ± 0.037
0.055TrpCys: 0.055 ± 0.009
0.445TrpAsp: 0.445 ± 0.034
0.428TrpGlu: 0.428 ± 0.025
0.544TrpPhe: 0.544 ± 0.032
0.729TrpGly: 0.729 ± 0.037
0.338TrpHis: 0.338 ± 0.029
0.758TrpIle: 0.758 ± 0.041
0.476TrpLys: 0.476 ± 0.026
1.316TrpLeu: 1.316 ± 0.052
0.249TrpMet: 0.249 ± 0.019
0.488TrpAsn: 0.488 ± 0.029
0.295TrpPro: 0.295 ± 0.021
0.77TrpGln: 0.77 ± 0.034
0.464TrpArg: 0.464 ± 0.03
0.551TrpSer: 0.551 ± 0.032
0.529TrpThr: 0.529 ± 0.035
0.652TrpVal: 0.652 ± 0.037
0.178TrpTrp: 0.178 ± 0.018
0.379TrpTyr: 0.379 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.472TyrAla: 2.472 ± 0.067
0.203TyrCys: 0.203 ± 0.021
2.058TyrAsp: 2.058 ± 0.079
1.888TyrGlu: 1.888 ± 0.075
1.874TyrPhe: 1.874 ± 0.059
2.427TyrGly: 2.427 ± 0.074
0.971TyrHis: 0.971 ± 0.042
2.055TyrIle: 2.055 ± 0.066
1.837TyrLys: 1.837 ± 0.06
3.987TyrLeu: 3.987 ± 0.09
0.821TyrMet: 0.821 ± 0.04
1.589TyrAsn: 1.589 ± 0.059
1.541TyrPro: 1.541 ± 0.055
2.268TyrGln: 2.268 ± 0.062
1.685TyrArg: 1.685 ± 0.056
1.98TyrSer: 1.98 ± 0.069
1.966TyrThr: 1.966 ± 0.082
2.456TyrVal: 2.456 ± 0.061
0.483TyrTrp: 0.483 ± 0.031
1.499TyrTyr: 1.499 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.002XaaLys: 0.002 ± 0.001
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.002XaaVal: 0.002 ± 0.002
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1916 proteins (585870 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski