Amino acid dipepetide frequency for Hephaestia caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.718AlaAla: 20.718 ± 0.209
1.008AlaCys: 1.008 ± 0.028
8.353AlaAsp: 8.353 ± 0.093
7.657AlaGlu: 7.657 ± 0.09
4.491AlaPhe: 4.491 ± 0.061
11.906AlaGly: 11.906 ± 0.105
2.547AlaHis: 2.547 ± 0.046
7.582AlaIle: 7.582 ± 0.086
3.733AlaLys: 3.733 ± 0.062
14.61AlaLeu: 14.61 ± 0.157
3.71AlaMet: 3.71 ± 0.066
3.083AlaAsn: 3.083 ± 0.052
6.897AlaPro: 6.897 ± 0.084
4.33AlaGln: 4.33 ± 0.066
10.775AlaArg: 10.775 ± 0.12
6.573AlaSer: 6.573 ± 0.085
7.254AlaThr: 7.254 ± 0.079
8.703AlaVal: 8.703 ± 0.103
1.778AlaTrp: 1.778 ± 0.045
2.628AlaTyr: 2.628 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.025CysAla: 1.025 ± 0.03
0.109CysCys: 0.109 ± 0.01
0.479CysAsp: 0.479 ± 0.02
0.371CysGlu: 0.371 ± 0.016
0.286CysPhe: 0.286 ± 0.014
0.745CysGly: 0.745 ± 0.026
0.181CysHis: 0.181 ± 0.013
0.319CysIle: 0.319 ± 0.014
0.155CysLys: 0.155 ± 0.011
0.659CysLeu: 0.659 ± 0.025
0.137CysMet: 0.137 ± 0.01
0.196CysAsn: 0.196 ± 0.012
0.437CysPro: 0.437 ± 0.021
0.177CysGln: 0.177 ± 0.012
0.542CysArg: 0.542 ± 0.019
0.389CysSer: 0.389 ± 0.018
0.371CysThr: 0.371 ± 0.016
0.526CysVal: 0.526 ± 0.021
0.104CysTrp: 0.104 ± 0.009
0.172CysTyr: 0.172 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
8.432AspAla: 8.432 ± 0.095
0.463AspCys: 0.463 ± 0.02
3.951AspAsp: 3.951 ± 0.065
3.399AspGlu: 3.399 ± 0.056
2.166AspPhe: 2.166 ± 0.039
5.826AspGly: 5.826 ± 0.083
1.461AspHis: 1.461 ± 0.037
2.836AspIle: 2.836 ± 0.048
1.636AspLys: 1.636 ± 0.035
6.108AspLeu: 6.108 ± 0.069
1.348AspMet: 1.348 ± 0.036
1.387AspAsn: 1.387 ± 0.032
4.016AspPro: 4.016 ± 0.062
1.893AspGln: 1.893 ± 0.042
5.365AspArg: 5.365 ± 0.07
2.404AspSer: 2.404 ± 0.044
2.993AspThr: 2.993 ± 0.062
4.117AspVal: 4.117 ± 0.058
1.209AspTrp: 1.209 ± 0.027
1.675AspTyr: 1.675 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.655GluAla: 7.655 ± 0.096
0.293GluCys: 0.293 ± 0.016
2.551GluAsp: 2.551 ± 0.05
2.447GluGlu: 2.447 ± 0.055
1.338GluPhe: 1.338 ± 0.031
4.193GluGly: 4.193 ± 0.061
1.224GluHis: 1.224 ± 0.032
2.953GluIle: 2.953 ± 0.056
1.697GluLys: 1.697 ± 0.037
4.456GluLeu: 4.456 ± 0.057
1.335GluMet: 1.335 ± 0.033
1.325GluAsn: 1.325 ± 0.031
2.558GluPro: 2.558 ± 0.053
1.952GluGln: 1.952 ± 0.04
5.073GluArg: 5.073 ± 0.066
2.176GluSer: 2.176 ± 0.041
3.27GluThr: 3.27 ± 0.054
3.305GluVal: 3.305 ± 0.051
0.694GluTrp: 0.694 ± 0.022
0.901GluTyr: 0.901 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.809PheAla: 4.809 ± 0.057
0.29PheCys: 0.29 ± 0.016
2.768PheAsp: 2.768 ± 0.052
1.969PheGlu: 1.969 ± 0.039
1.208PhePhe: 1.208 ± 0.035
3.539PheGly: 3.539 ± 0.067
0.722PheHis: 0.722 ± 0.027
1.345PheIle: 1.345 ± 0.034
0.815PheLys: 0.815 ± 0.025
2.999PheLeu: 2.999 ± 0.053
0.669PheMet: 0.669 ± 0.022
0.955PheAsn: 0.955 ± 0.027
1.494PhePro: 1.494 ± 0.037
0.837PheGln: 0.837 ± 0.025
2.168PheArg: 2.168 ± 0.042
1.905PheSer: 1.905 ± 0.041
2.07PheThr: 2.07 ± 0.04
2.699PheVal: 2.699 ± 0.041
0.528PheTrp: 0.528 ± 0.022
0.89PheTyr: 0.89 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
10.572GlyAla: 10.572 ± 0.103
0.816GlyCys: 0.816 ± 0.029
5.443GlyAsp: 5.443 ± 0.075
4.567GlyGlu: 4.567 ± 0.058
3.542GlyPhe: 3.542 ± 0.057
8.103GlyGly: 8.103 ± 0.115
1.903GlyHis: 1.903 ± 0.041
4.59GlyIle: 4.59 ± 0.064
3.082GlyLys: 3.082 ± 0.059
8.371GlyLeu: 8.371 ± 0.097
2.225GlyMet: 2.225 ± 0.047
2.236GlyAsn: 2.236 ± 0.056
3.606GlyPro: 3.606 ± 0.055
2.704GlyGln: 2.704 ± 0.045
6.657GlyArg: 6.657 ± 0.074
4.57GlySer: 4.57 ± 0.09
5.011GlyThr: 5.011 ± 0.072
6.33GlyVal: 6.33 ± 0.068
1.647GlyTrp: 1.647 ± 0.039
2.401GlyTyr: 2.401 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.717HisAla: 2.717 ± 0.057
0.199HisCys: 0.199 ± 0.011
1.351HisAsp: 1.351 ± 0.034
1.013HisGlu: 1.013 ± 0.026
0.767HisPhe: 0.767 ± 0.023
1.96HisGly: 1.96 ± 0.038
0.608HisHis: 0.608 ± 0.023
0.952HisIle: 0.952 ± 0.02
0.418HisLys: 0.418 ± 0.02
1.997HisLeu: 1.997 ± 0.036
0.401HisMet: 0.401 ± 0.016
0.443HisAsn: 0.443 ± 0.018
1.353HisPro: 1.353 ± 0.033
0.53HisGln: 0.53 ± 0.019
1.633HisArg: 1.633 ± 0.035
0.865HisSer: 0.865 ± 0.028
0.744HisThr: 0.744 ± 0.02
1.546HisVal: 1.546 ± 0.036
0.407HisTrp: 0.407 ± 0.018
0.609HisTyr: 0.609 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
8.624IleAla: 8.624 ± 0.093
0.373IleCys: 0.373 ± 0.018
4.355IleAsp: 4.355 ± 0.057
3.753IleGlu: 3.753 ± 0.062
1.412IlePhe: 1.412 ± 0.031
5.224IleGly: 5.224 ± 0.073
0.89IleHis: 0.89 ± 0.024
1.962IleIle: 1.962 ± 0.045
1.155IleLys: 1.155 ± 0.033
3.885IleLeu: 3.885 ± 0.061
0.826IleMet: 0.826 ± 0.024
1.223IleAsn: 1.223 ± 0.028
2.185IlePro: 2.185 ± 0.038
1.144IleGln: 1.144 ± 0.03
3.211IleArg: 3.211 ± 0.049
2.302IleSer: 2.302 ± 0.046
2.689IleThr: 2.689 ± 0.055
4.457IleVal: 4.457 ± 0.063
0.593IleTrp: 0.593 ± 0.024
0.962IleTyr: 0.962 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.959LysAla: 3.959 ± 0.062
0.134LysCys: 0.134 ± 0.009
1.389LysAsp: 1.389 ± 0.032
1.075LysGlu: 1.075 ± 0.029
0.677LysPhe: 0.677 ± 0.024
2.362LysGly: 2.362 ± 0.046
0.502LysHis: 0.502 ± 0.022
1.278LysIle: 1.278 ± 0.03
0.961LysLys: 0.961 ± 0.031
2.844LysLeu: 2.844 ± 0.056
0.636LysMet: 0.636 ± 0.023
0.64LysAsn: 0.64 ± 0.024
1.874LysPro: 1.874 ± 0.043
0.865LysGln: 0.865 ± 0.028
2.255LysArg: 2.255 ± 0.04
1.433LysSer: 1.433 ± 0.032
1.692LysThr: 1.692 ± 0.038
1.923LysVal: 1.923 ± 0.042
0.35LysTrp: 0.35 ± 0.018
0.509LysTyr: 0.509 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.649LeuAla: 14.649 ± 0.142
0.724LeuCys: 0.724 ± 0.023
6.749LeuAsp: 6.749 ± 0.069
4.242LeuGlu: 4.242 ± 0.063
3.562LeuPhe: 3.562 ± 0.061
8.482LeuGly: 8.482 ± 0.081
1.765LeuHis: 1.765 ± 0.037
4.882LeuIle: 4.882 ± 0.063
2.744LeuLys: 2.744 ± 0.045
9.139LeuLeu: 9.139 ± 0.112
1.955LeuMet: 1.955 ± 0.041
2.292LeuAsn: 2.292 ± 0.043
5.68LeuPro: 5.68 ± 0.064
2.316LeuGln: 2.316 ± 0.046
6.794LeuArg: 6.794 ± 0.081
5.638LeuSer: 5.638 ± 0.069
5.553LeuThr: 5.553 ± 0.073
7.195LeuVal: 7.195 ± 0.079
1.183LeuTrp: 1.183 ± 0.03
2.02LeuTyr: 2.02 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.085MetAla: 3.085 ± 0.058
0.146MetCys: 0.146 ± 0.011
0.964MetAsp: 0.964 ± 0.026
0.868MetGlu: 0.868 ± 0.031
0.643MetPhe: 0.643 ± 0.023
1.704MetGly: 1.704 ± 0.039
0.422MetHis: 0.422 ± 0.017
1.33MetIle: 1.33 ± 0.035
0.853MetLys: 0.853 ± 0.028
2.48MetLeu: 2.48 ± 0.046
0.613MetMet: 0.613 ± 0.023
0.641MetAsn: 0.641 ± 0.02
1.468MetPro: 1.468 ± 0.031
0.639MetGln: 0.639 ± 0.021
1.776MetArg: 1.776 ± 0.034
1.356MetSer: 1.356 ± 0.037
1.805MetThr: 1.805 ± 0.034
1.512MetVal: 1.512 ± 0.031
0.209MetTrp: 0.209 ± 0.013
0.263MetTyr: 0.263 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.166AsnAla: 3.166 ± 0.054
0.19AsnCys: 0.19 ± 0.011
1.418AsnAsp: 1.418 ± 0.04
1.071AsnGlu: 1.071 ± 0.03
0.882AsnPhe: 0.882 ± 0.028
2.317AsnGly: 2.317 ± 0.045
0.468AsnHis: 0.468 ± 0.018
1.201AsnIle: 1.201 ± 0.031
0.568AsnLys: 0.568 ± 0.019
2.379AsnLeu: 2.379 ± 0.045
0.501AsnMet: 0.501 ± 0.019
0.623AsnAsn: 0.623 ± 0.029
1.711AsnPro: 1.711 ± 0.041
0.778AsnGln: 0.778 ± 0.024
1.786AsnArg: 1.786 ± 0.039
1.114AsnSer: 1.114 ± 0.035
1.137AsnThr: 1.137 ± 0.033
1.84AsnVal: 1.84 ± 0.043
0.419AsnTrp: 0.419 ± 0.018
0.704AsnTyr: 0.704 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
7.445ProAla: 7.445 ± 0.082
0.328ProCys: 0.328 ± 0.015
4.113ProAsp: 4.113 ± 0.058
3.417ProGlu: 3.417 ± 0.057
1.924ProPhe: 1.924 ± 0.038
4.965ProGly: 4.965 ± 0.069
1.107ProHis: 1.107 ± 0.032
2.779ProIle: 2.779 ± 0.045
1.423ProLys: 1.423 ± 0.037
4.867ProLeu: 4.867 ± 0.059
1.207ProMet: 1.207 ± 0.028
1.272ProAsn: 1.272 ± 0.031
3.225ProPro: 3.225 ± 0.069
1.582ProGln: 1.582 ± 0.04
3.324ProArg: 3.324 ± 0.053
2.771ProSer: 2.771 ± 0.053
2.823ProThr: 2.823 ± 0.054
4.246ProVal: 4.246 ± 0.063
0.743ProTrp: 0.743 ± 0.025
1.103ProTyr: 1.103 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.108GlnAla: 4.108 ± 0.057
0.193GlnCys: 0.193 ± 0.011
1.313GlnAsp: 1.313 ± 0.034
1.19GlnGlu: 1.19 ± 0.034
1.037GlnPhe: 1.037 ± 0.029
2.27GlnGly: 2.27 ± 0.038
0.633GlnHis: 0.633 ± 0.023
1.641GlnIle: 1.641 ± 0.039
0.802GlnLys: 0.802 ± 0.026
2.776GlnLeu: 2.776 ± 0.047
0.751GlnMet: 0.751 ± 0.023
0.749GlnAsn: 0.749 ± 0.027
1.821GlnPro: 1.821 ± 0.045
1.172GlnGln: 1.172 ± 0.033
2.537GlnArg: 2.537 ± 0.046
1.658GlnSer: 1.658 ± 0.041
1.668GlnThr: 1.668 ± 0.041
2.166GlnVal: 2.166 ± 0.045
0.421GlnTrp: 0.421 ± 0.019
0.611GlnTyr: 0.611 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
9.693ArgAla: 9.693 ± 0.105
0.517ArgCys: 0.517 ± 0.02
4.619ArgAsp: 4.619 ± 0.06
3.853ArgGlu: 3.853 ± 0.072
3.216ArgPhe: 3.216 ± 0.049
5.32ArgGly: 5.32 ± 0.069
1.858ArgHis: 1.858 ± 0.041
4.238ArgIle: 4.238 ± 0.056
2.075ArgLys: 2.075 ± 0.044
8.454ArgLeu: 8.454 ± 0.105
1.8ArgMet: 1.8 ± 0.032
1.781ArgAsn: 1.781 ± 0.035
3.898ArgPro: 3.898 ± 0.059
2.472ArgGln: 2.472 ± 0.042
6.212ArgArg: 6.212 ± 0.095
3.619ArgSer: 3.619 ± 0.047
3.909ArgThr: 3.909 ± 0.059
5.12ArgVal: 5.12 ± 0.057
1.313ArgTrp: 1.313 ± 0.033
2.043ArgTyr: 2.043 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.382SerAla: 6.382 ± 0.08
0.383SerCys: 0.383 ± 0.019
3.107SerAsp: 3.107 ± 0.048
2.383SerGlu: 2.383 ± 0.04
2.057SerPhe: 2.057 ± 0.049
5.365SerGly: 5.365 ± 0.073
0.936SerHis: 0.936 ± 0.031
2.657SerIle: 2.657 ± 0.039
1.252SerLys: 1.252 ± 0.034
4.752SerLeu: 4.752 ± 0.065
1.109SerMet: 1.109 ± 0.031
1.291SerAsn: 1.291 ± 0.03
2.894SerPro: 2.894 ± 0.05
1.405SerGln: 1.405 ± 0.035
3.371SerArg: 3.371 ± 0.053
2.656SerSer: 2.656 ± 0.063
2.639SerThr: 2.639 ± 0.049
3.536SerVal: 3.536 ± 0.052
0.736SerTrp: 0.736 ± 0.026
1.269SerTyr: 1.269 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.905ThrAla: 6.905 ± 0.086
0.377ThrCys: 0.377 ± 0.017
3.141ThrAsp: 3.141 ± 0.051
2.339ThrGlu: 2.339 ± 0.043
1.782ThrPhe: 1.782 ± 0.038
5.574ThrGly: 5.574 ± 0.074
1.044ThrHis: 1.044 ± 0.025
3.379ThrIle: 3.379 ± 0.054
1.232ThrLys: 1.232 ± 0.029
6.157ThrLeu: 6.157 ± 0.068
1.216ThrMet: 1.216 ± 0.031
1.367ThrAsn: 1.367 ± 0.043
3.763ThrPro: 3.763 ± 0.053
1.459ThrGln: 1.459 ± 0.034
3.843ThrArg: 3.843 ± 0.048
2.707ThrSer: 2.707 ± 0.054
2.964ThrThr: 2.964 ± 0.051
4.163ThrVal: 4.163 ± 0.06
0.666ThrTrp: 0.666 ± 0.026
1.197ThrTyr: 1.197 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
10.086ValAla: 10.086 ± 0.111
0.495ValCys: 0.495 ± 0.018
4.346ValAsp: 4.346 ± 0.054
4.094ValGlu: 4.094 ± 0.057
2.208ValPhe: 2.208 ± 0.047
5.456ValGly: 5.456 ± 0.072
1.342ValHis: 1.342 ± 0.034
3.729ValIle: 3.729 ± 0.06
1.806ValLys: 1.806 ± 0.045
6.724ValLeu: 6.724 ± 0.098
1.576ValMet: 1.576 ± 0.034
1.737ValAsn: 1.737 ± 0.04
3.971ValPro: 3.971 ± 0.058
1.913ValGln: 1.913 ± 0.038
5.332ValArg: 5.332 ± 0.068
4.031ValSer: 4.031 ± 0.057
4.706ValThr: 4.706 ± 0.061
5.283ValVal: 5.283 ± 0.08
0.856ValTrp: 0.856 ± 0.027
1.362ValTyr: 1.362 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.489TrpAla: 1.489 ± 0.036
0.114TrpCys: 0.114 ± 0.009
0.696TrpAsp: 0.696 ± 0.024
0.58TrpGlu: 0.58 ± 0.02
0.604TrpPhe: 0.604 ± 0.023
0.951TrpGly: 0.951 ± 0.028
0.379TrpHis: 0.379 ± 0.018
0.724TrpIle: 0.724 ± 0.023
0.438TrpLys: 0.438 ± 0.018
1.777TrpLeu: 1.777 ± 0.04
0.357TrpMet: 0.357 ± 0.016
0.459TrpAsn: 0.459 ± 0.02
0.708TrpPro: 0.708 ± 0.024
0.63TrpGln: 0.63 ± 0.021
1.403TrpArg: 1.403 ± 0.035
0.86TrpSer: 0.86 ± 0.027
0.86TrpThr: 0.86 ± 0.024
0.862TrpVal: 0.862 ± 0.027
0.284TrpTrp: 0.284 ± 0.018
0.309TrpTyr: 0.309 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.816TyrAla: 2.816 ± 0.051
0.229TyrCys: 0.229 ± 0.012
1.581TyrAsp: 1.581 ± 0.035
1.106TyrGlu: 1.106 ± 0.033
0.881TyrPhe: 0.881 ± 0.026
2.112TyrGly: 2.112 ± 0.042
0.52TyrHis: 0.52 ± 0.021
0.848TyrIle: 0.848 ± 0.028
0.514TyrLys: 0.514 ± 0.022
2.129TyrLeu: 2.129 ± 0.043
0.405TyrMet: 0.405 ± 0.017
0.574TyrAsn: 0.574 ± 0.022
1.105TyrPro: 1.105 ± 0.026
0.72TyrGln: 0.72 ± 0.022
1.952TyrArg: 1.952 ± 0.038
1.154TyrSer: 1.154 ± 0.034
1.114TyrThr: 1.114 ± 0.033
1.523TyrVal: 1.523 ± 0.032
0.345TyrTrp: 0.345 ± 0.014
0.629TyrTyr: 0.629 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4251 proteins (1356717 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski